M Sawabe

Summary

Affiliation: Tokyo Metropolitan Institute of Gerontology
Country: Japan

Publications

  1. ncbi Smoking confers a MTHFR 677C>T genotype-dependent risk for systemic atherosclerosis: results from a large number of elderly autopsy cases that died in a community-based general geriatric hospital
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    J Atheroscler Thromb 16:91-104. 2009
  2. pmc Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Breast Cancer Res 11:R48. 2009
  3. pmc Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases
    Koichi Fujimoto
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    BMC Med Genet 11:159. 2010
  4. pmc Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men
    Miao Liu
    Department of Urology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    BMC Genet 10:37. 2009
  5. pmc Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases
    Kako Takei
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 101 0062, Japan
    BMC Cancer 8:235. 2008
  6. ncbi Early pathogenesis of cardiac amyloid deposition in senile systemic amyloidosis: close relationship between amyloid deposits and the basement membranes of myocardial cells
    Motoji Sawabe
    Departments of Pathology and Cardiology, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakae cho, Itabashi, 173 0015, Tokyo, Japan
    Virchows Arch 442:252-7. 2003
  7. doi Vascular aging: from molecular mechanism to clinical significance
    Motoji Sawabe
    Department of Pathology and Bioresource Center for Geriatric Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 10:S213-20. 2010
  8. ncbi Developments of geriatric autopsy database and Internet-based database of Japanese single nucleotide polymorphisms for geriatric research (JG-SNP)
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, 35 2 Sakae cho, Itabashi, Tokyo 173 0015, Japan
    Mech Ageing Dev 125:547-52. 2004
  9. doi High lipoprotein(a) level promotes both coronary atherosclerosis and myocardial infarction: a path analysis using a large number of autopsy cases
    M Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Itabashi, Tokyo 173 0015, Japan
    Heart 95:1997-2002. 2009
  10. ncbi Three-dimensional organization of the hepatic microvasculature in hereditary hemorrhagic telangiectasia
    M Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Arch Pathol Lab Med 125:1219-23. 2001

Collaborators

Detail Information

Publications96

  1. ncbi Smoking confers a MTHFR 677C>T genotype-dependent risk for systemic atherosclerosis: results from a large number of elderly autopsy cases that died in a community-based general geriatric hospital
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    J Atheroscler Thromb 16:91-104. 2009
    ..We attempted to explore interactions between smoking and the genetic polymorphism of 24 atherosclerosis-related candidate genes in systemic atherosclerosis...
  2. pmc Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Breast Cancer Res 11:R48. 2009
    ..The aim of the present study is to elucidate whether there are any specific patterns in use of multiple exons 1 in elderly breast tissue...
  3. pmc Polymorphism of SERPINE2 gene is associated with pulmonary emphysema in consecutive autopsy cases
    Koichi Fujimoto
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    BMC Med Genet 11:159. 2010
    ..Whether they are associated with emphysema is not known...
  4. pmc Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men
    Miao Liu
    Department of Urology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    BMC Genet 10:37. 2009
    ..Here, we evaluated whether the single-nucleotide polymorphisms rs1447295 and rs6983267 were associated with the risk of sporadic prostate cancer as well as latent prostate cancer in a native Japanese population...
  5. pmc Lymphotoxin-alpha polymorphisms and presence of cancer in 1,536 consecutive autopsy cases
    Kako Takei
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 101 0062, Japan
    BMC Cancer 8:235. 2008
    ..Lymphotoxin-alpha (LTA) is a pro-inflammatory cytokine with anti-tumor activity. The objective of this study was to determine whether LTA polymorphisms influence the presence of cancer...
  6. ncbi Early pathogenesis of cardiac amyloid deposition in senile systemic amyloidosis: close relationship between amyloid deposits and the basement membranes of myocardial cells
    Motoji Sawabe
    Departments of Pathology and Cardiology, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakae cho, Itabashi, 173 0015, Tokyo, Japan
    Virchows Arch 442:252-7. 2003
    ..Our results indicate that the basement membrane of myocardial cells is the initial site of amyloid deposition, providing a suitable place for concentration of TTR...
  7. doi Vascular aging: from molecular mechanism to clinical significance
    Motoji Sawabe
    Department of Pathology and Bioresource Center for Geriatric Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 10:S213-20. 2010
    ..In conclusion, the ARMDS is a distinct pathological entity with clinical significance. The pathogenesis of ARMDS is unclear; the mechanical stress of elastin, endothelial dysfunction, and glycation of elastin are proposed...
