Masayoshi Shichiri

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities
    Masayoshi Shichiri
    Tokyo Medical and Dental University Medical Hospital, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Nat Med 9:1166-72. 2003
  2. ncbi Antiangiogenesis signals by endostatin
    M Shichiri
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    FASEB J 15:1044-53. 2001
  3. ncbi Regulation of cell growth and apoptosis by adrenomedullin
    Masayoshi Shichiri
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Hypertens Res 26:S9-14. 2003
  4. doi Rifampicin as an oral angiogenesis inhibitor targeting hepatic cancers
    Masayoshi Shichiri
    Medical Hospital and Department of General Medicine, Tokyo Medical and Dental University Medical Hospital, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Res 69:4760-8. 2009
  5. ncbi Adrenomedullin inhibits angiotensin II-induced oxidative stress and gene expression in rat endothelial cells
    Takanobu Yoshimoto
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Hypertens Res 28:165-72. 2005
  6. ncbi Concomitant expression of adrenomedullin and its receptor components in rat adipose tissues
    Nozomi Fukai
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8513, Japan
    Am J Physiol Endocrinol Metab 288:E56-62. 2005
  7. doi Systemic distribution of salusin expression in the rat
    Noriko Suzuki
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University, Tokyo, Japan
    Hypertens Res 30:1255-62. 2007
  8. ncbi Urotensin II is an autocrine/paracrine growth factor for the porcine renal epithelial cell line, LLCPK1
    Mika Matsushita
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, 113 8519, Japan
    Endocrinology 144:1825-31. 2003
  9. ncbi Aldosterone induces angiotensin converting enzyme gene expression via a JAK2-dependent pathway in rat endothelial cells
    Toru Sugiyama
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8513, Japan
    Endocrinology 146:3900-6. 2005
  10. ncbi Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice
    Kyoichiro Tsuchiya
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Endocrinology 148:4548-56. 2007

Collaborators

Detail Information

Publications55

  1. ncbi Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities
    Masayoshi Shichiri
    Tokyo Medical and Dental University Medical Hospital, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Nat Med 9:1166-72. 2003
    ....
  2. ncbi Antiangiogenesis signals by endostatin
    M Shichiri
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    FASEB J 15:1044-53. 2001
    ....
  3. ncbi Regulation of cell growth and apoptosis by adrenomedullin
    Masayoshi Shichiri
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Hypertens Res 26:S9-14. 2003
    ..Signaling pathways independent of cyclic AMP, such as protein tyrosine kinase(s) and mitogen-activated protein kinases, may play key roles in the regulation of mitogenesis and apoptosis by adrenomedullin...
  4. doi Rifampicin as an oral angiogenesis inhibitor targeting hepatic cancers
    Masayoshi Shichiri
    Medical Hospital and Department of General Medicine, Tokyo Medical and Dental University Medical Hospital, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Res 69:4760-8. 2009
    ..Considering the clinical pharmacokinetics of rifampicin, which enters the enterohepatic circulation and undergoes subsequent hepatic accumulation, it may be especially beneficial as an antitumor agent targeting hepatobiliary tumors...
  5. ncbi Adrenomedullin inhibits angiotensin II-induced oxidative stress and gene expression in rat endothelial cells
    Takanobu Yoshimoto
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Hypertens Res 28:165-72. 2005
    ....
  6. ncbi Concomitant expression of adrenomedullin and its receptor components in rat adipose tissues
    Nozomi Fukai
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8513, Japan
    Am J Physiol Endocrinol Metab 288:E56-62. 2005
    ..These data suggest that AM may act as a new member of adipokines, although its functional role, as well as its pathophysiological significance in obesity, remains to be determined...
  7. doi Systemic distribution of salusin expression in the rat
    Noriko Suzuki
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University, Tokyo, Japan
    Hypertens Res 30:1255-62. 2007
    ....
