Ichiro Sekiya

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi request reprint Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle
    Hideya Yoshimura
    Section of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cell Tissue Res 327:449-62. 2007
  2. ncbi request reprint Exogenous synovial stem cells adhere to defect of meniscus and differentiate into cartilage cells
    Keisuke Mizuno
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 55:101-11. 2008
  3. doi request reprint Human mesenchymal stem cells in synovial fluid increase in the knee with degenerated cartilage and osteoarthritis
    Ichiro Sekiya
    Section of Cartilage Regeneration, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Orthop Res 30:943-9. 2012
  4. pmc Arthroscopic, histological and MRI analyses of cartilage repair after a minimally invasive method of transplantation of allogeneic synovial mesenchymal stromal cells into cartilage defects in pigs
    Tomomasa Nakamura
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cytotherapy 14:327-38. 2012
  5. ncbi request reprint Periodic knee injections of BMP-7 delay cartilage degeneration induced by excessive running in rats
    Ichiro Sekiya
    Section of Cartilage Regeneration, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Orthop Res 27:1088-92. 2009
  6. pmc Ketoprofen absorption by muscle and tendon after topical or oral administration in patients undergoing anterior cruciate ligament reconstruction
    Ichiro Sekiya
    Section of Cartilage Regeneration, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    AAPS PharmSciTech 11:154-8. 2010
  7. pmc Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect
    Hideyuki Koga
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Res Ther 10:R84. 2008
  8. doi request reprint [Articular cartilage regeneration with synovial mesenchymal stem cells]
    Ichiro Sekiya
    Section of Cartilage Regeneration, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Calcium 21:879-89. 2011
  9. ncbi request reprint Transplantation of Achilles tendon treated with bone morphogenetic protein 7 promotes meniscus regeneration in a rat model of massive meniscal defect
    Nobutake Ozeki
    Tokyo Medical and Dental University, Tokyo, Japan Yokohama City University, Yokohama, Japan
    Arthritis Rheum 65:2876-86. 2013
  10. pmc Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration
    Shiro Suzuki
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arthritis Res Ther 14:R136. 2012

Collaborators

Detail Information

Publications77

  1. ncbi request reprint Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle
    Hideya Yoshimura
    Section of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cell Tissue Res 327:449-62. 2007
    ..In particular, synovium-derived cells had the greatest potential for both proliferation and chondrogenesis, indicating their usefulness for cartilage study in a rat model...
  2. ncbi request reprint Exogenous synovial stem cells adhere to defect of meniscus and differentiate into cartilage cells
    Keisuke Mizuno
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 55:101-11. 2008
    ..GFP mRNA expressions were not observed in distant organs at day 1. After intra-articular injection, synovial MSCs attached to the meniscal defect and differentiated into cartilage cells...
  3. doi request reprint Human mesenchymal stem cells in synovial fluid increase in the knee with degenerated cartilage and osteoarthritis
    Ichiro Sekiya
    Section of Cartilage Regeneration, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Orthop Res 30:943-9. 2012
    ..We listed 20 genes which were expressed higher in both SYN MSCs and SF MSCs than in BM MSCs, and 3 genes were confirmed by quantitative RT-PCR. MSCs in SF increased along with degenerated cartilage and osteoarthritis...
  4. pmc Arthroscopic, histological and MRI analyses of cartilage repair after a minimally invasive method of transplantation of allogeneic synovial mesenchymal stromal cells into cartilage defects in pigs
    Tomomasa Nakamura
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cytotherapy 14:327-38. 2012
    ..We transplanted synovial MSCs into cartilage defects using a simple method and investigated its usefulness and repair process in a pig model...
  5. ncbi request reprint Periodic knee injections of BMP-7 delay cartilage degeneration induced by excessive running in rats
    Ichiro Sekiya
    Section of Cartilage Regeneration, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Orthop Res 27:1088-92. 2009
    ..The effect of BMP-7 could be monitored by serum keratan sulfate concentration. Periodical injections of BMP-7 delayed progression of cartilage degeneration induced by excessive running in rats...