  8. ncbi Developments of geriatric autopsy database and Internet-based database of Japanese single nucleotide polymorphisms for geriatric research (JG-SNP)
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, 35 2 Sakae cho, Itabashi, Tokyo 173 0015, Japan
    Mech Ageing Dev 125:547-52. 2004
    ..As autopsy studies can provide large amounts of accurate medical information, including the presence of undiagnosed diseases such as latent cancers, the GEAD is a unique and excellent database for research on genetic polymorphisms...
  9. doi High lipoprotein(a) level promotes both coronary atherosclerosis and myocardial infarction: a path analysis using a large number of autopsy cases
    M Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Itabashi, Tokyo 173 0015, Japan
    Heart 95:1997-2002. 2009
    ..To investigate whether hyper-lipoproteinaemia(a) (Lp(a)) promotes coronary atherosclerosis, acute thrombosis resulting in myocardial infarction (MI), or both...
  10. ncbi Three-dimensional organization of the hepatic microvasculature in hereditary hemorrhagic telangiectasia
    M Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Arch Pathol Lab Med 125:1219-23. 2001
    ..The 3-dimensional reconstruction study of hepatic microvasculature was successful in identifying the pathological changes responsible for the intrahepatic shunts in HHT...
  11. ncbi Elderly patients with minimal common carotid atherosclerosis not infrequently have severe coronary atherosclerosis and myocardial infarction
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Circ J 72:1946-52. 2008
    ..The presence of discordances between common carotid and coronary atherosclerosis in the same individual has not been previously reported...
  12. ncbi Sustained progression and loss of the gender-related difference in atherosclerosis in the very old: a pathological study of 1074 consecutive autopsy cases
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakae cho, Itabashi, Tokyo 173 0015, Japan
    Atherosclerosis 186:374-9. 2006
    ..The objective of this paper is to reveal whether the atherosclerosis continues to progress, or the gender-related difference exists in the very old...
  13. ncbi Mitochondrial haplogroups A and M7a confer a genetic risk for coronary atherosclerosis in the Japanese elderly: an autopsy study of 1,536 patients
    Motoji Sawabe
    Department of Pathology and Bioresource Center for Geriatric Research, Tokyo Metropolitan Geriatric Hospital, Itabashi, Tokyo, Japan
    J Atheroscler Thromb 18:166-75. 2011
    ..Here, we assessed the hypothesis that mtSNPs may confer a risk for atherosclerosis, the most important intermediate phenotype of ischemic cardiovascular events...
  14. ncbi Aortic pulse wave velocity and the degree of atherosclerosis in the elderly: a pathological study based on 304 autopsy cases
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, 35 2 Sakae cho, Itabashi, Tokyo 173 0015, Japan
    Atherosclerosis 179:345-51. 2005
    ..Studies examining the correlation between aortic pulse wave velocity (PWV) and atherosclerosis have reported conflicting results. The present paper verifies this correlation by conducting autopsy examination of elderly subjects...
  15. ncbi Standard organ weights among elderly Japanese who died in hospital, including 50 centenarians
    Motoji Sawabe
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Pathol Int 56:315-23. 2006
    ..In conclusion, the standard organ weights of elderly patients who died while hospitalized were determined. Undernutrition contributed significantly to a reduction in organ weights...
  16. ncbi Fulminant hepatic failure in the elderly: a clinicopathological study of autopsy cases aged over 65 years
    M Sawabe
    Departments of Pathology and Internal Medicine, Tokyo Metropolitan Geriatric Hospital, Tokyo
    Pathol Int 50:98-105. 2000
    ..However, impaired hepatic regeneration is occasionally observed in the elderly cases and AH-BHN is often lethal because of frequent underlying diseases and severe complications...
  17. ncbi Age is a major pathobiological determinant of aortic dilatation: a large autopsy study of community deaths
    Motoji Sawabe
    Department of Pathology and Bioresource Center for Geriatric Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Itabashi, Tokyo, Japan
    J Atheroscler Thromb 18:157-65. 2011
    ..Aortic dilatation is a well-known phenomenon in the elderly. We therefore aimed to study the pathobiological determinants of aortic dilatation...
  18. ncbi Expression of oestrogen receptor-beta in apocrine carcinomas of the breast
    N Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Histopathology 50:425-33. 2007
    ..The aim was to study ER-beta status in apocrine carcinoma...
