Sei Sasaki

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi request reprint Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice
    Kozue Yamauchi
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Biochem Biophys Res Commun 332:750-5. 2005
  2. ncbi request reprint Aquaporin-2 protein dynamics within the cell
    Sei Sasaki
    Department of Nephrology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Curr Opin Nephrol Hypertens 16:348-52. 2007
  3. doi request reprint Actin directly interacts with different membrane channel proteins and influences channel activities: AQP2 as a model
    Sei Sasaki
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113 8519, Japan Electronic address
    Biochim Biophys Acta 1838:514-20. 2014
  4. pmc Murine colon proteome and characterization of the protein pathways
    Sameh Magdeldin
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    BioData Min 5:11. 2012
  5. pmc Applicability of fibroblast growth factor 23 for evaluation of risk of vertebral fracture and chronic kidney disease-mineral bone disease in elderly chronic kidney disease patients
    Eiichiro Kanda
    Department of Nephrology, Tokyo Kyosai Hospital, Nakameguro 2 3 8, Meguroku, Tokyo, 153 8934, Japan
    BMC Nephrol 13:122. 2012
  6. doi request reprint Hereditary nephrogenic diabetes insipidus in Japanese patients: analysis of 78 families and report of 22 new mutations in AVPR2 and AQP2
    Sei Sasaki
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Clin Exp Nephrol 17:338-44. 2013
  7. doi request reprint Aquaporin 2: from its discovery to molecular structure and medical implications
    Sei Sasaki
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mol Aspects Med 33:535-46. 2012
  8. doi request reprint Daily variance of urinary excretion of AQP2 determined by sandwich ELISA method
    Sei Sasaki
    Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Exp Nephrol 16:406-10. 2012
  9. pmc Immunological profile in a family with nephrogenic diabetes insipidus with a novel 11 kb deletion in AVPR2 and ARHGAP4 genes
    Masaya Fujimoto
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    BMC Med Genet 9:42. 2008
  10. doi request reprint Introduction for Special issue for Aquaporin: expanding the world of aquaporins: new members and new functions
    Sei Sasaki
    Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan
    Pflugers Arch 456:647-9. 2008

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice
    Kozue Yamauchi
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Biochem Biophys Res Commun 332:750-5. 2005
    ..This result indicates that the mutant WNK4 does not have a dominant effect on the cellular localization of ROMK in vivo...
  2. ncbi request reprint Aquaporin-2 protein dynamics within the cell
    Sei Sasaki
    Department of Nephrology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Curr Opin Nephrol Hypertens 16:348-52. 2007
    ..The understanding of the molecular and cellular mechanisms of these events is advancing rapidly, and recent new findings characterizing such processes are reviewed...
  3. doi request reprint Actin directly interacts with different membrane channel proteins and influences channel activities: AQP2 as a model
    Sei Sasaki
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113 8519, Japan Electronic address
    Biochim Biophys Acta 1838:514-20. 2014
    ..This article is part of a Special Issue entitled: Reciprocal influences between cell cytoskeleton and membrane channels, receptors and transporters. Guest Editor: Jean Claude Hervé. ..
  4. pmc Murine colon proteome and characterization of the protein pathways
    Sameh Magdeldin
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    BioData Min 5:11. 2012
    ..abstract:..
  5. pmc Applicability of fibroblast growth factor 23 for evaluation of risk of vertebral fracture and chronic kidney disease-mineral bone disease in elderly chronic kidney disease patients
    Eiichiro Kanda
    Department of Nephrology, Tokyo Kyosai Hospital, Nakameguro 2 3 8, Meguroku, Tokyo, 153 8934, Japan
    BMC Nephrol 13:122. 2012
    ..It has been reported that FGF23 is related to the overall fracture risk. We investigated the usefulness of FGF23 as a marker for evaluating the risk of vertebral fracture and CKD-MBD in elderly CKD patients...
  6. doi request reprint Hereditary nephrogenic diabetes insipidus in Japanese patients: analysis of 78 families and report of 22 new mutations in AVPR2 and AQP2
    Sei Sasaki
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Clin Exp Nephrol 17:338-44. 2013
    ..It is also unknown whether these percentages vary in different ethnic groups...
  7. doi request reprint Aquaporin 2: from its discovery to molecular structure and medical implications
    Sei Sasaki
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mol Aspects Med 33:535-46. 2012
    ..Finally, it has become increasingly clear that AQP2 is greatly involved in many human abnormal water balance disorders that await new therapies and clinical markers...
  8. doi request reprint Daily variance of urinary excretion of AQP2 determined by sandwich ELISA method
    Sei Sasaki
    Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Exp Nephrol 16:406-10. 2012
    ..A specific and convenient method to measure AQP2 in human urine would help to treat water balance disorders. It is unknown whether urinary excretion of AQP2 shows any daily variance...
