Naoya Sakamoto

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. doi request reprint New therapeutic approaches to hepatitis C virus
    Naoya Sakamoto
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    J Gastroenterol 44:643-9. 2009
  2. doi request reprint Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b
    Naoya Sakamoto
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    J Med Virol 83:871-8. 2011
  3. ncbi request reprint Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA
    Naoya Sakamoto
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    J Gastroenterol Hepatol 23:1437-47. 2008
  4. doi request reprint IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis
    Takayuki Tomita
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 39:2737-47. 2009
  5. doi request reprint Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis
    Teruji Totsuka
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 38:1275-86. 2008
  6. ncbi request reprint Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon- alpha
    Yoko Tanabe
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    J Infect Dis 189:1129-39. 2004
  7. doi request reprint IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis
    Kaori Kameyama
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 40:2423-36. 2010
  8. doi request reprint Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic mice
    Takayuki Tomita
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Inflamm Bowel Dis 14:1630-40. 2008
  9. ncbi request reprint Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3
    Tsuyoshi Yamashiro
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    J Gastroenterol 41:750-7. 2006
  10. doi request reprint Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection
    Mina Nakagawa
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    J Gastroenterol 45:656-65. 2010

Collaborators

Detail Information

Publications63

  1. doi request reprint New therapeutic approaches to hepatitis C virus
    Naoya Sakamoto
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    J Gastroenterol 44:643-9. 2009
    ..This article reviews the current status of preclinical drug development, ongoing clinical trials, and near future perspectives in the field of HCV therapeutics...
  2. doi request reprint Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b
    Naoya Sakamoto
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    J Med Virol 83:871-8. 2011
    ..In conclusion, IL-28B polymorphism affects responses to PEG-IFN-based treatment in difficult-to-treat HCV patients...
  3. ncbi request reprint Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA
    Naoya Sakamoto
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    J Gastroenterol Hepatol 23:1437-47. 2008
    ..In this study, we investigated the effects of the siRNA targeting HCV-RNA in vivo...
  4. doi request reprint IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis
    Takayuki Tomita
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 39:2737-47. 2009
    ..They also provide a basis for the timing of IL-7/IL-7R blockade for the treatment of inflammatory bowel diseases...
  5. doi request reprint Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis
    Teruji Totsuka
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 38:1275-86. 2008
    ..Thus, colitogenic LP CD4(+) cells may be exhausted over time, become non-functional, convert to regulatory cells, and finally suppress colitis in the process of immunosenescence...
  6. ncbi request reprint Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon- alpha
    Yoko Tanabe
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    J Infect Dis 189:1129-39. 2004
    ..Our results suggest that the direct effects of ribavirin on the genetic stability of the HCV subgenome and its synergistic action combined, with IFN-alpha, may explain the improved clinical responses to combination therapy...
  7. doi request reprint IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis
    Kaori Kameyama
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 40:2423-36. 2010
    ..These results show that IL-2 is critically involved in the establishment and maintenance of IL-7-dependent colitogenic memory CD4(+)IL-7R alpha(high) T cells...
  8. doi request reprint Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic mice
    Takayuki Tomita
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Inflamm Bowel Dis 14:1630-40. 2008
    ....
  9. ncbi request reprint Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3
    Tsuyoshi Yamashiro
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    J Gastroenterol 41:750-7. 2006
    ..In the present study, we evaluated the effects of IRF-3 expression and activation on intracellular hepatitis C virus (HCV) replication using an HCV replicon system...
  10. doi request reprint Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection
    Mina Nakagawa
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    J Gastroenterol 45:656-65. 2010
    ..The aims of this study were to analyze the clinical and virological factors associated with a higher rate of response in patients with HCV genotype 1b infection treated with combination therapy...
  11. doi request reprint Age and total ribavirin dose are independent predictors of relapse after interferon therapy in chronic hepatitis C revealed by data mining analysis
    Masayuki Kurosaki
    Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
    Antivir Ther 17:35-43. 2012
    ..This study aimed to define factors associated with relapse among responders to pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy in chronic hepatitis C...