  19. ncbi Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast
    N Honma
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo, Japan
    Histopathology 47:195-201. 2005
    ..Apocrine lesions reportedly exhibit an unusual immunohistochemical status, expressing androgen receptors (AR) instead of oestrogen receptors (ER), progesterone receptors (PR), or bcl-2. Their expression was also examined...
  20. ncbi Early carcinoma of the distal second part of the duodenum treated by wedge resection
    Y Tanaka
    Department of Gastroenterology and Hepatology, Tokyo Metropolitan Geriatric Hospital, Japan
    J Clin Gastroenterol 28:67-9. 1999
    ..However, this requires careful observation of the entire duodenal mucosa, including that of the distal duodenum, at duodenoscopy...
  21. ncbi Multiple colorectal cancers in the elderly: a retrospective study of both surgical and autopsy cases
    T Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Japan
    J Gastroenterol 36:748-52. 2001
    ..CONCLUSIONS: These results indicate that the incidence of multiple CRCs in elderly patients with CRC is approximately 8%-10%, with no age-related difference, while extracolorectal malignancies increase with advancing age...
  22. ncbi Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations
    A Kimura
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Tissue Antigens 69:265-9. 2007
    ..These observations showed that, while the LTA 252GG genotype might modify the development of coronary atherosclerosis, the relation of LTA and LGALS2 to MI itself remained much less certain...
  23. ncbi Correlation of telomere lengths in normal and cancers tissue in the large bowel
    K Nakamura
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, 32 5, Sakaecho Itabashi ku, 173 0015, Tokyo, Japan
    Cancer Lett 158:179-84. 2000
    ..Straight, essentially parallel, lines were obtained for the two cases, normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level...
  24. doi Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease
    Kunihiko Hinohara
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Hum Genet 54:642-6. 2009
    ..Failure to replicate the association with the other SNPs, which were reported in the European populations, suggested that their contributions to CAD were not large enough to be readily captured in the East Asian populations...
  25. ncbi Primary adenocarcinoma of the duodenum in the elderly: clinicopathological and immunohistochemical study of 17 cases
    T Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Japan
    Pathol Int 49:23-9. 1999
    ..Furthermore, it is concluded that invasive duodenal adenocarcinomas with high PR should be considered as potentially aggressive tumors, although their histology may indicate a high degree of differentiation...
  26. ncbi Telomere shortening with aging in human liver
    K Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    J Gerontol A Biol Sci Med Sci 55:B533-6. 2000
    ..Despite the slow turnover of liver tissue, the overall reduction rate of telomere length decrease in 1 year was almost the same as that of digestive tract mucosa, with its very rapid renewal...
  27. ncbi Age-related mitochondrial DNA deletion in human heart: its relationship with cardiovascular diseases
    Tomio Arai
    Departments of Pathology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan
    Aging Clin Exp Res 15:1-5. 2003
    ..The aim of the present study was to clarify the relationship between aging, mtDNA deletion and cardiovascular (CV) diseases...
  28. doi Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma
    Kaiyo Takubo
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Hum Pathol 40:65-74. 2009
    ..Also, it seems better to define Barrett esophagus as metaplastic columnar-lined esophagus alone, without requiring the presence of goblet cells, in accordance with histogenetic and practical standpoints...
  29. doi The normal anatomy around the oesophagogastric junction: a histopathologic view and its correlation with endoscopy
    Kaiyo Takubo
    Research Team for Geriatric Diseases Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Sakae cho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Best Pract Res Clin Gastroenterol 22:569-83. 2008
    ..The nature of the OGJ is clarified in detail through comparison between endoscopically evident and histological features...
  30. ncbi Estrogen-metabolizing enzymes in breast cancers from women over the age of 80 years
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    J Clin Endocrinol Metab 91:607-13. 2006
    ..These estrogen-metabolizing enzymes (EMEs) are important in postmenopausal breast cancers, but have never been systematically examined in breast cancers of the elderly...
  31. ncbi Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, 35 2, Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    Exp Gerontol 43:833-9. 2008
    ..The reduction of telomere length with age and in each cell layer is consistent with the telomere biology theory of cell proliferation and differentiation in oral mucosa...
  32. ncbi Telomere shortening with aging in the human pancreas
    Akio Ishii
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    Exp Gerontol 41:882-6. 2006
    ..4 kilobase pairs (kbp) in 16 neonates, as opposed to 8.4 kbp in 2 centenarians. Mean telomere length (+/-SD) in four age groups, 0-24, 25-49, 50-74, and 75-100 yr, was 13.5+/-1.5, 12.3+/-0.7, 11.3+/-2.5, and 10.7+/-1.8, respectively...