  8. ncbi Urotensin II is an autocrine/paracrine growth factor for the porcine renal epithelial cell line, LLCPK1
    Mika Matsushita
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, 113 8519, Japan
    Endocrinology 144:1825-31. 2003
    ..These data suggest that hUII is an autocrine/paracrine growth factor for renal epithelial cells via activation of both protein kinase C and ERK1/2 pathways as well as Ca(2+) influx via voltage-dependent Ca(2+) channels...
  9. ncbi Aldosterone induces angiotensin converting enzyme gene expression via a JAK2-dependent pathway in rat endothelial cells
    Toru Sugiyama
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8513, Japan
    Endocrinology 146:3900-6. 2005
    ..This may constitute a positive feedback loop for a local renin-angiotensin system, possibly involved in the development of aldosterone-induced endothelial dysfunction and vascular injury...
  10. ncbi Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice
    Kyoichiro Tsuchiya
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Endocrinology 148:4548-56. 2007
    ....
  11. ncbi Adrenomedullin is an autocrine/paracrine growth factor for rat vascular smooth muscle cells
    Masayoshi Shichiri
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45, Yushima, Tokyo 113 8519, Bunkyo, Japan
    Regul Pept 112:167-73. 2003
    ..Our results suggest that adrenomedullin is an autocrine/paracrine growth factor for rat VSMCs via p42/p44 ERK/MAP kinase and phosphatidylinositol 3-kinase pathways and that it is not mediated by human RAMP-CRLR receptors...
  12. ncbi Regulation of adrenomedullin gene transcription and degradation by the c-myc gene
    Naoko Ozawa
    Tokyo Medical and Dental University Medical Hospital, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Endocrinology 145:4244-50. 2004
    ..These results indicate that c-myc transactivates rat and human adrenomedullin genes and accelerates the degradation rate of adrenomedullin mRNA. However, c-myc is not essential for basal expression of the adrenomedullin gene...
  13. ncbi Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: the possible role of local renin-angiotensin system
    Yuki Hirono
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Endocrinology 148:1688-96. 2007
    ....
  14. ncbi Antioxidant effect of adrenomedullin on angiotensin II-induced reactive oxygen species generation in vascular smooth muscle cells
    Takanobu Yoshimoto
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8513, Japan
    Endocrinology 145:3331-7. 2004
    ..These data suggest that AM plays a protective role as an endogenous antioxidant in Ang II-induced vascular injury...
  15. doi Salusin-β accelerates inflammatory responses in vascular endothelial cells via NF-κB signaling in LDL receptor-deficient mice in vivo and HUVECs in vitro
    Takayuki Koya
    Department of Biochemistry, Showa University School of Medicine, Hatanodai, Shinagawa ku, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 303:H96-105. 2012
    ..These findings are suggestive of a novel role of salusin-β in atherogenesis...
  16. ncbi Endothelin-1 induces cyclooxygenase-2 expression and generation of reactive oxygen species in endothelial cells
    Toru Sugiyama
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Cardiovasc Pharmacol 44:S332-5. 2004
    ....
  17. ncbi Expression of prosalusin in human neuroblastoma cells
    Chisato Nakayama
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Peptides 30:1362-7. 2009
    ..In summary, the preprosalusin gene and prosalusin protein are expressed in a neuroblastoma cell line and upregulated by reduced serum. The Jak-2 pathway may be involved in the regulation of salusin expression...
  18. doi Serum levels and urinary excretion of salusin-alpha in renal insufficiency
    Shigeaki Kimoto
    Department of Internal Medicine, Ohme Municipal Hospital, Tokyo, Japan
    Regul Pept 162:129-32. 2010
    ..Urinary salusin-alpha may originate from the renal tubules, and may not necessarily represent the peptides filtered at the glomerulus...
  19. ncbi Differential gene expression in ACTH -secreting and non-functioning pituitary tumors
    Toru Tateno
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45, Yushima, Bunkyo ku, Tokyo, Japan
    Eur J Endocrinol 157:717-24. 2007
    ..Differential expression of several genes between ACTH-secreting pituitary tumors causing Cushing' disease (CD), silent corticotroph adenoma (SCA), and non-functioning pituitary tumors (NFT) was investigated...
