Yujiro Tanaka

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi request reprint Generation of hybrid hepatocytes by cell fusion from monkey embryoid body cells in the injured mouse liver
    Kentaro Okamura
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo, Japan
    Histochem Cell Biol 125:247-57. 2006
  2. pmc Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression
    Yujiro Tanaka
    Genome Structure and Regulation, School of Biomedical Science and Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 6:e28171. 2011
  3. pmc Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway
    Yujiro Tanaka
    Laboratory of Genome Structure and Regulation, School of Biomedical Science and Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 6:e26848. 2011
  4. ncbi request reprint Trithorax-group protein ASH1 methylates histone H3 lysine 36
    Yujiro Tanaka
    Genome Structure and Expression, School of Biomedical Science, and Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo, Japan
    Gene 397:161-8. 2007
  5. ncbi request reprint A splice variant of stress response gene ATF3 counteracts NF-kappaB-dependent anti-apoptosis through inhibiting recruitment of CREB-binding protein/p300 coactivator
    Bayin Hua
    Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    J Biol Chem 281:1620-9. 2006
  6. pmc Differential usage of alternate promoters of the human stress response gene ATF3 in stress response and cancer cells
    Keisuke Miyazaki
    Department of Biochemical Genetics, Medical Research Institute and Laboratory of Genome Structure and Regulation, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, 113 8510, Japan
    Nucleic Acids Res 37:1438-51. 2009
  7. doi request reprint Vascular endothelial growth factor promotes proliferation and function of hepatocyte-like cells in embryoid bodies formed from mouse embryonic stem cells
    Hiroaki Fujimori
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo 101 0062, Japan
    J Hepatol 48:962-73. 2008
  8. ncbi request reprint Regulation of early T cell development by the PHD finger of histone lysine methyltransferase ASH1
    Yujiro Tanaka
    Genome Structure and Expression, School of Biomedical Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo 113 8610, Japan
    Biochem Biophys Res Commun 365:589-94. 2008
  9. ncbi request reprint Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes
    Ryoko Chinzei
    Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Hepatology 36:22-9. 2002
  10. ncbi request reprint Clinical significance of medial approach for suprapancreatic lymph node dissection during laparoscopic gastric cancer surgery
    Toshihiko Shinohara
    Department of Surgery, Machida Municipal Hospital, 2 15 41 Asahicho, Machida, Tokyo, 194 0023, Japan
    Surg Endosc 28:1678-85. 2014

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Generation of hybrid hepatocytes by cell fusion from monkey embryoid body cells in the injured mouse liver
    Kentaro Okamura
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo, Japan
    Histochem Cell Biol 125:247-57. 2006
    ..These results indicate that the differentiated cells in developing monkey EBs, but not contaminating ES cells, generate functional hepatocytes by cell fusion with recipient mouse hepatocytes, and repopulate injured mouse liver...
  2. pmc Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression
    Yujiro Tanaka
    Genome Structure and Regulation, School of Biomedical Science and Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 6:e28171. 2011
    ..Taken together, our data suggest that ASH1 and MLL1 synergize in activation of Hox genes and thereby regulate development of myelomonocytic lineages from haematopoietic stem cells...
  3. pmc Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway
    Yujiro Tanaka
    Laboratory of Genome Structure and Regulation, School of Biomedical Science and Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 6:e26848. 2011
    ..Taken together, our data reveal an extensive network of stress-inducible transcription factors and demonstrate that ATF3 has opposing, cell context-dependent effects on p53 target genes in DNA damage response and cancer development...
  4. ncbi request reprint Trithorax-group protein ASH1 methylates histone H3 lysine 36
    Yujiro Tanaka
    Genome Structure and Expression, School of Biomedical Science, and Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo, Japan
    Gene 397:161-8. 2007
    ..Taken together, our data suggest that ASH1 subfamily of SET domain proteins have K36-specific methyltransferase activities evolutionarily conserved from flies to mammals...
  5. ncbi request reprint A splice variant of stress response gene ATF3 counteracts NF-kappaB-dependent anti-apoptosis through inhibiting recruitment of CREB-binding protein/p300 coactivator
    Bayin Hua
    Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    J Biol Chem 281:1620-9. 2006
    ....
  6. pmc Differential usage of alternate promoters of the human stress response gene ATF3 in stress response and cancer cells
    Keisuke Miyazaki
    Department of Biochemical Genetics, Medical Research Institute and Laboratory of Genome Structure and Regulation, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, 113 8510, Japan
    Nucleic Acids Res 37:1438-51. 2009
    ....
  7. doi request reprint Vascular endothelial growth factor promotes proliferation and function of hepatocyte-like cells in embryoid bodies formed from mouse embryonic stem cells
    Hiroaki Fujimori
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo 101 0062, Japan
    J Hepatol 48:962-73. 2008
    ..The aim of this study was to induce proliferation and function of ESC-derived HLCs in EBs using HLC-endothelial cell interaction...
  8. ncbi request reprint Regulation of early T cell development by the PHD finger of histone lysine methyltransferase ASH1
    Yujiro Tanaka
    Genome Structure and Expression, School of Biomedical Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo 113 8610, Japan
    Biochem Biophys Res Commun 365:589-94. 2008
    ..Moreover, the C-terminal part of ASH1 interacts with HDAC1 repression complexes, suggesting that the PHD finger of ASH1 may be involved in down-regulation of genes for normal development of alphabeta T cells...
  9. ncbi request reprint Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes
    Ryoko Chinzei
    Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Hepatology 36:22-9. 2002
    ..In conclusion, our in vitro and in vivo experiments revealed that cultured EBs contain functional hepatocytes or hepatocyte-like cells...
