Masaru Takeuchi

Summary

Affiliation: Tokyo Medical University
Country: Japan

Publications

  1. ncbi request reprint Immune responses to retinal self-antigens in CD25(+)CD4(+) regulatory T-cell-depleted mice
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 45:1879-86. 2004
  2. ncbi request reprint Possibility of inducing anterior chamber-associated immune deviation by TGF-beta2 treatment of monocytes isolated from Behcet's patients
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku, Tokyo 160 0023, Japan
    Exp Eye Res 83:981-8. 2006
  3. doi request reprint Effects of dioxin on vascular endothelial growth factor (VEGF) production in the retina associated with choroidal neovascularization
    Aya Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:3410-6. 2009
  4. ncbi request reprint Risk and prognostic factors of poor visual outcome in Behcet's disease with ocular involvement
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
    Graefes Arch Clin Exp Ophthalmol 243:1147-52. 2005
  5. ncbi request reprint Elevated serum levels of CXCL9/monokine induced by interferon-gamma and CXCL10/interferon-gamma-inducible protein-10 in ocular sarcoidosis
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:1063-8. 2006
  6. ncbi request reprint Residual triamcinolone acetonide in the macular hole after vitrectomy
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Am J Ophthalmol 136:1174-6. 2003
  7. pmc Coxsackievirus B4 associated uveoretinitis in an adult
    M Takeuchi
    Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo, Japan
    Br J Ophthalmol 87:501-2. 2003
  8. doi request reprint Immune responses to interphotoreceptor retinoid-binding protein and S-antigen in Behcet's patients with uveitis
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:3067-75. 2010
  9. doi request reprint Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice
    Yoshihiko Usui
    Department of Ophthalmology, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Arch Ophthalmol 127:514-9. 2009
  10. doi request reprint Expression and function of inducible costimulator on peripheral blood CD4+ T cells in Behçet's patients with uveitis: a new activity marker?
    Yoshihiko Usui
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:5099-104. 2010

Detail Information

Publications65

  1. ncbi request reprint Immune responses to retinal self-antigens in CD25(+)CD4(+) regulatory T-cell-depleted mice
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 45:1879-86. 2004
    ....
  2. ncbi request reprint Possibility of inducing anterior chamber-associated immune deviation by TGF-beta2 treatment of monocytes isolated from Behcet's patients
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku, Tokyo 160 0023, Japan
    Exp Eye Res 83:981-8. 2006
    ..These results suggest a possibility that adherent monocytes isolated from BD patients may acquire a property to induce ACAID by treatment with TGF-beta2...
  3. doi request reprint Effects of dioxin on vascular endothelial growth factor (VEGF) production in the retina associated with choroidal neovascularization
    Aya Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:3410-6. 2009
    ..However, the effects of dioxins on the eye remain elusive. In this study, the authors examined the association between dioxins and neovascularization in the eye...
  4. ncbi request reprint Risk and prognostic factors of poor visual outcome in Behcet's disease with ocular involvement
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
    Graefes Arch Clin Exp Ophthalmol 243:1147-52. 2005
    ..The purpose of the study was to determine factors correlated with the progression of irreversible visual disturbance in Behcet's disease (BD) with ocular involvement...
  5. ncbi request reprint Elevated serum levels of CXCL9/monokine induced by interferon-gamma and CXCL10/interferon-gamma-inducible protein-10 in ocular sarcoidosis
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:1063-8. 2006
    ..Chemokines are required for the extravasation of leukocytes to the inflammation site. This study was undertaken to determine which chemokines are augmented in the serum of patients with active ocular sarcoidosis...
  6. ncbi request reprint Residual triamcinolone acetonide in the macular hole after vitrectomy
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Am J Ophthalmol 136:1174-6. 2003
    ..To report a case of vitrectomy using intraocular triamcinolone acetonide (TA), in which TA remained in the macular hole after surgery...
  7. pmc Coxsackievirus B4 associated uveoretinitis in an adult
    M Takeuchi
    Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo, Japan
    Br J Ophthalmol 87:501-2. 2003
  8. doi request reprint Immune responses to interphotoreceptor retinoid-binding protein and S-antigen in Behcet's patients with uveitis
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:3067-75. 2010
    ..In this study, the authors examined whether immune responses to IRBP and S-Ag in BD patients can be characterized by cytokine production profiles...