  6. pmc Ketoprofen absorption by muscle and tendon after topical or oral administration in patients undergoing anterior cruciate ligament reconstruction
    Ichiro Sekiya
    Section of Cartilage Regeneration, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    AAPS PharmSciTech 11:154-8. 2010
    ..In conclusion, following topical application in a patch, ketoprofen shows rapid and sustained delivery to the underlying tissues without a significant increase of the plasma drug concentration...
  7. pmc Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect
    Hideyuki Koga
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Res Ther 10:R84. 2008
    ..We have developed a novel transplantation method with synovial mesenchymal stem cells (MSCs) to adhere to the cartilage defect...
  8. doi request reprint [Articular cartilage regeneration with synovial mesenchymal stem cells]
    Ichiro Sekiya
    Section of Cartilage Regeneration, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Calcium 21:879-89. 2011
    ..To date, no adverse events have been reported in the study. Regeneration of cartilage, reduction in defect size and an improvement of symptoms have been obtained in most patients over the last 3 years...
  9. ncbi request reprint Transplantation of Achilles tendon treated with bone morphogenetic protein 7 promotes meniscus regeneration in a rat model of massive meniscal defect
    Nobutake Ozeki
    Tokyo Medical and Dental University, Tokyo, Japan Yokohama City University, Yokohama, Japan
    Arthritis Rheum 65:2876-86. 2013
    ..Additionally, we analyzed the relative contributions of host and donor cells on the healing process after tendon transplantation in a rat model...
  10. pmc Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration
    Shiro Suzuki
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arthritis Res Ther 14:R136. 2012
    ..The use of aggregated MSCs may be one of the solutions. Here, we investigated the handling, properties and effectiveness of aggregated MSCs for cartilage regeneration...
  11. ncbi request reprint Revision anterior cruciate ligament reconstruction by double-bundle technique using multi-strand semitendinosus tendon
    Takeshi Muneta
    Department of Orthopaedic Surgery, School of Medicine, Tokyo Medical and Dental University Hospital, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Arthroscopy 26:769-81. 2010
    ....
  12. ncbi request reprint FGF2 and dexamethasone increase the production of hyaluronan in two-dimensional culture of elastic cartilage-derived cells: in vitro analyses and in vivo cartilage formation
    Akiko Yokoyama
    Section of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cell Tissue Res 329:469-78. 2007
    ..The synthesis of gelatinous matrix in vitro and the formation of cartilage tissue in vivo could be obtained only for the combination of elastic cartilage-derived cells with redifferentiation medium...
  13. doi request reprint Analysis of the chondrogenic potential of human synovial stem cells according to harvest site and culture parameters in knees with medial compartment osteoarthritis
    Tsuyoshi Nagase
    Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 58:1389-98. 2008
    ....
  14. ncbi request reprint Synovial stem cells are regionally specified according to local microenvironments after implantation for cartilage regeneration
    Hideyuki Koga
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519 Japan
    Stem Cells 25:689-96. 2007
    ..Our results will advance MSC-based therapeutic strategies for cartilage injury and provide the clues for the mechanisms that govern multilineage differentiation of MSCs...
  15. doi request reprint Intra-articular Injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect
    Masafumi Horie
    Section of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    Stem Cells 27:878-87. 2009
    ..Synovium-MSCs injected into the massive meniscectomized knee adhered to the lesion, differentiated into meniscal cells directly, and promoted meniscal regeneration without mobilization to distant organs...
  16. doi request reprint Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit
    Hideyuki Koga
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cell Tissue Res 333:207-15. 2008
    ..Higher cell density and a periosteum patch were needed to obtain a high production of cartilage matrix by synovium-MSCs...
  17. doi request reprint Mesenchymal stem cells derived from synovium, meniscus, anterior cruciate ligament, and articular chondrocytes share similar gene expression profiles
    Yuko Segawa
    Section of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    J Orthop Res 27:435-41. 2009
    ....