  33. ncbi Age-related alteration in the association of microsatellite instability with absent hMLH1 expression and histological types of colorectal carcinoma
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Pathol Int 56:597-603. 2006
    ..These results indicate that an age-related increase of medullary-type tumors in poorly differentiated adenocarcinoma may play an important role in the increase of absent hMLH1 expression and MSI in colorectal carcinoma...
  34. ncbi Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older
    Ken ichi Nakamura
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Exp Gerontol 42:944-50. 2007
    ..Our study lends indispensable support to the hypothesis that longer telomeres protect the genome from instability (a major cause of carcinogenesis) and are beneficial for longevity...
  35. ncbi Microsatellite-unstable mucinous colorectal carcinoma occurring in the elderly: comparison with medullary type poorly differentiated adenocarcinoma
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Sakaecho, Tokyo, Japan
    Pathol Int 57:205-12. 2007
    ....
  36. ncbi Telomere lengths are characteristic in each human individual
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, 173 0015, Japan
    Exp Gerontol 37:523-31. 2002
    ..However, there is no simple link between telomeres and tissue turnover. We recently proposed a hypothesis that telomere shortening with aging and telomere lengths in different organs are characteristic for human individuals...
  37. doi Alcoholics show reduced telomere length in the oesophagus
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Pathol 223:410-6. 2011
    ..Further studies to clarify the reason for the large annual loss of telomere length with rapid turnover or lower telomerase activity in the oesophageal epithelium of alcoholics will be necessary...
  38. ncbi Oncocytic adenocarcinoma of the stomach: parietal cell carcinoma
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology and Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Am J Surg Pathol 26:458-65. 2002
    ..Previously reported cases of parietal cell carcinoma have been said to have a favorable prognosis, but it will be necessary to study a larger number of cases to determine the prognosis of oncocytic adenocarcinoma...
  39. ncbi Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, Tokyo, Japan
    Mod Pathol 17:172-9. 2004
    ..These results indicated that hMLH1 hypermethylation, concurrent with a lack of its protein expression, may play an important role in the development of medullary-type poorly differentiated colorectal adenocarcinomas in the elderly...
  40. doi Differences in the definitions used for esophageal and gastric diseases in different countries: endoscopic definition of the esophagogastric junction, the precursor of Barrett's adenocarcinoma, the definition of Barrett's esophagus, and histologic criteri
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology and Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Digestion 80:248-57. 2009
    ..Definitions and opinions in the field of gastroenterology vary widely in different countries...
  41. doi Changes of telomere length with aging
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 10:S197-206. 2010
    ..Our Q-FISH method using our original software program "Tissue Telo" is excellent for measuring telomere lengths using tissue sections and PNA probes...
  42. doi Role of methylation of the hMLH1 gene promoter in the development of gastric and colorectal carcinoma in the elderly
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Geriatr Gerontol Int 10:S207-12. 2010
    ....
  43. doi Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Mech Ageing Dev 131:614-24. 2010
    ..6%). Our results indicate that chromosomes having excessively shortened telomeres at late PDLs begin to show features of instability such as fusions and anaphase bridges...
  44. doi Telomere lengths in the oral epithelia with and without carcinoma
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo 173 0015, Japan
    Eur J Cancer 46:430-8. 2010
    ..Thus we have conclusively demonstrated that CIS arises from epithelium with short telomeres...
  45. doi Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations
    Kunihiko Hinohara
    Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    J Hum Genet 54:248-51. 2009
    ..02-1.14, P=0.0057), suggesting that the contribution of PSMA6 to CAD was not large enough to be readily replicated. Further studies are required to establish the contribution of this variant in the susceptibility to CAD...
  46. ncbi Ciliated surface in the esophagogastric junction zone: a precursor of Barrett's mucosa or ciliated pseudostratified metaplasia?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Am J Surg Pathol 29:211-7. 2005
    ..These findings may suggest that squamous metaplasia-like change at the EGJ is not a precursor of Barrett's mucosa but rather is a form of pseudostratified metaplasia...
  47. ncbi Is there a set of histologic changes that are invariably reflux associated?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Sakae cho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Arch Pathol Lab Med 129:159-63. 2005
    ..To develop a set of characteristic reflux-associated features, endoscopists may perform targeted biopsies from several sites with various endoscopic features and at different stages of disease...
