Research Topics
Genomes and Genes
| Naoya SakamotoSummaryAffiliation: Tokyo Medical and Dental University Country: Japan Publications
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Detail Information
Publications
New therapeutic approaches to hepatitis C virusNaoya Sakamoto
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
J Gastroenterol 44:643-9. 2009..This article reviews the current status of preclinical drug development, ongoing clinical trials, and near future perspectives in the field of HCV therapeutics...
Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNANaoya Sakamoto
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
J Gastroenterol Hepatol 23:1437-47. 2008..In this study, we investigated the effects of the siRNA targeting HCV-RNA in vivo...- Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2bNaoya Sakamoto
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
J Med Virol 83:871-8. 2011..In conclusion, IL-28B polymorphism affects responses to PEG-IFN-based treatment in difficult-to-treat HCV patients... - IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitisTakayuki Tomita
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Eur J Immunol 39:2737-47. 2009..They also provide a basis for the timing of IL-7/IL-7R blockade for the treatment of inflammatory bowel diseases... - Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitisTeruji Totsuka
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Eur J Immunol 38:1275-86. 2008..Thus, colitogenic LP CD4(+) cells may be exhausted over time, become non-functional, convert to regulatory cells, and finally suppress colitis in the process of immunosenescence... - Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic miceTakayuki Tomita
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Inflamm Bowel Dis 14:1630-40. 2008.... - IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitisKaori Kameyama
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Eur J Immunol 40:2423-36. 2010..These results show that IL-2 is critically involved in the establishment and maintenance of IL-7-dependent colitogenic memory CD4(+)IL-7R alpha(high) T cells... - Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon- alphaYoko Tanabe
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
J Infect Dis 189:1129-39. 2004..Our results suggest that the direct effects of ribavirin on the genetic stability of the HCV subgenome and its synergistic action combined, with IFN-alpha, may explain the improved clinical responses to combination therapy... - Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infectionMina Nakagawa
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
J Gastroenterol 45:656-65. 2010..The aims of this study were to analyze the clinical and virological factors associated with a higher rate of response in patients with HCV genotype 1b infection treated with combination therapy... - Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3Tsuyoshi Yamashiro
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
J Gastroenterol 41:750-7. 2006..In the present study, we evaluated the effects of IRF-3 expression and activation on intracellular hepatitis C virus (HCV) replication using an HCV replicon system... - Pretreatment prediction of anemia progression by pegylated interferon alpha-2b plus ribavirin combination therapy in chronic hepatitis C infection: decision-tree analysisNaoki Hiramatsu
Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan
J Gastroenterol 46:1111-9. 2011..This study aimed to develop a model to predict the development of severe anemia during pegylated interferon alpha-2b plus ribavirin combination therapy... - Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-alpha plus ribavirin combination therapyKosei Hamano
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan
J Gastroenterol Hepatol 20:1401-9. 2005..CONCLUSIONS: Particular amino acid changes in the NS5B region of HCV may correlate with outcomes of IFN plus RBV combination therapy... - Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitisYasuhiro Nemoto
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
J Immunol 183:5059-68. 2009..Thus, blocking a stimulus of colitogenic memory CD4(+) cells such as IL-7 may have therapeutic benefit for treatment of inflammatory bowel disease... - Cell culture and in vivo analyses of cytopathic hepatitis C virus mutantsKako Mishima
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
Virology 405:361-9. 2010..The cytopathic HCV clones exhibit high replication competence in vivo but may be eliminated during the early stages of infection... - Specific inhibition of hepatitis C virus replication by cyclosporin AMina Nakagawa
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Biochem Biophys Res Commun 313:42-7. 2004..Further defining its mode of action against HCV replication potentially may be important for identifying novel molecular targets to treat HCV infection... - Data mining model using simple and readily available factors could identify patients at high risk for hepatocellular carcinoma in chronic hepatitis CMasayuki Kurosaki
Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
J Hepatol 56:602-8. 2012..We aimed to build a simple model for the identification of patients at high risk of developing HCC... - Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitisXiu Zheng
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Inflamm Bowel Dis 17:2251-60. 2011..This study shows that the undifferentiated state is maintained by the suppression of the Hath1 gene in human intestine... 
Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91Yusuke Funaoka
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
J Virol 85:5986-94. 2011..In conclusion, HCV R70 and L91 core mutants were resistant to interferon in vitro, and the resistance may be induced by IL-6-induced upregulation of SOCS3. Those mechanisms may explain clinical interferon resistance of HCV core mutants...- RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitisTeruji Totsuka
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo
J Immunol 182:6079-87. 2009..Together, these results suggest that the RANK-RANKL signaling pathway is critically involved in regulating the function of CD4(+)CD25(+) T(R) cells in colitis... - Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesisYasuhiro Nemoto
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, Juntendo University School of Medicine, Tokyo, Japan
Inflamm Bowel Dis 14:1491-503. 2008..Based on this background we here investigate whether granulocytes promote or suppress the expansion of colitogenic CD4(+) T cells... - FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrowToshimitsu Fujii
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Eur J Immunol 38:3290-303. 2008..Altogether, the present results indicate that FTY720 treatment may offer an additional role to direct trafficking of CD4(+) T cells in BM, resulting in the prevention of colitis... - Regulation of hepatitis C virus replication by interferon regulatory factor 1Nobuhiko Kanazawa
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
J Virol 78:9713-20. 2004..Taken together, IRF-1 is one of the key host factors that regulate intracellular HCV replication through modulation of interferon-stimulated-gene-mediated antiviral responses... - Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferon-α2b plus ribavirinMayumi Ueyama
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Antivir Ther 16:1081-91. 2011..In this study, we investigated the association of serum IL-6 levels with outcomes of pegylated interferon (PEG-IFN) plus ribavirin (RBV) combination therapy... - Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replicationAkiko Kusano-Kitazume
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Antimicrob Agents Chemother 56:1315-23. 2012..In conclusion, N-(morpholine-4-carbonyloxy) amidine and other related morpholine compounds specifically suppressed HCV replication and may have potential as novel chemotherapeutic agents... - Development of plaque assays for hepatitis C virus-JFH1 strain and isolation of mutants with enhanced cytopathogenicity and replication capacityYuko Sekine-Osajima
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Virology 371:71-85. 2008..Taken together, the cytopathic effect of HCV infection involves ER-stress-induced apoptotic cell death. Certain HCV genomic structures may determine the viral replication capacity and cytopathogenicity... - Suppression of hepatitis C virus replication by cyclosporin a is mediated by blockade of cyclophilinsMina Nakagawa
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Gastroenterology 129:1031-41. 2005..CONCLUSIONS: The anti-HCV activity of cyclosporin A is mediated through a specific blockade of cyclophilins, and these molecules may constitute novel targets for anti-HCV therapeutics... - Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon responseMegumi Tasaka
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
J Gen Virol 88:3323-33. 2007..These mechanisms may contribute to the clinical persistence of HCV infection and could constitute a novel antiviral therapeutic target... - Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factorsMasayuki Kurosaki
Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Musashino shi, Tokyo, Japan
J Hepatol 54:439-48. 2011..Recent studies revealed an association between the IL28B genotype and treatment response. We aimed to develop a model for the pre-treatment prediction of response using host and viral factors... - Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral responseYasuhiro Asahina
Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
Hepatology 55:20-9. 2012..Both IL28B minor allele and higher RIG-I and ISG15 expressions and RIG-I/IPS-1 ratio are independent factors for NVR... - Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B proteinYasuhiro Itsui
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Hepatology 50:1727-37. 2009..These mechanisms may contribute to resistance to innate, IFN-mediated antiviral defense and to the clinical persistence of HCV infection... - Inhibitory effect of a triterpenoid compound, with or without alpha interferon, on hepatitis C virus infectionTakako Watanabe
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Antimicrob Agents Chemother 55:2537-45. 2011..Antiviral effects of treatment with α-IFN can be enhanced by pretreatment with TSN. Its mechanisms of action could potentially be important to identify novel molecular targets to treat HCV infection... - [Virus factors determining the outcome of IFN treatment for chronic hepatitis C]Nobuhiko Kanazawa
