Research Topics
Genomes and Genes | H OkamotoSummaryAffiliation: Tokyo Women's Medical University Country: Japan Publications
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Publications
Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient miceKazutake Tsujikawa
Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
Proc Natl Acad Sci U S A 104:16702-7. 2007..These results indicate that CGRP signaling through CLR/RAMP1 receptors plays a crucial role in the regulation of both blood pressure by vascular relaxation and proinflammatory cytokine production from dendritic cells...
A role for TARC/CCL17, a CC chemokine, in systemic lupus erythematosusHiroshi Okamoto
Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
J Rheumatol 30:2369-73. 2003..We examined serum and plasma concentrations of TARC/CCL17 in patients with systemic lupus erythematosus (SLE)...- Plasma concentration of TARC/CCL17 is elevated in nonepisodic angioedema associated with eosinophiliaH Okamoto
Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku, Tokyo 162-0054, Japan
Allergy 60:1091-2. 2005 - Molecular targets of rheumatoid arthritisHiroshi Okamoto
Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
Inflamm Allergy Drug Targets 7:53-66. 2008..In this review, we will summarize the use of biologics, the pros and cons of the use of biologics, and discuss on the potential molecular targets of RA... 
Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritisHiroshi Okamoto
Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
Arthritis Rheum 62:82-92. 2010....- Vitamin K and rheumatoid arthritisHiroshi Okamoto
Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
IUBMB Life 60:355-61. 2008..We concluded that MK-4 may represent a new agent for the treatment of RA in the setting of combination therapy with other disease-modifying antirheumatic drugs... - Beneficial action of statins in patients with rheumatoid arthritis in a large observational cohortHiroshi Okamoto
Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
J Rheumatol 34:964-8. 2007..To analyze the possible beneficial effects of statins on the disease activity of patients with rheumatoid arthritis (RA) using a database from a large observational cohort study... - Molecular aspects of rheumatoid arthritis: role of transcription factorsHiroshi Okamoto
Institute of Rheumatology, Tokyo Women s Medical University, Japan
FEBS J 275:4463-70. 2008..and matrix metalloproteinases. Expression of these molecules is controlled at the transcription level and activation of a limited number of transcription factors is involved in this process... - Anti-arthritis effects of vitamin K(2) (menaquinone-4)--a new potential therapeutic strategy for rheumatoid arthritisHiroshi Okamoto
Institute of Rheumatology, Tokyo Women s Medical University, Japan
FEBS J 274:4588-94. 2007..We conclude that MK-4 may represent a new agent for the treatment of rheumatoid arthritis in the setting of combination therapy with other disease-modifying antirheumatic drugs... - A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritisS Kobayashi
Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
Rheumatology (Oxford) 47:1317-22. 2008..The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is one of the major toxic components in cigarettes. To clarify the biological effects of smoking in RA, we investigated the role of TCDD in RA pathogenesis... - Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritisH Okamoto
Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
Clin Exp Rheumatol 23:323-30. 2005..Ligands for peroxisome proliferator-activated receptor (PPAR) -gamma have recently been reported to inhibit the development of RA. In this study, we investigated the role of PPARalpha in RA... - Raised monocyte chemotactic protein-1 (MCP-1)/CCL2 in cerebrospinal fluid of patients with neuropsychiatric lupusN Iikuni
Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku, Tokyo 162-0054, Japan
Ann Rheum Dis 65:253-6. 2006..These results indicate that CSF MCP-1/CCL2 reflects an inflammatory activity in the brain, suggesting that it might be used as a diagnostic tool and a monitor for therapeutic responses in patients with NPSLE... - What's in season for rheumatoid arthritis patients? Seasonal fluctuations in disease activityN Iikuni
Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054 Japan
Rheumatology (Oxford) 46:846-8. 2007..To examine whether a seasonal fluctuation exists with rheumatoid arthritis (RA) activity and to analyse seasonal effects of varying components that express disease activity in RA patients... - Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritisT Iwamoto
Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku, Tokyo 162-0054, Japan
