Research Topics
Genomes and Genes | Yujiro TanakaSummaryAffiliation: Tokyo Medical and Dental University Country: Japan Publications
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Detail Information
Publications
Generation of hybrid hepatocytes by cell fusion from monkey embryoid body cells in the injured mouse liverKentaro Okamura
Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, Japan
Histochem Cell Biol 125:247-57. 2006..These results indicate that the differentiated cells in developing monkey EBs, but not contaminating ES cells, generate functional hepatocytes by cell fusion with recipient mouse hepatocytes, and repopulate injured mouse liver...
Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expressionYujiro Tanaka
Genome Structure and Regulation, School of Biomedical Science and Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
PLoS ONE 6:e28171. 2011..Taken together, our data suggest that ASH1 and MLL1 synergize in activation of Hox genes and thereby regulate development of myelomonocytic lineages from haematopoietic stem cells...- Trithorax-group protein ASH1 methylates histone H3 lysine 36Yujiro Tanaka
Genome Structure and Expression, School of Biomedical Science, and Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo, Japan
Gene 397:161-8. 2007..Taken together, our data suggest that ASH1 subfamily of SET domain proteins have K36-specific methyltransferase activities evolutionarily conserved from flies to mammals... - Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathwayYujiro Tanaka
Laboratory of Genome Structure and Regulation, School of Biomedical Science and Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
PLoS ONE 6:e26848. 2011..Taken together, our data reveal an extensive network of stress-inducible transcription factors and demonstrate that ATF3 has opposing, cell context-dependent effects on p53 target genes in DNA damage response and cancer development... - A splice variant of stress response gene ATF3 counteracts NF-kappaB-dependent anti-apoptosis through inhibiting recruitment of CREB-binding protein/p300 coactivatorBayin Hua
Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
J Biol Chem 281:1620-9. 2006.... - Differential usage of alternate promoters of the human stress response gene ATF3 in stress response and cancer cellsKeisuke Miyazaki
Department of Biochemical Genetics, Medical Research Institute and Laboratory of Genome Structure and Regulation, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, 113 8510, Japan
Nucleic Acids Res 37:1438-51. 2009.... - Regulation of early T cell development by the PHD finger of histone lysine methyltransferase ASH1Yujiro Tanaka
Genome Structure and Expression, School of Biomedical Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo 113 8610, Japan
Biochem Biophys Res Commun 365:589-94. 2008..Moreover, the C-terminal part of ASH1 interacts with HDAC1 repression complexes, suggesting that the PHD finger of ASH1 may be involved in down-regulation of genes for normal development of alphabeta T cells... - Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytesRyoko Chinzei
Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Hepatology 36:22-9. 2002..In conclusion, our in vitro and in vivo experiments revealed that cultured EBs contain functional hepatocytes or hepatocyte-like cells... 
Vascular endothelial growth factor promotes proliferation and function of hepatocyte-like cells in embryoid bodies formed from mouse embryonic stem cellsHiroaki Fujimori
Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo 101 0062, Japan
J Hepatol 48:962-73. 2008..The aim of this study was to induce proliferation and function of ESC-derived HLCs in EBs using HLC-endothelial cell interaction...- Expression of the liver-specific gene Cyp7a1 reveals hepatic differentiation in embryoid bodies derived from mouse embryonic stem cellsKinji Asahina
Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
Genes Cells 9:1297-308. 2004..These results demonstrate that ES cells can differentiate in vitro into hepatocytes derived from definitive endoderm... - Rifampicin as an oral angiogenesis inhibitor targeting hepatic cancersMasayoshi Shichiri
Medical Hospital and Department of General Medicine, Tokyo Medical and Dental University Medical Hospital, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Cancer Res 69:4760-8. 2009..Considering the clinical pharmacokinetics of rifampicin, which enters the enterohepatic circulation and undergoes subsequent hepatic accumulation, it may be especially beneficial as an antitumor agent targeting hepatobiliary tumors... - ERas is expressed in primate embryonic stem cells but not related to tumorigenesisYujiro Tanaka
Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan Department of Pediatric Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Cell Transplant 18:381-9. 2009..Therefore, cynomolgus ES cells are more similar to human than mouse ES cells despite that ERas is expressed in cynomolgus and mouse ES cells but not in human ES cells... - Human umbilical cord blood as a source of transplantable hepatic progenitor cellsSei Kakinuma
Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Japan
Stem Cells 21:217-27. 2003..Our findings may have relevance to clinical application of UCB-derived cell transplantation as a novel therapeutic option for liver failure... - Enrichment of hepatocytes differentiated from mouse embryonic stem cells as a transplantable sourceYuji Kumashiro
Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
Transplantation 79:550-7. 2005..CONCLUSIONS: Functional hepatocytes can be differentiated from mouse ES cells by way of EB formation. The elimination of undifferentiated cells from the EBs provides transplantable cells for liver failure without tumorigenicity... - Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferationKiyoshi Tamura
Department of Biochemical Genetics, Medical Research Institute and Laboratory of Genome Structure and Regulation, School of Biomedical Science, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
EMBO J 24:2590-601. 2005..Our results provide a novel insight into the functional link of the stress response gene ATF3 and the proto-oncogene c-myc... - Laparoscopic fundoplication for gastroesophageal reflux disease in infants and childrenTadashi Iwanaka
Department of Pediatric Surgery, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
Surg Today 40:393-7. 2010.... - Hepatocyte differentiation from embryonic stem cells and umbilical cord blood cellsKenichi Teramoto
Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan
J Hepatobiliary Pancreat Surg 12:196-202. 2005..In this review, we consider recent studies of the differentiation of hepatocytes from nonhepatic origins, especially ES cells and umbilical cord blood... - Maternal administration of busulfan before in utero transplantation of human hematopoietic stem cells enhances engraftments in sheepTomoyuki Abe
Department of Agriculture, Utsunomiya University, Tochigi, Japan
Exp Hematol 40:436-44. 2012..72 to 2.4 million CD34(+) cells when BU was used. BU can be administered to pregnant ewes to effectively condition the fetal recipient for IUT with enhanced engraftment of donor cells... - Varicose bleeding after liver transplantation in a patient with severe portosystemic shuntsToshihisa Nosaka
Department of Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
J Gastroenterol 38:700-3. 2003..Based on our experience, extreme care should be exercised to avoid varicose bleeding after ligating the portosystemic shunts of liver transplantation patients... - Improved safety of hematopoietic transplantation with monkey embryonic stem cells in the allogeneic settingHiroaki Shibata
Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
Stem Cells 24:1450-7. 2006..Purging pluripotent cells with this surface marker would be a promising method of producing clinical progenitor cell preparations using human ESCs...