Department of Gastroenterology and Hepatology, School of Medicine, Tokyo Medical and Dental University
Nippon Rinsho 62:474-80. 2004 - Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAsTakanori Yokota
Department of Neurology and Neurological Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
EMBO Rep 4:602-8. 2003..Our results support the feasibility of using siRNA-based gene therapy to inhibit HCV replication, which may prove to be valuable in the treatment of hepatitis C... - Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinaseYuko Karakama
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Antimicrob Agents Chemother 54:3179-86. 2010..Our results demonstrate that SRPKs are host factors essential for HCV replication and that functional inhibitors of these kinases may constitute a new class of antiviral agents against HCV infection... - Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cellsMinekazu Murayama
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
J Gastroenterol 44:173-82. 2009..However, little is known about the function of Msi-1 within human intestinal epithelial cells (IECs). Thus, the present study aimed to clarify the role of Msi-1 in differentiation and proliferation of IECs... - Sequences in the interferon sensitivity-determining region and core region of hepatitis C virus impact pretreatment prediction of response to PEG-interferon plus ribavirin: data mining analysisMasayuki Kurosaki
Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
J Med Virol 83:445-52. 2011..A decision-tree model that includes these viral factors as predictors could identify patients with a high probability of sustained virological response... - Continuous generation of colitogenic CD4(+) T cells in persistent colitisTakayuki Tomita
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Eur J Immunol 38:1264-74. 2008..In conclusion, the continuous generation of colitogenic CD4(+) cells that compensate for exhausted CD4(+) cells may be one of the mechanisms involved in the persistence of colitis... - MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitisTakayuki Tomita
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
J Immunol 180:5291-9. 2008..Collectively, the MyD88-dependent pathway that controls TLR signaling in T cells may directly promote the proliferation and survival of colitogenic CD4(+) T cells to sustain chronic colitis... - [A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient]Daisuke Kubota
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
Nippon Shokakibyo Gakkai Zasshi 103:1044-9. 2006..Myelosuppression was prolonged and required the administration of granulocyte colony stimulating factor (G-CSF). G-CSF was continued for 17 days to achieve recovery of his WBC count to a normal level... - Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagyTomokazu Mizui
Department of Gastroenterology, Juntendo University, School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
J Gastroenterol 45:195-203. 2010..In this study, we investigated the role of autophagy on hepatitis C virus (HCV) RNA replication and demonstrated anti-HCV effects of an autophagic proteolysis inhibitor, chloroquine... - [Role of interferon-sensitivity-determining region in replication of hepatitis C virus]Shinya Maekawa
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
Nippon Rinsho 62:89-95. 2004 - Potential relevance of cytoplasmic viral sensors and related regulators involving innate immunity in antiviral responseYasuhiro Asahina
Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
Gastroenterology 134:1396-405. 2008..The aim is to elucidate the mechanisms underlying resistance to antiviral therapy and predictive usefulness of gene quantification in chronic hepatitis C (CH-C)... - IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clonesGoki Suda
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Virology 407:80-90. 2010..In conclusion, intergenotypic differences of IFN sensitivity of HCV may be attributable to the sequences of HCV structural proteins and can be determined by SOCS3 and IL-6 expression levels... - Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunitySayuri Nitta
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Hepatology 57:46-58. 2013..Disruption of that interaction may restore cellular antiviral responses and may constitute a novel therapeutic strategy for the eradication of HCV... - Age and total ribavirin dose are independent predictors of relapse after interferon therapy in chronic hepatitis C revealed by data mining analysisMasayuki Kurosaki
Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan
Antivir Ther 17:35-43. 2012..This study aimed to define factors associated with relapse among responders to pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy in chronic hepatitis C... - Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4Michiko Iwasaki
