Y Okubo

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography
    Y Okubo
    Department of Neurobehavioral Medicine, Graduate School of Tokyo Medical and Dental University, Japan
    Life Sci 66:2455-64. 2000
  2. ncbi Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET
    Y Okubo
    Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, Japan
    Nature 385:634-6. 1997
  3. ncbi Ten year progressive ventricular enlargement in schizophrenia: an MRI morphometrical study
    T Saijo
    Section of Psychiatry and Behavioural Science, Graduate School of Tokyo Medical and Dental University, Japan
    Psychiatry Clin Neurosci 55:41-7. 2001
  4. ncbi Neural responses to human voice and hemisphere dominance for lexical-semantic processing--an fMRI study
    M Koeda
    Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8510, Japan
    Methods Inf Med 46:247-50. 2007
  5. ncbi An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample
    A Kurumaji
    Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, Tokyo, Japan
    J Neural Transm 107:491-500. 2000
  6. ncbi Dipole estimation of alpha EEG during alcohol ingestion in males genotypes for ALDH2
    K Hara
    Department of Neurobehavioral Medicine, Graduate School of Tokyo Medical and Dental University, Japan
    Life Sci 67:1163-73. 2000
  7. ncbi A functional MRI study: cerebral laterality for lexical-semantic processing and human voice perception
    M Koeda
    Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    AJNR Am J Neuroradiol 27:1472-9. 2006
  8. ncbi Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking
    T Suhara
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Anagawa 4-Chome, Inage-ku, Chiba, 263-8555, Japan
    Neuroimage 13:891-5. 2001
  9. ncbi Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples
    T Yoshikawa
    Laboratory for Molecular Psychiatry, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Mol Psychiatry 6:202-10. 2001
  10. ncbi Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals that inactivate H enzyme
    M Kaneko
    Division of Cell Biology, Institute of Life Science, Soka University, Hachioji, Tokyo, Japan
    Blood 90:839-49. 1997

