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Genomes and Genes | Masaru TakeuchiSummaryAffiliation: Tokyo Medical University Country: Japan Publications
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Publications
Residual triamcinolone acetonide in the macular hole after vitrectomyMasaru Takeuchi
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Am J Ophthalmol 136:1174-6. 2003..To report a case of vitrectomy using intraocular triamcinolone acetonide (TA), in which TA remained in the macular hole after surgery...- Possibility of inducing anterior chamber-associated immune deviation by TGF-beta2 treatment of monocytes isolated from Behcet's patientsMasaru Takeuchi
Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku, Tokyo 160 0023, Japan
Exp Eye Res 83:981-8. 2006..These results suggest a possibility that adherent monocytes isolated from BD patients may acquire a property to induce ACAID by treatment with TGF-beta2... 
Effects of dioxin on vascular endothelial growth factor (VEGF) production in the retina associated with choroidal neovascularizationAya Takeuchi
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Invest Ophthalmol Vis Sci 50:3410-6. 2009..However, the effects of dioxins on the eye remain elusive. In this study, the authors examined the association between dioxins and neovascularization in the eye...- Risk and prognostic factors of poor visual outcome in Behcet's disease with ocular involvementMasaru Takeuchi
Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
Graefes Arch Clin Exp Ophthalmol 243:1147-52. 2005..The purpose of the study was to determine factors correlated with the progression of irreversible visual disturbance in Behcet's disease (BD) with ocular involvement... - Elevated serum levels of CXCL9/monokine induced by interferon-gamma and CXCL10/interferon-gamma-inducible protein-10 in ocular sarcoidosisMasaru Takeuchi
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Invest Ophthalmol Vis Sci 47:1063-8. 2006..Chemokines are required for the extravasation of leukocytes to the inflammation site. This study was undertaken to determine which chemokines are augmented in the serum of patients with active ocular sarcoidosis... - Immune responses to retinal self-antigens in CD25(+)CD4(+) regulatory T-cell-depleted miceMasaru Takeuchi
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Invest Ophthalmol Vis Sci 45:1879-86. 2004.... 
Coxsackievirus B4 associated uveoretinitis in an adultM Takeuchi
Tokyo Medical University, 6-7-1 Nishishinjuku Shinjuku-ku, Tokyo, Japan
Br J Ophthalmol 87:501-2. 2003- Immune responses to interphotoreceptor retinoid-binding protein and S-antigen in Behcet's patients with uveitisMasaru Takeuchi
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Invest Ophthalmol Vis Sci 51:3067-75. 2010..In this study, the authors examined whether immune responses to IRBP and S-Ag in BD patients can be characterized by cytokine production profiles... - Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in miceYoshihiko Usui
Department of Ophthalmology, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
Arch Ophthalmol 127:514-9. 2009..To examine the effects of bone marrow-derived regulatory dendritic cells (DCs) with potent immunoregulatory properties on the development of experimental autoimmune uveoretinitis (EAU)... - Expression and function of inducible costimulator on peripheral blood CD4+ T cells in Behçet's patients with uveitis: a new activity marker?Yoshihiko Usui
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Invest Ophthalmol Vis Sci 51:5099-104. 2010..Inducible costimulator (ICOS) is an important costimulatory molecule involved in T-cell activation. In this study, the role of ICOS in the pathogenesis of uveitis in Behçet's disease (BD) was investigated... - Suppression of experimental autoimmune uveoretinitis by inducing differentiation of regulatory T cells via activation of aryl hydrocarbon receptorLina Zhang