  12. doi request reprint Pretreatment prediction of anemia progression by pegylated interferon alpha-2b plus ribavirin combination therapy in chronic hepatitis C infection: decision-tree analysis
    Naoki Hiramatsu
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
    J Gastroenterol 46:1111-9. 2011
    ..This study aimed to develop a model to predict the development of severe anemia during pegylated interferon alpha-2b plus ribavirin combination therapy...
  13. doi request reprint Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis
    Yasuhiro Nemoto
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 183:5059-68. 2009
    ..Thus, blocking a stimulus of colitogenic memory CD4(+) cells such as IL-7 may have therapeutic benefit for treatment of inflammatory bowel disease...
  14. doi request reprint Cell culture and in vivo analyses of cytopathic hepatitis C virus mutants
    Kako Mishima
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Virology 405:361-9. 2010
    ..The cytopathic HCV clones exhibit high replication competence in vivo but may be eliminated during the early stages of infection...
  15. ncbi request reprint Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-alpha plus ribavirin combination therapy
    Kosei Hamano
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan
    J Gastroenterol Hepatol 20:1401-9. 2005
    ..However, mechanisms of the action of the combination regimen are not well understood. To elucidate the viral genetic basis of IFN plus RBV combination therapy, genetic variabilities of HCV-1b were analyzed...
  16. ncbi request reprint Specific inhibition of hepatitis C virus replication by cyclosporin A
    Mina Nakagawa
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 313:42-7. 2004
    ..Further defining its mode of action against HCV replication potentially may be important for identifying novel molecular targets to treat HCV infection...
  17. doi request reprint Data mining model using simple and readily available factors could identify patients at high risk for hepatocellular carcinoma in chronic hepatitis C
    Masayuki Kurosaki
    Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
    J Hepatol 56:602-8. 2012
    ..We aimed to build a simple model for the identification of patients at high risk of developing HCC...
  18. doi request reprint Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis
    Xiu Zheng
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Inflamm Bowel Dis 17:2251-60. 2011
    ..This study shows that the undifferentiated state is maintained by the suppression of the Hath1 gene in human intestine...
  19. doi request reprint RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis
    Teruji Totsuka
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo
    J Immunol 182:6079-87. 2009
    ..Together, these results suggest that the RANK-RANKL signaling pathway is critically involved in regulating the function of CD4(+)CD25(+) T(R) cells in colitis...
  20. doi request reprint Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis
    Yasuhiro Nemoto
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, Juntendo University School of Medicine, Tokyo, Japan
    Inflamm Bowel Dis 14:1491-503. 2008
    ..Based on this background we here investigate whether granulocytes promote or suppress the expansion of colitogenic CD4(+) T cells...
  21. doi request reprint FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow
    Toshimitsu Fujii
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 38:3290-303. 2008
    ..Altogether, the present results indicate that FTY720 treatment may offer an additional role to direct trafficking of CD4(+) T cells in BM, resulting in the prevention of colitis...
  22. pmc Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91
    Yusuke Funaoka
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Virol 85:5986-94. 2011
    ..In conclusion, HCV R70 and L91 core mutants were resistant to interferon in vitro, and the resistance may be induced by IL-6-induced upregulation of SOCS3. Those mechanisms may explain clinical interferon resistance of HCV core mutants...
  23. pmc Regulation of hepatitis C virus replication by interferon regulatory factor 1
    Nobuhiko Kanazawa
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Virol 78:9713-20. 2004
    ..Taken together, IRF-1 is one of the key host factors that regulate intracellular HCV replication through modulation of interferon-stimulated-gene-mediated antiviral responses...
  24. doi request reprint Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferon-α2b plus ribavirin
    Mayumi Ueyama
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    Antivir Ther 16:1081-91. 2011
    ..In this study, we investigated the association of serum IL-6 levels with outcomes of pegylated interferon (PEG-IFN) plus ribavirin (RBV) combination therapy...
