Shoichi Sasaki

Summary

Affiliation: Tokyo Women's Medical University
Country: Japan

Publications

  1. doi request reprint Unique nuclear vacuoles in the motor neurons of conditional ADAR2-knockout mice
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan Electronic address
    Brain Res 1550:36-46. 2014
  2. ncbi request reprint Neuronal nitric oxide synthase (nNOS) immunoreactivity in the spinal cord of transgenic mice with G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical College, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Acta Neuropathol 103:421-7. 2002
  3. ncbi request reprint Mitochondrial alterations in the spinal cord of patients with sporadic amyotrophic lateral sclerosis
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    J Neuropathol Exp Neurol 66:10-6. 2007
  4. ncbi request reprint Parvalbumin and calbindin D-28k immunoreactivity in transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Res 1083:196-203. 2006
  5. ncbi request reprint Ultrastructural study of mitochondria in the spinal cord of transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666, Tokyo, Japan
    Acta Neuropathol 107:461-74. 2004
  6. ncbi request reprint Slow component of axonal transport is impaired in the proximal axon of transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666 Tokyo, Japan
    Acta Neuropathol 107:452-60. 2004
  7. ncbi request reprint Parkin-positive autosomal recessive juvenile Parkinsonism with alpha-synuclein-positive inclusions
    Shoichi Sasaki
    Department of Neurology, Neurologic Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Neurology 63:678-82. 2004
  8. ncbi request reprint Neuronal inclusions in sporadic motor neuron disease are negative for alpha-synuclein
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Neurosci Lett 397:15-9. 2006
  9. ncbi request reprint Ultrastructural study of aggregates in the spinal cord of transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666, Tokyo, Japan
    Acta Neuropathol 109:247-55. 2005
  10. ncbi request reprint Mitochondrial alterations in dorsal root ganglion cells in sporadic amyotrophic lateral sclerosis
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, 162 8666, Japan
    Acta Neuropathol 114:633-9. 2007

