Y Saito

Summary

Affiliation: Tokyo Metropolitan Institute for Neuroscience
Country: Japan

Publications

  1. ncbi request reprint Phenytoin-induced choreoathetosis in patients with severe myoclonic epilepsy in infancy
    Y Saito
    Department of Pediatrics, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Neuropediatrics 32:231-5. 2001
  2. ncbi request reprint Characterization of subspecies of apolipoprotein A-I-containing lipoprotein in homozygotes for familial lecithin:cholesterol acyltransferase deficiency
    T Ohta
    Department of Pediatrics, Kumamoto University School of Medicine, Japan
    Arterioscler Thromb 14:1137-45. 1994
  3. ncbi request reprint Hypolipidemic effect of NK-104 and other 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in guinea pigs
    H Suzuki
    Tokyo Research Laboratories, Pharmaceutical Division, Kowa Company, Ltd, Higashimurayama, Tokyo, Japan
    Arzneimittelforschung 51:38-45. 2001
  4. ncbi request reprint Lipid-lowering and antiatherosclerotic effect of NK-104, a potent 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in Watanabe heritable hyperlipidemic rabbits
    H Suzuki
    Tokyo Research Laboratories, Pharmaceutical Division, Kowa Company, Ltd, Higashimurayama, Tokyo, Japan
    Arzneimittelforschung 50:995-1003. 2000
  5. ncbi request reprint An algorithm for the identification of heparin-induced thrombocytopenia using a medical information database
    T Hanatani
    Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan
    J Clin Pharm Ther 38:423-8. 2013
  6. ncbi request reprint Renal vascular walls in patients with preeclampsia superimposed on essential hypertension
    Y Nagai
    Second Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    Am J Kidney Dis 37:728-35. 2001
  7. doi request reprint Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease brains
    J Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    Neuropathol Appl Neurobiol 39:817-30. 2013
  8. ncbi request reprint Accumulation of a repulsive axonal guidance molecule RGMa in amyloid plaques: a possible hallmark of regenerative failure in Alzheimer's disease brains
    J Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan, Department of Pathology and Laboratory Medicine, Kohnodai Hospital, NCGM, 1 7 1 Kohnodai, Ichikawa, Chiba 272 8516, Japan, Department of Laboratory Medicine, National Center Hospital, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan, and Department of Psychiatry, National Center Hospital, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neuropathol Appl Neurobiol . 2012
  9. ncbi request reprint Effect of an ectokinase inhibitor, K252b, on degranulation and Ca2+ signals of RBL-2H3 cells and human basophils
    R Teshima
    Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    J Immunol 159:964-9. 1997
  10. ncbi request reprint Interferon-associated retinopathy in a uniform regimen of natural interferon-alpha therapy for chronic hepatitis C
    H Saito
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Liver 21:192-7. 2001

