N Shinoura

Summary

Affiliation: Tokyo Metropolitan Komagome Hospital
Country: Japan

Publications

  1. ncbi request reprint Early prediction of infection after craniotomy for brain tumours
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, Bunkyo ku, Tokyo, Japan
    Br J Neurosurg 18:598-603. 2004
  2. doi request reprint Marked and rapid recovery of motor strength in premotor area compared with primary motor area in surgery for brain tumors
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, 3 18 22 Hon Komagome, Bunkyo ku, Tokyo 113 8677, Japan
    Br J Neurosurg 23:309-14. 2009
  3. doi request reprint Combined damage to the right hemispheric hand area in the primary motor and sensory area plays a critical role in motor hemineglect
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, Tokyo, Japan
    Eur Neurol 63:17-23. 2010
  4. doi request reprint Assessment of the corona radiata sensory tract using awake surgery and tractography
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, and Department of Radiologic Technology, Tokyo Metropolitan University of Health Sciences, 3 18 22 Hon Komagome, Bunkyo ku, Tokyo 113 8677, Japan
    J Clin Neurosci 16:764-70. 2009
  5. ncbi request reprint Over-expression of APAF-1 and caspase-9 augments radiation-induced apoptosis in U-373MG glioma cells
    N Shinoura
    Department of Molecular Biotherapy Research, Cancer Chemotherapy Center, Cancer Institute, Tokyo, Japan
    Int J Cancer 93:252-61. 2001
  6. doi request reprint Damage to the right superior longitudinal fasciculus in the inferior parietal lobe plays a role in spatial neglect
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, Tokyo, Japan
    Neuropsychologia 47:2600-3. 2009
  7. ncbi request reprint Functional magnetic resonance imaging is more reliable than somatosensory evoked potential or mapping for the detection of the primary motor cortex in proximity to a tumor
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, Tokyo, Japan
    Stereotact Funct Neurosurg 85:99-105. 2007
  8. ncbi request reprint Restored activation of primary motor area from motor reorganization and improved motor function after brain tumor resection
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, 3 18 22 Hon Komagome, Bunkyo ku, Tokyo 113 8677, Japan
    AJNR Am J Neuroradiol 27:1275-82. 2006
  9. ncbi request reprint Intraoperative cortical mapping has low sensitivity for the detection of motor function in proximity to a tumor in the primary motor area
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, Tokyo, Japan
    Stereotact Funct Neurosurg 83:135-41. 2005
  10. ncbi request reprint Degree of apoptosis induced by adenovirus-mediated transduction of p53 or p73alpha depends on the p53 status of glioma cells
    N Shinoura
    Department of Molecular Biotherapy Research, Cancer Chemotherapy Center, Cancer Institute, 1 37 1 Kami Ikebukuro, Toshima ku, 170 8455, Tokyo, Japan
    Cancer Lett 160:67-73. 2000