  18. pmc Analysis of human synovial and bone marrow mesenchymal stem cells in relation to heat-inactivation of autologous and fetal bovine serums
    Akimoto Nimura
    Section of Cartilage Regeneration, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    BMC Musculoskelet Disord 11:208. 2010
    ..To examine whether heat-inactivation of serum affected the proliferation and whether autologous human serum influenced their multipotentiality...
  19. doi request reprint Increased proliferation of human synovial mesenchymal stem cells with autologous human serum: comparisons with bone marrow mesenchymal stem cells and with fetal bovine serum
    Akimoto Nimura
    Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Arthritis Rheum 58:501-10. 2008
    ..Since effectiveness of the sera might depend on the origin of the MSCs, we also examined bone marrow MSCs...
  20. pmc Serum keratan sulfate transiently increases in the early stage of osteoarthritis during strenuous running of rats: protective effect of intraarticular hyaluronan injection
    Tao Tang
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arthritis Res Ther 10:R13. 2008
    ....
  21. doi request reprint Morphological differences during in vitro chondrogenesis of bone marrow-, synovium-MSCs, and chondrocytes
    Shizuko Ichinose
    Instrumental Analysis Research Center, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Lab Invest 90:210-21. 2010
    ..In this study, we revealed morphological differences of bone marrow-MSCs, synovium-MSCs, and chondrocytes during in vitro chondrogenesis. The most obvious differences in the three populations were observed at day 1 in the deep zone...
  22. ncbi request reprint Teneurin-4, a transmembrane protein, is a novel regulator that suppresses chondrogenic differentiation
    Nobuharu Suzuki
    Department of Biochemistry and Biophysics, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8510, Japan
    J Orthop Res 32:915-22. 2014
    ..These results suggested that Ten-4 suppresses chondrogenic differentiation and regulates the expression and activation of the key molecules for chondrogenesis...
  23. ncbi request reprint Meniscus regeneration by syngeneic, minor mismatched, and major mismatched transplantation of synovial mesenchymal stem cells in a rat model
    Makiko Okuno
    Department of Joint Surgery and Sports Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan Department of Orthopaedic Surgery, Hyogo College of Medicine, Tokyo, Japan
    J Orthop Res 32:928-36. 2014
    ..Syngeneic and minor mismatched transplantation of synovial MSCs promoted meniscus regeneration better than major mismatched transplantation in a rat meniscectmized model...
  24. doi request reprint Remnant volume of anterior cruciate ligament correlates preoperative patients' status and postoperative outcome
    Takeshi Muneta
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Knee Surg Sports Traumatol Arthrosc 21:906-13. 2013
    ..A cohort study was conducted to evaluate the correlation of anterior cruciate ligament (ACL) remnant volume with preoperative status and postoperative outcome of the patients after a remnant-preserving double-bundle (DB) ACL reconstruction...
  25. doi request reprint Effect of posterolateral bundle graft fixation angles on graft tension curves and load sharing in double-bundle anterior cruciate ligament reconstruction using a transtibial drilling technique
    Hideyuki Koga
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital of Medicine, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arthroscopy 29:529-38. 2013
    ..To evaluate the effect of posterolateral bundle (PLB) graft fixation angles on graft tension curves and load sharing between the anteromedial bundle (AMB) and the PLB in double-bundle anterior cruciate ligament (ACL) reconstruction...
  26. ncbi request reprint Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source
    Yusuke Sakaguchi
    Tokyo Medical and Dental University, Japan
    Arthritis Rheum 52:2521-9. 2005
    ..To compare the properties of human mesenchymal stem cells (MSCs) isolated from bone marrow, synovium, periosteum, skeletal muscle, and adipose tissue...
  27. doi request reprint Radiographic description of femoral tunnel placement expressed as intercondylar clock time in double-bundle anterior cruciate ligament reconstruction
    Junya Yamazaki
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital, Tokyo, Japan
    Knee Surg Sports Traumatol Arthrosc 19:418-23. 2011
    ..The reproducibility of the method was evaluated in double-bundle (DB) reconstructions...