  10. ncbi request reprint Clinical significance of medial approach for suprapancreatic lymph node dissection during laparoscopic gastric cancer surgery
    Toshihiko Shinohara
    Department of Surgery, Machida Municipal Hospital, 2 15 41 Asahicho, Machida, Tokyo, 194 0023, Japan
    Surg Endosc 28:1678-85. 2014
    ..The aim of this study was to compare surgical outcomes of the medial approach and conventional approach in laparoscopic gastric surgery...
  11. ncbi request reprint Hepatic stellate cells mediate differentiation of dendritic cells from monocytes
    Rie Ozeki
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo 101 0062, Japan
    J Med Dent Sci 59:43-52. 2012
    ..We further found that UCB cells rather differentiated into dendritic-shaped cells by coculture with a human stellate cell (HSC) line, LI90...
  12. ncbi request reprint Expression of the liver-specific gene Cyp7a1 reveals hepatic differentiation in embryoid bodies derived from mouse embryonic stem cells
    Kinji Asahina
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    Genes Cells 9:1297-308. 2004
    ..These results demonstrate that ES cells can differentiate in vitro into hepatocytes derived from definitive endoderm...
  13. doi request reprint Rifampicin as an oral angiogenesis inhibitor targeting hepatic cancers
    Masayoshi Shichiri
    Medical Hospital and Department of General Medicine, Tokyo Medical and Dental University Medical Hospital, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Res 69:4760-8. 2009
    ..Considering the clinical pharmacokinetics of rifampicin, which enters the enterohepatic circulation and undergoes subsequent hepatic accumulation, it may be especially beneficial as an antitumor agent targeting hepatobiliary tumors...
  14. doi request reprint ERas is expressed in primate embryonic stem cells but not related to tumorigenesis
    Yujiro Tanaka
    Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan Department of Pediatric Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cell Transplant 18:381-9. 2009
    ..Therefore, cynomolgus ES cells are more similar to human than mouse ES cells despite that ERas is expressed in cynomolgus and mouse ES cells but not in human ES cells...
  15. ncbi request reprint Human umbilical cord blood as a source of transplantable hepatic progenitor cells
    Sei Kakinuma
    Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Japan
    Stem Cells 21:217-27. 2003
    ..Our findings may have relevance to clinical application of UCB-derived cell transplantation as a novel therapeutic option for liver failure...
  16. ncbi request reprint Enrichment of hepatocytes differentiated from mouse embryonic stem cells as a transplantable source
    Yuji Kumashiro
    Department of Hepato Biliary Pancreatic Surgery, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
    Transplantation 79:550-7. 2005
    ..In the present study, we eliminated the tumorigenic cells from EB outgrowths and examined the effects of enriched ES-cell-derived hepatocyte transplantation into an injured liver...
  17. doi request reprint Laparoscopic fundoplication for gastroesophageal reflux disease in infants and children
    Tadashi Iwanaka
    Department of Pediatric Surgery, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Today 40:393-7. 2010
    ....
  18. pmc Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation
    Kiyoshi Tamura
    Department of Biochemical Genetics, Medical Research Institute and Laboratory of Genome Structure and Regulation, School of Biomedical Science, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
    EMBO J 24:2590-601. 2005
    ..Our results provide a novel insight into the functional link of the stress response gene ATF3 and the proto-oncogene c-myc...
  19. ncbi request reprint Hepatocyte differentiation from embryonic stem cells and umbilical cord blood cells
    Kenichi Teramoto
    Department of Hepato Biliary Pancreatic Surgery, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    J Hepatobiliary Pancreat Surg 12:196-202. 2005
    ..In this review, we consider recent studies of the differentiation of hepatocytes from nonhepatic origins, especially ES cells and umbilical cord blood...
  20. pmc Video-assisted thoracoscopic surgery for localized neurofibroma of the esophagus: case report and review of the literature
    Katsunori Nishikawa
    1 Department of Surgery, Jikei University, Tokyo, Japan
    Int Surg 98:461-5. 2013
    ..This is a rare case of isolated esophageal neurofibroma without classic systemic manifestations of generalized neurofibromatosis, and it is the first reported case treated by video-assisted thoracoscopic surgery. ..
  21. ncbi request reprint Totally laparoscopic complete resection of the remnant stomach for gastric cancer
    Toshihiko Shinohara
    Department of Surgery, Machida Municipal Hospital, 2 15 41 Asahicho, Machida, Tokyo, Japan
    Langenbecks Arch Surg 398:341-5. 2013
    ..In patients having carcinoma in the remnant stomach, total resection of the remnant stomach with lymph node dissection is a prerequisite...
  22. doi request reprint Maternal administration of busulfan before in utero transplantation of human hematopoietic stem cells enhances engraftments in sheep
    Tomoyuki Abe
    Department of Agriculture, Utsunomiya University, Tochigi, Japan
    Exp Hematol 40:436-44. 2012
    ..72 to 2.4 million CD34(+) cells when BU was used. BU can be administered to pregnant ewes to effectively condition the fetal recipient for IUT with enhanced engraftment of donor cells...
  23. ncbi request reprint Varicose bleeding after liver transplantation in a patient with severe portosystemic shunts
    Toshihisa Nosaka
    Department of Surgery, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Gastroenterol 38:700-3. 2003
    ..Based on our experience, extreme care should be exercised to avoid varicose bleeding after ligating the portosystemic shunts of liver transplantation patients...
  24. ncbi request reprint Improved safety of hematopoietic transplantation with monkey embryonic stem cells in the allogeneic setting
    Hiroaki Shibata
    Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Stem Cells 24:1450-7. 2006
    ..Purging pluripotent cells with this surface marker would be a promising method of producing clinical progenitor cell preparations using human ESCs...