N Shibata

Summary

Affiliation: Tokyo Women's Medical University
Country: Japan

Publications

  1. ncbi request reprint Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model
    Noriyuki Shibata
    Department of Pathology, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    Neuropathology 27:49-61. 2007
  2. pmc Involvement of 4-hydroxy-2-nonenal Accumulation in Multiple System Atrophy
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Acta Histochem Cytochem 43:69-75. 2010
  3. pmc Immunohistochemical Detection of 13(R)-hydroxyoctadecadienoic Acid in Atherosclerotic Plaques of Human Carotid Arteries Using a Novel Specific Antibody
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Acta Histochem Cytochem 42:197-203. 2009
  4. pmc Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cells
    Toru Furukawa
    Institute for Integrated Medical Sciences, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Mol Cancer 11:88. 2012
  5. doi request reprint 4-Hydroxy-2-nonenal upregulates and phosphorylates cytosolic phospholipase A(2) in cultured Ra2 microglial cells via MAPK pathways
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Neuropathology 31:122-8. 2011
  6. doi request reprint Activation of signal transducer and activator of transcription-3 in the spinal cord of sporadic amyotrophic lateral sclerosis patients
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Neurodegener Dis 6:118-26. 2009
  7. doi request reprint Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis
    Noriyuki Shibata
    Department of Pathology, Tokyo Woman s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, Japan
    Neuropathology 28:387-98. 2008
  8. doi request reprint Persistent cleavage and nuclear translocation of apoptosis-inducing factor in motor neurons in the spinal cord of sporadic amyotrophic lateral sclerosis patients
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Acta Neuropathol 118:755-62. 2009
  9. doi request reprint Activation of STAT3 and inhibitory effects of pioglitazone on STAT3 activity in a mouse model of SOD1-mutated amyotrophic lateral sclerosis
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Neuropathology 30:353-60. 2010
  10. doi request reprint Increased expression and activation of cytosolic phospholipase A2 in the spinal cord of patients with sporadic amyotrophic lateral sclerosis
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku 162 8666, Tokyo, Japan
    Acta Neuropathol 119:345-54. 2010

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model
    Noriyuki Shibata
    Department of Pathology, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    Neuropathology 27:49-61. 2007
    ....
  2. pmc Involvement of 4-hydroxy-2-nonenal Accumulation in Multiple System Atrophy
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Acta Histochem Cytochem 43:69-75. 2010
    ..The present results provide in vivo evidence that HNE participates in alpha-synuclein-induced cytotoxicity and neuroinflammation in MSA...
  3. pmc Immunohistochemical Detection of 13(R)-hydroxyoctadecadienoic Acid in Atherosclerotic Plaques of Human Carotid Arteries Using a Novel Specific Antibody
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Acta Histochem Cytochem 42:197-203. 2009
    ..The present results provide in vivo evidence for the formation of 13(R)-HODE in atherosclerotic lesions of carotid arteries...
  4. pmc Targeting of MAPK-associated molecules identifies SON as a prime target to attenuate the proliferation and tumorigenicity of pancreatic cancer cells
    Toru Furukawa
    Institute for Integrated Medical Sciences, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Mol Cancer 11:88. 2012
    ..We hypothesized that knockdown of these MAPK-associated molecules could produce notable anticancer phenotypes...
  5. doi request reprint 4-Hydroxy-2-nonenal upregulates and phosphorylates cytosolic phospholipase A(2) in cultured Ra2 microglial cells via MAPK pathways
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Neuropathology 31:122-8. 2011
    ..The present results provide in vitro evidence that HNE upregulates and phosphorylates cPLA(2) in microglia via the ERK and p38 MAPK pathways...
  6. doi request reprint Activation of signal transducer and activator of transcription-3 in the spinal cord of sporadic amyotrophic lateral sclerosis patients
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Neurodegener Dis 6:118-26. 2009
    ..It is known that signal transducer and activator of transcription-3 (STAT3) is a proinflammatory transcription factor. However, it remains to be determined whether STAT3 is involved in ALS...