  28. ncbi request reprint A retrospective study of the midterm outcome of two-bundle anterior cruciate ligament reconstruction using quadrupled semitendinosus tendon in comparison with one-bundle reconstruction
    Takeshi Muneta
    Department of Orthopedic Surgery, School of Medicine, Tokyo Medical and Dental University Hospital, Tokyo, Japan
    Arthroscopy 22:252-8. 2006
    ....
  29. ncbi request reprint Fibrous change of the infrapatellar fat pad due to strenuous running exercise and its treatment with intraarticular hyaluronan injection in a rat model
    Tao Tang
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 55:163-73. 2008
    ..Strenuous running exercise may cause fibrosis in the IFP of runners. Intraarticular HA injection will inhibit arthrofibrosis of painful runners...
  30. ncbi request reprint Humeral insertion of the supraspinatus and infraspinatus. New anatomical findings regarding the footprint of the rotator cuff. Surgical technique
    Tomoyuki Mochizuki
    Unit of Clinical Anatomy, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Bone Joint Surg Am 91:1-7. 2009
    ..This fact cannot be fully explained by our current understanding of the anatomical insertions of the supraspinatus and infraspinatus. The purpose of this study was to reinvestigate the humeral insertions of these tendons...
  31. ncbi request reprint Mesenchymal stem cells in synovial fluid increase after meniscus injury
    Yu Matsukura
    Department of Joint Surgery and Sports Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Orthop Relat Res 472:1357-64. 2014
    ..Although relatively uncommon, spontaneous healing from a meniscus injury has been observed even within the avascular area. This may be the result of the existence of mesenchymal stem cells in synovial fluid...
  32. doi request reprint [Articular cartilage regenerative therapy with synovial mesenchymal stem cells in a pig model]
    Tomomasa Nakamura
    Sports Medicine Clinical Center, Medical Hospital of Tokyo Medical and Dental University Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University Department of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, Japan
    Clin Calcium 23:1741-9. 2013
    ..Based on this and other preclinical studies, we have started a clinical study for cartilage regeneration with autologous synovial MSCs. ..
  33. ncbi request reprint A prospective randomized study of 4-strand semitendinosus tendon anterior cruciate ligament reconstruction comparing single-bundle and double-bundle techniques
    Takeshi Muneta
    Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthroscopy 23:618-28. 2007
    ..A randomized clinical study was conducted to compare the outcome between double-bundle (DB) and single-bundle (SB) anterior cruciate ligament (ACL) reconstructions with 4-strand semitendinosus tendon (ST)...
  34. doi request reprint Synovial mesenchymal stem cells accelerate early remodeling of tendon-bone healing
    Young Jin Ju
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cell Tissue Res 332:469-78. 2008
    ..DiI-labeled cells could no longer be observed. Implantation of synovial MSCs into bone tunnel thus accelerated early remodeling of tendon-bone healing, as shown histologically...
  35. ncbi request reprint In vitro chondrogenesis of human synovium-derived mesenchymal stem cells: optimal condition and comparison with bone marrow-derived cells
    Shinichi Shirasawa
    Section of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Cell Biochem 97:84-97. 2006
    ....
  36. doi request reprint Intraarticular injection of synovial stem cells promotes meniscal regeneration in a rabbit massive meniscal defect model
    Daisuke Hatsushika
    Department of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, Tokyo, Bunkyo ku, Japan
    J Orthop Res 31:1354-9. 2013
    ..Synovial MSCs injected into the knee adhered around the meniscal defect, and promoted meniscal regeneration in rabbits...
  37. doi request reprint Human YKL39 (chitinase 3-like protein 2), an osteoarthritis-associated gene, enhances proliferation and type II collagen expression in ATDC5 cells
    Kazumasa Miyatake
    Department of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 431:52-7. 2013
    ..These data suggest that hYKL-39 is a novel growth and differentiation factor involved in cartilage homeostasis...