Collaborators

Detail Information

Publications21

  1. ncbi Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography
    Y Okubo
    Department of Neurobehavioral Medicine, Graduate School of Tokyo Medical and Dental University, Japan
    Life Sci 66:2455-64. 2000
    ..Our results do not rule out the role of 5-HT2 function as a crucial site of therapeutic activity of schizophrenia, but they do suggest that cortical 5-HT2 receptors might not be primarily involved in the pathophysiology of schizophrenia...
  2. ncbi Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET
    Y Okubo
    Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, Japan
    Nature 385:634-6. 1997
    ..We propose that dysfunction of D1R signalling in the prefrontal cortex may contribute to the negative symptoms and cognitive deficits seen in schizophrenia...
  3. ncbi Ten year progressive ventricular enlargement in schizophrenia: an MRI morphometrical study
    T Saijo
    Section of Psychiatry and Behavioural Science, Graduate School of Tokyo Medical and Dental University, Japan
    Psychiatry Clin Neurosci 55:41-7. 2001
    ..9%) but not in controls (5.1%). Although our results are not in disagreement with the neurodevelopmental hypothesis, they do provide strong evidence that in schizophrenia progressive brain reduction occurs even in its chronic stage...
  4. ncbi Neural responses to human voice and hemisphere dominance for lexical-semantic processing--an fMRI study
    M Koeda
    Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8510, Japan
    Methods Inf Med 46:247-50. 2007
    ..In the present study, we aimed to clarify the correlation between the degree of right-handedness and language dominance in the fronto-temporo-parietal cortices by examining cerebral activation for lexical-semantic processing...
  5. ncbi An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample
    A Kurumaji
    Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, Tokyo, Japan
    J Neural Transm 107:491-500. 2000
    ..1016). These results do not suggest that the two missense polymorphisms play a major role in the genetic predisposition of schizophrenia in the Japanese sample...
  6. ncbi Dipole estimation of alpha EEG during alcohol ingestion in males genotypes for ALDH2
    K Hara
    Department of Neurobehavioral Medicine, Graduate School of Tokyo Medical and Dental University, Japan
    Life Sci 67:1163-73. 2000
    ..These results suggest that the dipole tracing method could provide an alternative neurophysiological marker for the risk for alcoholism...
  7. ncbi A functional MRI study: cerebral laterality for lexical-semantic processing and human voice perception
    M Koeda
    Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    AJNR Am J Neuroradiol 27:1472-9. 2006
    ..This finding suggests that the influence of human voice perception should be adequately taken into account when language dominance is determined...
  8. ncbi Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking
    T Suhara
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Anagawa 4-Chome, Inage-ku, Chiba, 263-8555, Japan
    Neuroimage 13:891-5. 2001
    ..No significant correlation was observed in any other region. Our result indicates that there is a significant association between dopamine D2 receptor binding and the human novelty seeking trait in the right insular cortex...
  9. ncbi Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples
    T Yoshikawa
    Laboratory for Molecular Psychiatry, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Mol Psychiatry 6:202-10. 2001
    ..Our findings suggest that IMPA2 or a gene nearby may contribute to the overall genetic risk for schizophrenia among Japanese...
  10. ncbi Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals that inactivate H enzyme
    M Kaneko
    Division of Cell Biology, Institute of Life Science, Soka University, Hachioji, Tokyo, Japan
    Blood 90:839-49. 1997
    ....
  11. ncbi Tolerable lifetime cadmium intake calculated from the inhabitants living in the Jinzu River basin, Japan
    K Watanabe
    Department of Occupational and Environmental Medicine (A2, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuohku, Chiba 260-8670, Japan
    Bull Environ Contam Toxicol 72:1091-7. 2004
  12. ncbi A follow-up study on the association of working conditions and lifestyles with the development of (perceived) mental symptoms in workers of a telecommunication enterprise
    Y Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Occup Med (Lond) 53:436-42. 2003
    ..This study investigated the association of working conditions and lifestyle with mental health in Japanese workers...
  13. ncbi Influence of years engaged in agriculture and number of pregnancies and deliveries on mortality of inhabitants of the Jinzu River basin area, Japan
    E Kobayashi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chuohku, Japan
    Occup Environ Med 59:847-50. 2002
    ..The occurrence of itai-itai disease is thought to be affected by such factors as pregnancy, lactation, hormonal disorders, aging, and calcium deficiency...
  14. ncbi An association between smoking habits and blood pressure in normotensive Japanese men
    Y Okubo
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hum Hypertens 16:91-6. 2002
    ..However, there were no significant dose-effect relationships between smoking amount and blood pressure when lifestyle and other confounding factors were considered...
  15. ncbi Association analysis of the pituitary adenyl cyclase activating peptide gene (PACAP) on chromosome 18p11 with schizophrenia and bipolar disorders
    H Ishiguro
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    J Neural Transm 108:849-54. 2001
    ..This study did not provide evidence for the contribution of the PACAP gene to the etiology of schizophrenia or bipolar disorders in the Japanese population...
  16. ncbi A retrospective study on the relation between renal dysfunction and cadmium concentration in rice in individual hamlets in the Jinzu River basin, Toyama Prefecture, Japan
    T Osawa
    Department of Hygiene, Chiba University School of Medicine, Chiba, 260-8670, Japan
    Environ Res 86:51-9. 2001
    ..The allowable values of Cd concentration in rice were estimated to be in the range of 0.05-0.20 ppm, representing values lower than the 0.4 ppm provisionally adopted by the Japanese government...
  17. ncbi Glycophorin SAT of the human erythrocyte membrane is specified by a hybrid gene reciprocal to glycophorin Dantu gene
    C H Huang
    Lindsley F Kimball Research Institute, New York Blood Center, NY 10021, USA
    Blood 85:2222-7. 1995
    ..The formation of such a hybrid junction not only explains why SAT homozygous erythrocytes lack S, s, and U antigens but also shows a reciprocal arrangement with respect to the B-A hybrid GPDantu gene...
  18. ncbi Molecular definition of red cell Rh haplotypes by tightly linked SphI RFLPs
    C H Huang
    Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    Am J Hum Genet 58:133-42. 1996
    ..The molecular definition of Rh haplotypes by SphI RFLP frameworks should provide a useful procedure for genetic counseling and prenatal assessment of Rh alloimmunization...
  19. ncbi Point mutations characterize KEL10, the KEL3, KEL4, and KEL21 alleles, and the KEL17 and KEL11 alleles
    S Lee
    Lindsley F Kimball Research Institute, New York Blood Center, New York, USA
    Transfusion 36:490-4. 1996
    ..The molecular basis for the KEL3 (Kpa), KEL4 (Kpb), and KEL21 (Kpc) alleles, the KEL11(Cote) and KEL17(Wka) alleles, and for KEL10 (UIa) is now reported...
  20. ncbi Molecular basis for Rh(null) syndrome: identification of three new missense mutations in the Rh50 glycoprotein gene
    C H Huang
    Laboratory of Biochemistry and Molecular Genetics, Lindsley F Kimball Research Institute, New York Blood Center, New York, New York 10021, USA
    Am J Hematol 62:25-32. 1999
    ..These results correlate each mutation with a structural defect in the respective TM domain of Rh50 glycoprotein...
  21. ncbi A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression
    A Vignal
    Institut National de la Sante et de la Recherche Medicale, Unité 76, Paris, France
    Eur J Biochem 191:619-25. 1990
    ..This model of gene organization provides a basis with which to explain the diversity of the glycophorin gene family...