  48. doi Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    J Pathol 221:201-9. 2010
    ..We have demonstrated conclusively that oesophageal CIS arises from epithelium with short telomeres and chromosomal instability in the absence of histological inflammation...
  49. ncbi Islands of squamous epithelium and their surrounding mucosa in columnar-lined esophagus: a pathognomonic feature of Barrett's esophagus?
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Japan
    Hum Pathol 36:269-74. 2005
    ..From a practical point of view, biopsy specimens from columnar-lined mucosa of the esophagus do not always show intestinal metaplasia (specialized intestinal metaplasia)...
  50. ncbi Detection of human papillomavirus infection of the cervix in very elderly women using PCR
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Clin Cancer Res 11:2919-23. 2005
    ....
  51. ncbi Role of DNA repair systems in malignant tumor development in the elderly
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Geriatr Gerontol Int 8:65-72. 2008
    ....
  52. doi Changes of human menisci in osteoarthritic knee joints
    Y Katsuragawa
    Department of Orthopaedic Surgery, National Center for Global Health and Medicine, Tokyo, Japan
    Osteoarthritis Cartilage 18:1133-43. 2010
    ..To investigate the changes of knee menisci in osteoarthritis (OA) in human...
  53. ncbi Early squamous cell carcinoma of the oesophagus: the Japanese viewpoint
    K Takubo
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Histopathology 51:733-42. 2007
    ..As a result of advances in the development of endoscopes, pathologists are now expected to diagnose very minute lesions, < 1 mm in size, in the oesophagus...
  54. ncbi Hepatocellular carcinoma arising in an elderly male with primary biliary cirrhosis
    Y Tanaka
    Department of Gastroenterology, Tokyo Metropolitan Geriatric Hospital, Japan
    Eur J Gastroenterol Hepatol 12:239-41. 2000
    ..We believe that, to date, this is the oldest reported patient to have had interventional radiology for the management of HCC...
  55. ncbi Breast carcinoma in women over the age of 85: distinct histological pattern and androgen, oestrogen, and progesterone receptor status
    N Honma
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, Department of Breast Pathology, Cancer Institute, Tokyo, Japan
    Histopathology 42:120-7. 2003
    ..In an effort to understand the pathogenesis of breast carcinoma in these women, this study was undertaken to compare the histological patterns and hormone receptor status of breast carcinomas arising in very elderly and younger women...
  56. ncbi Haplotyping of TNFalpha gene promoter using melting temperature analysis: detection of a novel -856(G/A) mutation
    Y Song
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda ku, Tokyo, Japan
    Tissue Antigens 66:284-90. 2005
    ..26%) contains a novel mutation of -856(G/A), instead of the predicted haplotype. These results indicate that melting temperature analysis provides a robust method to determine the polymorphisms in the TNFalpha promoter...
  57. ncbi Age-related hypermethylation of the hMLH1 promoter in gastric cancers
    T Nakajima
    Department of Molecular Oncology, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Cancer 94:208-11. 2001
    ..The frequency of hMLH1 methylation significantly increased with age. These results suggest that hMLH1 methylation plays an important role in gastric carcinogenesis in old people...
  58. ncbi Poor prognosis of colorectal cancer in patients over 80 years old is associated with down-regulation of tumor suppressor genes
    Sakae Nagaoka
    Department of Pathology and Immunology, Aging and Developmental Sciences, Tokyo Medical and Dental University, Graduate School, Tokyo, Japan
    J Clin Gastroenterol 37:48-54. 2003
    ..GOALS, BACKGROUND: The elderly population has been increasing during the last half a century and it would be important to know how aging influences the occurrence and biologic behavior of cancers...
  59. ncbi Association of estrogen receptor alpha gene polymorphisms with neurofibrillary tangles
    Hirohito Kazama
    Department of Endocrinology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Dement Geriatr Cogn Disord 18:145-50. 2004
    ..In conclusion, the PvuII polymorphism of the ERalpha gene is associated with Braak NFT stages and possession of the P allele may act as a risk factor for AD in Japanese men, especially in those without the epsilon4 allele...
  60. doi Undiagnosed cirrhosis occurs frequently in the elderly and requires periodic follow ups and medical treatments
    Koichi Fujimoto
    Department of Gastroenterology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Geriatr Gerontol Int 8:198-203. 2008
    ..Autopsy examinations frequently reveal undiagnosed cirrhosis, but its characteristics have rarely been addressed in the elderly...