  9. pmc Immunological profile in a family with nephrogenic diabetes insipidus with a novel 11 kb deletion in AVPR2 and ARHGAP4 genes
    Masaya Fujimoto
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    BMC Med Genet 9:42. 2008
    ....
  10. doi request reprint Introduction for Special issue for Aquaporin: expanding the world of aquaporins: new members and new functions
    Sei Sasaki
    Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan
    Pflugers Arch 456:647-9. 2008
  11. doi request reprint Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure
    Akihito Ohta
    Department of Nephrology, Tokyo Medical and Dental University, Japan
    Hum Mol Genet 18:3978-86. 2009
    ..Thus, wild-type WNK4 is a positive regulator for the WNK-OSR1/SPAK-NCC cascade, and WNK4 is a potential target of anti-hypertensive drugs...
  12. doi request reprint FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells
    Naofumi Yui
    Dept of Nephrology, Tokyo Medical and Dental University, Japan
    Am J Physiol Cell Physiol 297:C1389-96. 2009
    ..These results suggest that FAPP2 is necessary to generate AQP2-bearing vesicles at trans-Golgi that will undergo phosphorylation by PKA in subapical regions...
  13. doi request reprint Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms
    Yutaro Mori
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 439:30-4. 2013
    ..Therefore, the KLHL3 mutants causing PHAII investigated in this study exhibited less ability to ubiquitinate WNK4 because of KLHL3's low stability and/or decreased binding to CUL3 or WNK4...
  14. pmc Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation
    Eisei Sohara
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo 113 8519, Japan
    Proc Natl Acad Sci U S A 103:14217-22. 2006
    ..Phosphodiesterase inhibitors may thus be useful drugs for the treatment of AD-NDI. This animal model demonstrates that a mutant monomer gains a dominant-negative effect that reverses the normal polarized sorting of multimers...
  15. pmc Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2
    Shinichi Uchida
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Mol Cell Biol 25:7357-63. 2005
    ..Thus, UT-A2 is important for maintaining a high concentration of urea in the inner medulla when urea supply to the kidney is limited...
  16. pmc Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking
    Yumi Noda
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    J Cell Biol 182:587-601. 2008
    ..These findings indicate a novel mechanism of channel protein trafficking, in which the channel protein itself critically regulates local actin reorganization to initiate its movement...
  17. doi request reprint KLHL2 interacts with and ubiquitinates WNK kinases
    Daiei Takahashi
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
    Biochem Biophys Res Commun 437:457-62. 2013
    ..These results suggest that KLHL2-Cullin3 also functions as an E3-ligase for WNK isoforms within the body. ..
  18. ncbi request reprint Overexpression of human WNK1 increases paracellular chloride permeability and phosphorylation of claudin-4 in MDCKII cells
    Akihito Ohta
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 349:804-8. 2006
    ..Thus, increased chloride shunt may be involved in the pathogenesis of PHAII caused by WNK1 mutations...
  19. ncbi request reprint Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model
    Sung Sen Yang
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo 113 8519, Japan
    Cell Metab 5:331-44. 2007
    ..Thus, the pathogenesis of PHAII caused by a missense mutation of WNK4 was identified to be increased function of NCC through activation of the OSR1/SPAK-NCC phosphorylation cascade...
  20. ncbi request reprint Expression and function of Ets-1 during experimental acute renal failure in rats
    Hiroyuki Tanaka
    Homeostasis Medicine and Nephrology, Tokyo Medical and Dental University, 5 45 Yushima 1 chome, Bunkyo ku, Tokyo 113 8519, Japan
    J Am Soc Nephrol 15:3083-92. 2004
    ..Taken together, these data suggest that Ets-1 plays a key role in the cell-cycle progression of renal tubules in ARF. The Ets-1 pathway may regulate the transcription of cyclin D1 and control the regeneration of renal tubules in ARF...
  21. ncbi request reprint Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter
    Shin Suda
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Biochem Biophys Res Commun 344:246-52. 2006
    ..These results suggest that KLF12 is involved in the maturation processes of collecting ducts after birth, and that UT-A1 is a target gene of KLF12...
  22. ncbi request reprint Aldosterone stimulates proliferation of mesangial cells by activating mitogen-activated protein kinase 1/2, cyclin D1, and cyclin A
    Yoshio Terada
    Department of Nephrology, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Am Soc Nephrol 16:2296-305. 2005
    ..MR antagonists may serve as a potential therapeutic approach to mesangial proliferative disease...
