K Takeda

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells
    K Takeda
    Department of Biomaterials Science, Faculty of Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Biol Chem 275:9805-13. 2000
  2. ncbi In vivo transfection of a cis element 'decoy' against signal transducers and activators of the transcription 6 (STAT6) binding site ameliorates the response of contact hypersensitivity
    K Sumi
    Department of Environmental Immunodermatology, Postgraduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Gene Ther 11:1763-71. 2004
  3. ncbi In vivo transfection of a cis element 'decoy' against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model
    H Yokozeki
    Department of Dermatology and Immunodermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Gene Ther 11:1753-62. 2004
  4. ncbi Expression of CD30 ligand (CD153) on murine activated T cells
    O Shimozato
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Biochem Biophys Res Commun 256:519-26. 1999
  5. ncbi Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase
    Y Sawada
    Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8549, Japan
    J Cell Sci 114:1221-7. 2001
  6. ncbi Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Nat Med 7:94-100. 2001
  7. ncbi Expression of tumour necrosis factor (TNF) ligand superfamily co-stimulatory molecules CD30L, CD27L, OX40L, and 4-1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3
    Y Seko
    Department of Cardiovascular Medicine, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Pathol 195:593-603. 2001
  8. ncbi ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
    K Tobiume
    Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    EMBO Rep 2:222-8. 2001
  9. ncbi Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Cell Immunol 214:194-200. 2001
  10. ncbi Th2 cytokines, IgE and mast cells play a crucial role in the induction of para-phenylenediamine-induced contact hypersensitivity in mice
    H Yokozeki
    Department of Dermatology and Immunodermatology, Tokyo Medical and Dental University, Japan
    Clin Exp Immunol 132:385-92. 2003

Detail Information

Publications67

  1. ncbi Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells
    K Takeda
    Department of Biomaterials Science, Faculty of Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Biol Chem 275:9805-13. 2000
    ..Together with previous reports indicating that ASK1 functions as a pro-apoptotic signaling intermediate, these results suggest that ASK1 has a broad range of biological activities depending on cell types and/or cellular context...
  2. ncbi In vivo transfection of a cis element 'decoy' against signal transducers and activators of the transcription 6 (STAT6) binding site ameliorates the response of contact hypersensitivity
    K Sumi
    Department of Environmental Immunodermatology, Postgraduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Gene Ther 11:1763-71. 2004
    ..We herein report the first successful in vivo transfer of STAT6 decoy ODN to inhibit acute and chronic CHS, thus providing a new therapeutic strategy not only for the treatment of CHS but also for atopic dermatitis...
  3. ncbi In vivo transfection of a cis element 'decoy' against signal transducers and activators of transcription 6 (STAT6)-binding site ameliorates IgE-mediated late-phase reaction in an atopic dermatitis mouse model
    H Yokozeki
    Department of Dermatology and Immunodermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Gene Ther 11:1753-62. 2004
    ..We herein report the first successful in vivo transfer of STAT6 decoy ODN to reduce the late-phase reaction, thereby providing a new therapeutic strategy for AD...
  4. ncbi Expression of CD30 ligand (CD153) on murine activated T cells
    O Shimozato
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113 8421, Japan
    Biochem Biophys Res Commun 256:519-26. 1999
    ..These results indicated a differential regulation of CD30 and CD153 expression in T cells, which may be relevant to immuno-regulatory role of the CD30-CD153 interaction...
  5. ncbi Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase
    Y Sawada
    Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8549, Japan
    J Cell Sci 114:1221-7. 2001
    ..Thus, Rap1 plays a unique role in force-initiated signal transduction...
  6. ncbi Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Nat Med 7:94-100. 2001
    ..These findings provide the first evidence for the physiological function of TRAIL as a tumor suppressor...
  7. ncbi Expression of tumour necrosis factor (TNF) ligand superfamily co-stimulatory molecules CD30L, CD27L, OX40L, and 4-1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3
    Y Seko
    Department of Cardiovascular Medicine, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Pathol 195:593-603. 2001
    ....
  8. ncbi ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
    K Tobiume
    Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    EMBO Rep 2:222-8. 2001
    ..TNF- but not Fas-induced apoptosis requires ROS-dependent activation of ASK1-JNK/p38 pathways. Thus, ASK1 is selectively required for TNF- and oxidative stress-induced sustained activations of JNK/p38 and apoptosis...
  9. ncbi Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Cell Immunol 214:194-200. 2001
    ..These results suggested a substantial role of TRAIL as the effector molecule that eliminates subcutaneously developing TRAIL-sensitive tumors...