  7. doi request reprint Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis
    Noriyuki Shibata
    Department of Pathology, Tokyo Woman s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, Japan
    Neuropathology 28:387-98. 2008
    ..Our results suggest that pioglitazone protects motor neurons against p38-mediated neuronal death and NF-kappaB-mediated glial inflammation via a PPARgamma-independent mechanism...
  8. doi request reprint Persistent cleavage and nuclear translocation of apoptosis-inducing factor in motor neurons in the spinal cord of sporadic amyotrophic lateral sclerosis patients
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Acta Neuropathol 118:755-62. 2009
    ..Our results provide evidence for persistent cleavage and nuclear translocation of AIF in ALS spinal cord, suggesting implications for the AIF-mediated motor neuron death in this disease...
  9. doi request reprint Activation of STAT3 and inhibitory effects of pioglitazone on STAT3 activity in a mouse model of SOD1-mutated amyotrophic lateral sclerosis
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Neuropathology 30:353-60. 2010
    ..Moreover, it is likely that pioglitazone may exert inhibitory effects on STAT3-mediated proinflammtory mechanisms in this disease...
  10. doi request reprint Increased expression and activation of cytosolic phospholipase A2 in the spinal cord of patients with sporadic amyotrophic lateral sclerosis
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku 162 8666, Tokyo, Japan
    Acta Neuropathol 119:345-54. 2010
    ....
  11. ncbi request reprint Molecular biological approaches to neurological disorders including knockout and transgenic mouse models
    Noriyuki Shibata
    First Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Neuropathology 22:337-49. 2002
    ..Noticing both the similarity and difference between human and animal disorders will help understand the nature of disease...
  12. ncbi request reprint Superoxide dismutase-1 mutation-related neurotoxicity in familial amyotrophic lateral sclerosis
    N Shibata
    Department of Pathology, Tokyo Women s Medical University, Japan
    Amyotroph Lateral Scler Other Motor Neuron Disord 1:143-61. 2000
    ....
  13. ncbi request reprint Selective formation of certain advanced glycation end products in spinal cord astrocytes of humans and mice with superoxide dismutase-1 mutation
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Kawada cho 8 1, Shinjuku ku, Tokyo 162 8666, Japan
    Acta Neuropathol 104:171-8. 2002
    ..Our results indicate that protein glycation, but not lipid peroxidation, is enhanced in ALS patients with an SOD1 mutation and mutant SOD1 transgenic mice, in which certain AGEs are selectively formed in the spinal cord astrocytes...
  14. ncbi request reprint Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients
    N Shibata
    Department of Pathology, Tokyo Women s Medical University, Kawada cho 8 1, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Res 917:97-104. 2001
    ....
  15. pmc Characteristics of neurons and glia in the brain of Fukuyama type congenital muscular dystrophy
    T Yamamoto
    Department of Pathology, Tokyo Women s Medical University, Japan
    Acta Myol 27:9-13. 2008
    ....
  16. ncbi request reprint iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis
    S Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical College, 8 1 Kawada cho, Shinjuku ku 162 8666, Tokyo, Japan
    Neurosci Lett 291:44-8. 2000
    ..These findings suggest that selective nitric oxide-mediated oxidative damage in the motor system plays a part in the pathomechanism of the neuronal degeneration in the spinal cord of sporadic ALS...
  17. ncbi request reprint Clinicopathological study on eyes from cases of Fukuyama type congenital muscular dystrophy
    N Hino
    Department of Pediatrics, Tokyo Women s Medical University, Kawada cho 8 1, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Dev 23:97-107. 2001
    ..The present findings suggest that the Müller cells are implicated in the retinal pathology of FCMD...
  18. ncbi request reprint Transgenic mouse model for familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation
    N Shibata
    Department of Pathology, Tokyo Women's Medical University, Japan
    Neuropathology 21:82-92. 2001
    ..Such a model would contribute to elucidating the pathomechanism of this disease and establishing new therapeutic agents...
  19. ncbi request reprint Apoptosis inhibitor expressed by macrophages tempers autoimmune colitis and the risk of colitis-based carcinogenesis in TCRalpha-/- mice
    Ikuko Haruta
    Department of Medicine and Gastroenterology, Tokyo Women s Medical University, Tokyo, Japan
    J Clin Immunol 27:549-56. 2007
    ..To study the development of mucosal inflammation, and chronic inflammation-based dysplasia and carcinoma formation, we examined possible roles of the apoptosis inhibitor expressed by macrophages (AIM) in an experimental IBD model...
