K Takubo

Summary

Affiliation: Tokyo Metropolitan Institute of Gerontology
Country: Japan

Publications

  1. ncbi request reprint Telomere shortening with aging in human liver
    K Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    J Gerontol A Biol Sci Med Sci 55:B533-6. 2000
  2. doi request reprint [Lymph node metastasis in superficial squamous carcinoma of the esophagus]
    K Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, and Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan
    Pathologe 34:148-54. 2013
  3. pmc Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Breast Cancer Res 11:R48. 2009
  4. doi request reprint Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Mech Ageing Dev 131:614-24. 2010
  5. ncbi request reprint Telomere lengths are characteristic in each human individual
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173 0015, Japan
    Exp Gerontol 37:523-31. 2002
  6. ncbi request reprint Oncocytic adenocarcinoma of the stomach: parietal cell carcinoma
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology and Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Am J Surg Pathol 26:458-65. 2002
  7. ncbi request reprint Ciliated surface in the esophagogastric junction zone: a precursor of Barrett's mucosa or ciliated pseudostratified metaplasia?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Am J Surg Pathol 29:211-7. 2005
  8. ncbi request reprint Islands of squamous epithelium and their surrounding mucosa in columnar-lined esophagus: a pathognomonic feature of Barrett's esophagus?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Japan
    Hum Pathol 36:269-74. 2005
  9. ncbi request reprint Detection of human papillomavirus infection of the cervix in very elderly women using PCR
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Clin Cancer Res 11:2919-23. 2005
  10. ncbi request reprint Early squamous cell carcinoma of the oesophagus: the Japanese viewpoint
    K Takubo
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Histopathology 51:733-42. 2007