Departments of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Invest Ophthalmol Vis Sci 51:2109-17. 2010..Conclusions. Activation of AHR by TCDD markedly suppressed autoimmune uveoretinitis through mechanisms that expand CD25(+)Foxp3(+) T(reg) cells and interfere with the activation of Th1 and Th17 cells... - Suppression of bystander T helper 1 cells by iris pigment epithelium-inducing regulatory T cells via negative costimulatory signalsSunao Sugita
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
Invest Ophthalmol Vis Sci 51:2529-36. 2010..To determine whether iris pigment epithelium (IPE)-induced T regulatory (Treg) cells can suppress the activation of bystander T cells with cell contact via costimulatory interactions... - Suppression of experimental autoimmune uveitis by angiotensin II type 1 receptor blocker telmisartanYoko Okunuki
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Invest Ophthalmol Vis Sci 50:2255-61. 2009..The aim of this study was to examine whether blockade of AT1-R is effective in the suppression of murine experimental autoimmune uveoretinitis (EAU)... - The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitisYoshihiko Usui
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
Eur J Immunol 36:3071-81. 2006..We also indicated that ICOS-mediated costimulation plays differential roles in EAU and experimental autoimmune encephalomyelitis, which is also a Th1 disease induced in the same manner as EAU... - T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditionsSunao Sugita
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
Invest Ophthalmol Vis Sci 50:2862-70. 2009..To determine whether retinal pigment epithelial (RPE) cells can inhibit in vitro T-cell activation during inflammatory conditions... - Functional expression of B7H1 on retinal pigment epithelial cellsYoshihiko Usui
Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
Exp Eye Res 86:52-9. 2008..These data suggest that B7H1 expressed on RPE cells plays an immunosuppressive role in ocular inflammation, which may contribute to immune privilege in the posterior segment of the eye... - CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context of a deviant effector responseAya Takeuchi
Department of Ophthalmology, Tokyo Medical University, Japan
Invest Ophthalmol Vis Sci 46:3753-60. 2005..In CCR5-deficient mice, we examined the role of CCR5 in the development of EAU induced by immunization with interphotoreceptor retinoid-binding protein (IRBP) peptide... - Upregulation of neurotrophic factor-related gene expression in retina with experimental autoimmune uveoretinitis by intravitreal injection of tacrolimus (FK506)Keiko Oh i
Department of Ophthalmology, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo, Japan 160 0023
Br J Ophthalmol 91:1537-40. 2007.... - Alpha-internexin as a corneal autoantigen in spontaneous autoimmune keratitis mouse modelTakaaki Hattori
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Invest Ophthalmol Vis Sci 47:249-55. 2006..CONCLUSIONS: These results suggest that alpha-internexin is one of the corneal antigens associated with keratitis, developing spontaneously in TG-nude mice, with a probable pathogenic role... - Proteomic surveillance of retinal autoantigens in endogenous uveitis: implication of esterase D and brain-type creatine kinase as novel autoantigensYoko Okunuki
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Mol Vis 14:1094-104. 2008..In this study, we aimed to investigate the possibility of such spreading of autoantigens in endogenous uveoretinitis using a proteomic approach... - Intravitreal injection of Tacrolimus (FK506) suppresses ongoing experimental autoimmune uveoretinitis in RatsKeiko Oh-I
Department of Ophthalmology, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
Br J Ophthalmol 91:237-42. 2007..To determine whether intravitreal injection of tacrolimus suppresses ongoing experimental autoimmune uveoretinitis (EAU) in rats... - Human uveal melanoma cells inhibit the immunostimulatory function of dendritic cellsJuan Ma
Department of Ophthalmology, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
Exp Eye Res 91:491-9. 2010..These findings suggest a mechanism by which uveal melanoma escape immune destruction and have significant implications for tumor-pulsed dendritic cell vaccines for the treatment of uveal melanoma... - Prevention of experimental autoimmune uveoretinitis by vasoactive intestinal peptideHiroshi Keino