  38. doi request reprint Comparative sequential morphological analyses during in vitro chondrogenesis and osteogenesis of mesenchymal stem cells embedded in collagen gels
    Shizuko Ichinose
    Research Center for Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Med Mol Morphol 46:24-33. 2013
    ..At day 21, chondrogenesis and osteogenesis of the MSC/collagen composite further progressed, respectively. In vitro chondrogenesis and osteogenesis using an MSC/collagen composite clarified the morphological differences...
  39. doi request reprint Surgical management of grade 3 medial knee injuries combined with cruciate ligament injuries
    Hideyuki Koga
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Knee Surg Sports Traumatol Arthrosc 20:88-94. 2012
    ..The purpose of this study was to assess clinical outcome for patients with grade 3 valgus instability who were treated according to our surgical management strategy...
  40. ncbi request reprint Higher chondrogenic potential of fibrous synovium- and adipose synovium-derived cells compared with subcutaneous fat-derived cells: distinguishing properties of mesenchymal stem cells in humans
    Tomoyuki Mochizuki
    Tokyo Medical and Dental University, Yushima, Tokyo, Japan
    Arthritis Rheum 54:843-53. 2006
    ....
  41. doi request reprint Anatomy of normal human anterior cruciate ligament attachments evaluated by divided small bundles
    Kenji Hara
    Department of Orthopaedic Surgery, School of Medicine, Tokyo Medical and Dental University Hospital, Tokyo, Japan
    Am J Sports Med 37:2386-91. 2009
    ..However, there are still controversies regarding tunnel placement in tibial and femoral attachments...
  42. pmc Human sclera maintains common characteristics with cartilage throughout evolution
    Yuko Seko
    Department of Reproductive Biology and Pathology, National Institute for Child and Health Development, Tokyo, Japan
    PLoS ONE 3:e3709. 2008
    ..The aim of this study is to identify characteristics of the human sclera as one of the connective tissues derived from the neural crest and mesoderm...
  43. pmc Osteopontin level in synovial fluid is associated with the severity of joint pain and cartilage degradation after anterior cruciate ligament rupture
    Mika Yamaga
    Department of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 7:e49014. 2012
    ....
  44. pmc Isolation and characterization of multipotential mesenchymal cells from the mouse synovium
    Ippei Futami
    Department of Medicine for Motor Organ, Juntendo University Graduate School of Medicine, Tokyo, Japan
    PLoS ONE 7:e45517. 2012
    ..The cells derived from the mouse synovium demonstrated both the ability to proliferate and multipotentiality similar or superior to the cells derived from muscle and bone marrow...
  45. ncbi request reprint Morphological examination during in vitro cartilage formation by human mesenchymal stem cells
    Shizuko Ichinose
    Instrumental Analysis Research Center, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Cell Tissue Res 322:217-26. 2005
    ..In vitro cartilage formation by MSCs makes it possible to clarify the detailed morphological events that occur during chondrogenesis...
  46. doi request reprint Intra-articular injections of bone morphogenetic protein-7 retard progression of existing cartilage degeneration
    Masaya Hayashi
    Section of Orthopaedic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Orthop Res 28:1502-6. 2010
    ..Micro CT analysis showed that osteophytes were smaller in the BMP-7 treated knee compared to that of the control. Weekly intra-articular injections of BMP-7 inhibited progression of existing cartilage degeneration...
  47. ncbi request reprint The effect of hyaluronan on tendon healing in rabbits
    Kazuyoshi Yagishita
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    Arthroscopy 21:1330-6. 2005
    ..We examined the effect of hyaluronan injection into the bone tunnel on the healing of the tendon-bone junction...
  48. doi request reprint Transplantation of aggregates of synovial mesenchymal stem cells regenerates meniscus more effectively in a rat massive meniscal defect
    Hiroki Katagiri
    Department of Joint Surgery and Sports Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 435:603-9. 2013
    ..We confirmed that MSCs transplanted as aggregates existed in the regenerated meniscus focally and partially. Transplantation of aggregates of synovial MSCs regenerated meniscus more effectively in a rat massive meniscal defect...