  10. ncbi Th2 cytokines, IgE and mast cells play a crucial role in the induction of para-phenylenediamine-induced contact hypersensitivity in mice
    H Yokozeki
    Department of Dermatology and Immunodermatology, Tokyo Medical and Dental University, Japan
    Clin Exp Immunol 132:385-92. 2003
    ..These data indicate that not only Th2 cytokines and IgE but also mast cells play an essential role in the induction of PPD-CHS...
  11. ncbi Normal development of the gut-associated lymphoid tissue except Peyer's patch in MyD88-deficient mice
    R Iiyama
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Scand J Immunol 58:620-7. 2003
    ..These results suggest that the TLRs/MyD88 pathway might be involved in the development of PPs only at early postnatal stage, and TLRs/MyD88-independent signalling is critically involved in the development of GALT in adult mice...
  12. ncbi Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways
    Y Hayakawa
    Department of Pathogenic Biochemistry, Research Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Immunol 166:6012-8. 2001
    ..These results indicate that CD28-CD80/CD86 and CD40-CD154 costimulatory pathways differentially contribute to the regulation of Th1 and Th2 functions of Valpha14 NKT cells in vivo...
  13. ncbi Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus
    S Mahalingam
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
    Proc Natl Acad Sci U S A 98:6812-7. 2001
    ..Furthermore, in the absence of this transcription factor, the immune system defaults toward a protective Th1-like response, conferring pronounced resistance to EV infection and disease progression...
  14. ncbi Critical role of Rho-kinase and MEK/ERK pathways for angiotensin II-induced plasminogen activator inhibitor type-1 gene expression
    K Takeda
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Arterioscler Thromb Vasc Biol 21:868-73. 2001
    ..The Rho-kinase pathway may be a novel target to inhibit Ang II signaling, and its inhibition may be useful in the treatment of hypertension as well as atherosclerosis...
  15. ncbi HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell
    R Geleziunas
    Gladstone Institute of Virology and Immunology, PO Box 419100, San Francisco, California 94141 9100, USA
    Nature 410:834-8. 2001
    ....
  16. ncbi Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation
    H Kadowaki
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    Cell Death Differ 12:19-24. 2005
    ..These results indicate that ROS-mediated ASK1 activation is a key mechanism for Abeta-induced neurotoxicity, which plays a central role in Alzheimer's disease...
  17. ncbi A Toll-like receptor recognizes bacterial DNA
    H Hemmi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Suita
    Nature 408:740-5. 2000
    ..The in vivo CpG-DNA-mediated T-helper type-1 response was also abolished in TLR9-/- mice. Thus, vertebrate immune systems appear to have evolved a specific Toll-like receptor that distinguishes bacterial DNA from self-DNA...
  18. ncbi IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells
    F D Shi
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    J Immunol 165:3099-104. 2000
    ..Thus, IL-18 can direct autoreactive T cells and promote autodestruction in the CNS at least in part via induction of IFN-gamma by NK cells...
  19. ncbi Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide
    Y Hayakawa
    Department of Pathogenic Biochemistry, Research Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Eur J Immunol 31:1720-7. 2001
    ....
  20. ncbi Complex regulation of CDK2 and G1 arrest during neuronal differentiation of human prostatic cancer TSU-Prl cells by staurosporine
    T Shimizu
    Department of Hygiene-Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo, 12 Ichigaya Funagawara-machi, Shinjuku-ku, Tokyo 162-0826, Japan
    Anticancer Res 21:893-8. 2001
    ..We propose that the complex regulation of CDK2 plays a key role in G1 arrest of TSU-Pr1 cells after treatment with staurosporine...
  21. ncbi Rho-kinase mediates angiotensin II-induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells
    Y Funakoshi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Hypertension 38:100-4. 2001
    ..The Rho-Rho-kinase pathway may be a novel target for the inhibition of Ang II signaling and the treatment of atherosclerosis...
  22. ncbi IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells
    M Dontenwill
    Cell Death Differ 10:933-5. 2003
  23. ncbi Toll-like receptors control activation of adaptive immune responses
    M Schnare
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Immunol 2:947-50. 2001
    ..These results suggest that distinct pathways of the innate immune system control activation of the two effector arms of adaptive immunity...