Detail Information

Publications44

  1. ncbi request reprint Telomere shortening with aging in human liver
    K Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    J Gerontol A Biol Sci Med Sci 55:B533-6. 2000
    ..Despite the slow turnover of liver tissue, the overall reduction rate of telomere length decrease in 1 year was almost the same as that of digestive tract mucosa, with its very rapid renewal...
  2. doi request reprint [Lymph node metastasis in superficial squamous carcinoma of the esophagus]
    K Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, and Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan
    Pathologe 34:148-54. 2013
    ....
  3. pmc Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Breast Cancer Res 11:R48. 2009
    ..The aim of the present study is to elucidate whether there are any specific patterns in use of multiple exons 1 in elderly breast tissue...
  4. doi request reprint Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Mech Ageing Dev 131:614-24. 2010
    ..6%). Our results indicate that chromosomes having excessively shortened telomeres at late PDLs begin to show features of instability such as fusions and anaphase bridges...
  5. ncbi request reprint Telomere lengths are characteristic in each human individual
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173 0015, Japan
    Exp Gerontol 37:523-31. 2002
    ..However, there is no simple link between telomeres and tissue turnover. We recently proposed a hypothesis that telomere shortening with aging and telomere lengths in different organs are characteristic for human individuals...
  6. ncbi request reprint Oncocytic adenocarcinoma of the stomach: parietal cell carcinoma
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology and Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Am J Surg Pathol 26:458-65. 2002
    ..Previously reported cases of parietal cell carcinoma have been said to have a favorable prognosis, but it will be necessary to study a larger number of cases to determine the prognosis of oncocytic adenocarcinoma...
  7. ncbi request reprint Ciliated surface in the esophagogastric junction zone: a precursor of Barrett's mucosa or ciliated pseudostratified metaplasia?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Am J Surg Pathol 29:211-7. 2005
    ..These findings may suggest that squamous metaplasia-like change at the EGJ is not a precursor of Barrett's mucosa but rather is a form of pseudostratified metaplasia...
  8. ncbi request reprint Islands of squamous epithelium and their surrounding mucosa in columnar-lined esophagus: a pathognomonic feature of Barrett's esophagus?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Japan
    Hum Pathol 36:269-74. 2005
    ..From a practical point of view, biopsy specimens from columnar-lined mucosa of the esophagus do not always show intestinal metaplasia (specialized intestinal metaplasia)...
  9. ncbi request reprint Detection of human papillomavirus infection of the cervix in very elderly women using PCR
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Clin Cancer Res 11:2919-23. 2005
    ....
  10. ncbi request reprint Early squamous cell carcinoma of the oesophagus: the Japanese viewpoint
    K Takubo
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Histopathology 51:733-42. 2007
    ..As a result of advances in the development of endoscopes, pathologists are now expected to diagnose very minute lesions, < 1 mm in size, in the oesophagus...
  11. doi request reprint The normal anatomy around the oesophagogastric junction: a histopathologic view and its correlation with endoscopy
    Kaiyo Takubo
    Research Team for Geriatric Diseases Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Sakae cho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Best Pract Res Clin Gastroenterol 22:569-83. 2008
    ..The nature of the OGJ is clarified in detail through comparison between endoscopically evident and histological features...
  12. doi request reprint Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma
    Kaiyo Takubo
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Hum Pathol 40:65-74. 2009
    ..Also, it seems better to define Barrett esophagus as metaplastic columnar-lined esophagus alone, without requiring the presence of goblet cells, in accordance with histogenetic and practical standpoints...
  13. doi request reprint Differences in the definitions used for esophageal and gastric diseases in different countries: endoscopic definition of the esophagogastric junction, the precursor of Barrett's adenocarcinoma, the definition of Barrett's esophagus, and histologic criteri
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology and Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Digestion 80:248-57. 2009
    ..Definitions and opinions in the field of gastroenterology vary widely in different countries...
  14. doi request reprint Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    J Pathol 221:201-9. 2010
    ..We have demonstrated conclusively that oesophageal CIS arises from epithelium with short telomeres and chromosomal instability in the absence of histological inflammation...
  15. doi request reprint Changes of telomere length with aging
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 10:S197-206. 2010
    ..Our Q-FISH method using our original software program "Tissue Telo" is excellent for measuring telomere lengths using tissue sections and PNA probes...
  16. ncbi request reprint Is there a set of histologic changes that are invariably reflux associated?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Sakae cho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Arch Pathol Lab Med 129:159-63. 2005
    ..To develop a set of characteristic reflux-associated features, endoscopists may perform targeted biopsies from several sites with various endoscopic features and at different stages of disease...