  25. pmc Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication
    Akiko Kusano-Kitazume
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    Antimicrob Agents Chemother 56:1315-23. 2012
    ..In conclusion, N-(morpholine-4-carbonyloxy) amidine and other related morpholine compounds specifically suppressed HCV replication and may have potential as novel chemotherapeutic agents...
  26. ncbi request reprint Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response
    Megumi Tasaka
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    J Gen Virol 88:3323-33. 2007
    ..These mechanisms may contribute to the clinical persistence of HCV infection and could constitute a novel antiviral therapeutic target...
  27. ncbi request reprint Development of plaque assays for hepatitis C virus-JFH1 strain and isolation of mutants with enhanced cytopathogenicity and replication capacity
    Yuko Sekine-Osajima
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    Virology 371:71-85. 2008
    ..Taken together, the cytopathic effect of HCV infection involves ER-stress-induced apoptotic cell death. Certain HCV genomic structures may determine the viral replication capacity and cytopathogenicity...
  28. doi request reprint Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors
    Masayuki Kurosaki
    Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino shi, Tokyo, Japan
    J Hepatol 54:439-48. 2011
    ..Recent studies revealed an association between the IL28B genotype and treatment response. We aimed to develop a model for the pre-treatment prediction of response using host and viral factors...
  29. pmc Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase
    Yuko Karakama
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Antimicrob Agents Chemother 54:3179-86. 2010
    ..Our results demonstrate that SRPKs are host factors essential for HCV replication and that functional inhibitors of these kinases may constitute a new class of antiviral agents against HCV infection...
  30. doi request reprint Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C
    Masayuki Kurosaki
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
    J Med Virol 85:449-58. 2013
    ..In conclusion, a predictive model incorporating the ITPA genotype could identify patients with a high risk of anemia and reduced probability of sustained virological response...
  31. doi request reprint Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity
    Sayuri Nitta
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    Hepatology 57:46-58. 2013
    ..NS4B suppressed residual IFN-β activation by an NS3/4A-cleaved Cardif (Cardif1-508), suggesting that NS3/4A and NS4B may cooperate in the blockade of IFN-β production...
  32. doi request reprint Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response
    Yasuhiro Asahina
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
    Hepatology 55:20-9. 2012
    ..IPS-1 down-regulation in IL28B minor patients was confirmed by western blotting, and the extent of IPS-1 protein cleavage was associated with the variable treatment response...
  33. ncbi request reprint [Virus factors determining the outcome of IFN treatment for chronic hepatitis C]
    Nobuhiko Kanazawa
    Department of Gastroenterology and Hepatology, School of Medicine, Tokyo Medical and Dental University
    Nihon Rinsho 62:474-80. 2004
  34. doi request reprint Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein
    Yasuhiro Itsui
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    Hepatology 50:1727-37. 2009
    ..Binding of NS5B with GBP-1 inhibited its guanosine triphosphatase GTPase activity, which is essential for its antiviral effect. Taken together, interferon-induced GBP-1 showed antiviral activity against HCV replication...
  35. pmc Inhibitory effect of a triterpenoid compound, with or without alpha interferon, on hepatitis C virus infection
    Takako Watanabe
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    Antimicrob Agents Chemother 55:2537-45. 2011
    ..Antiviral effects of treatment with α-IFN can be enhanced by pretreatment with TSN. Its mechanisms of action could potentially be important to identify novel molecular targets to treat HCV infection...
  36. ncbi request reprint Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilins
    Mina Nakagawa
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    Gastroenterology 129:1031-41. 2005
    ..Cyclosporin A specifically suppresses hepatitis C virus (HCV) replication in vitro at clinically achievable concentrations. In this study, we investigated the mechanisms of action of cyclosporin A against HCV replication...