  24. ncbi Abundance of unconventional CD8(+) natural killer T cells in the large intestine
    M Bannai
    Department of Immunology, Niigata University School of Medicine, Niigata, Japan
    Eur J Immunol 31:3361-9. 2001
    ..These findings suggest that the large intestine is a site in which unconventional NKT cells carrying the CD8(+) phenotype (or DN CD4(-)8(-)) are abundant and that these cells are independent of MHC and MHC-like antigens...
  25. ncbi Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7
    M Yanagisawa
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    Genes Cells 6:1091-9. 2001
    ..This cytokine has been reported to induce neurite outgrowth in rat pheochromocytoma PC12 cells via the activation of a p38 MAP kinase, although its regulatory mechanism remains largely to be elucidated...
  26. ncbi Multi-functional roles of Stat3 revealed by conditional gene targeting
    K Takeda
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Arch Immunol Ther Exp (Warsz) 49:279-83. 2001
    ..By this method, Stat3 was disrupted in several types of tissue, including T cells, macrophages, skin, and mammary gland. Analyses of these Stat3-mutant mice revealed important roles of Stat3 in biological functions in each tissue...
  27. ncbi 15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells
    K Takeda
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, 812-8582 Fukuoka, Japan
    J Biol Chem 276:48950-5. 2001
    ..These findings indicate a novel regulatory mechanism of gene expression by 15-d-PGJ2 and thiazolidinediones...
  28. ncbi Enhanced gamma interferon production through activation of Valpha14(+) natural killer T cells by alpha-galactosylceramide in interleukin-18-deficient mice with systemic cryptococcosis
    K Kawakami
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Infect Immun 69:6643-50. 2001
    ..Our results indicated that in IL-18KO mice, IFN-gamma synthesis was enhanced through overproduction of IL-12 and IL-4 after intravenous infection with C. neoformans and a ligand-specific activation of Valpha14(+) NKT cells...
  29. ncbi The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol
    C A Byrd-Leifer
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Eur J Immunol 31:2448-57. 2001
    ..These results suggest that Taxol and LPS not only share a TLR4/MyD88-dependent pathway in generating inflammatory mediators, but also share a TLR4-dependent/MyD88-independent pathway leading to activation of MAPK and NF-kappa B...
  30. ncbi Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice
    T Okazaki
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 167:1977-81. 2001
    ..Thus, manipulation of the CD28-mediated costimulation could be a potential therapeutic strategy for the prevention of lung fibrosis...
  31. ncbi In vivo evaluation of the early events associated with liver metastasis of circulating cancer cells
    L Ding
    First Department of Surgery, Tohoku University School of Medicine, Seiryo cho 1 1, Aoba ku, Sendai, 980 8574, Japan
    Br J Cancer 85:431-8. 2001
    ....
  32. ncbi Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice
    E Hamelmann
    Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 23:327-34. 2000
    ....
  33. ncbi Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice
    I Sugawara
    Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo 204 0022, Japan
    Infect Immun 67:2585-9. 1999
    ..Therefore, IL-18 is important for the generation of protective immunity to mycobacteria, and its main function is the induction of IFN-gamma expression...
  34. ncbi CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells
    H Akiba
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 162:7058-66. 1999
    ..These results indicated that OX40L and CD70 expressed on surface Ig- and CD40-stimulated B cells can provide CD28-independent costimulatory signals to T cells...
  35. ncbi TLR6: A novel member of an expanding toll-like receptor family
    O Takeuchi
    Department of Biochemistry, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Gene 231:59-65. 1999
    ..The TLR6 gene, as well as the TLR1 gene, mapped to the proximal region of murine chromosome 5 within 1.7cM of each other. These results suggest that TLR6 is a novel member of an expanding TLR family...
  36. ncbi Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor
    K Hoshino
    Department of Appropriate Technology Development, Research Institute, International Medical Center of Japan, Tokyo, Japan
    J Immunol 162:5041-4. 1999
    ..Th1 cell development was also impaired in IL-1Rrp-deficient mice. These data demonstrate that IL-1Rrp is a ligand-binding receptor that is essential for IL-18-mediated signaling events...
  37. ncbi Critical role of NK1+ T cells in IL-12-induced immune responses in vivo
    T Kawamura
    Department of Immunology, Niigata University School of Medicine, Japan
    J Immunol 160:16-9. 1998
    ..These results indicate that NK1+ T cells play a critical role in IL-12-induced production of IFN-gamma to initiate Th1 immune responses and as IL-12-induced cytotoxic effector cells to initiate antitumor immunity...