  23. ncbi request reprint Physiological roles of AQP7 in the kidney: Lessons from AQP7 knockout mice
    Eisei Sohara
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo, Tokyo 113 8519, Japan
    Biochim Biophys Acta 1758:1106-10. 2006
    ..007+/-0.005 mg/ml; cisplatin, 0.063+/-0.043 mg/ml; ischemia, 0.076+/-0.02 mg/ml), suggesting that urine glycerol could be used as a new biomarker for detecting proximal straight tubule injury...
  24. ncbi request reprint Regulation of aquaporin-2 trafficking and its binding protein complex
    Yumi Noda
    Department of Nephrology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    Biochim Biophys Acta 1758:1117-25. 2006
    ..In addition, a multiprotein "force generator" complex which directly binds to AQP2 has been discovered. This review summarizes recent advances related to the mechanism for AQP2 trafficking...
  25. doi request reprint Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II
    Moko Zeniya
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo 113 8519, Japan
    Hypertension 62:872-8. 2013
    ..Our data also clarified a novel mechanism for regulation of vascular tonus by angiotensin II. Inhibition of this cascade could, therefore, be a novel therapeutic target in hypertension. ..
  26. doi request reprint The impact of hyporesponsiveness to erythropoietin-stimulating agents on time-dependent mortality risk among CKD stage 5D patients: a single-center cohort study
    Junichi Ishigami
    Department of Nephrology, Shuwa General Hospital, 1200 Yahara Shinden Kasukabe shi, Saitama 344 0035, Japan
    Clin Exp Nephrol 17:106-14. 2013
    ..This study aimed to assess a safe dose of ESA and the impact of hyporesponsiveness to ESA on mortality risk among hemodialyzed patients...
  27. ncbi request reprint Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels
    Koichiro Susa
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 0034, Japan
    Clin Exp Nephrol 16:530-8. 2012
    ..Although WNK1(+/-) mice have been reported to have hypotension, detailed analyses of the WNK signal cascade in the kidney and other organs of WNK1(+/-) mice have not been performed...
  28. ncbi request reprint Intracellular localization of ClC chloride channels and their ability to form hetero-oligomers
    Tatsunori Suzuki
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo Tokyo, Japan
    J Cell Physiol 206:792-8. 2006
    ..These results suggest that within cells ClC-3, ClC-4, and ClC-5 may have combinatorial functions, whereas ClC-6 and ClC-7 are more likely to function as homo-oligomers...
  29. doi request reprint Immunolocalization of WNK4 in mouse kidney
    Mayuko Ohno
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjyuku ku, Tokyo, Japan
    Histochem Cell Biol 136:25-35. 2011
    ..These results are consistent with the finding that WNK4 constitutes a kinase cascade with OSR1/SPAK and NCC in the DCT, and highlights a novel role for WNK4 in nephron segments newly identified as being WNK4-positive in this study...
  30. doi request reprint Effects of sevelamer hydrochloride on mortality, lipid abnormality and arterial stiffness in hemodialyzed patients: a propensity-matched observational study
    Soichiro Iimori
    Department of Nephrology, Shuwa General Hospital, Saitama, Japan
    Clin Exp Nephrol 16:930-7. 2012
    ..The effects of sevelamer HCl on mortality, lipid abnormality and arterial stiffness were examined in patients with chronic kidney disease stage 5D...
  31. doi request reprint Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination
    Muhammad Zakir Hossain Khan
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 425:456-61. 2012
    ..Thus, we demonstrated that NCC phosphorylation decreased NCC ubiquitination, which may contribute to the increase of NCC abundance mostly on plasma membranes...
  32. doi request reprint Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade
    Motoko Chiga
    Department of Nephrology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Cell Sci 124:1391-5. 2011
    ....
  33. doi request reprint Regulation of WNK1 kinase by extracellular potassium
    Shotaro Naito
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo 113 8519, Japan
    Clin Exp Nephrol 15:195-202. 2011
    ..In the present study, we focused on anisosmotic conditions as the initial clues for clarifying a stimulating factor for WNK kinase activity...
  34. doi request reprint Anti-centromere antibody is an independent risk factor for chronic kidney disease in patients with primary biliary cirrhosis
    Shintaro Mandai
    Department of Nephrology, Yokosuka Kyosai Hospital, 1 16 Yonegahamadori, Yokosuka, Kanagawa, 238 8558, Japan
    Clin Exp Nephrol 17:405-10. 2013
    ..However, its pathogenic role is not fully understood. The aim of this study was to determine the association between ACA and kidney function in PBC...
  35. doi request reprint Immunolocalization and translocation of aquaporin-5 water channel in sweat glands
    Risako Inoue
    Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    J Dermatol Sci 70:26-33. 2013
    ..Aquaporin-5 (AQP5) is a member of the water channel protein family. Although AQP5 was shown to be present in sweat glands, the presence or absence of regulated intracellular translocation of AQP5 in sweat glands remained to be determined...
