H Okamoto

Summary

Affiliation: Tokyo Women's Medical University
Country: Japan

Publications

  1. pmc Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice
    Kazutake Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 104:16702-7. 2007
  2. ncbi request reprint A role for TARC/CCL17, a CC chemokine, in systemic lupus erythematosus
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    J Rheumatol 30:2369-73. 2003
  3. ncbi request reprint Anti-arthritis effects of vitamin K(2) (menaquinone-4)--a new potential therapeutic strategy for rheumatoid arthritis
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    FEBS J 274:4588-94. 2007
  4. ncbi request reprint Plasma concentration of TARC/CCL17 is elevated in nonepisodic angioedema associated with eosinophilia
    H Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Allergy 60:1091-2. 2005
  5. ncbi request reprint Molecular targets of rheumatoid arthritis
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Inflamm Allergy Drug Targets 7:53-66. 2008
  6. doi request reprint Vitamin K and rheumatoid arthritis
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    IUBMB Life 60:355-61. 2008
  7. doi request reprint Molecular aspects of rheumatoid arthritis: role of transcription factors
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    FEBS J 275:4463-70. 2008
  8. ncbi request reprint Beneficial action of statins in patients with rheumatoid arthritis in a large observational cohort
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 34:964-8. 2007
  9. doi request reprint Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Rheum 62:82-92. 2010
  10. doi request reprint A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis
    S Kobayashi
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Rheumatology (Oxford) 47:1317-22. 2008