Rheumatology (Oxford) 45:421-4. 2006..Our results suggest that MCP-4/CCL13 is secreted from chondrocytes and activates the proliferation of rheumatoid synovial cells, thereby leading to joint destruction in RA... - Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in JapaneseK Nishimoto
Institute of Rheumatology, Tokyo Women s Medical University, Japan
Ann Rheum Dis 69:368-73. 2010..Gene expression levels of TRAF1 and C5 to assess the functional significance of genotypes were also analysed... - Interferon-inducible protein 10/CXCL10 is increased in the cerebrospinal fluid of patients with central nervous system lupusHiroshi Okamoto
Tokyo Women's Medical University, Tokyo, Japan
Arthritis Rheum 50:3731-2. 2004 - High CCL18/PARC expression in articular cartilage and synovial tissue of patients with rheumatoid arthritisShigeki Momohara
Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
J Rheumatol 34:266-71. 2007..We studied the role of CCL18/pulmonary and activation-regulated chemokine (PARC) in rheumatoid arthritis (RA)... - Dermatan sulfate in the synovial fluid of patients with knee osteoarthritisShigeki Momohara
Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada, Shinjuku ku, Tokyo, 162 0054, Japan
Mod Rheumatol 17:301-5. 2007..This suggests that metabolism of the small leucine-rich repeat proteoglycans decorin and biglycan, which contain chains of DSDeltaDi4S, is similar to that of aggrecan... - Evaluation of Pneumocystis pneumonia infection risk factors in patients with connective tissue diseaseNoriko Iikuni
Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
Mod Rheumatol 16:282-8. 2006.... - Serum amyloid A activates nuclear factor-kappaB in rheumatoid synovial fibroblasts through binding to receptor of advanced glycation end-productsHiroshi Okamoto
Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
J Rheumatol 35:752-6. 2008..Rheumatoid arthritis (RA) is a chronic, symmetric polyarticular joint disease and serum amyloid A (SAA) is an acute-phase protein that is upregulated during the course of RA. We investigated the role of SAA in the pathogenesis of RA... - [A case of recurrent hemophagocytic syndrome complicated with systemic sclerosis: relationship between disease activity and serum level of IL-18]A Tochimoto
Institute of Rheumatology and Aoyama Hospital, Tokyo Women's Medical University, Shinjuku-ku, Tokyo
Ryumachi 41:659-64. 2001..Therefore, the significance of IL-18 in the pathophysiology of HPS was recently reported. In this case, we investigated the significance of IL-18 and revealed the levels of serum IL-18 were well correlated with disease activity of HPS... - The serum concentration of infliximab in cases of autologous blood donation for patients with rheumatoid arthritisTakeshi Mochizuki
Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada, Tokyo 162 0054, Japan
Mod Rheumatol 17:24-7. 2007..However, even after autotransfusion those levels were decreased compared with levels measured just before the operation. Therefore, we conclude that there is little influence of AB donation on the risks of infliximab... - Molecular aspects of rheumatoid arthritis: chemokines in the joints of patientsTakuji Iwamoto
Institute of Rheumatology, Tokyo Women s Medical University, Japan
FEBS J 275:4448-55. 2008..Therefore, chemokines and chemokine-receptors are considered to be important molecules in RA pathology... - Molecular aspects of rheumatoid arthritis: chemokines, environmental factors and transcription factorsHiroshi Okamoto
Institute of Rheumatology, Tokyo Women's Medical University, Japan
FEBS J 275:4447. 2008 - Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese populationShu Kobayashi
Tokyo Women s Medical University, Tokyo, Japan
Arthritis Rheum 58:1940-6. 2008..The present study was undertaken to investigate the effect of STAT4 on susceptibility to RA and SLE in the Japanese... - Ocular and cerebellar defects in zebrafish induced by overexpression of the LIM domains of the islet-3 LIM/homeodomain proteinY Kikuchi
Department of Physiology, Keio University, School of Medicine, Shinjuku, Tokyo, Japan
Neuron 18:369-82. 1997.... - Single nucleotide polymorphisms in the gene encoding the major histocompatibility complex class II transactivator (CIITA) in systemic lupus erythematosusK Koizumi
Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
Ann Rheum Dis 64:947-50. 2005..Insufficient up regulation of MHC class II molecules is reported to be one of the major immunological mechanisms in systemic lupus erythematosus (SLE)... - Disturbances of the symphysis pubis in rheumatoid arthritis: report of two casesSo Tsukahara
Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada, Shinjuku ku, Tokyo, 162 0054, Japan