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Arch Ophthalmol 122:1179-84. 2004..08). CONCLUSION: Treatment with VIP is a highly effective therapy to suppress EAU. CLINICAL RELEVANCE: As a result of its efficacy in preventing EAU, VIP might be considered as a novel therapeutic modality for human uveitis... - Blockade of the OX40 ligand prolongs corneal allograft survivalTakaaki Hattori
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Eur J Immunol 37:3597-604. 2007..These results demonstrate that OX40L blockade is effective for prolongation of corneal allograft survival by inhibiting recipient T cell activation... - Human iris pigment epithelial cells suppress T-cell activation via direct cell contactTakaaki Hattori
Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
Exp Eye Res 89:358-64. 2009..Our data indicates that cultured hIPE cells inhibit T-cell activation by T-cell receptor ligation, which is mediated by cell-to-cell contact in part via the PD-L1 and PD-L2 pathways... - Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathyYoshihiro Wakabayashi
Department of Ophthalmology, Hachiouji Medical Center, Tokyo Medical University, Tokyo, Japan
Retina 31:1951-7. 2011..To investigate whether concurrent hypertension affects vitreous cytokine levels in diabetic retinopathy... - Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditionsSunao Sugita
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Tokyo, Japan
J Immunol 183:5013-22. 2009..In both EAU models, there was significant suppression of the ocular inflammation. These results indicate that RPE secretes CTLA-2alpha, thereby enabling the bystander T cells to be converted into Treg cells via TGF-beta promotion... - Expression of costimulatory molecules on human retinoblastoma cells Y-79: functional expression of CD40 and B7H1Yoshihiko Usui
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Invest Ophthalmol Vis Sci 47:4607-13. 2006..The dual effects of CD40 and B7H1 on Y-79 cells may contribute to positive or negative regulation of antitumor immune responses in human retinoblastoma... - Circulating neutrophils in Behçet disease is resistant for apoptotic cell death in the remission phase of uveitisKeita Fujimori
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Graefes Arch Clin Exp Ophthalmol 246:285-90. 2008..Hypopyon consists of inflammatory cells infiltrating the eye, with polymorphonuclear cells (PMNs) as the main component. The present study was conducted to investigate the apoptosis property of PMNs in BD patients with uveitis... - Functional and morphological changes in the eyes of Behçet's patients with uveitisMasaru Takeuchi
Department of Ophthalmology, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
Acta Ophthalmol 88:257-62. 2010..In this study, we evaluated the morphological and functional changes of ocular features related to duration of uveitis from onset in BD patients, and analysed their association with visual acuity... - Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathyYoshihiro Wakabayashi
Department of Ophthalmology, Hachiouji Medical Center of Tokyo Medical University, Tokyo, Japan
Retina 30:339-44. 2010.... - Relation of intraocular concentrations of inflammatory factors and improvement of macular edema after vitrectomy in branch retinal vein occlusionYoko Okunuki
Department of Ophthalmology, Hachioji Medical Center of Tokyo Medical University, Tokyo, Japan
Am J Ophthalmol 151:610-616.e1. 2011..To investigate the association of intraocular concentrations of inflammatory factors and improvement of macular edema after vitrectomy for patients with macular edema in branch retinal vein occlusion (BRVO)... - Presumed Vogt-Koyanagi-Harada disease with unilateral ocular involvement: report of three casesYoshihiko Usui
Department of Ophthalmology, Tokyo Medical University Hospital, 6 7 1 Nishihinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
Graefes Arch Clin Exp Ophthalmol 247:1127-32. 2009..To report three cases of presumed Vogt-Koyanagi-Harada (VKH) disease with unilateral ocular manifestations... - Four cases of bilateral acute retinal necrosis with a long interval after the initial onsetYoko Okunuki
Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjyuku, Shinjyuku ku, Tokyo 160 0023, Japan
Br J Ophthalmol 95:1251-4. 2011..To report the clinical features and causative virus of bilateral acute retinal necrosis (BARN) with a long interval after the initial onset... - Peritoneal exudate cells treated with calcitonin gene-related peptide suppress murine experimental autoimmune uveoretinitis via IL-10Takeshi Kezuka
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
J Immunol 173:1454-62. 2004..The present results indicate that PEC treated with CGRP suppress murine EAU in an Ag-specific manner, even in the efferent phase, and IL-10 secreted from PEC might play an important role in the CGRP-mediated suppression of murine EAU... - Roles of CD4+CD25+ T cells in the development of experimental murine allergic conjunctivitisAtsuki Fukushima
Department of Ophthalmology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, 783 8505, Japan
Graefes Arch Clin Exp Ophthalmol 245:705-14. 2007..We therefore investigated whether T reg cells play a role in the development of experimental AC (EC)... - Thymus-derived CD4+ CD25+ T cells suppress the development of murine allergic conjunctivitisTamaki Sumi
Department of Ophthalmology, Kochi Medical School, Nankoku City, Japan
Int Arch Allergy Immunol 143:276-81. 2007..Taken together, these results suggest that CD4+ CD25+ T cells regulate the development of EC... - Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviationRintaro Tsukahara
Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
Int Immunol 17:523-30. 2005..The present results indicated that CD80 and CD86 play a critical role in induction of ACAID, possibly by co-stimulating expansion and IL-10 production of regulatory T cells in response to TGF-beta-conditioned APC... - [Pars plana vitrectomy in patients with acute retinal necrosis syndrome: surgical results in 52 patients]Yoshihiko Usui
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Nihon Ganka Gakkai Zasshi 114:362-8. 2010..To analyze results of pars plana vitrectomy for acute retinal necrosis (ARN) syndrome... - Immune tolerance and autoimmune uveoretinitis: the role of the ocular microenvironmentMasaru Takeuchi
Department of Ophthalmology, National Defense Medical College, 3 2 Namiki Tokorozawa Saitama, 359 8513, Japan
Immunotherapy 3:1103-11. 2011..In addition, the eye is an immune privileged site where indigenous immunomodulatory mechanisms allow immune protection of the eye in a manner that is largely devoid of immunogenic inflammation... - Effects of 3-methylcholanthrene on the transcriptional activity and mRNA accumulation of the oncogene hWAPLMasahiko Kuroda
Department of Pathology, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, Tokyo 160 8402, Japan
Cancer Lett 221:21-8. 2005..Furthermore, mRNA level of a mouse homolog of hWAPL in mouse uterus was induced by 3-MC injection into the abdominal cavity. Thus, some effects from 3-MC exposure on uterus may be mediated by the unscheduled overexpression of hWAPL... - Clinical evaluation of blue-light blocker foldable acrylic IOL (HMY)Tsuyoshi Hibino
Department of Ophthalmology, Kinki University School of Medicine, Osaka, Japan
Ann Ophthalmol (Skokie) 38:311-6. 2006..8% of them achieved higher than 6/6. The rate of mean corneal endothelial cell density decrease stood at 5.0%. Mild complications were observed, but none were serious... - Type I interferons as immunoregulatory molecules; implications for therapy in experimental autoimmune uveoretinitisJunichiro Mizuguchi
Department of Immunology, Tokyo Medical University, Japan
Arch Immunol Ther Exp (Warsz) 50:243-54. 2002..Thus, the immuno-modulatory action of IFN-alpha/beta may be dependent on the context of cytokine combination and/or their concentrations... - A relationship between varicella-zoster virus-specific delayed hypersensitivity and varicella-zoster virus-induced anterior uveitisTakeshi Kezuka
Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, 1163, Tate machi, Hachioji City, Tokyo, 193 8639, Japan
Arch Ophthalmol 120:1183-8. 2002.... - A case of sebaceous adenoma of the eyelid showing excessively rapid growthKei Takayama