  37. pmc Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs
    Takanori Yokota
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    EMBO Rep 4:602-8. 2003
    ..Our results support the feasibility of using siRNA-based gene therapy to inhibit HCV replication, which may prove to be valuable in the treatment of hepatitis C...
  38. doi request reprint Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells
    Minekazu Murayama
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    J Gastroenterol 44:173-82. 2009
    ..However, little is known about the function of Msi-1 within human intestinal epithelial cells (IECs). Thus, the present study aimed to clarify the role of Msi-1 in differentiation and proliferation of IECs...
  39. doi request reprint Continuous generation of colitogenic CD4(+) T cells in persistent colitis
    Takayuki Tomita
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Immunol 38:1264-74. 2008
    ..In conclusion, the continuous generation of colitogenic CD4(+) cells that compensate for exhausted CD4(+) cells may be one of the mechanisms involved in the persistence of colitis...
  40. doi request reprint Sequences in the interferon sensitivity-determining region and core region of hepatitis C virus impact pretreatment prediction of response to PEG-interferon plus ribavirin: data mining analysis
    Masayuki Kurosaki
    Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
    J Med Virol 83:445-52. 2011
    ..A decision-tree model that includes these viral factors as predictors could identify patients with a high probability of sustained virological response...
  41. doi request reprint Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy
    Tomokazu Mizui
    Department of Gastroenterology, Juntendo University, School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    J Gastroenterol 45:195-203. 2010
    ..In this study, we investigated the role of autophagy on hepatitis C virus (HCV) RNA replication and demonstrated anti-HCV effects of an autophagic proteolysis inhibitor, chloroquine...
  42. ncbi request reprint MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis
    Takayuki Tomita
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 180:5291-9. 2008
    ..Collectively, the MyD88-dependent pathway that controls TLR signaling in T cells may directly promote the proliferation and survival of colitogenic CD4(+) T cells to sustain chronic colitis...
  43. ncbi request reprint [Role of interferon-sensitivity-determining region in replication of hepatitis C virus]
    Shinya Maekawa
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
    Nihon Rinsho 62:89-95. 2004
  44. doi request reprint Potential relevance of cytoplasmic viral sensors and related regulators involving innate immunity in antiviral response
    Yasuhiro Asahina
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
    Gastroenterology 134:1396-405. 2008
    ..The aim is to elucidate the mechanisms underlying resistance to antiviral therapy and predictive usefulness of gene quantification in chronic hepatitis C (CH-C)...
  45. doi request reprint IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones
    Goki Suda
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    Virology 407:80-90. 2010
    ..In conclusion, intergenotypic differences of IFN sensitivity of HCV may be attributable to the sequences of HCV structural proteins and can be determined by SOCS3 and IL-6 expression levels...
  46. ncbi request reprint [Establishment of cell lines expressing HCV replicon and its applications]
    Naoya Sakamoto
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
    Nihon Rinsho 62:116-20. 2004
  47. doi request reprint Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis
    Michio Onizawa
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Physiol Gastrointest Liver Physiol 296:G850-9. 2009
    ....
  48. doi request reprint Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4
    Michiko Iwasaki
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Gastroenterol 46:191-202. 2011
    ..The present study aimed to elucidate the regulation of cell formation in the human small intestine using biopsy specimens collected from an entire individual small intestine by DBE...
  49. ncbi request reprint [Case of severe ulcerative colitis successfully treated with intravenous cyclosporine without high dose corticosteroid]
    Daisuke Kubota
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan
    Nihon Shokakibyo Gakkai Zasshi 104:42-6. 2007
    ..The treatment was successful and she obtained complete remission. Cyclosporine A monotherapy is considered to be a valuable alternative to proctocolectomy for severe ulcerative colitis patients who cannot tolerate corticosteroid...
  50. doi request reprint Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice
    Kei Kiyohashi
    Department of Gastroenterology and Hepatology, Tokyo, Japan
    Hepatology 57:2502-13. 2013
    ..These findings also suggest that activation of CaMKII by Wnt5a signaling suppresses biliary differentiation. (HEPATOLOGY 2013;)...