  36. doi request reprint Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension
    Mai Wakabayashi
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo 113 8519, Japan
    Cell Rep 3:858-68. 2013
    ..Thus, WNK4 is a target for KLHL3-mediated ubiquitination, and the impaired ubiquitination of WNK4 is a common mechanism of human hereditary hypertension...
  37. ncbi request reprint Expression of CLC-KB gene promoter in the mouse cochlea
    Hirofumi Maehara
    Department of Otorhinolaryngology, Tokyo Medical and Dental University, Japan
    Neuroreport 14:1571-3. 2003
    ..Moreover, these fibrocytes may recycle Cl- through CLC that accompany Na+ and K+ into the cell via NKCC...
  38. pmc Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium
    Yoshio Terada
    Department of Blood Purification and Nephrology, Tokyo Medical and Dental University, 5 45, Yushima 1 chome, Bunkyo ku, Tokyo 113 8519, Japan
    J Am Soc Nephrol 19:298-309. 2008
    ....
  39. doi request reprint WNK-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone
    Koichiro Susa
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 427:743-7. 2012
    ..Thus, the activity of the WNK4-OSR1/SPAK-NCC cascade was shown to have a diurnal rhythm in the kidney that may be governed by aldosterone...
  40. ncbi request reprint The C-terminal tail of aquaporin-2 determines apical trafficking
    Michio Kuwahara
    Department of Nephrology, Tokyo Medical and Dental University Graduate School, Japan
    Kidney Int 68:1999-2009. 2005
    ..When one of these mutant AQP-2s was expressed in Madin-Darby canine kidney (MDCK) cells, it was mistargeted to the basolateral membrane, suggesting a critical role of the C-terminal tail in the apical trafficking of AQP-2...
  41. doi request reprint Severe hyperparathyroidism in a pre-dialysis chronic kidney disease patient treated with a very low protein diet
    Eriko Ohta
    Department of Nephrology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo, 113 8519, Japan
    J Bone Miner Metab 30:238-42. 2012
    ..Furthermore, initiation of dialysis should not be excessively delayed by strict protein restriction dietary therapy...
  42. pmc Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney
    Eisei Sohara
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 6:e24277. 2011
    ..The present results demonstrated that insulin is a potent regulator of NCC phosphorylation in the kidney, and that WNK4 and SPAK are involved in this mechanism of NCC phosphorylation by insulin...
  43. doi request reprint Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney
    Gulibaha Talati
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 393:844-8. 2010
    ..Although angiotensin II is identified as an upstream regulator for the WNK-OSR1/SPAK-NCC cascade in vivo, aldosterone appears to be the major regulator of this signal cascade in the long-term regulation by angiotensin II...
  44. doi request reprint Aquaporins in kidney pathophysiology
    Yumi Noda
    Department of Nephrology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Nat Rev Nephrol 6:168-78. 2010
    ..This Review describes recent progress in uncovering the physiology and pathophysiology of aquaporins in the kidney, with particular attention devoted to AQP2, the most well-studied member of this protein group...
  45. ncbi request reprint Calcium-alkali syndrome-like symptoms manifested by daily alphacalcidol and thiazide
    Fumie Satoh
    Department of Nephrology, Tokyo Medical and Dental University
    Intern Med 49:837-40. 2010
    ..This case suggests that the calcium-alkali syndrome can occur without calcium and alkali, but rather with alphacalcidol and a thiazide diuretic...
  46. doi request reprint Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone
    Motoko Chiga
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Kidney Int 74:1403-9. 2008
    ..These studies suggest that that the WNK-OSR1/SPAK-NCC cascade may be a novel effector system of aldosterone action in the kidney...
  47. pmc Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins
    Kozue Yamauchi
    Department of Nephrology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo, Tokyo 113 8519, Japan
    Proc Natl Acad Sci U S A 101:4690-4. 2004
    ..The increased paracellular "chloride shunt" caused by the mutant WNK4 could be the pathogenic mechanism of PHAII...
  48. pmc Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice
    Hidenori Nishida
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo 113 8519, Japan
    Hypertension 60:981-90. 2012
    ..This mechanism may play a role in the pathogenesis of salt-sensitive hypertension in human hyperinsulinemic conditions, such as the metabolic syndrome...
  49. ncbi request reprint Polarized trafficking of the aquaporin-3 water channel is mediated by an NH2-terminal sorting signal
    Tatemitsu Rai
    Dept of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental Univ, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Physiol Cell Physiol 290:C298-304. 2006
    ..On the basis of these results, we conclude that an NH2-terminal sorting signal mediates the basolateral targeting of AQP3...