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Early prediction of infection after craniotomy for brain tumours
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, Bunkyo ku, Tokyo, Japan
    Br J Neurosurg 18:598-603. 2004
    ..This possibility allows for improved care and better clinical outcomes in patients that undergo craniotomies for brain tumours...
  2. doi request reprint Marked and rapid recovery of motor strength in premotor area compared with primary motor area in surgery for brain tumors
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, 3 18 22 Hon Komagome, Bunkyo ku, Tokyo 113 8677, Japan
    Br J Neurosurg 23:309-14. 2009
    ..Recovery of motor strength after awake surgery for those with brain tumors located in PM was relatively marked and rapid when compared with those with brain tumors in the M1...
  3. doi request reprint Combined damage to the right hemispheric hand area in the primary motor and sensory area plays a critical role in motor hemineglect
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, Tokyo, Japan
    Eur Neurol 63:17-23. 2010
    ..These results suggest that the combination of damage to the right hemispheric hand area in M1 and S1 plays a critical role in the development of motor hemineglect...
  4. doi request reprint Assessment of the corona radiata sensory tract using awake surgery and tractography
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, and Department of Radiologic Technology, Tokyo Metropolitan University of Health Sciences, 3 18 22 Hon Komagome, Bunkyo ku, Tokyo 113 8677, Japan
    J Clin Neurosci 16:764-70. 2009
    ....
  5. ncbi request reprint Over-expression of APAF-1 and caspase-9 augments radiation-induced apoptosis in U-373MG glioma cells
    N Shinoura
    Department of Molecular Biotherapy Research, Cancer Chemotherapy Center, Cancer Institute, Tokyo, Japan
    Int J Cancer 93:252-61. 2001
    ..Expression of Apaf-1 and caspase-9 in tumors may be an important determinant of the therapeutic effect of irradiation in cancer treatment...
  6. doi request reprint Damage to the right superior longitudinal fasciculus in the inferior parietal lobe plays a role in spatial neglect
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, Tokyo, Japan
    Neuropsychologia 47:2600-3. 2009
    ..These results suggest that damage to the right SLF in the inferior parietal lobe plays a critical role in the development of spatial neglect...
  7. ncbi request reprint Functional magnetic resonance imaging is more reliable than somatosensory evoked potential or mapping for the detection of the primary motor cortex in proximity to a tumor
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, Tokyo, Japan
    Stereotact Funct Neurosurg 85:99-105. 2007
    ..Finally, the location of M1 was successfully determined by fMRI in 16 of 17 cases. These data indicate that fMRI was more reliable than SEP or brain mapping for the detection of M1 in proximity to a tumor...
  8. ncbi request reprint Restored activation of primary motor area from motor reorganization and improved motor function after brain tumor resection
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, 3 18 22 Hon Komagome, Bunkyo ku, Tokyo 113 8677, Japan
    AJNR Am J Neuroradiol 27:1275-82. 2006
    ..The goal of the present study was to investigate whether function of the primary motor area (M1) was restored and whether motor function improved after brain tumor resection...
  9. ncbi request reprint Intraoperative cortical mapping has low sensitivity for the detection of motor function in proximity to a tumor in the primary motor area
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, Tokyo, Japan
    Stereotact Funct Neurosurg 83:135-41. 2005
    ..Therefore, this technique may not be sufficient to prevent compromise of motor areas during tumor resection...
  10. ncbi request reprint Degree of apoptosis induced by adenovirus-mediated transduction of p53 or p73alpha depends on the p53 status of glioma cells
    N Shinoura
    Department of Molecular Biotherapy Research, Cancer Chemotherapy Center, Cancer Institute, 1 37 1 Kami Ikebukuro, Toshima ku, 170 8455, Tokyo, Japan
    Cancer Lett 160:67-73. 2000
    ..The results indicate that Adv-mediated transduction of p73alpha might be beneficial to overcome the resistance mechanism of glioma cells harboring wild-type p53...
  11. ncbi request reprint Association of motor deficits with head position during awake surgery for resection of medial motor area brain tumors
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, 3 18 22 Hon Komagome, Bunkyo ku, Tokyo 113 8677, Japan
    Minim Invasive Neurosurg 48:315-21. 2005
    ..Thus, the goal of this study was to evaluate the relationship between head position and development of intraoperative or postoperative motor deficits in five patients with motor area tumors...
  12. ncbi request reprint Precentral knob corresponds to the primary motor and premotor area
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, Hon komagome, Bunkyo ku, Japan
    Can J Neurol Sci 36:227-33. 2009
    ..The goal of the present study was to analyze the reliability of the identification of the precentral knob in the axial image of magnetic resonance imaging or functional MRI (fMRI) for the detection of M1...
  13. ncbi request reprint High level calcineurin activity predisposes neuronal cells to apoptosis
    A Asai
    Laboratory for Neuroscience, Department of Neurosurgery, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 274:34450-8. 1999
    ..These data indicate that high level constitutive activity of calcineurin predisposes neuronal cells to cytochrome c/caspase-3 dependent apoptosis even under sublethal conditions...
  14. ncbi request reprint Navigation-guided Ommaya reservoir placement: implications for the treatment of leptomeningeal metastases
    M Takahashi
    Department of Neurosurgery, Komagome Metropolitan Hospital, Bunkyo ku, Tokyo, Japan
    Minim Invasive Neurosurg 50:340-5. 2007
    ..In conclusion, navigation-guided Ommaya reservoir placement was associated with a very low incidence of complications. This method appears to be safe and effective when employed in patients with intracranial malignancy...
  15. ncbi request reprint Caspase-9 transduction overrides the resistance mechanism against p53-mediated apoptosis in U-87MG glioma cells
    N Shinoura
    Department of Molecular Biotherapy Research, Cancer Institute, Tokyo, Japan
    Neurosurgery 49:177-86; discussion 186-7. 2001
    ..In addition, we tested whether transduction of Bax or caspase-9, which are downstream components of p53-induced apoptosis, can override the resistance mechanism of U-87MG cells to apoptosis...
  16. ncbi request reprint Preoperative fMRI, tractography and continuous task during awake surgery for maintenance of motor function following surgical resection of metastatic tumor spread to the primary motor area
    N Shinoura
    Department of Neurosurgery, Komagome Metropolitan Hospital, Tokyo, Japan
    Minim Invasive Neurosurg 48:85-90. 2005
    ..The combination of preoperative fMRI, tractography and continuous task during awake surgery helped to maintain motor function following surgical management of metastatic brain tumors of the primary motor cortex...
  17. ncbi request reprint Adenovirus-mediated transfer of p53 augments hyperthermia-induced apoptosis in U251 glioma cells
    K Okamoto
    Department of Neurosurgery, Komagome Metropolitan Hospital, Tokyo, Japan
    Int J Radiat Oncol Biol Phys 50:525-31. 2001
    ..Treatment with combined hyperthermia and Adv-p53 infection induced cleavage of caspase-3 in U251 cells. CONCLUSION: These results indicate that Adv-mediated transduction of p53 would render glioma cells highly sensitive to hyperthermia...
  18. pmc Co-transduction of Apaf-1 and caspase-9 highly enhances p53-mediated apoptosis in gliomas
    N Shinoura
    Department of Molecular Biotherapy Research, Cancer Chemotherapy Center, Cancer Institute, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Br J Cancer 86:587-95. 2002
    ..These results are important for analyzing the mechanism of tumour development and for predicting the therapeutic effect of p53 replacement gene therapy in a particular patient...
  19. ncbi request reprint Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors
    N Shinoura
    Department of Molecular Genetics, University of Cincinnati, College of Medicine, OH 45267 0524
    Cancer Lett 89:215-21. 1995
    ..Whereas low level expression was seen in kidney, esophagus, liver, lymph node, ovary and testis, none of the other tissues from a total of 18 different human organs showed any MM1 expression...