H Okazawa

Summary

Affiliation: Tokyo Metropolitan Institute for Neuroscience
Country: Japan

Publications

  1. ncbi Polyglutamine diseases: a transcription disorder?
    H Okazawa
    Department of Molecular Therapeutics, Tokyo Metropolitan Institute for Neuroscience, PRESTO, Japan Science Technology Corporation, 2 6, Musashi dai, Fuchu, Tokyo 183 8526, Japan
    Cell Mol Life Sci 60:1427-39. 2003
  2. ncbi Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death
    Hitoshi Okazawa
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Japan
    Neuron 34:701-13. 2002
  3. ncbi PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival
    M Waragai
    Group of Molecular Neurobiology, Department of Neurology, Graduate School of Medicine, University of Tokyo, Japan
    Hum Mol Genet 8:977-87. 1999
  4. ncbi PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain
    M Waragai
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Biochem Biophys Res Commun 273:592-5. 2000
  5. ncbi PQBP-1 (Np/PQ): a polyglutamine tract-binding and nuclear inclusion-forming protein
    H Okazawa
    Department of Neurology, University of Tokyo, Tokyo, Japan
    Brain Res Bull 56:273-80. 2001
  6. ncbi Polar amino acid-rich sequences bind to polyglutamine tracts
    I Imafuku
    Department of Neurology, Graduate School of Medicine, University of Tokyo, Japan
    Biochem Biophys Res Commun 253:16-20. 1998
  7. ncbi A decrease in regional cerebral blood volume and hematocrit in crossed cerebellar diaschisis
    H Yamauchi
    Department of Neurology, Brain Pathophysiology Faculty of Medicine, Kyoto University, Japan
    Stroke 30:1429-31. 1999
  8. ncbi A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells
    K Okamoto
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Cell 60:461-72. 1990
  9. pmc The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer
    H Okazawa
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    EMBO J 10:2997-3005. 1991
  10. ncbi PQBP-1 increases vulnerability to low potassium stress and represses transcription in primary cerebellar neurons
    Y Enokido
    Division of Protein Biosynthesis, Institute for Protein Research, Osaka University, Japan
    Biochem Biophys Res Commun 294:268-71. 2002