  20. pmc A role of fukutin, a gene responsible for Fukuyama type congenital muscular dystrophy, in cancer cells: a possible role to suppress cell proliferation
    Tomoko Yamamoto
    Department of Pathology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Int J Exp Pathol 89:332-41. 2008
    ..The result may propose a possibility of another function of fukutin in addition to the glycosylation of alpha-DG in cancer cells...
  21. pmc Lipoteichoic acid may affect the pathogenesis of PBC-like bile duct damage and might be involved in systemic multifocal epithelial inflammations in chronic colitis-harboring TCRalpha-/-xAIM-/- mice
    Ikuko Haruta
    Department of Medicine and Gastroenterology, Tokyo Women s Medical University, Tokyo, Japan
    Autoimmunity 40:372-9. 2007
    ..The aim of this study was to investigate the pathophysiology of the liver and other organs in TCRalpha(- / - ) x AIM(- / - ) mice...
  22. doi request reprint Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation
    Ikuko Haruta
    Departments of Microbiology and Immunology, Tokyo Women s Medical University, 8 1 Kawada cho, Tokyo, Shinjuku ku, Japan
    Lab Invest 90:577-88. 2010
    ..Bacteria triggered PBC-like cholangitis, multifocal epithelial inflammation, and autoantibody production. Bacteria are likely involved in the pathogenesis of PBC and of associated multifocal epithelial inflammation...
  23. ncbi request reprint Crotonaldehyde accumulates in glial cells of Alzheimer's disease brain
    Motoko Kawaguchi-Niida
    Department of Surgical Pathology, Tokyo Women s Medical University, 162 8666, Tokyo, Japan
    Acta Neuropathol 111:422-9. 2006
    ..Our results suggest that increased oxidative stress and CRA formation in glial cells is implicated in the disease processes of AD...
  24. ncbi request reprint Functions of fukutin, a gene responsible for Fukuyama type congenital muscular dystrophy, in neuromuscular system and other somatic organs
    Tomoko Yamamoto
    Department of Pathology, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    Cent Nerv Syst Agents Med Chem 10:169-79. 2010
    ..Toward effective therapies with minimal side effects, precise evaluation of the pathomechanism of FCMD and the function of fukutin would be required...
  25. ncbi request reprint Intracellular binding of fukutin and alpha-dystroglycan: relation to glycosylation of alpha-dystroglycan
    Tomoko Yamamoto
    Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Neurosci Res 56:391-9. 2006
    ..Fukutin may directly interact with alpha-dystroglycan during glycosylation, but further examinations are needed to confirm these details...
  26. ncbi request reprint Expression of genes related to muscular dystrophy with lissencephaly
    Tomoko Yamamoto
    Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Pediatr Neurol 31:183-90. 2004
    ..The roles of fukutin in mature neurons may be less critical compared with the other two genes. Additional functions of fukutin, especially in the liver, are suspected...
  27. ncbi request reprint Oxidative stress in the brain of Fukuyama type congenital muscular dystrophy: immunohistochemical study on astrocytes
    Tomoko Yamamoto
    Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    J Child Neurol 17:793-9. 2002
    ..Function of astrocytes might be impaired or immature in severe or heterozygous cases. These results may confirm that astrocytes play an important role in the etiology of the brain lesion...
  28. doi request reprint Alterations in subcellular localization of TDP-43 immunoreactivity in the anterior horns in sporadic amyotrophic lateral sclerosis
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Neurosci Lett 478:72-6. 2010
    ....
  29. ncbi request reprint Accumulation of protein-bound 4-hydroxy-2-hexenal in spinal cords from patients with sporadic amyotrophic lateral sclerosis
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Kawada cho 8 1, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Res 1019:170-7. 2004
    ..Our results indicate that enhanced HHE formation occurs in the entire gray matter of sporadic ALS spinal cords and suggest that the selective vulnerability of motor neurons to HHE mediates the pathomechanism of this disease...