Mod Rheumatol 17:344-7. 2007..Both cases had received long-term corticosteroid therapy, including pulse therapy. We recommend reducing the corticosteroid dose to prevent disturbances of the symphysis pubis especially in RA patients on long-term steroid therapy... - Spontaneous multiple insufficiency fractures after pelvic abscess and sepsis in a rheumatoid arthritis patient treated with high-load corticosteroid therapy: a case reportTakeshi Mochizuki
Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada, Shinjuku, Tokyo, 162 0054, Japan
Clin Rheumatol 26:1925-8. 2007.... - Vasopressin cell antibodies and central diabetes insipidus in a patient with systemic lupus erythematosus and dermatomyositisHiroshi Kajiyama
Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
J Rheumatol 31:1218-21. 2004 - Cytokines and chemokines in neuropsychiatric syndromes of systemic lupus erythematosusHiroshi Okamoto
Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
J Biomed Biotechnol 2010:268436. 2010..Based on the number of recently published studies, this review overviewed the roles of cytokines and chemokines in NPSLE... - A role of monocyte chemoattractant protein-4 (MCP-4)/CCL13 from chondrocytes in rheumatoid arthritisTakuji Iwamoto
Institute of Rheumatology, Tokyo Women s Medical University, Japan
FEBS J 274:4904-12. 2007.... - Molecular aspects of rheumatoid arthritis: role of environmental factorsShu Kobayashi
Institute of Rheumatology, Tokyo Women s Medical University, Japan
FEBS J 275:4456-62. 2008..have been extensively studied previously. Understanding of how these factors contribute to the development of RA may lead to the better understanding of pathogenesis of RA... - A case of severe acute pancreatitis, in overlap syndrome of systemic sclerosis and systemic lupus erythematosus, successfully treated with plasmapheresisYukie Suzuki
Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan
Mod Rheumatol 16:172-5. 2006..This is the first case report of severe acute pancreatitis in the setting of overlap syndrome of SLE and SSc. The advantages and disadvantages of the use of corticosteroids are discussed... - Neglected spontaneous rupture of the Achilles' tendon in patients with systemic lupus erythematosusKaoru Murakoshi
Department of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan
Mod Rheumatol 16:324-6. 2006..We concluded that careful diagnosis, surgical suture, and careful treatment after operation are necessary for Achilles' tendon rupture in those patients with SLE... - Enhancement of cell viability in cryopreserved rat vascular grafts by administration of regenerating gene (REG) inducersTatsuya Kiji
Department of Surgery III, Nara Medical University, Kashihara, Nara, Japan
J Vasc Res 40:132-9. 2003..01). We conclude that REG-inductive therapy shows promise as a novel strategy for enhancing the viability of vascular allografts. Moreover, FK506 may be involved in tissue regeneration as well as immunosuppression... - Tumor necrosis factor inhibitors for rheumatoid arthritisHiroshi Okamoto
N Engl J Med 355:2047; author reply 2048. 2006 - Cholesteryl ester transfer protein promotes the formation of cholesterol-rich remnant like lipoprotein particles in human plasmaHiroshi Okamoto
Central Pharmaceutical Research Institute, Japan Tobacco Inc, Takatsuki, Osaka, 569 1125, Japan
Clin Chim Acta 375:92-8. 2007..Cholesteryl ester transfer protein (CETP) is suggested to be involved in the cholesterol level in remnant like lipoprotein particles (RLP), but there is no direct evidence that CETP increases cholesterol-rich RLP in plasma... - Pravastatin attenuates left ventricular remodeling and diastolic dysfunction in angiotensin II-induced hypertensive miceZhujie Xu
Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
J Cardiovasc Pharmacol 51:62-70. 2008..However, the exact mechanisms of statins possibly explaining the decreased cardiovascular morbidity and mortality in patients with DHF have not been elucidated... - Rituximab for rheumatoid arthritisHiroshi Okamoto
N Engl J Med 351:1909; author reply 1909. 2004 - Myelodysplastic syndrome associated with low-dose methotrexate in rheumatoid arthritisHiroshi Okamoto
Ann Pharmacother 38:172-3. 2004 - Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathyFumio Terasaki
Department of Internal Medicine III, Osaka Medical College, Takatsuki, Japan
Circ J 71:327-30. 2007..Therefore, the expression of TN-C might be useful for detecting the clinical characteristics of, and ventricular remodeling in, dilated cardiomyopathy (DCM)... - Chaperonin 10 for rheumatoid arthritisHiroshi Okamoto
Lancet 368:1961; author reply 1961-2. 2006 - Interleukin-12/23 monoclonal antibody for psoriasisHiroshi Okamoto
N Engl J Med 356:2003; author reply 2003. 2007 - Antibodies to bovine serum albumin do not affect the results of enzyme-linked immunosorbent assays for IgG anti-NR2 glutamate receptor antibodies: reply to the letter by Hirohata et alTaku Yoshio