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Phenytoin-induced choreoathetosis in patients with severe myoclonic epilepsy in infancy
    Y Saito
    Department of Pediatrics, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Neuropediatrics 32:231-5. 2001
    ..Patients with SME appear to be particularly vulnerable to this side effect of phenytoin, indicating the possible involvement of basal ganglia in the pathophysiology of this type of epilepsy...
  2. ncbi request reprint Characterization of subspecies of apolipoprotein A-I-containing lipoprotein in homozygotes for familial lecithin:cholesterol acyltransferase deficiency
    T Ohta
    Department of Pediatrics, Kumamoto University School of Medicine, Japan
    Arterioscler Thromb 14:1137-45. 1994
    ..These data, taken together, emphasize the importance of LCAT in modifying the chemical composition, size, and shape of LpA-I and LpA-I/A-II particles...
  3. ncbi request reprint Hypolipidemic effect of NK-104 and other 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in guinea pigs
    H Suzuki
    Tokyo Research Laboratories, Pharmaceutical Division, Kowa Company, Ltd, Higashimurayama, Tokyo, Japan
    Arzneimittelforschung 51:38-45. 2001
    ....
  4. ncbi request reprint Lipid-lowering and antiatherosclerotic effect of NK-104, a potent 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in Watanabe heritable hyperlipidemic rabbits
    H Suzuki
    Tokyo Research Laboratories, Pharmaceutical Division, Kowa Company, Ltd, Higashimurayama, Tokyo, Japan
    Arzneimittelforschung 50:995-1003. 2000
    ..9% increase in medial smooth muscle cells, p < 0.01). Thus NK-104 preferentially reduced TG-rich lipoproteins (VLDL and IDL) without affecting LDL-C levels and prevented progression of atherosclerosis in WHHL rabbits...
  5. ncbi request reprint An algorithm for the identification of heparin-induced thrombocytopenia using a medical information database
    T Hanatani
    Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan
    J Clin Pharm Ther 38:423-8. 2013
    ..To this end, we aimed to develop and validate a novel algorithm for detecting heparin-induced thrombocytopenia (HIT) using a medical information database (MID) and for identifying possible risk factors for HIT...
  6. ncbi request reprint Renal vascular walls in patients with preeclampsia superimposed on essential hypertension
    Y Nagai
    Second Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    Am J Kidney Dis 37:728-35. 2001
    ....
  7. doi request reprint Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease brains
    J Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    Neuropathol Appl Neurobiol 39:817-30. 2013
    ..Although previous studies suggested a key role of ubiquilin-1 in the pathogenesis of Alzheimer's disease (AD), a direct relationship between ubiquilin-1 and Hirano bodies in AD brains remains unknown...
  8. ncbi request reprint Accumulation of a repulsive axonal guidance molecule RGMa in amyloid plaques: a possible hallmark of regenerative failure in Alzheimer's disease brains
    J Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan, Department of Pathology and Laboratory Medicine, Kohnodai Hospital, NCGM, 1 7 1 Kohnodai, Ichikawa, Chiba 272 8516, Japan, Department of Laboratory Medicine, National Center Hospital, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan, and Department of Psychiatry, National Center Hospital, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neuropathol Appl Neurobiol . 2012
    ..2012 The Authors. Neuropathology and Applied Neurobiology © 2012 British Neuropathological Society...
  9. ncbi request reprint Effect of an ectokinase inhibitor, K252b, on degranulation and Ca2+ signals of RBL-2H3 cells and human basophils
    R Teshima
    Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    J Immunol 159:964-9. 1997
    ....
  10. ncbi request reprint Interferon-associated retinopathy in a uniform regimen of natural interferon-alpha therapy for chronic hepatitis C
    H Saito
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Liver 21:192-7. 2001
    ..The development of retinal lesions induced by a uniform regimen of interferon-alpha therapy for chronic hepatitis C was prospectively investigated...
  11. doi request reprint Acute encephalitis with refractory, repetitive partial seizures (AERRPS): a peculiar form of childhood encephalitis
    H Sakuma
    Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, Tokyo, Japan
    Acta Neurol Scand 121:251-6. 2010
    ..We conducted a nationwide multicenter study in Japan to elucidate the clinical and laboratory characteristics of acute encephalitis with refractory, repetitive partial seizures (AERRPS)...
  12. ncbi request reprint Activation of protein kinase C alpha enhances human growth hormone-binding protein release
    Y Saito
    Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Setagaya, Tokyo, Japan
    Mol Cell Endocrinol 146:197-205. 1998
    ..These results suggest that activation of PKCalpha is involved in PDBu-enhanced hGH-BP release...
  13. doi request reprint Feasibility of endoscopic mucosal resection as salvage treatment for patients with local failure after definitive chemoradiotherapy for stage IB, II, and III esophageal squamous cell cancer
    M Makazu
    Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, Japan Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
    Dis Esophagus 27:42-9. 2014
    ..6%. Salvage EMR is a feasible treatment option for local recurrent or residual lesions after definitive chemotherapy and/or radiotherapy for stage IB, II, and III esophageal squamous cell cancer. ..
  14. ncbi request reprint Characterization of an antagonist monoclonal antibody, GHBP116, specific for human growth hormone receptors
    K Takagi
    Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Setagaya, Tokyo, Japan
    Biol Pharm Bull 22:734-7. 1999
    ..These results suggest that GHBP116 acts as a specific antagonist of hGH...
  15. doi request reprint Is endoscopic submucosal dissection an effective treatment for operable patients with clinical submucosal invasive early gastric cancer?
    H Suzuki
    Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
    Endoscopy 45:93-7. 2013
    ..The aim of this study was to determine the effectiveness of ESD in these operable patients...
  16. ncbi request reprint Apparent low frequency of sequence variability within the proximal promoter region of the cytochrome P450 (CYP) 3A5 gene in established cell lines from Japanese individuals
    T Nakamura
    Project Team for Pharmacogenetics, Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan
    Biol Pharm Bull 24:954-7. 2001
    ..However, no SNP was detected in the promoter region of the CYP3A5 gene isolated from the cell lines used, suggesting other causal factors for the observed polymorphism of CYP3A5-dependent drug metabolism...
  17. ncbi request reprint Determination of tomatine in foods by liquid chromatography after derivatization
    K Takagi
    National Institute of Health Sciences, Tokyo, Japan
    J Chromatogr A 659:127-31. 1994
    ..The limit of determination was 1 microgram g-1. Tomatine was detected in the green portions of tomatoes and in tomato ketchups and juices at levels below 7 micrograms g-1...
  18. doi request reprint Development of a detection algorithm for statin-induced myopathy using electronic medical records
    K Sai
    Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan
    J Clin Pharm Ther 38:230-5. 2013
    ..This study aimed to develop a detection algorithm, highly selective for SIM using EMRs...
  19. ncbi request reprint Widespread expression of alpha-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course
    Y Saito
    Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Neurol Sci 177:48-59. 2000
    ....
  20. doi request reprint Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains
    J Satoh
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Tokyo, Japan
    Neuropathol Appl Neurobiol 38:132-41. 2012
    ..Therefore, GSAP is an ideal target for designing γ-secretase modulators with least side effects in Alzheimer's disease (AD). However, at present, the precise distribution of GSAP in AD brains remains to be characterized...
  21. ncbi request reprint Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin
    N Hanioka
    Division of Environmental Chemistry, National Institute of Health Sciences, Tokyo, Japan
    Xenobiotica 31:687-99. 2001
    ..5. These results demonstrate that at least four UGT1A isoforms are responsible for SN-38 glucuronidation in human livers, and suggest that the role and contribution of each differ substantially...
  22. ncbi request reprint Impaired proteolytic processing of presenilin-1 in chromosome 14-linked familial Alzheimer's disease patient lymphocytes
    H Takahashi
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Neurosci Lett 260:121-4. 1999
    ..This result suggests that impaired proteolysis of PS1 may be associated with the pathogenesis of FAD. Moreover, our simple test using lymphocytes from FAD patients might be useful from a diagnostic point of view...
  23. ncbi request reprint Human herpesvirus 6 infection after living related liver transplantation
    T Yoshikawa
    Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    J Med Virol 62:52-9. 2000
    ..Detection of the viral DNA in plasma by PCR is useful for monitoring active HHV-6 infection in these patients. Seronegative recipients were more likely to have evidence of active HHV-6 infection after liver transplantation...
  24. ncbi request reprint Dose-dependent effect of niceritrol on plasma lipoprotein-a
    T Teramoto
    First Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Scand J Clin Lab Invest 56:359-65. 1996
    ..The results suggest that the reduction of Lp(a) was dependent on the dose of niceritrol and on the pretreatment level of Lp(a). In conclusion, niceritrol is effective, in a dose-dependent manner, for reducing Lp(a) levels...
  25. ncbi request reprint Cholesterol-lowering effect of NK-104, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, in guinea pig model of hyperlipidemia
    T Aoki
    Tokyo Research Laboratories, Pharmaceutical Division, Kowa Company, Ltd, Higashimurayama, Tokyo, Japan
    Arzneimittelforschung 51:197-203. 2001
    ....
  26. doi request reprint A multicenter study on the health-related quality of life of cataract patients: baseline data
    Masakazu Yamada
    Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Jpn J Ophthalmol 53:470-6. 2009
    ..This study examines the impact of cataracts on health-related quality of life (HR-QOL) and health events in the older population...
  27. doi request reprint Imaging-pathologic correlation in corticobasal degeneration
    A M Tokumaru
    Department of Diagnostic Radiology, Tokyo Metropolitan Medical Center of Gerontology, Itabashi ku, Tokyo, Japan
    AJNR Am J Neuroradiol 30:1884-92. 2009
    ..Furthermore, imaging findings in CBD were compared with neuropathologically confirmed progressive supranuclear palsy (PSP) for a differential diagnosis...
  28. ncbi request reprint Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells
    Y Saito
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Oncogene 28:2738-44. 2009
    ....
  29. ncbi request reprint Characteristics of breathing abnormality in Leigh and its overlap syndromes
    E Yasaki
    Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan
    Neuropediatrics 32:299-306. 2001
    ..The role of DRG lesions in the pathophysiology of respiratory symptoms in Leigh syndrome is discussed...
  30. ncbi request reprint Nitric oxide buffers renal medullary vasoconstriction induced by prostaglandins synthesis blockade
    K Nakanishi
    Second Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan
    Hypertens Res 24:699-704. 2001
    ....
  31. ncbi request reprint Interferon regulatory factor 1 promoter polymorphism and response to type 1 interferon
    H Saito
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Cell Biochem Suppl . 2001
    ..These results suggest that single nucleotide polymorphisms of the interferon regulatory factor-1 promoter contribute, at least in part, to determining responses to type 1 interferons. J. Cell. Biochem. Suppl. 36: 191-200, 2001...
  32. ncbi request reprint Reduced expression of neuropeptides can be related to respiratory disturbances in Rett syndrome
    Y Saito
    Department of Pediatrics, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan
    Brain Dev 23:S122-6. 2001
    ..A widespread altered expression of antagonistic neuropeptides, SP and met-enk, may be involved in the pathogenesis of RS, especially in its respiratory manifestation...
  33. ncbi request reprint Evidence for impaired cellular cholesterol removal mediated by apo A-I containing lipoproteins in patients with familial lecithin: cholesterol acyltransferase deficiency
    T Ohta
    Department of Pediatrics, Kumamoto University School of Medicine, Japan
    Biochim Biophys Acta 1213:295-301. 1994
    ..We conclude that factors other than reverse cholesterol transport via apo A-I containing lipoproteins have to be considered to explain why homozygotes for LCAT deficiency are not at high risk for premature atherosclerosis...