  9. doi request reprint Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice
    Yoshihiko Usui
    Department of Ophthalmology, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Arch Ophthalmol 127:514-9. 2009
    ..To examine the effects of bone marrow-derived regulatory dendritic cells (DCs) with potent immunoregulatory properties on the development of experimental autoimmune uveoretinitis (EAU)...
  10. doi request reprint Expression and function of inducible costimulator on peripheral blood CD4+ T cells in Behçet's patients with uveitis: a new activity marker?
    Yoshihiko Usui
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:5099-104. 2010
    ..Inducible costimulator (ICOS) is an important costimulatory molecule involved in T-cell activation. In this study, the role of ICOS in the pathogenesis of uveitis in Behçet's disease (BD) was investigated...
  11. doi request reprint Suppression of experimental autoimmune uveoretinitis by inducing differentiation of regulatory T cells via activation of aryl hydrocarbon receptor
    Lina Zhang
    Departments of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:2109-17. 2010
    ..Conclusions. Activation of AHR by TCDD markedly suppressed autoimmune uveoretinitis through mechanisms that expand CD25(+)Foxp3(+) T(reg) cells and interfere with the activation of Th1 and Th17 cells...
  12. ncbi request reprint The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis
    Yoshihiko Usui
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Immunol 36:3071-81. 2006
    ..We also indicated that ICOS-mediated costimulation plays differential roles in EAU and experimental autoimmune encephalomyelitis, which is also a Th1 disease induced in the same manner as EAU...
  13. doi request reprint Suppression of bystander T helper 1 cells by iris pigment epithelium-inducing regulatory T cells via negative costimulatory signals
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Invest Ophthalmol Vis Sci 51:2529-36. 2010
    ..To determine whether iris pigment epithelium (IPE)-induced T regulatory (Treg) cells can suppress the activation of bystander T cells with cell contact via costimulatory interactions...
  14. doi request reprint Suppression of experimental autoimmune uveitis by angiotensin II type 1 receptor blocker telmisartan
    Yoko Okunuki
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:2255-61. 2009
    ..The aim of this study was to examine whether blockade of AT1-R is effective in the suppression of murine experimental autoimmune uveoretinitis (EAU)...
  15. ncbi request reprint Functional expression of B7H1 on retinal pigment epithelial cells
    Yoshihiko Usui
    Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Exp Eye Res 86:52-9. 2008
    ..These data suggest that B7H1 expressed on RPE cells plays an immunosuppressive role in ocular inflammation, which may contribute to immune privilege in the posterior segment of the eye...
  16. doi request reprint T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:2862-70. 2009
    ..To determine whether retinal pigment epithelial (RPE) cells can inhibit in vitro T-cell activation during inflammatory conditions...
  17. ncbi request reprint CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context of a deviant effector response
    Aya Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Japan
    Invest Ophthalmol Vis Sci 46:3753-60. 2005
    ..In CCR5-deficient mice, we examined the role of CCR5 in the development of EAU induced by immunization with interphotoreceptor retinoid-binding protein (IRBP) peptide...
  18. pmc Upregulation of neurotrophic factor-related gene expression in retina with experimental autoimmune uveoretinitis by intravitreal injection of tacrolimus (FK506)
    Keiko Oh-I
    Department of Ophthalmology, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo, Japan 160 0023
    Br J Ophthalmol 91:1537-40. 2007
    ....
  19. ncbi request reprint Alpha-internexin as a corneal autoantigen in spontaneous autoimmune keratitis mouse model
    Takaaki Hattori
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:249-55. 2006
    ..The purpose of this study was to identify target antigens of autoimmune keratitis with a disease-prone mouse model...
  20. pmc Proteomic surveillance of retinal autoantigens in endogenous uveitis: implication of esterase D and brain-type creatine kinase as novel autoantigens
    Yoko Okunuki
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Mol Vis 14:1094-104. 2008
    ..In this study, we aimed to investigate the possibility of such spreading of autoantigens in endogenous uveoretinitis using a proteomic approach...
  21. doi request reprint Human uveal melanoma cells inhibit the immunostimulatory function of dendritic cells
    Juan Ma
    Department of Ophthalmology, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Exp Eye Res 91:491-9. 2010
    ..These findings suggest a mechanism by which uveal melanoma escape immune destruction and have significant implications for tumor-pulsed dendritic cell vaccines for the treatment of uveal melanoma...