  50. pmc Phosphorylation of aquaporin-2 regulates its water permeability
    Kayoko Eto
    Department of Nephrology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Biol Chem 285:40777-84. 2010
    ..The water permeability of S261A-AQP2 and S261D-AQP2 was similar to that of non-phosphorylated WT-AQP2. This study shows that PKA phosphorylation of AQP2 at Ser-256 enhances its water permeability...
  51. ncbi request reprint Identification of a multiprotein "motor" complex binding to water channel aquaporin-2
    Yumi Noda
    Department of Nephrology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 330:1041-7. 2005
    ..Our findings show for the first time an AQP2-binding multiprotein "force generator" complex. This multiprotein complex may provide the machinery of driving AQP2 movement...
  52. ncbi request reprint Barttin binds to the outer lateral surface of the ClC-K2 chloride channel
    Masato Tajima
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 362:858-64. 2007
    ..This information regarding the binding sites will be useful for designing a new class of diuretics or anti-hypertensive agents that inhibit the interaction of ClC-K and barttin...
  53. doi request reprint AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts
    Rie Okutsu
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Kidney Int 74:1429-33. 2008
    ..Forskolin-mediated phosphorylation of AQP2, transiently expressed in COS cells, was increased by AKAP220 co-expression. Our results suggest that AKAP220 may be involved in the phosphorylation of AQP2 by recruiting protein kinase A...
  54. ncbi request reprint Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury
    Yoshio Terada
    Department of Nephrology and Blood Purification, Tokyo Medical and Dental University, 5 45, Yushima 1 chome, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 364:1043-9. 2007
    ..These results demonstrated that ASK1 is activated in I/R-induced AKI, and blockage of ASK1 attenuates renal tubular apoptosis, MCP-1 expression, and renal function...
  55. ncbi request reprint Role of the E2F1-p19-p53 pathway in ischemic acute renal failure
    Hiroyuki Tanaka
    Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan
    Nephron Physiol 101:p27-34. 2005
    ..The p16(INK4a)/p19(ARF) (alternative reading frame) locus encodes two proteins involved in cell cycle regulation. We investigated the transcriptional regulation and tissue distribution of p19(ARF) in ischemic acute renal failure (ARF)...
  56. ncbi request reprint Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells
    Tomohiro Itoh
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 330:832-8. 2005
    ..The selective localization of AQP12 in pancreatic acinar cells and possibly in the intracellular organelles suggests a role of AQP12 in digestive enzyme secretion such as maturation and exocytosis of secretory granules...
  57. ncbi request reprint Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells
    Sung Sen Yang
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 330:410-4. 2005
    ..The regulation of intracellular localization of NCC by WNK4 might not be involved in the pathogenesis of PHAII...
  58. doi request reprint Generation and analyses of R8L barttin knockin mouse
    Naohiro Nomura
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
    Am J Physiol Renal Physiol 301:F297-307. 2011
    ..These results suggest that the major cause of Bartter syndrome type IV caused by R8L barttin mutation is its aberrant intracellular localization...
  59. ncbi request reprint Wnt4-transformed mouse embryonic stem cells differentiate into renal tubular cells
    Takahiko Kobayashi
    Department of Nephrology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 336:585-95. 2005
    ....
  60. pmc Baseline characteristics and prevalence of cardiovascular disease in newly visiting or referred chronic kidney disease patients to nephrology centers in Japan: a prospective cohort study
    Soichiro Iimori
    Department of Nephrology, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo ku, Tokyo 113 8519, Japan
    BMC Nephrol 14:152. 2013
    ..In this report, we describe the baseline characteristics and risk factors for cardiovascular disease (CVD) prevalence among this cohort...
  61. ncbi request reprint Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats
    Yoshio Terada
    Homeostasis Medicine and Nephrology, Tokyo Medical and Dental University, 5 45 Yushima 1 chome, Bunkyo ku, Tokyo 113 8519, Japan
    J Am Soc Nephrol 14:1223-33. 2003
    ..The Wnt-4-beta-catenin pathway may regulate the transcription of cyclin D1 and control the regeneration of renal tubules in ARF...
  62. ncbi request reprint The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad
    Haruko Shimamura
    The Homeostasis Medicine and Nephrology, Tokyo Medical and Dental University, Tokyo, Japan
    J Am Soc Nephrol 14:1427-34. 2003
    ..The findings suggest that the PI3-kinase-Akt pathway acts as a survival signal and plays a key role in the regulation of apoptotic change in mesangial cells principally via NF-kappa B...