  30. ncbi request reprint Expression and localization of fukutin, POMGnT1, and POMT1 in the central nervous system: consideration for functions of fukutin
    Tomoko Yamamoto
    Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, 162 8666, Japan
    Med Electron Microsc 37:200-7. 2004
    ..FCMD is a rather mild disease among FCMD, MEB, and WWS, and POMGnT1 and POMT1 seems to have more critical roles compared to fukutin in mature neurons...
  31. ncbi request reprint Ultrastructural study of aggregates in the spinal cord of transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666, Tokyo, Japan
    Acta Neuropathol 109:247-55. 2005
    ....
  32. ncbi request reprint Glyoxal inactivates glutamate transporter-1 in cultured rat astrocytes
    Motoko Kawaguchi
    Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Neuropathology 25:27-36. 2005
    ..Our results indicate that glyoxal modifies GLT-1 to form CML and simultaneously deprives its glutamate uptake activity. Thus, these toxic effects of glyoxal on astrocytes might be implicated in motor neuron death in ALS...
  33. ncbi request reprint Neuronal nitric oxide synthase immunoreactivity in the spinal cord in amyotrophic lateral sclerosis
    S Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women's Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan
    Acta Neuropathol 101:351-7. 2001
    ..Further studies are needed to determine whether the increased nNOS immunoreactivity plays a neuroprotective or neurotoxic role in the anterior horn neurons, and to show nitric oxide production in ALS...
  34. ncbi request reprint Lysophosphatidylcholine enhances cytokine production of endothelial cells via induction of L-type amino acid transporter 1 and cell surface antigen 4F2
    Wakako Takabe
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1 Komaba, Meguro, Tokyo, 153 8904, Japan
    Arterioscler Thromb Vasc Biol 24:1640-5. 2004
    ..We performed DNA microarray experiments to explore novel responses of human umbilical vein endothelial cells (HUVECs) to oxLDL and its components...
  35. ncbi request reprint Oxidative stress in the human fetal brain: an immunohistochemical study
    Tomoko Yamamoto
    Department of Pathology, Tokyo Women s Medical College, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Pediatr Neurol 26:116-22. 2002
    ..4-Hydroxynonenal is generally positive in the cytoplasm but was positive in the nucleus of immature neurons and glial cells in the present study, suggesting a unique metabolism of the fetal brain...
  36. ncbi request reprint Granulocyte-macrophage colony-stimulating factor ensures macrophage survival and generation of the superoxide anion: a study using a monocytic-differentiated HL60 subline
    M Ujihara
    Department of Medicine, Institute of Clinical Endocrinology, Tokyo, Japan
    Free Radic Biol Med 31:1396-404. 2001
    ..This unique function may play an important role in ensuring survival and promoting function in atherosclerotic lesions...
  37. ncbi request reprint Early ultrastructural changes in the central nervous system in Fukuyama congenital muscular dystrophy
    T Yamamoto
    Department of Pathology, Tokyo Women s Medical College, Japan
    Ultrastruct Pathol 21:355-60. 1997
    ....
  38. ncbi request reprint [The role for oxidative stress in neurodegenerative diseases]
    Noriyuki Shibata
    Graduate School of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Nerve 60:157-70. 2008
    ..These observations could indicate crucial implications for oxidative stress in several steps of the pathomechanisms of neurodegenerative diseases...
  39. doi request reprint Transcription factor Spi-B-dependent and -independent pathways for the development of Peyer's patch M cells
    S Sato
    Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Mucosal Immunol 6:838-46. 2013
    ....
  40. doi request reprint Angiotensin II type 1 receptor blocker telmisartan reduces cerebral infarct volume and peri-infarct cytosolic phospholipase A(2) level in experimental stroke
    Tomonori Kobayashi
    Department of Neurosurgery, Tokyo Women s Medical University, Tokyo, Japan
    J Neurotrauma 26:2355-64. 2009
    ....
  41. ncbi request reprint Covalent binding of oxidized cholesteryl esters to protein: implications for oxidative modification of low density lipoprotein and atherosclerosis
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 278:21040-9. 2003
    ..The results of this study suggest that the binding of cholesteryl ester core aldehydes to LDL might represent the process common to the oxidative modification of lipoproteins...