Arthritis Rheum 56:2813-4. 2007 - Protective effect of A at position - 168 in the type III promoter of the MHCIITA gene in systemic lupus erythematosusHiroshi Okamoto
Ann Rheum Dis 66:1263-4. 2007 - Lipopolysaccharide injection into the cerebral ventricle evokes kininogen induction in the rat brainMasaoki Takano
Department of Pharmacology, Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University, Ikawadani cho, Nishi ku, Kobe 651 2180, Japan
Brain Res 978:72-82. 2003..These results suggest that LPS stimulates the induction of kininogens in the brain, especially the choroid plexus, by stimulating the production of arachidonic metabolites such as prostaglandin E(2)... - Lipopolysaccharide activates the kallikrein-kinin system in mouse choroid plexus cell line ECPC4Masaoki Takano
Department of Life Sciences Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, 1 1 3 Minatojima, Chuo Ku, Kobe 650 8586, Japan
Neurosci Lett 434:310-4. 2008..These results suggest that LPS activates the kallikrein-kinin system in the choroid plexus via autocrine induction of IL-1beta and TNF-alpha... - Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal deathAsuka Iwanaga
Division of Molecular Cell Signaling, Department of Molecular and Cellular Biology, Cancer Research Institute, Kanazawa University, Ishikawa 920 0934, Japan
Neurosci Lett 429:43-8. 2007..These results strongly suggest that the neonatal death of jsap1-deficient mice is caused by defects in the nervous system... - Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome accompanied by Parkinson's diseaseEiichi Ito
Department of Neurology, Neurological Institute, Tokyo Women s Medical University
Intern Med 46:1139-42. 2007.... - An angiotensin receptor blocker suppresses monocyte chemoattractant protein 1 production from rheumatoid synovial fibroblasts: comment on the article by Sagawa et alNoriko Iikuni
Arthritis Rheum 52:4047-8. 2005 - Transgenic overexpression of Reg protein caused gastric cell proliferation and differentiation along parietal cell and chief cell lineagesYouichi Miyaoka
Second Department of Internal Medicine, Shimane Medical University, Izumo 693 8501, Japan
Oncogene 23:3572-9. 2004..In the injured gastric mucosa, Reg may play a unique and important part in the reconstruction of the properly organized mucosal architecture... - S-(2-(acylamino)phenyl) 2,2-dimethylpropanethioates as CETP inhibitorsKimiya Maeda
Central Pharmaceutical Research Institute, JT Inc, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan
Bioorg Med Chem Lett 14:2589-91. 2004..The most potent compound showed 50% inhibition of CETP activity in human plasma at a concentration of 2 microM... - Rationale for the use of combination angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker therapy in heart failureYoshio Yasumura
Division of Cardiology, Department of Medicine, University of Tsukuba, Japan
Circ J 68:361-6. 2004..A larger study is required to assess the effects of the combination therapy on major clinical outcomes... - A newly developed angiotensin II type 1 receptor antagonist, CS866, promotes regression of cardiac hypertrophy by reducing integrin beta1 expressionNan Jia
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan
Hypertens Res 26:737-42. 2003..The correlation between the expression of integrin beta1 and AT1 receptor was significant. Our results also suggest that integrin expression by myocytes might be modulated by angiotensin II via AT1 receptor... - REG gene expression is associated with the infiltrating growth of gastric carcinomaYutaka Yonemura
Gastric Surgery Division, Shizuoka Cancer Center, Shizuoka, Japan
Cancer 98:1394-400. 2003..The Reg gene is known to be involved in the growth of not only pancreatic B-cells, but also epithelial cells of the gastrointestinal tract and carcinoma of its lineage... - Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution modelHitoshi Ogawa
Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
Inflamm Bowel Dis 9:162-70. 2003..Epithelial expression of Reg III or HIP/PAP was induced under mucosal inflammation initiated by exposure to commensal bacteria or DSS as well as inflamed IBD colon... - Effect of JTT-705 on cholesteryl ester transfer protein and plasma lipid levels in normolipidemic animalsHiroshi Okamoto
Central Pharmaceutical Research Institute, Japan Tobacco Inc, 1 1 Murasaki cho, Takatsuki, 569 1125, Osaka, Japan
Eur J Pharmacol 466:147-54. 2003..These results indicate that JTT-705 can be expected to inhibit plasma CETP activity and improve plasma lipoprotein profiles in a wide range of animal species, including humans... - RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actionsNorio Takada
Department of Molecular Genetics, Nagoya City University Medical School, Japan