  20. doi Upregulation of CDKN2A and suppression of cyclin D1 gene expressions in ACTH-secreting pituitary adenomas
    Yuji Tani
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Tokyo, Japan
    Eur J Endocrinol 163:523-9. 2010
    ..The aim of the current study was to evaluate and compare the gene expression profile of cell cycle regulators and cell growth-related transcription factors in CD, SCA, and non-functioning adenomas (NFA)...
  21. doi Release of salusin-beta from human monocytes/macrophages
    Kengo Sato
    Laboratory of Molecular Genetics and Hematology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
    Regul Pept 162:68-72. 2010
    ..These data demonstrate that salusin-beta, which induces macrophage foam cell formation, is secreted in its authentic form from human monocytes/macrophages...
  22. ncbi [Adrenomedullin: vascular action]
    Naoko Ozawa
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School
    Nihon Rinsho 62:220-3. 2004
  23. doi Serum salusin-alpha levels are decreased and correlated negatively with carotid atherosclerosis in essential hypertensive patients
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan
    Hypertens Res 31:463-8. 2008
    ..Our results suggest that the decrease in serum salusin-alpha, an anti-atherogenic peptide, may be associated with carotid atherosclerosis in hypertensive patients...
  24. ncbi Laminar shear stress up-regulates inducible nitric oxide synthase in the endothelium
    Naoko Ozawa
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Hypertens Res 27:93-9. 2004
    ..The present results demonstrate that shear stress induces iNOS in the endothelium, mainly via the activation of NF-kappaB...
  25. ncbi Role of endothelin-1/endothelin receptor system in endotoxic shock rats
    S Ishimaru
    Department of Clinical and Molecular Endocrinology, Graduate School, Tokyo Medical and Dental University, Japan
    Hypertens Res 24:119-26. 2001
    ....
  26. doi Anti-salusin-β antibody enhances angiogenesis after myocardial ischemia reperfusion injury
    Mayumi Masumura
    Tokyo Medical and Dental University, Department of Cardiovascular Medicine, 1 5 45 Yushima, Bunkyo, Tokyo 113 8510, Japan
    Expert Opin Ther Targets 17:1003-9. 2013
    ..Salusin-β stimulates proliferation of vascular smooth muscle cells and fibroblasts and regulates myocardial growth and hypertrophy. Salusin-β has potent hypotensive, bradycardic and proatherosclerotic effects...
  27. ncbi Differential expression of genes related to drug responsiveness between sparsely and densely granulated somatotroph adenomas
    Masako Kato
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Endocr J 59:221-8. 2012
    ..There was positive correlation between mRNA and protein levels of SSTR2. These data suggested that the differences of responsiveness to octreotide between DG- and SG-type adenomas are based on the expression levels of SSTR2...
  28. ncbi Presence of immunoreactive salusin-beta in human plasma and urine
    Kengo Sato
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
    Regul Pept 158:63-7. 2009
    ..16+/-0.84 nmol/l, n=10). These data present the first evidence that salusin-beta circulates and is excreted in its authentic form, thereby verifying the initially predicted processing sites for salusin-beta in humans...
  29. pmc Circulating levels of human salusin-β, a potent hemodynamic and atherogenesis regulator
    Kazumi Fujimoto
    Laboratory of Molecular Genetics of Hematology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan Department of Endocrinology, Diabetes and Metabolism, Kitasato University School of Medicine, Kanagawa, Japan
    PLoS ONE 8:e76714. 2013
    ..The obtained results suggest a limited contribution of the neuroendocrine system to peripheral total salusin-β concentrations and a role for plasma total salusin-β concentrations as an indicator of systemic vascular diseases. ..
  30. pmc Endogenous bioactive peptides as potential biomarkers for atherosclerotic coronary heart disease
    Takuya Watanabe
    Laboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
    Sensors (Basel) 12:4974-85. 2012
    ..Therefore, salusin-α, heregulin-β(1), adiponectin, and/or GLP-1, alone or in various combinations, may be useful as biomarkers for atherosclerotic CAD...