Department of Ophthalmology, National Defense Medical College, Tokorozawa, Saitama, Japan
Clin Ophthalmol 7:667-70. 2013..Sebaceous adenomas are found mainly in elderly individuals and are usually tan, pink, or yellow nodules or papules, usually approximately 5 mm in the largest size... - The 2009 prospective multi-center epidemiologic survey of uveitis in JapanNobuyuki Ohguro
Japanese Ocular Inflammation Society, Tokyo, Japan
Jpn J Ophthalmol 56:432-5. 2012..To investigate etiologic data on intraocular inflammation in Japan collected in the 2009 epidemiologic survey of uveitis in Japan and assess the current state of etiology compared with that reported in a previous survey... - [A case of neuromyelitis optica presenting ileus as a neurologic finding]Kei Takayama
Department of Ophthalmology, National Defense Medical College, Japan
Nihon Ganka Gakkai Zasshi 116:967-71. 2012..To report an atypical case of neuromyelitis optica (NMO) with Sjögren syndrome that presented only ileus as a neurologic finding... - Non-aspiration technique to induce posterior vitreous detachment in minimum incision vitrectomy systemMasaru Takeuchi
Department of Ophthalmology, National Defense Medical College, 3 2 Namiki Tokorozawa, Saitama 359 8513, Japan
Br J Ophthalmol 96:1378-9. 2012..Complete PVD is confirmed by observation of the Weiss ring in front of the retina. Using this technique, PVD can be achieved in vitrectomies using MIVS, even when the posterior hyaloid attaches tightly to the retina... - Differentiation of Th1 and Th2 cells in lymph nodes and spleens of mice during experimental autoimmune uveoretinitisM Takeuchi
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Jpn J Ophthalmol 45:463-9. 2001..Th2-type responses were generated in the spleen only as the disease receded, suggesting a role for Th2 cells in the spontaneous termination of EAU... - Identification of Th2-type suppressor T cells among in vivo expanded ocular T cells in mice with experimental autoimmune uveoretinitisH Keino
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
Clin Exp Immunol 124:1-8. 2001..These findings demonstrate that p518-529 reactive Th2-type T cells expand oligoclonally in the uveitic eyes in the late stage of EAU and may function as Th2-type suppressor T cells for improvement of the disease... - Supplementation of CD4+CD25+ regulatory T cells suppresses experimental autoimmune uveoretinitisH Keino
Department of Ophthalmology, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
Br J Ophthalmol 91:105-10. 2007..To investigate whether supplementation of natural CD4+CD25+ regulatory T cells ameliorates mouse experimental autoimmune uveoretinitis (EAU) induced by CD4+ T cell-dependent interphotoreceptor retinoid-binding protein (IRBP)... - The eye's view of antigen presentationJ Wayne Streilein
Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
Hum Immunol 63:435-43. 2002..The lack of these potent stimulators of Th1 cell differentiation is central to the induction of ACAID... - Chemokine and chemokine receptor expression during experimental autoimmune uveoretinitis in miceHiroshi Keino
Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
Graefes Arch Clin Exp Ophthalmol 241:111-5. 2003.... - Acute retinal necrosis in JapanYoshihiko Usui
Ophthalmology 115:1632-3. 2008 - Proteomic surveillance of autoimmunity in Behcet's disease with uveitis: selenium binding protein is a novel autoantigen in Behcet's diseaseYoko Okunuki
Department of Bioregulation and Proteomics, Institute of Medical Science, St Marianna University School of Medicine, 2 16 1 Sugao, Kawasaki, Kanagawa 216 8512, Japan
Exp Eye Res 84:823-31. 2007..Autoimmunity against the retinal SBP may contribute to the pathogenesis of uveitis in BD patients... - Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cellsHiroshi Keino
Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
Invest Ophthalmol Vis Sci 47:1047-55. 2006..Finally, OVA induced ACAID in mice depleted of CD25+ cells. CONCLUSIONS: Some of the CD4+ T regs of ACAID arise from CD25- precursors, and the induction of ACAID is not dependent on the presence of natural CD4+CD25+ T regs...