  49. pmc Arthroscopic centralization of an extruded lateral meniscus
    Hideyuki Koga
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan
    Arthrosc Tech 1:e209-12. 2012
    ..The sutures were then tied by use of a self-locking sliding knot, achieving centralization and secure stabilization of the lateral meniscus...
  50. ncbi request reprint Detailed examination of cartilage formation and endochondral ossification using human mesenchymal stem cells
    Shizuko Ichinose
    Instrumental Analysis Research Center, Tokyo Medical and Dental University, Japan
    Clin Exp Pharmacol Physiol 32:561-70. 2005
    ..8. The findings of the present study indicate that our three-dimensional culture is a convenient in vitro model for the investigation of the regulatory mechanisms of cartilage formation and endochondral ossification...
  51. pmc Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits
    Takashi Miyamoto
    Section of Orthopaedic Surgery, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arthritis Res Ther 12:R206. 2010
    ..Here, we examined the effect of intradiscal transplantation of synovial MSCs after aspiration of nucleus pulposus in rabbits...
  52. doi request reprint BMP-7 inhibits cartilage degeneration through suppression of inflammation in rat zymosan-induced arthritis
    Toru Takahashi
    Section of Orthopedic Surgery, Division of Bio Matrix, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Cell Tissue Res 344:321-32. 2011
    ..Thus, intra-articular injections of BMP-7 had a protective effect on cartilage degeneration in the inflammatory arthritis model by enhancing levels of BMP-7 in cartilage and suppressing the production of IL-1β in synovium...
  53. pmc Weekly intra-articular injections of bone morphogenetic protein-7 inhibits osteoarthritis progression
    Masaya Hayashi
    Section of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, 113 8519 Japan
    Arthritis Res Ther 10:R118. 2008
    ..We investigated the ability of a weekly intra-articular injection of bone morphogenetic protein (BMP)-7 to prevent osteoarthritis in rabbits with anterior cruciate ligament transections...
  54. ncbi request reprint Arthroscopic evaluation of the articular cartilage after anterior cruciate ligament reconstruction: a short-term prospective study of 105 patients
    Hiroshi Asano
    Department of Orthopedics, Tokyo Medical and Dental University, Tokyo, Japan
    Arthroscopy 20:474-81. 2004
    ..No report has been published about early cartilage change after ACL reconstruction. The purpose of this study was to evaluate the articular cartilage after ACL reconstruction in a short postoperative period by arthroscopy...
  55. ncbi request reprint In vivo pharmacokinetics of ketoprofen after patch application in the Mexican hairless pig
    Masafumi Horie
    Section of Orthopedic Surgery, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Biopharm Drug Dispos 30:204-8. 2009
    ..While the data of drug concentration in human tissue are difficult to test, the Mexican hairless pig model appears to be attractive for in vivo pharmacokinetic studies of topically applied ketoprofen...
  56. doi request reprint The kinematic analysis of female subjects after double-bundle anterior cruciate ligament reconstruction during single-leg squatting
    Junya Yamazaki
    Section of Orthopedic Surgery, School of Medicine, Tokyo Medical and Dental University Hospital, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Orthop Sci 18:284-9. 2013
    ....
  57. ncbi request reprint Suspended cells from trabecular bone by collagenase digestion become virtually identical to mesenchymal stem cells obtained from marrow aspirates
    Yusuke Sakaguchi
    Section of Orthopedic Surgery, Division of Bio Matrix, Graduate School, Tokyo Medical and Dental University, Japan
    Blood 104:2728-35. 2004
    ..Enzymatically released cells from trabecular bone became virtually identical to marrow aspirate-derived MSCs, demonstrating that a trabecular bone fragment can be an alternative source of MSCs...