  61. ncbi Pathologic characteristics of gastric cancer in the elderly: a retrospective study of 994 surgical patients
    Tomio Arai
    Department of Pathology, Tokyo Metropolitan Geriatric Medical Center, 35 2 Sakae cho, Itabashi ku, 173 0015 Tokyo, Japan
    Gastric Cancer 7:154-9. 2004
    ..The clinicopathologic features of gastric carcinoma in elderly people have been reported previously. The present study examined the patterns and distribution of gastric carcinomas in the elderly, especially in patients aged 85 and older...
  62. ncbi Lewy body-related alpha-synucleinopathy in aging
    Yuko Saito
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neuropathol Exp Neurol 63:742-9. 2004
    ..Our findings indicate that LBs are associated with cognitive decline, either independently or synergistically with neurofibrillary tangles and senile plaques...
  63. ncbi Polymorphisms in pro- and anti-inflammatory cytokine genes and susceptibility to atherosclerosis: a pathological study of 1503 consecutive autopsy cases
    Kanae Oda
    Department of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Hum Mol Genet 16:592-9. 2007
    ....
  64. ncbi [Analysis of multiple cancers in autopsy cases of elderly hematological malignancies]
    Yuko Osajima
    Division of Hematology, Tokyo Metropolitan Geriatric Hospital, Japan
    Rinsho Ketsueki 49:1599-603. 2008
    ..6%). Of 10 cases showing duplication of other hematological malignancies, 9 cases had NHL. The rate of multiple cancers in elderly patients with hematological malignancy was higher than that of non-hematological cancers...
  65. doi Cervical tuberculous lymphadenitis in the elderly: comparative diagnostic findings
    T Kato
    Department of Otolaryngology, Tokyo Metropolitan Geriatric Hospital, Itabashi ku, Tokyo, Japan
    J Laryngol Otol 123:1343-7. 2009
    ..However, these investigations are intended for primary tuberculosis infection. The majority of cervical tuberculous lymphadenitis cases in the elderly are thought to be caused by reactivation...
  66. doi Markedly different clinical features in 2 diabetes mellitus patients with extremely high tissue levels of the mitochondrial DNA A3243G mutation
    Shinji Harihara
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan
    Gerontology 54:168-72. 2008
    ..Mitochondrial DNA (mtDNA) A3243G mutation is one of the major causative factors of mitochondrial diabetes mellitus. We found that tissues from 2 of 142 diabetes mellitus patients showed extremely high levels of the mutation...
  67. ncbi The Val158Met polymorphism of the catechol-O-methyltransferase gene is not associated with the risk of sporadic or latent prostate cancer in Japanese men
    Motofumi Suzuki
    Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Urol 14:800-4. 2007
    ..We attempted to investigate whether the Val158Met polymorphism of COMT was associated with the risk of prostate cancer...
  68. ncbi Patients with mild-to-moderate asthma may develop clinically significant chronic obstructive pulmonary disease
    Yasunari Tsuda
    Division of Respiratory Medicine, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    Respirology 14:529-36. 2009
    ..Little is known about the aetiology and clinical characteristics of COPD among people who have never smoked...
  69. doi Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations
    Kunihiko Hinohara
    Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Chiyoda ku, Tokyo, Japan
    J Hum Genet 53:357-9. 2008
    ..13-1.49, p=0.00027, allele count model] and Koreans (OR=1.19, 95% CI; 1.02-1.38, p=0.025, allele count model). These observations demonstrated that chromosome 9p21 was the susceptibility locus for CAD also in East Asians...
  70. doi Lewy body pathology involves cutaneous nerves
    Masako Ikemura
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Graduate School of Medicine, The University of Tokyo, and Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
    J Neuropathol Exp Neurol 67:945-53. 2008
    ..We demonstrate for the first time that the skin is involved and may be a highly specific and useful biopsy site for the pathological diagnosis of LB diseases...
  71. ncbi A clinical study of idiopathic pulmonary fibrosis based on autopsy studies in elderly patients
    Takehiko Araki
    Pulmonary Division, Tokyo Metropolitan Geriatric Medical Center, Tokyo
    Intern Med 42:483-9. 2003
    ..The present study investigated the outcome of IPF in elderly patients whose pathological diagnosis corresponded to usual interstitial pneumonia (UIP) on autopsy findings...