J Virol 76:8019-30. 2002..These findings indicate that RAI acts as an efficient inhibitor of HIV-1 gene expression in which both NF-kappaB and Sp1 play major roles... - Development of atherosclerosis in osteopontin transgenic miceSatoru Chiba
Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
Heart Vessels 16:111-7. 2002..Thus, these results suggest that OPN is atherogenic and that macrophages expressing OPN can be easily activated and thus promote atheromatous lesions if a high fat diet is consumed... - Effect of HDL, from Japanese white rabbit administered a new cholesteryl ester transfer protein inhibitor JTT-705, on cholesteryl ester accumulation induced by acetylated low density lipoprotein in J774 macrophageJunji Kobayashi
Second Department of Internal Medicine, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
Atherosclerosis 162:131-5. 2002.... - Blockade of macrophage migration inhibitory factor ameliorates experimental autoimmune myocarditisYutaka Matsui
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
J Mol Cell Cardiol 37:557-66. 2004..These results demonstrate an important role of MIF in the pathogenesis of EAM and suggest that MIF blockade may be a promising new strategy for the treatment of myocarditis... - Matrix metalloproteinase 28/epilysin expression in cartilage from patients with rheumatoid arthritis and osteoarthritis: comment on the article by Kevorkian et alShigeki Momohara
Arthritis Rheum 50:4074-5; author reply 4075. 2004 - Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cellsHaruhiro Higashida
Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
Neurosci Res 57:339-46. 2007..These results indicate that cADPR is an intracellular messenger of Ca(2+) signalling, suggesting that CD38 can contribute to mAChR-cADPR signalling... - MHC2TA is associated with rheumatoid arthritis in Japanese patientsNoriko Iikuni
Ann Rheum Dis 66:274-5. 2007 - Stimulatory autoantibodies to the PDGF receptor in sclerodermaHiroshi Okamoto
N Engl J Med 355:1278; author reply 1279. 2006 - Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitisMartin H Bluth
Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, New York, USA
World J Gastroenterol 12:4511-6. 2006..This suggests that reg I and its receptor may play a role in recovery after pancreatic injury. We hypothesized that reg I and its receptor are induced in acute pancreatitis... - Corticosteroids in ARDSHiroshi Okamoto
N Engl J Med 355:317; author reply 318-9. 2006 - Development of a human mammary epithelial cell culture model for evaluation of drug transfer into milkSoichiro Kimura
Hospital Pharmacy, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan
Arch Pharm Res 29:424-9. 2006..These results indicate that the 3-t-HMEC monolayer is potentially useful for the evaluation of carrier-mediated secretion of drugs including organic cations into human milk... - Mouse monoclonal anti-human thrombomodulin antibodies bind to and activate endothelial cells through NF-kappaB activation in vitroHiroyuki Nara
Jichi Medical School, Tochigi-ken, Japan
Arthritis Rheum 54:1629-37. 2006..Such events on ECs may lead to vascular inflammation and damage in patients with connective tissue diseases and vasculitis in which AECA are present... - Identification of mouse orthologue of endogenous secretory receptor for advanced glycation end-products: structure, function and expressionAi Harashima
Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science, Kanazawa 920 8640, Japan
Biochem J 396:109-15. 2006..The esRAGE expression was increased in the kidney of diabetic wild-type mice. The present study has thus provided an animal orthologue of esRAGE for clarification of its roles in health and disease... - Activation of regenerating gene Reg in rat and human hearts in response to acute stressTatsuya Kiji
Dept of Thoracic and Cardiovascular Surgery, Nara Medical Univ School of Medicine, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
Am J Physiol Heart Circ Physiol 289:H277-84. 2005..In view of emerging evidence of Reg for tissue regeneration in a variety of tissues/organs, it is proposed that the damaged heart may be a target for Reg action and that Reg may protect against acute heart stress... - REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancerAkira Sekikawa
Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Gastroenterology 128:642-53. 2005.... - Blockade of T cell costimulatory signals using adenovirus vectors prevents both the induction and the progression of experimental autoimmune myocarditisYutaka Matsui
Division of Molecular Immunology, Institute for Genetic Medicine, Sapporo 060-0815, Japan
J Mol Cell Cardiol 34:279-95. 2002..This study indicates the therapeutic potential of costimulatory pathway blockade by gene-transfer in myocarditis...