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
J Gastroenterol 46:191-202. 2011..The present study aimed to elucidate the regulation of cell formation in the human small intestine using biopsy specimens collected from an entire individual small intestine by DBE... - Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesisMichio Onizawa
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Am J Physiol Gastrointest Liver Physiol 296:G850-9. 2009.... - [Establishment of cell lines expressing HCV replicon and its applications]Naoya Sakamoto
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
Nippon Rinsho 62:116-20. 2004 - [Case of severe ulcerative colitis successfully treated with intravenous cyclosporine without high dose corticosteroid]Daisuke Kubota
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan
Nihon Shokakibyo Gakkai Zasshi 104:42-6. 2007..The treatment was successful and she obtained complete remission. Cyclosporine A monotherapy is considered to be a valuable alternative to proctocolectomy for severe ulcerative colitis patients who cannot tolerate corticosteroid... - Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replicationYuko Sekine-Osajima
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
Hepatol Res 39:60-9. 2009..Further elucidation of their mechanisms of action and evaluation of in vivo effects and safety might constitute a new anti-HCV therapeutics... - Hepatitis C virus nonstructural protein 5A inhibits tumor necrosis factor-alpha-mediated apoptosis in Huh7 cellsYuka Miyasaka
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
J Infect Dis 188:1537-44. 2003..These findings suggest that the NS5A protein inhibits the apoptotic effect of TNF-alpha upstream of caspase-8 in the apoptosis cascade... - Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cellsYuki Nishimura-Sakurai
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
J Gastroenterol 45:523-36. 2010..Here, we screened host genes and molecular pathways that are involved in HCV replication by comprehensive analyses using two genotypes of HCV replicon-expressing cells, their cured cells and naïve Huh7 cells... - Bone morphogenetic protein-7 and interferon-alpha synergistically suppress hepatitis C virus repliconNaoya Sakamoto
Department for Hepatitis Control, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Biochem Biophys Res Commun 357:467-73. 2007..Taken together, BMP-7 may constitute a novel molecule to suppress HCV replication... - Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient miceIzumi Onozuka
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan
Biochem Biophys Res Commun 406:134-40. 2011..Our study demonstrated, using 2 experimental murine models, that loss of MMP-2 exacerbates liver fibrosis, and suggested that MMP-2 suppresses tissue inhibitor of metalloproteinase 1 up-regulation during liver fibrosis... - [Hepatitis C virus infection]Mina Nakagawa
Department of Gastroenterology and Hepatology, Faculty of Medicine, Tokyo Medical and Dental University
Nippon Rinsho 61:627-33. 2003 - Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitisTakayuki Tomita
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
J Immunol 180:383-90. 2008.... - Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancerMikayo Aragaki
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Biochem Biophys Res Commun 368:923-9. 2008..This means that Hath1 protein degradation may be required for maintaining the undifferentiated state of colon cancers, and that GSK3 inhibitors have potential for use in cancer therapy... - [Antiviral mechanism of ribavirin against RNA virus]Kosei Hamano
Department of Gastroenterology and Hepatology, School of Medicine, Tokyo Medical and Dental University
Nippon Rinsho 62:459-62. 2004 - [Structure and functions of HCV non-structural proteins]Jun Itakura
Department of Gastroenterology and Hepatology, School of Medicine, Tokyo Medical and Dental University
Nippon Rinsho 62:64-8. 2004 - [A case of sacroiliitis complicated by ulcerative colitis that was successfully treated with steroid]Daisuke Kubota
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University
Nippon Shokakibyo Gakkai Zasshi 103:936-42. 2006..The efficacy of steroids on pain relief of sacroiliitis and ankylosing spondylitis is unclear... - Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4. Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiationMimi Tamamori-Adachi
Department of Biochemical Genetics, Medical Research Institute and Laboratory of Genome Structure and Regulation, School of Biomedical Science, Tokyo Medcal and Dental Universuty, Tokyo, Japan
J Biol Chem 279:50429-36. 2004..This provides a novel insight in understanding the molecular mechanism by which mammalian cardiomyocytes cease to proliferate during terminal differentiation...