  58. doi request reprint Hyaluronan injection therapy for athletic patients with patellar tendinopathy
    Takeshi Muneta
    Department of Orthopaedic Surgery, School of Medicine, Tokyo Medical and Dental University Hospital, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Orthop Sci 17:425-31. 2012
    ..The purpose of this study was to summarize the clinical experience of and to describe the appropriate indication for this injection therapy...
  59. doi request reprint The effect of graft fixation angles on anteroposterior and rotational knee laxity in double-bundle anterior cruciate ligament reconstruction: evaluation using computerized navigation
    Hideyuki Koga
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Sports Med 40:615-23. 2012
    ....
  60. doi request reprint Autologous synovial fluid enhances migration of mesenchymal stem cells from synovium of osteoarthritis patients in tissue culture system
    Sheng Zhang
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, 113 8519 Japan
    J Orthop Res 26:1413-8. 2008
    ..We demonstrated that autologous synovial fluid enhanced expansion of MSCs in tissue culture of synovium from osteoarthritis patients by promoting cell migration. This effect was partially affected by TGFbeta...
  61. doi request reprint Soft tissue tension in extension in total knee arthroplasty affects postoperative knee extension and stability
    Hiroshi Asano
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyouku, Tokyo, corrected Japan
    Knee Surg Sports Traumatol Arthrosc 16:999-1003. 2008
    ..05). Our results demonstrated that soft tissue tension during operation affects postoperative knee extension and stability...
  62. doi request reprint Methylation status of CpG islands in the promoter regions of signature genes during chondrogenesis of human synovium-derived mesenchymal stem cells
    Yoichi Ezura
    Department of Molecular Pharmacology, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 60:1416-26. 2009
    ..The purpose of this study was to investigate the CpG methylation status in human synovium-derived MSCs during experimental chondrogenesis, with a view toward potential therapeutic use in osteoarthritis...
  63. doi request reprint High-flex posterior cruciate-retaining vs posterior cruciate-substituting designs in simultaneous bilateral total knee arthroplasty: a prospective, randomized study
    Kazuyoshi Yagishita
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    J Arthroplasty 27:368-74. 2012
    ..However, postoperative arc of range of motion, patient satisfaction, and posterior knee pain at passive flexion in the PS design were significantly superior to that of the CR design...
  64. doi request reprint Hip acetabular dysplasia and joint laxity of female anterior cruciate ligament-injured patients
    Junya Yamazaki
    Section of Orhopedic Surgery, School of Medicine, Tokyo Medical and Dental University Hospital, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Sports Med 39:410-4. 2011
    ..It has been noted that some female anterior cruciate ligament-injured patients have complaints of both coxalgia and joint laxity...
  65. ncbi request reprint Healing potential of meniscal tears without repair in knees with anterior cruciate ligament reconstruction
    Kazuyoshi Yagishita
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Sports Med 32:1953-61. 2004
    ..Few previous studies have documented the healing potential of meniscal tears that are left to heal without repair...
  66. ncbi request reprint Cadaveric knee observation study for describing anatomic femoral tunnel placement for two-bundle anterior cruciate ligament reconstruction
    Tomoyuki Mochizuki
    Section of Orthopedic Surgery, Division of Bio Matrix, Graduate School, Tokyo Medical and Dental University, Yushima, Tokyo, Japan
    Arthroscopy 22:356-61. 2006
    ..Our hypothesis was that the core functional area of the femoral ACL attachment will be revealed by removing the surface fibrous membranous tissue of the ACL midsubstance and the attachment area...
  67. ncbi request reprint Substance P immunoreactive fibers of synovial tissue in patients with anterior cruciate ligament injury
    Bo Zhang
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, 113 8519, Bunkyo ku, Tokyo, Japan
    Knee Surg Sports Traumatol Arthrosc 14:404-10. 2006
    ..In the male group, there was no such correlation. Substance P was well- correlated with pain and inflammatory reaction in the female joint. Neural inflammation and neural pain occur more strongly in female joints...