  22. pmc Intravitreal injection of Tacrolimus (FK506) suppresses ongoing experimental autoimmune uveoretinitis in Rats
    Keiko Oh-I
    Department of Ophthalmology, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Br J Ophthalmol 91:237-42. 2007
    ..To determine whether intravitreal injection of tacrolimus suppresses ongoing experimental autoimmune uveoretinitis (EAU) in rats...
  23. ncbi request reprint Expression of costimulatory molecules on human retinoblastoma cells Y-79: functional expression of CD40 and B7H1
    Yoshihiko Usui
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:4607-13. 2006
    ..To examine the expression of various costimulatory molecules on the human retinoblastoma cell line Y-79 and assess the functional roles of selected costimulatory molecules...
  24. ncbi request reprint Blockade of the OX40 ligand prolongs corneal allograft survival
    Takaaki Hattori
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Eur J Immunol 37:3597-604. 2007
    ..These results demonstrate that OX40L blockade is effective for prolongation of corneal allograft survival by inhibiting recipient T cell activation...
  25. ncbi request reprint Prevention of experimental autoimmune uveoretinitis by vasoactive intestinal peptide
    Hiroshi Keino
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Arch Ophthalmol 122:1179-84. 2004
    ..Vasoactive intestinal peptide (VIP), a neuropeptide that is known to be present in lymphoid tissue microenvironments, shows prominent anti-inflammatory actions...
  26. doi request reprint Human iris pigment epithelial cells suppress T-cell activation via direct cell contact
    Takaaki Hattori
    Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Exp Eye Res 89:358-64. 2009
    ..Our data indicates that cultured hIPE cells inhibit T-cell activation by T-cell receptor ligation, which is mediated by cell-to-cell contact in part via the PD-L1 and PD-L2 pathways...
  27. doi request reprint Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy
    Yoshihiro Wakabayashi
    Department of Ophthalmology, Hachiouji Medical Center, Tokyo Medical University, Tokyo, Japan
    Retina 31:1951-7. 2011
    ..To investigate whether concurrent hypertension affects vitreous cytokine levels in diabetic retinopathy...
  28. ncbi request reprint Circulating neutrophils in Behçet disease is resistant for apoptotic cell death in the remission phase of uveitis
    Keita Fujimori
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Graefes Arch Clin Exp Ophthalmol 246:285-90. 2008
    ..Hypopyon consists of inflammatory cells infiltrating the eye, with polymorphonuclear cells (PMNs) as the main component. The present study was conducted to investigate the apoptosis property of PMNs in BD patients with uveitis...
  29. doi request reprint Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine and Dental Sciences, Tokyo, Japan
    J Immunol 183:5013-22. 2009
    ..In both EAU models, there was significant suppression of the ocular inflammation. These results indicate that RPE secretes CTLA-2alpha, thereby enabling the bystander T cells to be converted into Treg cells via TGF-beta promotion...
  30. doi request reprint Functional and morphological changes in the eyes of Behçet's patients with uveitis
    Masaru Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Acta Ophthalmol 88:257-62. 2010
    ..In this study, we evaluated the morphological and functional changes of ocular features related to duration of uveitis from onset in BD patients, and analysed their association with visual acuity...
  31. doi request reprint Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathy
    Yoshihiro Wakabayashi
    Department of Ophthalmology, Hachiouji Medical Center of Tokyo Medical University, Tokyo, Japan
    Retina 30:339-44. 2010
    ....
  32. doi request reprint Relation of intraocular concentrations of inflammatory factors and improvement of macular edema after vitrectomy in branch retinal vein occlusion
    Yoko Okunuki
    Department of Ophthalmology, Hachioji Medical Center of Tokyo Medical University, Tokyo, Japan
    Am J Ophthalmol 151:610-616.e1. 2011
    ..To investigate the association of intraocular concentrations of inflammatory factors and improvement of macular edema after vitrectomy for patients with macular edema in branch retinal vein occlusion (BRVO)...