  17. ncbi request reprint Barrett's adenocarcinoma of the esophagus with lymphoid stroma
    K Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Clin Gastroenterol 33:141-4. 2001
    ..The data suggest that this tumor arose as a mucosal, well-differentiated adenocarcinoma without lymphoid stroma and that EBV had no relation to either its pathogenesis or progression...
  18. ncbi request reprint Effectiveness of preoperative chemotherapy using carboplatin (CBDCA) and surgery against an esophageal small cell carcinoma
    H Makino
    Department of Surgery I, Nippon Medical School, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Dis Esophagus 15:237-41. 2002
    ..5 x 0.5 cm. The lesion consisted mainly of small anaplastic cells, but included a small focus of squamous cell carcinoma. The patient has survived for more than 7 months with no further treatment and no evidence of recurrent disease...
  19. ncbi request reprint Correlation of telomere lengths in normal and cancers tissue in the large bowel
    K Nakamura
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, 32 5, Sakaecho Itabashi ku, 173 0015, Tokyo, Japan
    Cancer Lett 158:179-84. 2000
    ..Straight, essentially parallel, lines were obtained for the two cases, normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level...
  20. ncbi request reprint Combined modality therapy for basaloid squamous carcinoma of the esophagus
    Y Tsuchiya
    First Department of Surgery, Nippon Medical School, Tokyo, Japan
    Hepatogastroenterology 46:2868-71. 1999
    ..Chemotherapy and radiotherapy resulted in the disappearance of the metastasis. The patient has survived for more than 3 years since surgery with a good quality of life...
  21. ncbi request reprint A case of bone metastasis from gastric carcinoma after a nine-year disease-free interval
    M Kammori
    Department of Gastrointestinal Surgery, The University of Tokyo, Tokyo, Japan
    Jpn J Clin Oncol 31:407-9. 2001
    ..Remission was achieved and she survived for a further 13 months without major symptoms...
  22. ncbi request reprint Telomerase activity in esophageal carcinoma
    K Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    J Surg Oncol 66:88-92. 1997
    ..In patients with esophageal carcinoma, no data have been reported concerning the relationship between telomerase activity and clinicopathological findings...
  23. ncbi request reprint Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast
    N Honma
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo, Japan
    Histopathology 47:195-201. 2005
    ..Apocrine lesions reportedly exhibit an unusual immunohistochemical status, expressing androgen receptors (AR) instead of oestrogen receptors (ER), progesterone receptors (PR), or bcl-2. Their expression was also examined...
  24. ncbi request reprint Expression of oestrogen receptor-beta in apocrine carcinomas of the breast
    N Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Histopathology 50:425-33. 2007
    ..The aim was to study ER-beta status in apocrine carcinoma...
  25. ncbi request reprint Cyclin D1 overexpression as a prognostic factor in patients with esophageal carcinoma
    S Nagasawa
    Department of Surgery I, Nippon Medical School, Tokyo, Japan
    J Surg Oncol 78:208-14. 2001
    ..We investigated the correlation between cyclin D1 overexpression and clinical characteristics to clarify its prognostic significance in patients with esophageal cancer...
  26. ncbi request reprint Wide-spread distribution of sentinel lymph nodes in esophageal cancer
    T Nomura
    Department of Surgery I, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 68:393-6. 2001
    ..The sentinel nodes were broadly distributed depending on the location of the tumor in esophageal cancer...
  27. ncbi request reprint Telomere shortening in gastric carcinoma with aging despite telomerase activation
    E Furugori
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    J Cancer Res Clin Oncol 126:481-5. 2000
    ....
  28. ncbi request reprint Primary malignant melanoma of the esophagus treated by esophagectomy and systemic chemotherapy
    T Matsutani
    Department of Surgery I, Nippon Medical School, Tokyo, Japan
    Dis Esophagus 14:241-4. 2001
    ..Malignant melanoma of the esophagus has an extremely poor prognosis despite various therapeutic efforts...
  29. ncbi request reprint Multiple primary malignant neoplasms in patients with esophageal cancer
    S Nagasawa
    Department of Surgery I, Nippon Medical School, Tokyo, Japan
    Dis Esophagus 13:226-30. 2000
    ..Frequent examination in these cancer patients, using fiberoptic esophagogastric endoscopy for example, may be helpful in the early diagnosis of esophageal cancer...
  30. ncbi request reprint Three-dimensional organization of the hepatic microvasculature in hereditary hemorrhagic telangiectasia
    M Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Arch Pathol Lab Med 125:1219-23. 2001
    ..The 3-dimensional reconstruction study of hepatic microvasculature was successful in identifying the pathological changes responsible for the intrahepatic shunts in HHT...
  31. ncbi request reprint Early carcinoma of the distal second part of the duodenum treated by wedge resection
    Y Tanaka
    Department of Gastroenterology and Hepatology, Tokyo Metropolitan Geriatric Hospital, Japan
    J Clin Gastroenterol 28:67-9. 1999
    ..However, this requires careful observation of the entire duodenal mucosa, including that of the distal duodenum, at duodenoscopy...
  32. ncbi request reprint Effects of preoperative chemotherapy on metastatic lymph nodes in esophageal squamous cell carcinoma
    Y Tsuchiya