  72. ncbi Quantitative analysis of mRNA in human temporal bones
    Yurika Kimura
    Department of Otolaryngology, Tokyo Metropolitan Geriatric Hospital, Japan
    Acta Otolaryngol 127:1024-30. 2007
    ..Well-preserved mRNA could be extracted from frozen human inner ears. Therefore, this study demonstrates that analysis of mRNA could be performed to study the molecular mechanisms of inner ear disorders using human specimens...
  73. ncbi Polymorphism of cytochrome P450 2B6 and prostate cancer risk: a significant association in a Japanese population
    Takayuki Kurosaki
    Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Urol 16:364-8. 2009
    ..To explore whether Lys262Arg polymorphism of the Cytochrome P450 2B6 (CYP2B6) gene could act as a genetic marker for prostate cancer risk among Japanese men...
  74. ncbi Histopathogenesis of early-stage mitral annular calcification
    Phetsamone Arounlangsy
    Department of Human Pathology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Med Dent Sci 51:35-44. 2004
    ..In conclusion, the microscopic calcification of mitral annulus is an early stage of MAC and caused by calcium-deposition on cellular degradation products, probably released from apoptotic or necrotic interstitial cells...
  75. ncbi In situ detection of apolipoprotein E epsilon 4 in archival human brain
    Yuko Saito
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    Neuroreport 15:1113-5. 2004
    ..Specific immunoreactivity was not obtained in those cases not carrying the epsilon4 allele. This method will allow in situ detection of apoE epsilon4 and contribute to studies of the effect of epsilon4 on Alzheimer's disease...
  76. ncbi Accumulation of phosphorylated alpha-synuclein in aging human brain
    Yuko Saito
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neuropathol Exp Neurol 62:644-54. 2003
    ....
  77. ncbi Pathology of the cerebral artery in Binswanger's disease in the aged: observation by serial sections and morphometry of the cerebral arteries
    Riki Okeda
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Neuropathology 24:21-9. 2004
    ..As the mechanism of such an especially severe involvement of the cerebral medullary artery in BD, some genetic abnormality in the functional response or vulnerability to hypertension of the artery should be considered...
  78. doi Differential expression of Toll-like receptors in follicular lymphoma, diffuse large B-cell lymphoma and peripheral T-cell lymphoma
    Thomas J Smith
    Department of Comprehensive Pathology, Ageing and Developmental Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45 Bunkyo Ku, Tokyo, Japan
    Exp Mol Pathol 89:284-90. 2010
    ..TLR expression is highly variable among lymphoma subtypes. However, despite this some significant differences exist that may prove useful in the development of novel therapeutic strategies...
  79. doi Validation of the association between AGTRL1 polymorphism and coronary artery disease in the Japanese and Korean populations
    Kunihiko Hinohara
    Department of Molecular Pathogenesis, Medical Research Institute, and Laboratory of Genome Diversity, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    J Hum Genet 54:554-6. 2009
    ..In addition, there was no trend of association between the risk allele and severity of coronary atherosclerosis. These data suggested that AGTRL1 did not contribute much to the atherosclerosis of the coronary artery...
  80. ncbi Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in lewy body disease
    Yuichi Fumimura
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neuropathol Exp Neurol 66:354-62. 2007
    ..Our results indicate that the adrenal gland can provide useful information for evaluation of the PANS in Lewy body disease...
  81. doi Incidence and extent of Lewy body-related alpha-synucleinopathy in aging human olfactory bulb
    Renpei Sengoku
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neuropathol Exp Neurol 67:1072-83. 2008
    ..These results indicate a high incidence of LBAS in the aging human OB; they also suggest that LBAS extends from the periphery to the anterior olfactory nucleus and results in clinical manifestations of LB disease...
  82. doi Angiogenic mediators of the angiopoietin system are highly expressed by CD10-positive lymphoma cells in angioimmunoblastic T-cell lymphoma
    Klio Konstantinou
    Department of Comprehensive Pathology, Ageing and Developmental Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Br J Haematol 144:696-704. 2009
    ....
  83. ncbi Staging of argyrophilic grains: an age-associated tauopathy
    Yuko Saito
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    J Neuropathol Exp Neurol 63:911-8. 2004
    ..Our study further confirms that dementia with grains is an age-associated tauopathy with relatively uniform distribution and may independently contribute to cognitive decline in the elderly...