  63. ncbi request reprint Molecular mechanisms of Bartter syndrome caused by mutations in the BSND gene
    Atsushi Hayama
    Department of Nephrology, Graduate School, School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo, 113 8519 Tokyo, Japan
    Histochem Cell Biol 119:485-93. 2003
    ..These results clarified that barttin determined cellular localization of CLC-K2 by protein-protein interaction. Thus, the mislocalization of CLC-K2 was identified as the molecular pathogenesis of Bartter syndrome by mutant barttins...
  64. doi request reprint Aquaporin-11 knockout mice and polycystic kidney disease animals share a common mechanism of cyst formation
    Shinji Okada
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    FASEB J 22:3672-84. 2008
    ..We also demonstrated the activation of apoptosis via the ER-stress pathway in the proximal tubule cells with vacuolized ER. These results provide new insights into the physiological roles of AQP11...
  65. doi request reprint Actin-binding channels
    Yumi Noda
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Prog Brain Res 170:551-7. 2008
    ..Furthermore, there are increasing evidences showing the direct interactions of channel to actin. This review focuses on actin-binding channel proteins and the role of the actin interaction in the channel protein regulation...
  66. ncbi request reprint Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice
    Eisei Sohara
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Am J Physiol Renal Physiol 289:F1195-200. 2005
    ..007 +/- 0.005 mg/ml; cisplatin, 0.063 +/- 0.043 mg/ml; ischemia, 0.076 +/- 0.02 mg/ml), suggesting that urine glycerol could be used as a new biomarker for detecting proximal straight tubule injury...
  67. ncbi request reprint [Regenerative medicine in nephrology]
    Yoshio Terada
    Department of Nephrology, Blood Purification, Tokyo Medical and Dental University
    Nihon Rinsho 64:7-13. 2006
  68. ncbi request reprint Morphologic and functional analysis of sperm and testes in Aquaporin 7 knockout mice
    Eisei Sohara
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Fertil Steril 87:671-6. 2007
    ..To investigate the functional and morphologic role of Aquaporin 7 (AQP7) in testis and sperm...
  69. ncbi request reprint Trafficking mechanism of water channel aquaporin-2
    Yumi Noda
    Department of Nephrology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Biol Cell 97:885-92. 2005
    ..This review summarizes recent advances related to the trafficking mechanisms of AQP2...
  70. doi request reprint Post-staphylococcal infection Henoch-Schönlein purpura nephritis: a case report and review of the literature
    Shintaro Mandai
    Department of Nephrology, Yokosuka Kyosai Hospital, Kanagawa, Japan
    Ren Fail 35:869-74. 2013
    ..Post-Staphylococcal infection HSPN may constitute a subgroup of IgA-PIGN...
  71. ncbi request reprint Pathogenesis of nephrogenic diabetes insipidus by aquaporin-2 C-terminus mutations
    Tomoki Asai
    Department of Homeostasis Medicine and Nephrology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Kidney Int 64:2-10. 2003
    ..The Xenopus oocyte expression study suggested that the trafficking of the mutant AQP2s was impaired...
  72. ncbi request reprint Differential effects of hyperosmolality on Na-K-ATPase and vasopressin-dependent cAMP generation in the medullary thick ascending limb and outer medullary collecting duct
    Yoriko Sakuma
    Department of Nephrology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Hypertens Res 28:671-9. 2005
    ..These findings demonstrate that Na-K-ATPase is upregulated short- and long-term hyperosmolality in the MAL, but not in OMCD...
  73. ncbi request reprint Role of cytokines in anaphylactoid reaction with marked eosinophilia in a hemodialysis patient
    Eiichiro Kanda
    Department of Nephrology, Toride Kyodo Hospital, 2 1 1 Hongo, Toride, Ibaraki 302 0022, Japan
    Clin Exp Nephrol 8:384-7. 2004
    ..In this report, we discuss the mechanism underlying drug-induced anaphylactoid reaction, particularly that involving eosinophilia and cytokines...
  74. pmc A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo
    Katsuyuki Oi
    Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biol Open 1:120-7. 2012
    ..Thus, WNK3 may have some role in the WNK-OSR1/SPAK-NCC/NKCC2 signal cascade in the kidney, but its contribution to total WNK kinase activity may be minimal...
  75. doi request reprint Type II diabetes mellitus is a risk factor for heart failure in pre-dialysis patients
    Michio Kuwahara
    Division of Nephrology, Shuuwa General Hospital, Kasukabe, Saitama, Japan
    Ther Apher Dial 16:541-7. 2012
    ..Our findings suggest that not only CKD, but also type II DM, is a potent risk for left ventricular dysfunction, which causes HF and IHD in pre-dialysis patients with CKD...
  76. doi request reprint Diagnostic usefulness of bone mineral density and biochemical markers of bone turnover in predicting fracture in CKD stage 5D patients--a single-center cohort study
    Soichiro Iimori
    Department of Nephrology, Shuwa General Hospital, Saitama, Japan
    Nephrol Dial Transplant 27:345-51. 2012
    ..The reason for this may be the heterogeneity of underlying pathogenesis of the fracture...