  31. doi The roles of salusins in atherosclerosis and related cardiovascular diseases
    Takuya Watanabe
    Laboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan
    J Am Soc Hypertens 5:359-65. 2011
    ..Therefore, salusin-α could be a candidate biomarker for atherosclerosis and may be therapeutically useful for prevention of atherosclerotic cardiovascular diseases...
  32. doi Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells
    Maya Sakurada
    Department of Clinical and Molecular Endocrinology, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
    Hypertension 52:903-9. 2008
    ..Thus, the DDAH-2-ADMA/MMA-endothelial NO synthase regulatory pathway and NO-induced cGMP constitute a positive feedback loop that ultimately serves to maintain NO levels in the endothelial environment...
  33. ncbi Octreotide-sensitive ectopic ACTH production by islet cell carcinoma with multiple liver metastases
    Masaru Doi
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Endocr J 50:135-43. 2003
    ....
  34. doi Distinct systemic distribution of salusin-α and salusin-β in the rat
    Noriko Suzuki
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Peptides 32:805-10. 2011
    ..These data support the processing of rat prosalusin into salusin-α and salusin-β despite absent dibasic amino acids between the two...
  35. ncbi [Physicochemical characteristics of salusin-beta and establishment of the radioimmunoassay]
    Kengo Sato
    Unit of Clinical Anatomy, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Rinsho Byori 59:121-7. 2011
    ..Successful establishment of a specific radioimmunoassay suitable for detection of immunoreactive human salusin-beta allowed to characterize the molecular form of salusin-beta released from a human-derived cultured cell line...
  36. ncbi Coexpression of calcitonin receptor-like receptor and receptor activity-modifying protein 2 or 3 mediates the antimigratory effect of adrenomedullin
    Nozomi Fukai
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Endocrinology 144:447-53. 2003
    ..Thus, coexpression of CRLR and RAMP2 or RAMP3 mediates the inhibitory effect of adrenomedullin on cell migration, independent of cAMP-dependent signaling pathways...
  37. ncbi Synthetic salusins as cardiac depressors in rat
    Hajime Izumiyama
    Tokyo Medical and Dental University Medical Hospital, Tokyo, Japan
    Hypertension 45:419-25. 2005
    ..Salusin-beta promotes its actions by facilitating vagal outflows to the heart, whereas the negative inotropism of salusin-beta is also mediated via a direct myotropic effect...
  38. ncbi Presence of immunoreactive salusin-alpha in human serum and urine
    Kengo Sato
    Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Peptides 27:2561-6. 2006
    ..These data indicate the presence of salusin-alpha in human serum and urine, thereby verifying the initially predicted processing sites for salusin-alpha in humans...
  39. doi Prolonged effects of intracerebroventricular angiotensin II on drinking, eating and locomotor behavior in mice
    Tae Nakano-Tateno
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Regul Pept 173:86-92. 2012
    ....
  40. ncbi Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival
    Masayoshi Shichiri
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Res 62:13-7. 2002
    ..005) and shorter relapse-free survival after surgery (P = 0.006). Thus, hBUB1 and hBUBR1 may contribute to a specific driving force in tumor metastasis and progression as a result of nonmutational, as well as mutational, inactivation...
  41. doi Biosynthesis and secretion of salusin-alpha from human cells
    Kengo Sato
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Peptides 29:2203-7. 2008
    ..These results present the first evidence that salusin-alpha is biosynthesized and released from human-derived cells...
  42. ncbi Biphasic regulation of the preproendothelin-1 gene by c-myc
    M Shichiri
    Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    Endocrinology 138:4584-90. 1997
    ..The present report, therefore, demonstrates the existence of a signal transduction pathway that regulates the synthesis and secretion of ET-1 via the immediate early transcription factor, c-Myc...
  43. ncbi Endothelin-1 inhibits apoptosis of vascular smooth muscle cells induced by nitric oxide and serum deprivation via MAP kinase pathway
    M Shichiri
    Second Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 20:989-97. 2000
    ....