  84. ncbi Value of CK14 and CD56 immunostaining in distinguishing small cell carcinoma from squamous cell carcinoma of the esophagus
    Gopi Aryal
    Department of Pathology, Nepal Medical College, Nepal
    Nepal Med Coll J 8:75-81. 2006
    ..6%; p = 0.04). These findings suggest that the CK14 and CD56 may be useful markers for differentiating SQC from SCC and vice versa. The p53 may also be useful to differentiate normal esophageal epithelium from SCC or SQC tissue...
  85. ncbi Chronological trend of calorie intake and the incidence of epithelial neoplasms of the large intestine during the past 30 years in Japan
    Kyotaro Kanazawa
    Department of Gastroenterological and General Surgery, Jichi Medical School, Tochigi, Japan
    Oncology 69:46-9. 2005
    ..The authors tried to elucidate the effects of food intake on the incidences of colorectal cancer and adenoma...
  86. ncbi [Biopsy methods and pathology of Barrett's esophagus]
    Kaiyo Takubo
    Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology
    Nihon Rinsho 63:1429-33. 2005
    ....
  87. ncbi Comparative analysis of telomere lengths and erosion with age in human epidermis and lingual epithelium
    Ken ichi Nakamura
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    J Invest Dermatol 119:1014-9. 2002
    ..842, p<0.0001). These results indicate that the telomeres in epidermis and lingual epithelium are characterized by tissue-specific loss rates...
  88. ncbi Incidence of apoptosis increases with age in colorectal cancer
    Kenichiro Tanaka
    Department of Pathology and Immunology, Aging and Developmental Sciences, Tokyo Medical and Dental University, Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Exp Gerontol 37:1469-79. 2002
    ..The potential roles of these regulatory molecules on age-change in the proliferation/apoptosis of colorectal cancers are discussed...
  89. doi Regional differences in chondrocyte metabolism in osteoarthritis: a detailed analysis by laser capture microdissection
    Naoshi Fukui
    National Hospital Organization Sagamihara Hospital, Sagamihara, Japan
    Arthritis Rheum 58:154-63. 2008
    ..To determine the change in metabolic activity of chondrocytes in osteoarthritic (OA) cartilage, considering regional difference and degree of cartilage degeneration...
  90. ncbi Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy
    Noritsugu Nakano
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Am J Physiol Heart Circ Physiol 293:H3396-403. 2007
    ..These observations suggested that hypertension induced expression of prohypertrophic BMP10, and the hypertrophic effect of BMP10 was modulated, at least in part, by its binding to Tcap at the Z disc...
  91. ncbi [An elderly case of non-Hodgkin's lymphoma (NHL) with hypercalcemia]
    Hidetaka Ota
    Department of Endocrinology, Tokyo Metropolitan Geriatric Medical Center
    Nihon Ronen Igakkai Zasshi 40:167-71. 2003
    ..PTHrP was also found in lymphoma cells of the spleen by the RT-PCR technique. These findings indicated that hypercalcemia was caused by overexpression of PTHrP from lymphoma cells...
  92. ncbi Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease
    Ikuko Mizuta
    Division of Clinical Genetics, Department of Medical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan
    Hum Mol Genet 15:1151-8. 2006
    ..SNCA expression levels tended to be positively correlated with the number of the associated allele in autopsied frontal cortices. These findings establish SNCA as a definite susceptibility gene for sporadic PD...
  93. ncbi The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progression-free survival in prostate cancer patients treated with estramustine phosphate
    Motofumi Suzuki
    Department of Urology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur Urol 48:752-9. 2005
    ....
  94. ncbi Diabetes mellitus complicated with rapidly progressive glomerulonephritis in an elderly patient
    Reiko Nishijima
    Department of Endocrinology, Tokyo Metropolitan Geriatric Hospital
    Intern Med 44:1078-83. 2005
    ..This experience highlighted the importance of the differential diagnosis of non-diabetic glomerulopathy even in elderly patients with diabetes mellitus...
  95. ncbi [Establishment of brain bank for aging research]
    Shigeo Murayama
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology
    Nihon Ronen Igakkai Zasshi 42:483-9. 2005
    ....
  96. ncbi [Marked decrease of intracranial atherosclerosis in contrast with unchanged coronary artery stenosis in Japan]
    Shunichi Koyama
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology
    Nihon Ronen Igakkai Zasshi 40:267-73. 2003
    ..Our study provides the first morphological confirmation of marked decrease of the intracranial atherosclerosis in the recent 28 years, in contrast with unchanged coronary stenosis in Japanese elderly subjects...