Collaborators

Detail Information

Publications17

  1. ncbi Polyglutamine diseases: a transcription disorder?
    H Okazawa
    Department of Molecular Therapeutics, Tokyo Metropolitan Institute for Neuroscience, PRESTO, Japan Science Technology Corporation, 2 6, Musashi dai, Fuchu, Tokyo 183 8526, Japan
    Cell Mol Life Sci 60:1427-39. 2003
    ..This article reviews 'transcription theory', a rapidly growing hypothesis in polyglutamine diseases...
  2. ncbi Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death
    Hitoshi Okazawa
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Japan
    Neuron 34:701-13. 2002
    ..Our results suggest the involvement of PQBP-1 in the pathology of spinocerebellar ataxia type 1 (SCA1) and support the idea that modified transcription underlies polyglutamine-mediated pathology...
  3. ncbi PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival
    M Waragai
    Group of Molecular Neurobiology, Department of Neurology, Graduate School of Medicine, University of Tokyo, Japan
    Hum Mol Genet 8:977-87. 1999
    ..These results suggest that PQBP-1 mediates important cellular functions under physiological and pathological conditions via its interaction with polyglutamine tracts...
  4. ncbi PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain
    M Waragai
    Department of Neurology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Biochem Biophys Res Commun 273:592-5. 2000
    ..This finding suggests physiological functions of PQBP-1 in splicing, cell cycle, and ubiquitination, through which we can speculate the pathological roles of PQBP-1 in triplet repeat diseases...
  5. ncbi PQBP-1 (Np/PQ): a polyglutamine tract-binding and nuclear inclusion-forming protein
    H Okazawa
    Department of Neurology, University of Tokyo, Tokyo, Japan
    Brain Res Bull 56:273-80. 2001
    ..In this review, we discuss the structure and function of the PQBP-1 protein, the relevance of its aggregation and possible roles in normal and disease processes...
  6. ncbi Polar amino acid-rich sequences bind to polyglutamine tracts
    I Imafuku
    Department of Neurology, Graduate School of Medicine, University of Tokyo, Japan
    Biochem Biophys Res Commun 253:16-20. 1998
    ..Three of these clones could form polar helical structures. These observations suggest that polar amino acid-rich sequences are essential for binding to the polyglutamine tract...
  7. ncbi A decrease in regional cerebral blood volume and hematocrit in crossed cerebellar diaschisis
    H Yamauchi
    Department of Neurology, Brain Pathophysiology Faculty of Medicine, Kyoto University, Japan
    Stroke 30:1429-31. 1999
    ....
  8. ncbi A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells
    K Okamoto
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    Cell 60:461-72. 1990
    ..We suggest that Oct-3 is a novel octamer binding transcription factor that is developmentally regulated during mouse embryogenesis...
  9. pmc The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer
    H Okazawa
    Department of Biochemistry, Faculty of Medicine, University of Tokyo, Japan
    EMBO J 10:2997-3005. 1991
    ..We suggest that RARE1 is a critical cis element for oct3 gene expression in embryonic stem cells and for the RA-mediated repression...
  10. ncbi PQBP-1 increases vulnerability to low potassium stress and represses transcription in primary cerebellar neurons
    Y Enokido
    Division of Protein Biosynthesis, Institute for Protein Research, Osaka University, Japan
    Biochem Biophys Res Commun 294:268-71. 2002
    ..Our results indicate that overexpression of PQBP-1 inhibits the basal transcription in cerebellar neurons and increases their vulnerability to low potassium conditions...
  11. ncbi A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus
    H Mori
    Second Department of Internal Medicine, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Diabetologia 44:373-6. 2001
    ..We screened the human UCP1 gene (UCP1) for polymorphisms associated with susceptibility to Type II diabetes...
  12. ncbi Expression and binding characteristics of the BDNF receptor chick trkB
    G Dechant
    Max Planck Institute for Psychiatry, Department of Neurobiochemistry, Martinsried, Germany
    Development 119:545-58. 1993
    ....
  13. ncbi Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2
    M Kawanishi
    Second Department of Internal Medicine, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 275:8240-7. 2000
    ..Together, these results demonstrate that SNAP23 contributes to insulin-dependent trafficking of GLUT4 to the plasma membrane in 3T3-L1 adipocytes by mediating the interaction between t-SNARE (syntaxin4) and v-SNARE (VAMP2)...
  14. ncbi Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan(2)
    F Yamane
    Cone Laboratory for Neurosurgical Research, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University St, H3A 2B4, Montreal, Quebec, Canada
    Biochem Pharmacol 62:1481-9. 2001
    ..In conclusion, the present data suggest that the effects of paroxetine on 5-HT synthesis in the cerebral cortex are different from its effects in the cell body area of the brainstem...
  15. ncbi Autosomal dominant epilepsy with febrile seizures plus with missense mutations of the (Na+)-channel alpha 1 subunit gene, SCN1A
    M Ito
    Department of Pediatrics, Shiga Medical Center for Children, 5 7 30 Moriyama, Moriyama 524 0022, Japan
    Epilepsy Res 48:15-23. 2002
    ..The spectrum of GEFS+ should be expanded to include partial epilepsies and better to be termed autosomal dominant epilepsy with febrile seizures plus (ADEFS+)...
  16. ncbi Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c
    S Araki
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    Biochem Biophys Res Commun 234:257-62. 1997
    ..These results suggest that the binding of SNAP-23 to syntaxin 4 is inhibited by Munc18c in adipocytes...
  17. ncbi Quantitative comparison of the bolus and steady-state methods for measurement of cerebral perfusion and oxygen metabolism: positron emission tomography study using 15O-gas and water
    H Okazawa
    PET Unit, Research Institute, Shiga Medical Center, Moriyama, Japan
    J Cereb Blood Flow Metab 21:793-803. 2001
    ..Increase in CBV without a change in V0 suggested the increase might mainly be caused by venous dilatation in the ischemic regions...