  33. doi request reprint Presumed Vogt-Koyanagi-Harada disease with unilateral ocular involvement: report of three cases
    Yoshihiko Usui
    Department of Ophthalmology, Tokyo Medical University Hospital, 6 7 1 Nishihinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Graefes Arch Clin Exp Ophthalmol 247:1127-32. 2009
    ..To report three cases of presumed Vogt-Koyanagi-Harada (VKH) disease with unilateral ocular manifestations...
  34. doi request reprint Four cases of bilateral acute retinal necrosis with a long interval after the initial onset
    Yoko Okunuki
    Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjyuku, Shinjyuku ku, Tokyo 160 0023, Japan
    Br J Ophthalmol 95:1251-4. 2011
    ..To report the clinical features and causative virus of bilateral acute retinal necrosis (BARN) with a long interval after the initial onset...
  35. ncbi request reprint Peritoneal exudate cells treated with calcitonin gene-related peptide suppress murine experimental autoimmune uveoretinitis via IL-10
    Takeshi Kezuka
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    J Immunol 173:1454-62. 2004
    ..The present results indicate that PEC treated with CGRP suppress murine EAU in an Ag-specific manner, even in the efferent phase, and IL-10 secreted from PEC might play an important role in the CGRP-mediated suppression of murine EAU...
  36. ncbi request reprint Roles of CD4+CD25+ T cells in the development of experimental murine allergic conjunctivitis
    Atsuki Fukushima
    Department of Ophthalmology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, 783 8505, Japan
    Graefes Arch Clin Exp Ophthalmol 245:705-14. 2007
    ..We therefore investigated whether T reg cells play a role in the development of experimental AC (EC)...
  37. ncbi request reprint Thymus-derived CD4+ CD25+ T cells suppress the development of murine allergic conjunctivitis
    Tamaki Sumi
    Department of Ophthalmology, Kochi Medical School, Nankoku City, Japan
    Int Arch Allergy Immunol 143:276-81. 2007
    ..Taken together, these results suggest that CD4+ CD25+ T cells regulate the development of EC...
  38. ncbi request reprint Critical contribution of CD80 and CD86 to induction of anterior chamber-associated immune deviation
    Rintaro Tsukahara
    Department of Ophthalmology, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Int Immunol 17:523-30. 2005
    ..The present results indicated that CD80 and CD86 play a critical role in induction of ACAID, possibly by co-stimulating expansion and IL-10 production of regulatory T cells in response to TGF-beta-conditioned APC...
  39. ncbi request reprint [Pars plana vitrectomy in patients with acute retinal necrosis syndrome: surgical results in 52 patients]
    Yoshihiko Usui
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Nihon Ganka Gakkai Zasshi 114:362-8. 2010
    ..To analyze results of pars plana vitrectomy for acute retinal necrosis (ARN) syndrome...
  40. doi request reprint Use of a comprehensive polymerase chain reaction system for diagnosis of ocular infectious diseases
    Sunao Sugita
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    Ophthalmology 120:1761-8. 2013
    ..To measure the genomic DNA of ocular infectious pathogens in ocular fluids and to analyze the clinical relevance of these pathogens in uveitis and endophthalmitis...
  41. ncbi request reprint Effects of 3-methylcholanthrene on the transcriptional activity and mRNA accumulation of the oncogene hWAPL
    Masahiko Kuroda
    Department of Pathology, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, Tokyo 160 8402, Japan
    Cancer Lett 221:21-8. 2005
    ..Furthermore, mRNA level of a mouse homolog of hWAPL in mouse uterus was induced by 3-MC injection into the abdominal cavity. Thus, some effects from 3-MC exposure on uterus may be mediated by the unscheduled overexpression of hWAPL...
  42. doi request reprint Immune tolerance and autoimmune uveoretinitis: the role of the ocular microenvironment
    Masaru Takeuchi
    Department of Ophthalmology, National Defense Medical College, 3 2 Namiki Tokorozawa Saitama, 359 8513, Japan
    Immunotherapy 3:1103-11. 2011
    ..In addition, the eye is an immune privileged site where indigenous immunomodulatory mechanisms allow immune protection of the eye in a manner that is largely devoid of immunogenic inflammation...
  43. pmc A case of sebaceous adenoma of the eyelid showing excessively rapid growth
    Kei Takayama
    Department of Ophthalmology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Clin Ophthalmol 7:667-70. 2013
    ..Sebaceous adenomas are found mainly in elderly individuals and are usually tan, pink, or yellow nodules or papules, usually approximately 5 mm in the largest size...