Detail Information

Publications47

  1. doi request reprint Unique nuclear vacuoles in the motor neurons of conditional ADAR2-knockout mice
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan Electronic address
    Brain Res 1550:36-46. 2014
    ..These findings suggest that ADAR2-reduction is associated with progressive deterioration of nuclear architecture, resulting in vacuolated nuclei due to a Ca(2+)-permeable AMPA receptor-mediated mechanism. ..
  2. ncbi request reprint Neuronal nitric oxide synthase (nNOS) immunoreactivity in the spinal cord of transgenic mice with G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical College, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Acta Neuropathol 103:421-7. 2002
    ....
  3. ncbi request reprint Mitochondrial alterations in the spinal cord of patients with sporadic amyotrophic lateral sclerosis
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    J Neuropathol Exp Neurol 66:10-6. 2007
    ..The findings in this study may reflect the metabolic disturbance of mitochondria, probably associated with the pathomechanism of degenerative processes of anterior horn neurons in sporadic ALS...
  4. ncbi request reprint Parvalbumin and calbindin D-28k immunoreactivity in transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Res 1083:196-203. 2006
    ....
  5. ncbi request reprint Ultrastructural study of mitochondria in the spinal cord of transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666, Tokyo, Japan
    Acta Neuropathol 107:461-74. 2004
    ..Moreover, giant mitochondrial vacuoles occupying almost the entire axonal caliber could be another contributing factor in motor neuron degeneration, in that they could physically block axonal transport...
  6. ncbi request reprint Slow component of axonal transport is impaired in the proximal axon of transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666 Tokyo, Japan
    Acta Neuropathol 107:452-60. 2004
    ....
  7. ncbi request reprint Parkin-positive autosomal recessive juvenile Parkinsonism with alpha-synuclein-positive inclusions
    Shoichi Sasaki
    Department of Neurology, Neurologic Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Neurology 63:678-82. 2004
    ..To report an autopsy case of an autosomal recessive juvenile parkinsonism patient with a homozygous exon 3 deletion in the parkin gene and alpha-synuclein-positive inclusions...
  8. ncbi request reprint Neuronal inclusions in sporadic motor neuron disease are negative for alpha-synuclein
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Neurosci Lett 397:15-9. 2006
    ..Our findings in this study do not support the hypothesis that MND could be classified as one of the diseases grouped as alpha-synucleinopathies...
  9. ncbi request reprint Ultrastructural study of aggregates in the spinal cord of transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666, Tokyo, Japan
    Acta Neuropathol 109:247-55. 2005
    ....
  10. ncbi request reprint Mitochondrial alterations in dorsal root ganglion cells in sporadic amyotrophic lateral sclerosis
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, 162 8666, Japan
    Acta Neuropathol 114:633-9. 2007
    ..These findings therefore suggest that ALS is a widespread, more generalized disorder than previously thought, and that the degeneration is not confined to the motor neuron system...
  11. ncbi request reprint Involvement of spinal motor neurons in parkin-positive autosomal recessive juvenile parkinsonism
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Neuropathology 28:74-80. 2008
    ....
  12. ncbi request reprint iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis
    S Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical College, 8 1 Kawada cho, Shinjuku ku 162 8666, Tokyo, Japan
    Neurosci Lett 291:44-8. 2000
    ..These findings suggest that selective nitric oxide-mediated oxidative damage in the motor system plays a part in the pathomechanism of the neuronal degeneration in the spinal cord of sporadic ALS...
  13. doi request reprint Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
    J Neuropathol Exp Neurol 70:349-59. 2011
    ..Thus, autophagy seems to be activated and upregulated in the cytoplasm of motor neurons and may be involved in the mechanisms of neurodegeneration of motor neurons in sporadic ALS...
  14. doi request reprint Alterations in subcellular localization of TDP-43 immunoreactivity in the anterior horns in sporadic amyotrophic lateral sclerosis
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Neurosci Lett 478:72-6. 2010
    ....
  15. ncbi request reprint Impairment of axonal transport in the axon hillock and the initial segment of anterior horn neurons in transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, Shinjuku ku, Japan
    Acta Neuropathol 110:48-56. 2005
    ..These findings suggest that both the slow axonal transport of neurofilaments and the fast axonal transport of mitochondria are impaired in AH and IS before the onset of disease in this animal model...
  16. doi request reprint Mitochondrial alterations in transgenic mice with an H46R mutant Cu/Zn superoxide dismutase gene
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
    J Neuropathol Exp Neurol 68:365-73. 2009
    ....
  17. doi request reprint Endoplasmic reticulum stress in motor neurons of the spinal cord in sporadic amyotrophic lateral sclerosis
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    J Neuropathol Exp Neurol 69:346-55. 2010