  38. ncbi Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
    M Saitoh
    Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170, Japan
    EMBO J 17:2596-606. 1998
    ..The evidence that Trx is a negative regulator of ASK1 suggests possible mechanisms for redox regulation of the apoptosis signal transduction pathway as well as the effects of antioxidants against cytokine- and stress-induced apoptosis...
  39. ncbi The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells
    H Kitamura
    Section of Genetic Engineering, Research Center for Genetic Engineering and Cell Transplantation, Tokai University School of Medicine, Isehara 259 1193, Japan
    J Exp Med 189:1121-8. 1999
    ..Our results also suggest a novel approach for immunotherapy of cancer...
  40. ncbi Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice
    T Akimoto
    New Product Research Laboratories IV, Daiichi Pharmaceutical Co, Ltd, 1 16 13 Kitakasai, Edogawa, Tokyo 134, Japan
    J Exp Med 187:1537-42. 1998
    ..Moreover STAT6-/- mice had much less airway reactivity than wild-type mice. These findings suggest that STAT6 plays a crucial role in the pathogenesis of allergen-induced airway inflammation...
  41. ncbi STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration of CD8+ T cells
    S Miyata
    Fifth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Clin Exp Allergy 29:114-23. 1999
    ..STAT6 has an essential role in IL-4 signalling and in production of TH2 cytokines from T cells and is involved in IgE and IgG1 responses after nematode infections, indicating that STAT6 has an important role in allergic diseases...
  42. ncbi Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    K Takeda
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 10:39-49. 1999
    ..The mice show a polarized immune response toward the Th1 type and develop chronic enterocolitis with age. Taken together, Stat3 plays a critical role in deactivation of macrophages and neutrophils mainly exerted by IL-10...
  43. ncbi Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice
    K Takeda
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    J Immunol 161:4652-60. 1998
    ..These results demonstrate that Stat3 activation is involved in IL-6-dependent T cell proliferation through prevention of apoptosis independently of Bcl-2...
  44. ncbi Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    O Adachi
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 9:143-50. 1998
    ..Taken together, these results demonstrate that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor...
  45. ncbi Defective NK cell activity and Th1 response in IL-18-deficient mice
    K Takeda
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 8:383-90. 1998
    ..We therefore generated mice lacking both IL-18 and IL-12. In these mice, NK activity and Th1 response were further impaired. This demonstrates the important role of both IL-18 and IL-12 in NK activity, as well as in in vivo Th1 response...
  46. ncbi Unresponsiveness of MyD88-deficient mice to endotoxin
    T Kawai
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 11:115-22. 1999
    ....
  47. ncbi Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function
    A Hashimoto
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    J Immunol 165:1738-42. 2000
    ..In contrast, T cell development and TCR-mediated proliferation were normal. Taken together, PLC-gamma 2 is a critical component of BCR signaling pathways and is required to promote B cell development...
  48. ncbi Essential role of Stat6 in IL-4 signalling
    K Takeda
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Nature 380:627-30. 1996
    ..These findings agreed with those obtained in IL-4 deficient mice or using antibodies to IL-4 and the IL-4 receptor. We conclude that Stat6 plays a central role in exerting IL-4 mediated biological responses...
  49. ncbi ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction
    Y Mochida
    Laboratory of Cell Signaling, Department of Hard Tissue Engineering, Division of Bio Matrix, Tokyo, Japan
    J Biol Chem 275:32747-52. 2000
    ..These results provide a new insight in the mode of action of MAPKKK family members; two distinct MAPKKKs in the same MAP kinase cascades directly interact and exert opposite effects in another signaling pathway, NF-kappaB...
  50. ncbi IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells
    K Kawakami
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    J Immunol 165:941-7. 2000
    ....
  51. ncbi STAT family of transcription factors in cytokine-mediated biological responses
    K Takeda
    Department of Host Defense, Research Institute for Microbial Diseases, and CREST of Japan Science and Technology Corporation, Osaka University, 3 1 Yamada oka, Suita, Osaka, Japan
    Cytokine Growth Factor Rev 11:199-207. 2000
    ..Conditional knockout study of Stat3 demonstrates its critical roles in cytokine-mediated functions in several tissues, including T cells, macrophages, skin, and mammary gland...
  52. ncbi Critical contribution of liver natural killer T cells to a murine model of hepatitis
    K Takeda
    Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Proc Natl Acad Sci U S A 97:5498-503. 2000
    ..These results implicated FasL expression on liver NKT cells in the pathogenesis of Con A-induced hepatitis, suggesting a similar pathogenic role in human liver diseases such as autoimmune hepatitis...