  44. ncbi request reprint [Solitary pigment epithelial lesion accompanied by uveal effusion with bullous retinal detachment]
    Kei Takayama
    Department of Ophthalmology, National Defense Medical College, 3 2 Namiki, Tokorozawa shi, Saitama ken 359 8513, Japan
    Nihon Ganka Gakkai Zasshi 117:554-7. 2013
    ..To report a case of solitary pigment epithelial lesion accompanied by uveal effusion (UE) with bullous retinal detachment (RD)...
  45. ncbi request reprint [A case of atypical serpiginous choroiditis with chorioretinal lesions along retinal blood vessels]
    Sho Ishikawa
    Department of Ophthalmology, National Defense Medical College, 3 2 Namiki, Tokorozawa shi, Saitama ken 359 8513, Japan
    Nihon Ganka Gakkai Zasshi 117:561-7. 2013
    ..This report describes a chorioretinal disease accompanied with retinal phlebitis finally diagnosed as serpiginous choroiditis by the characteristic extension of the lesions...
  46. ncbi request reprint Type I interferons as immunoregulatory molecules; implications for therapy in experimental autoimmune uveoretinitis
    Junichiro Mizuguchi
    Department of Immunology, Tokyo Medical University, Japan
    Arch Immunol Ther Exp (Warsz) 50:243-54. 2002
    ..Thus, the immuno-modulatory action of IFN-alpha/beta may be dependent on the context of cytokine combination and/or their concentrations...
  47. ncbi request reprint Clinical evaluation of blue-light blocker foldable acrylic IOL (HMY)
    Tsuyoshi Hibino
    Department of Ophthalmology, Kinki University School of Medicine, Osaka, Japan
    Ann Ophthalmol (Skokie) 38:311-6. 2006
    ..8% of them achieved higher than 6/6. The rate of mean corneal endothelial cell density decrease stood at 5.0%. Mild complications were observed, but none were serious...
  48. ncbi request reprint Evaluation of mouse experimental autoimmune uveoretinitis by spectral domain optical coherence tomography
    Kohzou Harimoto
    Department of Ophthalmology, National Defense Medical College, Saitama, Tokorozawa, Japan
    Br J Ophthalmol 98:808-12. 2014
    ....
  49. doi request reprint Short-term outcomes of coaxial microincision cataract surgery for uveitis-associated cataract without postoperative systemic steroid therapy
    Kei Takayama
    Department of Ophthalmology, National Defense Medical College, Tokorozawa, Japan
    Ophthalmologica 231:111-6. 2014
    ..To study the necessity of prophylactic systemic steroid therapy after coaxial microincision cataract surgery (MICS) conducted in aged patients during remission of uveitis...
  50. doi request reprint Deep stromal opacity after corneal cross-linking
    Naoko Kato
    Department of Ophthalmology, National Defense Medical College, Saitama, Japan
    Cornea 32:895-8. 2013
    ..To describe 3 cases with deep corneal stromal opacity that occurred several months after corneal cross-linking...
  51. doi request reprint Phototoxicity of indocyanine green and Brilliant Blue G under continuous fluorescent illumination on cultured human retinal pigment epithelial cells
    Kei Takayama
    Department of Ophthalmology, National Defense Medical College, Saitama, Japan
    Invest Ophthalmol Vis Sci 53:7389-94. 2012
    ..We compared the phototoxicity of indocyanine green (ICG) and Brilliant Blue G (BBG) in cultured RPE cells under fluorescent lamp illumination imitating ambient light...
  52. ncbi request reprint A relationship between varicella-zoster virus-specific delayed hypersensitivity and varicella-zoster virus-induced anterior uveitis
    Takeshi Kezuka
    Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, 1163, Tate machi, Hachioji City, Tokyo, 193 8639, Japan
    Arch Ophthalmol 120:1183-8. 2002
    ....
  53. doi request reprint The 2009 prospective multi-center epidemiologic survey of uveitis in Japan
    Nobuyuki Ohguro
    Japanese Ocular Inflammation Society, Tokyo, Japan
    Jpn J Ophthalmol 56:432-5. 2012
    ..To investigate etiologic data on intraocular inflammation in Japan collected in the 2009 epidemiologic survey of uveitis in Japan and assess the current state of etiology compared with that reported in a previous survey...