    Department of Surgery I, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Dis Esophagus 15:226-31. 2002
    ..07). Preoperative chemotherapy reduced the number of metastatic lymph nodes and may contribute to improving the outcome of the patients who have undergone esophagectomy for squamous cell carcinoma of the esophagus...
  33. doi request reprint Detailed comparison between endocytoscopy and horizontal histology of an esophageal intraepithelial squamous cell carcinoma
    M Fujishiro
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Dis Esophagus 21:181-5. 2008
    ..Further horizontal histological investigations of this case also showed the variety of endocytoscopic images in non-cancerous and cancerous epithelia...
  34. ncbi request reprint Fulminant hepatic failure in the elderly: a clinicopathological study of autopsy cases aged over 65 years
    M Sawabe
    Departments of Pathology and Internal Medicine, Tokyo Metropolitan Geriatric Hospital, Tokyo
    Pathol Int 50:98-105. 2000
    ..However, impaired hepatic regeneration is occasionally observed in the elderly cases and AH-BHN is often lethal because of frequent underlying diseases and severe complications...
  35. ncbi request reprint Multiple colorectal cancers in the elderly: a retrospective study of both surgical and autopsy cases
    T Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Japan
    J Gastroenterol 36:748-52. 2001
    ..CONCLUSIONS: These results indicate that the incidence of multiple CRCs in elderly patients with CRC is approximately 8%-10%, with no age-related difference, while extracolorectal malignancies increase with advancing age...
  36. ncbi request reprint Ex-vivo study of high-magnification chromoendoscopy in the gastrointestinal tract to determine the optimal staining conditions for endocytoscopy
    S Kodashima
    Department of Gastroenterology, The University of Tokyo, Tokyo, Japan
    Endoscopy 38:1115-21. 2006
    ..Consistently clear views are essential for clinical application of the technique, but these are not always obtained. The aim of this study was to determine an appropriate staining regimen for endocytoscopy...
  37. ncbi request reprint Liver abscesses associated with stromal tumour of the stomach in a young woman
    T Matsutani
    Department of Surgery I, Nippon Medical School, Tokyo, Japan
    Eur J Gastroenterol Hepatol 13:1485-9. 2001
    ..This is a rare case of a liver abscess associated with a stromal tumour of the stomach in a young patient. The bacteriological examinations suggested a possible association between these diseases...
  38. ncbi request reprint Hepatocellular carcinoma arising in an elderly male with primary biliary cirrhosis
    Y Tanaka
    Department of Gastroenterology, Tokyo Metropolitan Geriatric Hospital, Japan
    Eur J Gastroenterol Hepatol 12:239-41. 2000
    ..We believe that, to date, this is the oldest reported patient to have had interventional radiology for the management of HCC...
  39. ncbi request reprint Breast carcinoma in women over the age of 85: distinct histological pattern and androgen, oestrogen, and progesterone receptor status
    N Honma
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Department of Breast Pathology, Cancer Institute, Tokyo, Japan
    Histopathology 42:120-7. 2003
    ..In an effort to understand the pathogenesis of breast carcinoma in these women, this study was undertaken to compare the histological patterns and hormone receptor status of breast carcinomas arising in very elderly and younger women...
  40. ncbi request reprint Primary adenocarcinoma of the duodenum in the elderly: clinicopathological and immunohistochemical study of 17 cases
    T Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Japan
    Pathol Int 49:23-9. 1999
    ..Furthermore, it is concluded that invasive duodenal adenocarcinomas with high PR should be considered as potentially aggressive tumors, although their histology may indicate a high degree of differentiation...
  41. ncbi request reprint Reconstruction of the portal vein using a peritoneal patch-graft
    M Yoshioka
    First Department of Surgery, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, 113 8603, Tokyo, Japan
    Am J Surg 181:247-50. 2001
    ..Prosthetic material is associated with an increased risk of infection. We therefore created an animal model of portal vein reconstruction using the peritoneum...
  42. ncbi request reprint Immunohistochemical prognostic indicators of gastrointestinal carcinoid tumours
    M Kawahara
    Department of Gastroenterological Surgery, University of Tokyo, Tokyo, Japan
    Eur J Surg Oncol 28:140-6. 2002
    ..The aim of this study was to determine whether expression of the oncoproteins p21, p53, E-cadherin (EC), cyclin D1, bcl-2 and Rb and the proliferation marker Ki-67 is predictive of malignant behaviour in gastrointestinal carcinoid tumours...
  43. ncbi request reprint Clinicopathological characteristics of left ventricular myocardium with transient asynergy: report of three cases
    K Chida
    Division of Cardiology, Tokyo Metropolitan Geriatric Hospital, Japan
    Jpn Heart J 42:235-48. 2001
    ..In conclusion, left ventricular myocardium with transient asynergy. detected clinically during acute ischemic attack, consists of normal myocardium or small ischemic lesions primarily in the subendocardium...
  44. ncbi request reprint Ex vivo pilot study using computed analysis of endo-cytoscopic images to differentiate normal and malignant squamous cell epithelia in the oesophagus
    S Kodashima
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan
    Dig Liver Dis 39:762-6. 2007
    ..To simplify discrimination between normal and malignant tissue in the oesophagus using endo-cytoscopy system, we analysed the nuclear (dark staining) area in the obtained images with the goal of an accurate, automatic diagnosis...