  53. ncbi Signal transducer and activator of transcription 6 is essential in the induction of contact hypersensitivity
    H Yokozeki
    Department of Dermatology, School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Exp Med 191:995-1004. 2000
    ..Our data suggest that the STAT6 signal plays a critical role in the induction phase of CHS...
  54. ncbi CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness
    A Haczku
    Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 161:952-60. 2000
    ....
  55. ncbi The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function
    K Hoshino
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    J Exp Med 190:1541-8. 1999
    ..In addition, differentiation and function of bone marrow-derived cultured mast cells were unaffected. These findings demonstrate that T1/ST2 does not play an essential role in development and function of Th2 cells and mast cells...
  56. ncbi Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice
    K Takeda
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    J Immunol 157:3220-2. 1996
    ..Taken together, these results suggest that the macrophage functions in response to IL-13 were impaired in STAT6-deficient mice, indicating that IL-13 and IL-4 share the signaling pathway via STAT6...
  57. ncbi ASK1 is essential for JNK/SAPK activation by TRAF2
    H Nishitoh
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Mol Cell 2:389-95. 1998
    ..In untransfected mammalian cells, ASK1 rapidly associates with TRAF2 in a TNF-dependent manner. Thus, ASK1 is a mediator of TRAF2-induced JNK activation...
  58. ncbi Expansion of an unusual population of Gr-1+CD3int cells in the lymph nodes and other peripheral organs of mice carrying the lpr gene
    S Honda
    Second Department of Internal Medicine, Niigata University School of Medicine, Japan
    Cell Immunol 177:144-53. 1997
    ..The present study thus yielded further information on an unusual property of abnormally expanding CD3int cells in mice carrying the lpr gene...
  59. ncbi Increase of cord blood cytokine-producing T cells in intrauterine infection
    T Matsuoka
    Department of Pediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Pediatr Int 43:453-7. 2001
    ..CONCLUSIONS: Our results suggest that the increase of CB IFN-gamma and IL-4- producing T cells is part of the immune system directed against perinatal intrauterine infections...
  60. ncbi Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease
    T Kanai
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    Gastroenterology 121:875-88. 2001
    ..Here we assess the role of macrophages and of IL-18 in the murine model of intestinal inflammation that mimics the immunologic characteristics of human CD...
  61. ncbi Limb and skin abnormalities in mice lacking IKKalpha
    K Takeda
    Department of Biochemistry and Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Department of Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Science 284:313-6. 1999
    ....
  62. ncbi Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting
    Y Sakao
    Department of Host Defense, Research Institute for Microbial Diseases, Suita, Osaka, Japan
    Genomics 67:1-7. 2000
    ..These findings indicate that Psmc3 and Psmc4 have similar and essential roles in early embryogenesis and further that both ATPases have noncompensatory functions in vivo...
  63. ncbi Discrimination of bacterial lipoproteins by Toll-like receptor 6
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Int Immunol 13:933-40. 2001
    ..Taken together, these results show that TLR6 recognizes MALP-2 cooperatively with TLR2, and appears to discriminate between the N-terminal lipoylated structures of MALP-2 and lipopeptides derived from other bacteria...
  64. ncbi Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cells
    M Lahn
    Division of Basic Immunology, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    Nat Med 5:1150-6. 1999
    ..This function of gammadelta T cells differs from previously described immune-dependent mechanisms and may reflect their interaction with innate systems of host defense...
  65. ncbi Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3
    R S Chapman
    Cancer Research Campaign CRC Laboratories, Department of Pathology, University of Edinburgh, Medical School, Edinburgh EH8 9AG UK
    Genes Dev 13:2604-16. 1999
    ..This is the first demonstration of the importance of a Stat factor in signaling the initiation of physiological apoptosis in vivo...
  66. ncbi Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection
    G C Pien
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Immunol 165:4787-91. 2000
    ..Taken together, our results delineate contrasting compartmental requirements for IL-18 and suggest that preservation of local, hepatic IFN-gamma production is critical for host defense during murine cytomegalovirus challenge...
  67. ncbi Irradiated pancreatic cancer cells undergo both apoptosis and necrosis, and could be phagocytized by dendritic cells
    H Shimamura
    Department of Gastroenterological Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Eur Surg Res 37:228-34. 2005
    ..These results suggest that irradiated pancreatic cancer cells, which undergo both apoptosis and necrosis, could be a good source of tumor-associated antigens for cross-presentation by DCs...