  77. ncbi request reprint Water channel aquaporin-2 directly binds to actin
    Yumi Noda
    Department of Nephrology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 322:740-5. 2004
    ..18x10(-8)M. In this experiment we have elucidated the direct binding of channel protein AQP2 to cytoskeletal protein actin, providing a novel mechanism for trafficking of not only AQP2 but also recycling channel proteins...
  78. doi request reprint Effect of sevelamer hydrochloride on bone in experimental uremic rats
    Michio Kuwahara
    Department of Nephrology, Shuwa General Hospital, Kasukabe, Japan
    Ther Apher Dial 13:42-8. 2009
    ..Sevelamer inhibited the elevation of PoAr/CtAr, OS/Es, and Es BFR. Our findings suggest that the decrease in PTH by sevelamer may be beneficial in the treatment of high PTH-induced bone disease...
  79. doi request reprint A familial case of mitochondrial disease resembling Alport syndrome
    Hayahiko Fujii
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Clin Exp Nephrol 12:159-63. 2008
    ..This syndrome should be recognized by nephrologists as a differential diagnosis of Alport syndrome, diabetic nephropathy, and primary glomerular diseases...
  80. ncbi request reprint The role of actin remodeling in the trafficking of intracellular vesicles, transporters, and channels: focusing on aquaporin-2
    Yumi Noda
    Department of Nephrology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Pflugers Arch 456:737-45. 2008
    ..In this review, we describe the role of actin at each step of intracellular reservation, exocytosis, docking, fusion with the plasma membrane, and endocytosis, focusing on aquaporin-2 trafficking...
  81. ncbi request reprint Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1
    Yumi Noda
    Department of Homeostasis Medicine and Nephrology, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    FEBS Lett 568:139-45. 2004
    ..AQP2 trafficking was impaired in SPA-1-deficient mice. Our results show that SPA-1 directly binds to AQP2 and regulates at least in part AQP2 trafficking...
  82. doi request reprint Assessment and significance of abdominal aortic calcification in chronic kidney disease
    Shigeru Hanada
    Department of Nephrology, Musashino Red Cross Hospital, Tokyo, Japan
    Nephrol Dial Transplant 25:1888-95. 2010
    ..Abdominal aortic calcification is a common complication and a predictor of cardiovascular mortality in dialysis patients. However, abdominal aortic calcification in pre-dialysis chronic kidney disease (CKD) is poorly understood...
  83. ncbi request reprint Human CLC-KB gene promoter drives the EGFP expression in the specific distal nephron segments and inner ear
    Katsuki Kobayashi
    Departments of Pediatrics, Homeostasis Medicine and Nephrology, and Audio Vestibular Neuroscience, Tokyo Medical and Dental University, Tokyo, Japan
    J Am Soc Nephrol 13:1992-8. 2002
    ....
  84. ncbi request reprint [Nephrogenic diabetes insipidus: Pathogenesis, pathophysiology, and therapy]
    Eriko Ota
    Department of Nephrology, Tokyo Medical and Dental University
    Nihon Rinsho 64:528-30. 2006
  85. ncbi request reprint Molecular mechanisms and drug development in aquaporin water channel diseases: molecular mechanism of water channel aquaporin-2 trafficking
    Yumi Noda
    Department of Nephrology, Graduate School, Tokyo Medical and Dental University, Japan
    J Pharmacol Sci 96:249-54. 2004
    ..This review summarizes recent advances related to the trafficking mechanism of AQP2 and its defect causing nephrogenic diabetes insipidus (NDI)...
  86. ncbi request reprint [Function of vasopressin in kidney]
    Shin Suda
    Department of Nephrology, Tokyo Medical and Dental University
    Nihon Rinsho 63:479-83. 2005
  87. ncbi request reprint Intracellular mislocalization of mutant podocin and correction by chemical chaperones
    Teiko Ohashi
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, 8 1 Kawada cho Shinjuku, 162 8666, Tokyo, Japan
    Histochem Cell Biol 119:257-64. 2003
    ..Our results reveal defective cellular processing of the mutant podocin, and provide evidence for pharmacological correction of the processing defect...
  88. ncbi request reprint Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney
    Yoshio Terada
    Homeostasis Medicine and Nephrology, Tokyo Medical and Dental University and Allergy Research Center, Juntendo University, School of Medicine, Tokyo, Japan
    Kidney Int 61:S94-8. 2002
    ....