  44. ncbi Induction of max by adrenomedullin and calcitonin gene-related peptide antagonizes endothelial apoptosis
    M Shichiri
    Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    Mol Endocrinol 13:1353-63. 1999
    ..The present results demonstrate that adrenomedullin antagonizes serum deprivation-induced endothelial apoptosis by up-regulation of the max gene in an autocrine/ paracrine manner...
  45. ncbi Endothelin-1 is a potent survival factor for c-Myc-dependent apoptosis
    M Shichiri
    Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    Mol Endocrinol 12:172-80. 1998
    ..These results demonstrate a hitherto unappreciated role of endothelin-1 as a potent survival factor for c-Myc-dependent apoptosis, a process mediated by the ET(A) receptor and the mitogen-activated protein kinase pathway...
  46. ncbi Endothelin-1 as an autocrine/paracrine apoptosis survival factor for endothelial cells
    M Shichiri
    Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    Hypertension 30:1198-203. 1997
    ..These data suggest that ET-1, as well as mitogen, functions as an apoptosis survival factor for endothelial cells in an autocrine/paracrine manner via the ET(B) receptor...
  47. ncbi Cytokine-activated Jak-2 is involved in inducible nitric oxide synthase expression independent from NF-kappaB activation in vascular smooth muscle cells
    Masaru Doi
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45, Yushima, Bunkyo ku 113 8519, Tokyo, Japan
    Atherosclerosis 160:123-32. 2002
    ..These data indicate that the cytokine-induced iNOS expression involves activation of Jak-2 signaling pathway independent from NF-kappaB activation in rat VSMCs...
  48. ncbi Non-viral in vivo thrombomodulin gene transfer prevents early loss of thromboresistance of grafted veins
    Noriyuki Tabuchi
    Department of Cardio Thoracic Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Eur J Cardiothorac Surg 26:995-1001. 2004
    ....
  49. ncbi Intravenous gene therapy for familial hypercholesterolemia using ligand-facilitated transfer of a liposome:LDL receptor gene complex
    M Shichiri
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Gene Ther 10:827-31. 2003
    ..Transferrin-facilitated intravenous delivery of cationic liposome LDLR gene complexes could serve as an important adjunct therapy for the treatment of FH...
  50. ncbi [Salusin]
    Masayoshi Shichiri
    Tokyo Medical and Dental University Medical Hospital
    Nihon Rinsho 63:621-2. 2005
  51. pmc Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas
    Koichi Shimizu
    The Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 114:300-8. 2004
    ..The findings establish important regulatory roles for a Th1/Th2 cytokine balance in modulating matrix remodeling and have important implications for the pathophysiology of AAAs and arteriosclerosis...
  52. doi Impact of salusin-alpha and -beta on human macrophage foam cell formation and coronary atherosclerosis
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Circulation 117:638-48. 2008
    ....
  53. ncbi Coexistence of salusin and vasopressin in the rat hypothalamo-hypophyseal system
    Fumiko Takenoya
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Neurosci Lett 385:110-3. 2005
    ..The functional significance of the coexistence of salusin with vasopressin is discussed, including the possibility that salusin participates in the regulation of blood pressure...
  54. ncbi High molecular weight form insulin-like growth factor II-producing mesenteric sarcoma causing hypoglycemia
    Ryuji Sato
    Division of Internal Medicine and Surgery, Tokyo Metropolitan Fuchu Hospital, Tokyo
    Intern Med 43:967-71. 2004
    ..The presence of high molecular weight (HMW) form IGF-II in patient's serum was confirmed by immunoblotting. This is the first report of a patient with HMW form IGF-II-producing mesenteric sarcoma causing hypoglycemia...
  55. ncbi Salusin beta is a surrogate ligand of the mas-like G protein-coupled receptor MrgA1
    Zhiwei Wang
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Eur J Pharmacol 539:145-50. 2006
    ..Our results show that human salusin beta is a surrogate ligand of the mouse MrgA1 and raises a cautionary flag for experiments that analyze the pharmacological profiles of mas-like G protein-coupled receptors from different species...