  68. ncbi request reprint In vitro cartilage formation of composites of synovium-derived mesenchymal stem cells with collagen gel
    Akiko Yokoyama
    Section of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cell Tissue Res 322:289-98. 2005
    ..The tissue engineering of autologous cartilage from the composites of synovium-derived MSCs with collagen gel in vitro for transplantation may be a future alternative to graft implantation for patients with cartilage defects...
  69. ncbi request reprint Enhancement of tissue engineered bone formation by a low pressure system improving cell seeding and medium perfusion into a porous scaffold
    Juyong Wang
    Department of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
    Biomaterials 27:2738-46. 2006
    ..The application of low pressure during the seeding of BMSCs in perfusing medium into a porous scaffold is useful for tissue-engineered bone formation...
  70. ncbi request reprint Protein-conjugated quantum dots effectively delivered into living cells by a cationic nanogel
    Sayaka Toita
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2 3 10, Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    J Nanosci Nanotechnol 8:2279-85. 2008
    ..The hybrid nanoparticles are a promising candidate as a cell tracer in tissue engineering...
  71. ncbi request reprint Incidence and risk factors for medial tibial stress syndrome and tibial stress fracture in high school runners
    Shigenori Yagi
    Department of Joint Surgery and Sports Medicine, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Knee Surg Sports Traumatol Arthrosc 21:556-63. 2013
    ..Medial tibial stress syndrome (MTSS) and tibial stress fracture (SF) are common lower leg disorders in runners. A prospective study was done to identify the incidence of MTSS and SF in high school runners and to determine risk factors...
  72. doi request reprint Humeral insertion of the supraspinatus and infraspinatus. New anatomical findings regarding the footprint of the rotator cuff
    Tomoyuki Mochizuki
    Section of Orthopaedic Surgery, Division of Cartilage Regeneration, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Bone Joint Surg Am 90:962-9. 2008
    ..This fact cannot be fully explained by our current understanding of the anatomical insertions of the supraspinatus and infraspinatus. The purpose of this study was to reinvestigate the humeral insertions of these tendons...
  73. doi request reprint Transplantation of neuronal cells induced from human mesenchymal stem cells improves neurological functions after stroke without cell fusion
    Haiyan Xu
    Department of Neurology and Neurological Science, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Neurosci Res 88:3598-609. 2010
    ..These findings suggested that hN-MSCs have greater therapeutic potential than hMSCs for stroke and that cell fusion does not primarily contribute to the therapeutic mechanism of MSC transplantation...
  74. pmc Effects of different initial bundle tensioning strategies on the outcome of double-bundle ACL reconstruction: a cohort study
    Takeshi Muneta
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital, Tokyo, Japan
    Sports Med Arthrosc Rehabil Ther Technol 3:15. 2011
    ..abstract:..
  75. pmc Intraoperative joint gaps affect postoperative range of motion in TKAs with posterior-stabilized prostheses
    Toshifumi Watanabe
    Department of Orthopaedic Surgery, Tokyo Medical and Dental University Hospital, 1 5 45, Yushima, Bunkyo ku, 113 8510, Tokyo, Japan
    Clin Orthop Relat Res 471:1326-33. 2013
    ..If specific relationships exist between soft tissue tension and patient function, then objective targets could be established to assist surgeons in achieving more consistent postoperative knee function...
  76. pmc Repair of olecranon fractures using fiberWire without metallic implants: report of two cases
    Akimoto Nimura
    Section of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519 Japan
    J Orthop Surg Res 5:73. 2010
    ..Using the method described, difficulty due to K-wire or other metallic implants was avoided...
  77. doi request reprint [Locomotive syndrome and frailty. Total knee arthroplasty supports active life of the elderly]
    Toshifumi Watanabe
    Section of Cartilage Regeneration, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Calcium 22:103-9. 2012
    ..In elderly patients, pre-existing conditions should be carefully controlled, and postoperative complications, including infection and thrombosis, should be treated prophylactically to promote safety and postoperative recovery...