  54. doi request reprint Hypotensive effect of latanoprost/timolol versus travoprost/timolol fixed combinations in NTG patients: a randomized, multicenter, crossover clinical trial
    Takuhei Shoji
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Invest Ophthalmol Vis Sci 54:6242-7. 2013
    ..To compare the ocular hypotensive effect of travoprost plus timolol (TTFC) and latanoprost plus timolol fixed combinations (LTFC) in patients with normal-tension glaucoma (NTG)...
  55. doi request reprint A systematic review of biologics for the treatment of noninfectious uveitis
    Masaru Takeuchi
    Department of Ophthalmology, National Defense Medical College, Saitama, Japan
    Immunotherapy 5:91-102. 2013
    ....
  56. ncbi request reprint [A case of neuromyelitis optica presenting ileus as a neurologic finding]
    Kei Takayama
    Department of Ophthalmology, National Defense Medical College, Japan
    Nihon Ganka Gakkai Zasshi 116:967-71. 2012
    ..To report an atypical case of neuromyelitis optica (NMO) with Sjögren syndrome that presented only ileus as a neurologic finding...
  57. doi request reprint Non-aspiration technique to induce posterior vitreous detachment in minimum incision vitrectomy system
    Masaru Takeuchi
    Department of Ophthalmology, National Defense Medical College, Tokorozawa, Saitama, Japan
    Br J Ophthalmol 96:1378-9. 2012
    ..Complete PVD is confirmed by observation of the Weiss ring in front of the retina. Using this technique, PVD can be achieved in vitrectomies using MIVS, even when the posterior hyaloid attaches tightly to the retina...
  58. pmc Identification of Th2-type suppressor T cells among in vivo expanded ocular T cells in mice with experimental autoimmune uveoretinitis
    H Keino
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Clin Exp Immunol 124:1-8. 2001
    ..These findings demonstrate that p518-529 reactive Th2-type T cells expand oligoclonally in the uveitic eyes in the late stage of EAU and may function as Th2-type suppressor T cells for improvement of the disease...
  59. pmc Supplementation of CD4+CD25+ regulatory T cells suppresses experimental autoimmune uveoretinitis
    H Keino
    Department of Ophthalmology, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Br J Ophthalmol 91:105-10. 2007
    ..To investigate whether supplementation of natural CD4+CD25+ regulatory T cells ameliorates mouse experimental autoimmune uveoretinitis (EAU) induced by CD4+ T cell-dependent interphotoreceptor retinoid-binding protein (IRBP)...
  60. ncbi request reprint Differentiation of Th1 and Th2 cells in lymph nodes and spleens of mice during experimental autoimmune uveoretinitis
    M Takeuchi
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Jpn J Ophthalmol 45:463-9. 2001
    ..Th2-type responses were generated in the spleen only as the disease receded, suggesting a role for Th2 cells in the spontaneous termination of EAU...
  61. doi request reprint Acute retinal necrosis in Japan
    Yoshihiko Usui
    Ophthalmology 115:1632-3. 2008
  62. ncbi request reprint Proteomic surveillance of autoimmunity in Behcet's disease with uveitis: selenium binding protein is a novel autoantigen in Behcet's disease
    Yoko Okunuki
    Department of Bioregulation and Proteomics, Institute of Medical Science, St Marianna University School of Medicine, 2 16 1 Sugao, Kawasaki, Kanagawa 216 8512, Japan
    Exp Eye Res 84:823-31. 2007
    ..Autoimmunity against the retinal SBP may contribute to the pathogenesis of uveitis in BD patients...
  63. ncbi request reprint Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells
    Hiroshi Keino
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 47:1047-55. 2006
    ..The current study was conducted to investigate the possibility that these T regs express CD25 and are derived from natural CD4+CD25+ T cells...
  64. ncbi request reprint Chemokine and chemokine receptor expression during experimental autoimmune uveoretinitis in mice
    Hiroshi Keino
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Graefes Arch Clin Exp Ophthalmol 241:111-5. 2003
    ....
  65. ncbi request reprint The eye's view of antigen presentation
    J Wayne Streilein
    Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    Hum Immunol 63:435-43. 2002
    ..The lack of these potent stimulators of Th1 cell differentiation is central to the induction of ACAID...