  89. ncbi request reprint Ligand-regulatable erythropoietin production by plasmid injection and in vivo electroporation
    Yoshio Terada
    Homeostasis Medicine and Nephrology, Tokyo Medical and Dental University, Tokyo, Japan
    Kidney Int 62:1966-76. 2002
    ..However, the ability to regulate transgene expression is of paramount importance for safe and effective gene transfer therapy...
  90. ncbi request reprint [Liddle syndrome: Pathogenesis, pathophysiology, and therapy]
    Akihito Ohta
    Department of Nephrology, Tokyo Medical and Dental University
    Nihon Rinsho 64:513-6. 2006
  91. ncbi request reprint [Aquaporin]
    Sei Sasaki
    Department of Nephrology, Graduate School, Tokyo Medical and Dental University
    Nihon Rinsho 63:609-11. 2005
  92. ncbi request reprint Function of chloride channels in the kidney
    Shinichi Uchida
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Annu Rev Physiol 67:759-78. 2005
    ....
  93. ncbi request reprint Molecular mechanisms and drug development in aquaporin water channel diseases: aquaporin superfamily (superaquaporins): expansion of aquaporins restricted to multicellular organisms
    Yoshiyuki Morishita
    Department of Nephrology, Jichi Medical School, Tochigi, Japan
    J Pharmacol Sci 96:276-9. 2004
    ..Their function is still unknown. AQP11 knockout mice suffer from polycystic kidneys and neonatal fatality. The identification of superaquaporins will provide new insights into the role of AQPs in organogenesis...
  94. ncbi request reprint Smad7 mediates transforming growth factor-beta-induced apoptosis in mesangial cells
    Tomokazu Okado
    Homeostasis Medicine and Nephrology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Kidney Int 62:1178-86. 2002
    ..To investigate the function of Smad proteins, we examined the effect of Smad overexpression using adenoviral vector in mesangial cells...
  95. ncbi request reprint CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis
    Momono Yoshikawa
    Homeostasis Medicine and Nephrology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo Tokyo 113 8519, Japan
    Genes Cells 7:597-605. 2002
    ..CLC-3 is a member of the CLC chloride channel family and is widely expressed in mammalian tissues. To determine the physiological role of CLC-3, we generated CLC-3-deficient mice (Clcn3-/- ) by targeted gene disruption...
  96. ncbi request reprint Anti-centromere antibody-positive subjects presenting with hypertensive emergency and renal dysfunction in the absence of skin manifestations: a variant of systemic sclerosis or a novel entity?
    Shintaro Mandai
    Department of Nephrology, Yokosuka Kyosai Hospital, Japan
    Intern Med 51:1567-72. 2012
    ..These subjects' manifestations may represent a novel entity...
  97. ncbi request reprint Catheter-related bacteremia caused by Agrobacterium radiobacter in a hemodialysis patient
    Shigeru Hanada
    Department of Nephrology, Musashino Red Cross Hospital, Tokyo
    Intern Med 48:455-7. 2009
    ..This case shows that A. radiobacter should be included in the list of pathogens that can cause catheter-related bacteremia in hemodialysis patients...
  98. doi request reprint A longer duration of polymyxin B-immobilized fiber column hemoperfusion improves pulmonary oxygenation in patients with septic shock
    Chieko Mitaka
    Department of Critical Care Medicine, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Tokyo, Japan
    Shock 32:478-83. 2009
    ..4 +/- 80.7 vs. 1.2 +/- 49.2 and -0.8 +/- 1.8 vs. 2.2 +/- 1.9 torr, respectively). We thus suggest that a longer duration of PMX treatment may improve the pulmonary oxygenation associated with decreased adhesion molecules in septic shock...
  99. ncbi request reprint Study of the oral microbial flora in patients with renal disease
    Yohei Takeuchi
    Sections of Dentistry for Persons with Disabilities, Tokyo Medical and Dental University, Tokyo 113 8549, Japan
    Nephrology (Carlton) 12:182-90. 2007
    ..The aim of this study is to bacteriologically investigate the oral environment in patients with renal disease and thereby reveal their influence on both caries and periodontal diseases...
  100. ncbi request reprint Water channel activities of Mimosa pudica plasma membrane intrinsic proteins are regulated by direct interaction and phosphorylation
    Yusuke Temmei
    Department of Chemistry, Faculty of Science and Technology, Sophia University, 7 1 Kioi, Chiyoda ku, Tokyo 102 8554, Japan
    FEBS Lett 579:4417-22. 2005
    ....
  101. ncbi request reprint BSC1 inhibition complements effects of vasopressin V2 receptor antagonist on hyponatremia in SIADH rats
    Itsuro Kazama
    Division of Molecular Medicine, Center for Translational and Advanced Animal Research, Tohoku University School of Medicine, Sendai, Japan
    Kidney Int 67:1855-67. 2005
    ....