  51. ncbi request reprint Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication
    Yuko Sekine-Osajima
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    Hepatol Res 39:60-9. 2009
    ..Further elucidation of their mechanisms of action and evaluation of in vivo effects and safety might constitute a new anti-HCV therapeutics...
  52. ncbi request reprint Bone morphogenetic protein-7 and interferon-alpha synergistically suppress hepatitis C virus replicon
    Naoya Sakamoto
    Department for Hepatitis Control, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 357:467-73. 2007
    ..Taken together, BMP-7 may constitute a novel molecule to suppress HCV replication...
  53. doi request reprint Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells
    Yuki Nishimura-Sakurai
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    J Gastroenterol 45:523-36. 2010
    ..Here, we screened host genes and molecular pathways that are involved in HCV replication by comprehensive analyses using two genotypes of HCV replicon-expressing cells, their cured cells and naïve Huh7 cells...
  54. ncbi request reprint Hepatitis C virus nonstructural protein 5A inhibits tumor necrosis factor-alpha-mediated apoptosis in Huh7 cells
    Yuka Miyasaka
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    J Infect Dis 188:1537-44. 2003
    ..These findings suggest that the NS5A protein inhibits the apoptotic effect of TNF-alpha upstream of caspase-8 in the apoptosis cascade...
  55. doi request reprint Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice
    Izumi Onozuka
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan
    Biochem Biophys Res Commun 406:134-40. 2011
    ..Our study demonstrated, using 2 experimental murine models, that loss of MMP-2 exacerbates liver fibrosis, and suggested that MMP-2 suppresses tissue inhibitor of metalloproteinase 1 up-regulation during liver fibrosis...
  56. ncbi request reprint Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis
    Takayuki Tomita
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 180:383-90. 2008
    ....
  57. ncbi request reprint [Hepatitis C virus infection]
    Mina Nakagawa
    Department of Gastroenterology and Hepatology, Faculty of Medicine, Tokyo Medical and Dental University
    Nihon Rinsho 61:627-33. 2003
  58. doi request reprint Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer
    Mikayo Aragaki
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 368:923-9. 2008
    ..This means that Hath1 protein degradation may be required for maintaining the undifferentiated state of colon cancers, and that GSK3 inhibitors have potential for use in cancer therapy...
  59. ncbi request reprint [A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient]
    Daisuke Kubota
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
    Nihon Shokakibyo Gakkai Zasshi 103:1044-9. 2006
    ..Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level...
  60. ncbi request reprint [Antiviral mechanism of ribavirin against RNA virus]
    Kosei Hamano
    Department of Gastroenterology and Hepatology, School of Medicine, Tokyo Medical and Dental University
    Nihon Rinsho 62:459-62. 2004
  61. ncbi request reprint [Structure and functions of HCV non-structural proteins]
    Jun Itakura
    Department of Gastroenterology and Hepatology, School of Medicine, Tokyo Medical and Dental University
    Nihon Rinsho 62:64-8. 2004
  62. ncbi request reprint [A case of sacroiliitis complicated by ulcerative colitis that was successfully treated with steroid]
    Daisuke Kubota
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
    Nihon Shokakibyo Gakkai Zasshi 103:936-42. 2006
    ..The efficacy of steroids on pain relief of sacroiliitis and ankylosing spondylitis is unclear...
  63. ncbi request reprint Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4. Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation
    Mimi Tamamori-Adachi
    Department of Biochemical Genetics, Medical Research Institute and Laboratory of Genome Structure and Regulation, School of Biomedical Science, Tokyo Medcal and Dental Universuty, Tokyo, Japan
    J Biol Chem 279:50429-36. 2004
    ..This provides a novel insight in understanding the molecular mechanism by which mammalian cardiomyocytes cease to proliferate during terminal differentiation...