    ....
  18. ncbi request reprint Immunohistochemical and ultrastructural study of basophilic inclusions in adult-onset motor neuron disease
    S Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical College, Japan
    Acta Neuropathol 102:200-6. 2001
    ..These findings suggest a certain relationship between BI, SI and LBHI in the pathomechanism of BI development. Further studies are needed to elucidate whether sporadic adult-onset MND characterized by BI forms a different subtype of MND...
  19. pmc Ultrastructural study of Betz cells in the primary motor cortex of the human brain
    S Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical College, Japan
    J Anat 199:699-708. 2001
    ....
  20. ncbi request reprint Motor neuron disease in transgenic mice with an H46R mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    J Neuropathol Exp Neurol 66:517-24. 2007
    ..The close pathologic similarity makes this animal model suitable for the investigation of human familial amyotrophic lateral sclerosis with the mutation...
  21. doi request reprint Persistent cleavage and nuclear translocation of apoptosis-inducing factor in motor neurons in the spinal cord of sporadic amyotrophic lateral sclerosis patients
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Acta Neuropathol 118:755-62. 2009
    ..Our results provide evidence for persistent cleavage and nuclear translocation of AIF in ALS spinal cord, suggesting implications for the AIF-mediated motor neuron death in this disease...
  22. ncbi request reprint Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model
    Noriyuki Shibata
    Department of Pathology, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    Neuropathology 27:49-61. 2007
    ....
  23. doi request reprint Activation of signal transducer and activator of transcription-3 in the spinal cord of sporadic amyotrophic lateral sclerosis patients
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Neurodegener Dis 6:118-26. 2009
    ..It is known that signal transducer and activator of transcription-3 (STAT3) is a proinflammatory transcription factor. However, it remains to be determined whether STAT3 is involved in ALS...
  24. doi request reprint Supranuclear ophthalmoparesis and vacuolar degeneration of the cerebral white matter in amyotrophic lateral sclerosis: a clinicopathological study
    Takahiro Takeda
    Department of Neurology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Amyotroph Lateral Scler 13:74-83. 2012
    ....
  25. doi request reprint Loss of TDP-43 causes age-dependent progressive motor neuron degeneration
    Yohei Iguchi
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Brain 136:1371-82. 2013
    ....
  26. ncbi request reprint Accumulation of protein-bound 4-hydroxy-2-hexenal in spinal cords from patients with sporadic amyotrophic lateral sclerosis
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Kawada cho 8 1, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Res 1019:170-7. 2004
    ..Our results indicate that enhanced HHE formation occurs in the entire gray matter of sporadic ALS spinal cords and suggest that the selective vulnerability of motor neurons to HHE mediates the pathomechanism of this disease...
  27. doi request reprint Intake of n-3 polyunsaturated fatty acids and non-alcoholic fatty liver disease: a cross-sectional study in Japanese men and women
    J Oya
    Department of Internal Medicine, Diabetes Center, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Eur J Clin Nutr 64:1179-85. 2010
    ..The supplementation of n-3 polyunsaturated fatty acids (n-3 PUFAs) improves NAFLD. The aim of this study is to assess the cross-sectional association between dietary n-3 PUFAs and NAFLD in Japanese men and women...
  28. ncbi request reprint Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients
    N Shibata
    Department of Pathology, Tokyo Women s Medical University, Kawada cho 8 1, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Res 917:97-104. 2001
    ....
  29. ncbi request reprint Inducible nitric oxide synthase (iNOS) and nitrotyrosine immunoreactivity in the spinal cords of transgenic mice with a G93A mutant SOD1 gene
    S Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women's Medical College, Japan
    J Neuropathol Exp Neurol 60:839-46. 2001
    ....
  30. ncbi request reprint Neuronal nitric oxide synthase immunoreactivity in the spinal cord in amyotrophic lateral sclerosis
    S Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women's Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan
    Acta Neuropathol 101:351-7. 2001
    ..Further studies are needed to determine whether the increased nNOS immunoreactivity plays a neuroprotective or neurotoxic role in the anterior horn neurons, and to show nitric oxide production in ALS...
  31. ncbi request reprint EAAT1 and EAAT2 immunoreactivity in transgenic mice with a G93A mutant SOD1 gene
    S Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women's Medical College, Japan
    Neuroreport 12:1359-62. 2001
    ..These findings suggest that EAAT1 and EAAT2 may not play a pivotal role in the degeneration of motoneurons in this animal model...
  32. ncbi request reprint [Phenotypic variation in ALS]
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University
    Rinsho Shinkeigaku 46:825-7. 2006
    ..Definition of clinicopathologic syndromes in patients with ALS/MND is an important challenging task that cannot be ignored...
