T C Saido

Summary

Affiliation: Tokyo Metropolitan Institute of Medical Science
Country: Japan

Publications

  1. ncbi request reprint Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain
    T C Saido
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Neurosci Lett 215:173-6. 1996
  2. ncbi request reprint Up- and down-regulation of calpain inhibitor polypeptide, calpastatin, in postischemic hippocampus
    T C Saido
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Japan
    Neurosci Lett 227:75-8. 1997
  3. ncbi request reprint Overexpression of a neuropeptide nociceptin/orphanin FQ precursor gene, N23K/N27K, induces neurite outgrowth in mouse NS20Y cells
    Y Saito
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science Rinshoken, Bunkyo ku, Japan
    J Neurosci Res 48:397-406. 1997
  4. ncbi request reprint Molecular cloning and characterization of a novel form of neuropeptide gene as a developmentally regulated molecule
    Y Saito
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science Rinshoken, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 271:15615-22. 1996
  5. ncbi request reprint Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain
    K Maruyama
    Department of Molecular Biology, Tokyo Institute of Psychiatry, Kamikitazawa, Setagaya, Tokyo 156 8585, Japan
    Int J Mol Med 5:269-73. 2000
  6. ncbi request reprint Multiple processing of procathepsin L to cathepsin L in vivo
    K Ishidoh
    Department of Biochemistry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113, Japan
    Biochem Biophys Res Commun 252:202-7. 1998
  7. ncbi request reprint N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin
    Y Saito
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Biochem Biophys Res Commun 217:539-45. 1995
  8. pmc Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis
    Y Kanai
    Department of Ultrastructural Research, Tokyo Metropolitan Institute of Medical Science, Japan
    J Cell Biol 133:667-81. 1996
  9. ncbi request reprint Autolysis of calpain large subunit inducing irreversible dissociation of stoichiometric heterodimer of calpain
    H Kitagaki
    Department of Molecular Biology, Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Biosci Biotechnol Biochem 64:689-95. 2000
  10. ncbi request reprint Molecular basis for oviductin-mediated processing from gp43 to gp41, the predominant glycoproteins of Xenopus egg envelopes
    H Kubo
    Department of Membrane Biochemistry, Tokyo Metropolitan Institute of Medical Science, Honkomagome, Bunkyo ku, Tokyo, Japan
    Dev Genet 25:123-9. 1999

Detail Information

Publications10

  1. ncbi request reprint Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain
    T C Saido
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Neurosci Lett 215:173-6. 1996
    ..A possible interpretation for these observations would be that proteolysis of A beta from its amino terminus may limit the rate of A beta catabolism...
  2. ncbi request reprint Up- and down-regulation of calpain inhibitor polypeptide, calpastatin, in postischemic hippocampus
    T C Saido
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Japan
    Neurosci Lett 227:75-8. 1997
    ..Calpastatin may participate in the stress responses together with the previously known ischemia-induced stress proteins such as heat shock proteins...
  3. ncbi request reprint Overexpression of a neuropeptide nociceptin/orphanin FQ precursor gene, N23K/N27K, induces neurite outgrowth in mouse NS20Y cells
    Y Saito
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science Rinshoken, Bunkyo ku, Japan
    J Neurosci Res 48:397-406. 1997
    ..Our results demonstrate that N23K and N27K participate in the regulation of neurite outgrowth...
  4. ncbi request reprint Molecular cloning and characterization of a novel form of neuropeptide gene as a developmentally regulated molecule
    Y Saito
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science Rinshoken, Bunkyo ku, Tokyo 113, Japan
    J Biol Chem 271:15615-22. 1996
    ..This remarkable redistribution suggests that N27K may be involved in a process in neurite outgrowth and nervous system development...
  5. ncbi request reprint Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain
    K Maruyama
    Department of Molecular Biology, Tokyo Institute of Psychiatry, Kamikitazawa, Setagaya, Tokyo 156 8585, Japan
    Int J Mol Med 5:269-73. 2000
    ..These results suggest a regulatory function of presenilin on the calpain system...
  6. ncbi request reprint Multiple processing of procathepsin L to cathepsin L in vivo
    K Ishidoh
    Department of Biochemistry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, 113, Japan
    Biochem Biophys Res Commun 252:202-7. 1998
    ..Percoll density gradient and fluorescence immunohistochemistry suggested that these three species of cathepsin L localize in the lysosomes where procathepsin L processing occurs...
  7. ncbi request reprint N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin
    Y Saito
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Biochem Biophys Res Commun 217:539-45. 1995
    ..These findings suggest that the N23K protein functions not only as a neuropeptide precursor but also as an important component in neuronal differentiation...
  8. pmc Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis
    Y Kanai
    Department of Ultrastructural Research, Tokyo Metropolitan Institute of Medical Science, Japan
    J Cell Biol 133:667-81. 1996
    ..Thus, these findings suggest that Sox17 may function as a transcriptional activator in the premeiotic germ cells, and that a splicing switch into t-Sox17 may lead to the loss of its function in the postmeiotic germ cells...
  9. ncbi request reprint Autolysis of calpain large subunit inducing irreversible dissociation of stoichiometric heterodimer of calpain
    H Kitagaki
    Department of Molecular Biology, Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Biosci Biotechnol Biochem 64:689-95. 2000
    ..This model could be expanded to other calpains and give a new perspective on calpain activation...
  10. ncbi request reprint Molecular basis for oviductin-mediated processing from gp43 to gp41, the predominant glycoproteins of Xenopus egg envelopes
    H Kubo
    Department of Membrane Biochemistry, Tokyo Metropolitan Institute of Medical Science, Honkomagome, Bunkyo ku, Tokyo, Japan
    Dev Genet 25:123-9. 1999
    ..We propose that oviductin possessing the substrate specificity of GSR simultaneously digests gp43 at Arg residues in GSR61 and GSR373 to generate the N- and C-terminus of gp41, respectively...