  42. ncbi request reprint Maillard reaction-like lysine modification by a lipid peroxidation product: immunochemical detection of protein-bound 2-hydroxyheptanal in vivo
    Koichi Itakura
    Faculty of Education, Aichi University of Education, Kariya, Japan
    Biochem Biophys Res Commun 308:452-7. 2003
    ..By using this antibody, it was revealed that the antigenic structure was indeed present in atherosclerotic lesions of the human aorta...
  43. ncbi request reprint Protein-bound 4-hydroxy-2-nonenal: an endogenous triggering antigen of antI-DNA response
    Kazuyo Toyoda
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 282:25769-78. 2007
    ..e. the native DNA and protein-bound 4-oxo-2-nonenal). The findings in this study provide evidence to suspect an etiologic role for lipid peroxidation in autoimmune diseases...
  44. ncbi request reprint Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids
    Satoshi Yamada
    Tsukuba Research Laboratory, NOF Corporation, Tsukuba 300 2635, Japan
    J Lipid Res 45:626-34. 2004
    ..The results of this study suggest that the reaction between oxidized n-3 PUFAs and protein might represent a process common to the formation of degenerative proteins during aging and its related diseases...
  45. ncbi request reprint Identification of a lipid peroxidation product as a potential trigger of the p53 pathway
    Takahiro Shibata
    Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    J Biol Chem 281:1196-204. 2006
    ..These data may suggest the potential critical role for ONE in the induction of a neuronal apoptosis program during oxidative processes...
  46. pmc 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis
    Mitsuhiro Kondo
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Proc Natl Acad Sci U S A 99:7367-72. 2002
    ..The 15d-PGJ(2)-induced accumulation of p53 resulted in the activation of a death-inducing caspase cascade mediated by Fas and the Fas ligand...
  47. ncbi request reprint 15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes
    Takahiro Shibata
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 277:10459-66. 2002
    ..Moreover, using a chiral high performance liquid chromatography method for separation of PGD(2) metabolites, we established a novel metabolic pathway, in which PGD(2) is converted to 15d-PGJ(2) via an albumin-independent mechanism...
  48. doi request reprint Immunochemical detection of flavonoid glycosides: development, specificity, and application of novel monoclonal antibodies
    Yoshichika Kawai
    Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima, Kuramoto cho 3 18 15, Tokushima 770 8503, Japan
    Arch Biochem Biophys 476:124-32. 2008
    ....
  49. doi request reprint Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids
    Yoshichika Kawai
    Department of Food Science, Graduate School of Nutrition and Biosciences, The University of Tokushima, Tokushima, Japan
    J Biol Chem 283:9424-34. 2008
    ..Our data provide a new insight into the bioavailability of dietary flavonoids and the mechanism for the prevention of cardiovascular diseases...
  50. ncbi request reprint Small-bowel hemorrhage caused by cytomegalovirus vasculitis following fulminant hepatitis
    Kaku Omori
    Department of Medicine, Institute of Gastroenterology, Tokyo Women s Medical University, 8 1 Kawadacho, Shinjuku ku, Tokyo 162 8666, Japan
    J Gastroenterol 37:954-60. 2002
    ....
  51. ncbi request reprint Identification of a serum component that regulates cyclooxygenase-2 gene expression in cooperation with 4-hydroxy-2-nonenal
    Masaya Kanayama
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 282:24166-74. 2007
    ..These findings represent a demonstration of a link between lipoprotein modification and activation of the inflammatory potential of macrophages...
  52. ncbi request reprint [Familial amyotrophic lateral sclerosis (FALS) with a novel SOD1 gene mutation: a clinicopathological study]
    Chizuru Kawamata
    Department of Neurology, Jichi Medical University
    Rinsho Shinkeigaku 47:211-6. 2007
    ..These findings together with the absence of Bunina bodies are compatible with the neuropathology of FALS with SOD1 gene mutation, although Lewy body-like inclusions characteristic for this condition were not observed...
  53. ncbi request reprint Demonstration and distribution of tau-positive glial coiled body-like structures in white matter and white matter threads in early onset Alzheimer's disease
    Takahiko Umahara
    Department of Geriatrics, Tokyo Medical University, Japan
    Neuropathology 22:9-12. 2002
    ..However, tau abnormalities may have fewer effects when they are located in white matter lesions in AD...