  33. ncbi request reprint [Phenotypes in ALS--clinical features and pathology]
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Nerve 59:1013-21. 2007
    ....
  34. ncbi request reprint Dendritic synapses of anterior horn neurons in amyotrophic lateral sclerosis: an ultrastructural study
    S Sasaki
    Department of Neurology, Tokyo Women s Medical College, Japan
    Acta Neuropathol 91:278-83. 1996
    ..The preservation of these synapses may be due to their relative resistance to degenerative processes, or may represent a compensatory mechanism of the synapses for diminished synaptic function in distal dendrites...
  35. ncbi request reprint Spreading depolarization waves triggered by vagal stimulation in the embryonic chick brain: optical evidence for intercellular communication in the developing central nervous system
    Y Momose-Sato
    Department of Physiology, Tokyo Medical and Dental University Graduate School and facility of Medicine, Bunkyo ku, 113 8519, Tokyo, Japan
    Neuroscience 102:245-62. 2001
    ..These results provide new evidence for intercellular functional communication between neural cells in the vertebrate central nervous system during embryonic development...
  36. ncbi request reprint Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence
    S Sasaki
    Dept of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    J Exp Clin Cancer Res 23:507-12. 2004
    ..This evidence suggests that hRFI may act as an oncogenic molecule affecting the apoptotic pathway...
  37. pmc 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis
    Mitsuhiro Kondo
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Proc Natl Acad Sci U S A 99:7367-72. 2002
    ..The 15d-PGJ(2)-induced accumulation of p53 resulted in the activation of a death-inducing caspase cascade mediated by Fas and the Fas ligand...
  38. ncbi request reprint Gene transfer to mouse testes by electroporation and its influence on spermatogenesis
    Yukihiro Umemoto
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Androl 26:264-71. 2005
    ....
  39. ncbi request reprint Spermatogenesis, fertility and sexual behavior in a hypospadiac mouse model
    Yoshiyuki Kojima
    Department of Urology, Nagoya City University Medical School, Nagoya, Japan
    J Urol 167:1532-7. 2002
    ..Administering of flutamide to pregnant mice causes hypospadias in male offspring. We investigated spermatogenesis, fertility and sexual behavior in this hypospadiac mouse model...
  40. ncbi request reprint Role of nitric oxide/cyclic GMP pathway in regulating spontaneous excitations in detrusor smooth muscle of the guinea-pig bladder
    Yoshimasa Yanai
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Neurourol Urodyn 27:446-53. 2008
    ..We have investigated the effects of NO donors and phosphodiesterase-5 (PDE5) inhibition on spontaneous excitations in DSM...
  41. ncbi request reprint Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction
    Yasue Kubota
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Neurourol Urodyn 27:330-40. 2008
    ..We investigated the effects of bladder outlet obstruction (BOO) on the distribution of interstitial cells (ICs) in the guinea-pig bladder...
  42. ncbi request reprint [Future treatment strategies for cryptorchidism to improve spermatogenesis]
    Yoshiyuki Kojima
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences
    Hinyokika Kiyo 53:517-22. 2007
    ..In this review, we discuss the potential approaches including epidermal growth facter therapy, gene therapy and stem-cell therapy for cryptorchid patients in the future...
  43. ncbi request reprint No evidence of germ-line transmission by adenovirus-mediated gene transfer to mouse testes
    Yoshiyuki Kojima
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Fertil Steril 89:1448-54. 2008
    ..To investigate the risk of germ-line transmission of vector sequences after in vivo adenovirus-mediated gene transfer to mouse testes and to discuss whether an adenovirus vector could be used in the future to treat male factor infertility...
  44. ncbi request reprint Quantification of alpha1-adrenoceptor subtypes by real-time RT-PCR and correlation with age and prostate volume in benign prostatic hyperplasia patients
    Yoshiyuki Kojima
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Prostate 66:761-7. 2006
    ....
  45. ncbi request reprint Microglial activation parallels system degeneration in multiple system atrophy
    Keisuke Ishizawa
    Department of Pathology, Saitama Medical School, Saitama, Japan
    J Neuropathol Exp Neurol 63:43-52. 2004
    ....
  46. ncbi request reprint Molecular evaluation of the SRY gene for gonads of patients with mixed gonadal dysgenesis
    Kentaro Mizuno
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Int J Urol 12:673-6. 2005
    ..To determine whether the SRY gene is present in the gonads of patients with mixed gonadal dysgenesis (MGD)...
  47. doi request reprint Early orchiopexy improves subsequent testicular development and spermatogenesis in the experimental cryptorchid rat model
    Kentaro Mizuno
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Urol 179:1195-9. 2008
    ..We performed histological analyses of undescended testes to evaluate the influence of orchiopexy timing in an experimental cryptorchid rat model. Furthermore, we extrapolated the timing of orchiopexy in humans from our results...