Detail Information

Publications75

  1. pmc Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice
    Kazutake Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 104:16702-7. 2007
    ..These results indicate that CGRP signaling through CLR/RAMP1 receptors plays a crucial role in the regulation of both blood pressure by vascular relaxation and proinflammatory cytokine production from dendritic cells...
  2. ncbi request reprint A role for TARC/CCL17, a CC chemokine, in systemic lupus erythematosus
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    J Rheumatol 30:2369-73. 2003
    ..We examined serum and plasma concentrations of TARC/CCL17 in patients with systemic lupus erythematosus (SLE)...
  3. ncbi request reprint Anti-arthritis effects of vitamin K(2) (menaquinone-4)--a new potential therapeutic strategy for rheumatoid arthritis
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    FEBS J 274:4588-94. 2007
    ..We conclude that MK-4 may represent a new agent for the treatment of rheumatoid arthritis in the setting of combination therapy with other disease-modifying antirheumatic drugs...
  4. ncbi request reprint Plasma concentration of TARC/CCL17 is elevated in nonepisodic angioedema associated with eosinophilia
    H Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Allergy 60:1091-2. 2005
  5. ncbi request reprint Molecular targets of rheumatoid arthritis
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Inflamm Allergy Drug Targets 7:53-66. 2008
    ..In this review, we will summarize the use of biologics, the pros and cons of the use of biologics, and discuss on the potential molecular targets of RA...
  6. doi request reprint Vitamin K and rheumatoid arthritis
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    IUBMB Life 60:355-61. 2008
    ..We concluded that MK-4 may represent a new agent for the treatment of RA in the setting of combination therapy with other disease-modifying antirheumatic drugs...
  7. doi request reprint Molecular aspects of rheumatoid arthritis: role of transcription factors
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    FEBS J 275:4463-70. 2008
    ..and matrix metalloproteinases. Expression of these molecules is controlled at the transcription level and activation of a limited number of transcription factors is involved in this process...
  8. ncbi request reprint Beneficial action of statins in patients with rheumatoid arthritis in a large observational cohort
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 34:964-8. 2007
    ..To analyze the possible beneficial effects of statins on the disease activity of patients with rheumatoid arthritis (RA) using a database from a large observational cohort study...
  9. doi request reprint Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Rheum 62:82-92. 2010
    ....
  10. doi request reprint A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis
    S Kobayashi
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Rheumatology (Oxford) 47:1317-22. 2008
    ..The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is one of the major toxic components in cigarettes. To clarify the biological effects of smoking in RA, we investigated the role of TCDD in RA pathogenesis...
  11. ncbi request reprint Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis
    H Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Clin Exp Rheumatol 23:323-30. 2005
    ..Ligands for peroxisome proliferator-activated receptor (PPAR) -gamma have recently been reported to inhibit the development of RA. In this study, we investigated the role of PPARalpha in RA...
  12. pmc Raised monocyte chemotactic protein-1 (MCP-1)/CCL2 in cerebrospinal fluid of patients with neuropsychiatric lupus
    N Iikuni
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Ann Rheum Dis 65:253-6. 2006
    ..An imbalance in cytokine homoeostasis is thought to have a key role in the neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE), and recently, a role for chemokines has been noted...
  13. ncbi request reprint What's in season for rheumatoid arthritis patients? Seasonal fluctuations in disease activity
    N Iikuni
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054 Japan
    Rheumatology (Oxford) 46:846-8. 2007
    ..To examine whether a seasonal fluctuation exists with rheumatoid arthritis (RA) activity and to analyse seasonal effects of varying components that express disease activity in RA patients...
  14. ncbi request reprint Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis
    T Iwamoto
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Rheumatology (Oxford) 45:421-4. 2006
    ....
  15. doi request reprint Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese
    K Nishimoto
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Ann Rheum Dis 69:368-73. 2010
    ..Gene expression levels of TRAF1 and C5 to assess the functional significance of genotypes were also analysed...
  16. ncbi request reprint Serum amyloid A activates nuclear factor-kappaB in rheumatoid synovial fibroblasts through binding to receptor of advanced glycation end-products
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 35:752-6. 2008
    ..Rheumatoid arthritis (RA) is a chronic, symmetric polyarticular joint disease and serum amyloid A (SAA) is an acute-phase protein that is upregulated during the course of RA. We investigated the role of SAA in the pathogenesis of RA...
  17. ncbi request reprint Evaluation of Pneumocystis pneumonia infection risk factors in patients with connective tissue disease
    Noriko Iikuni
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 16:282-8. 2006
    ....
  18. ncbi request reprint Dermatan sulfate in the synovial fluid of patients with knee osteoarthritis
    Shigeki Momohara
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 17:301-5. 2007
    ..This suggests that metabolism of the small leucine-rich repeat proteoglycans decorin and biglycan, which contain chains of DSDeltaDi4S, is similar to that of aggrecan...
  19. ncbi request reprint Interferon-inducible protein 10/CXCL10 is increased in the cerebrospinal fluid of patients with central nervous system lupus
    Hiroshi Okamoto
    Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Rheum 50:3731-2. 2004
  20. ncbi request reprint High CCL18/PARC expression in articular cartilage and synovial tissue of patients with rheumatoid arthritis
    Shigeki Momohara
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 34:266-71. 2007
    ..We studied the role of CCL18/pulmonary and activation-regulated chemokine (PARC) in rheumatoid arthritis (RA)...
  21. ncbi request reprint [A case of recurrent hemophagocytic syndrome complicated with systemic sclerosis: relationship between disease activity and serum level of IL-18]
    A Tochimoto
    Institute of Rheumatology and Aoyama Hospital, Tokyo Women's Medical University, Shinjuku-ku, Tokyo
    Ryumachi 41:659-64. 2001
    ..Therefore, the significance of IL-18 in the pathophysiology of HPS was recently reported. In this case, we investigated the significance of IL-18 and revealed the levels of serum IL-18 were well correlated with disease activity of HPS...
  22. doi request reprint Molecular aspects of rheumatoid arthritis: chemokines, environmental factors and transcription factors
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    FEBS J 275:4447. 2008
  23. doi request reprint Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients
    Takuji Iwamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    FEBS J 275:4448-55. 2008
    ..Therefore, chemokines and chemokine-receptors are considered to be important molecules in RA pathology...
  24. doi request reprint Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population
    Shu Kobayashi
    Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Rheum 58:1940-6. 2008
    ..The present study was undertaken to investigate the effect of STAT4 on susceptibility to RA and SLE in the Japanese...
  25. ncbi request reprint The serum concentration of infliximab in cases of autologous blood donation for patients with rheumatoid arthritis
    Takeshi Mochizuki
    Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada, Tokyo 162 0054, Japan
    Mod Rheumatol 17:24-7. 2007
    ..However, even after autotransfusion those levels were decreased compared with levels measured just before the operation. Therefore, we conclude that there is little influence of AB donation on the risks of infliximab...
  26. ncbi request reprint Fate of the asymptomatic contralateral limb after initial intervention for ipsilateral critical limb ischemia
    K Yamamoto
    Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int Angiol 32:526-31. 2013
    ..Information on the contralateral limb at initial surgery may help to speculate the fate of the asymptomatic contralateral limb. ..
  27. pmc Single nucleotide polymorphisms in the gene encoding the major histocompatibility complex class II transactivator (CIITA) in systemic lupus erythematosus
    K Koizumi
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Ann Rheum Dis 64:947-50. 2005
    ..Insufficient up regulation of MHC class II molecules is reported to be one of the major immunological mechanisms in systemic lupus erythematosus (SLE)...
  28. ncbi request reprint Ocular and cerebellar defects in zebrafish induced by overexpression of the LIM domains of the islet-3 LIM/homeodomain protein
    Y Kikuchi
    Department of Physiology, Keio University, School of Medicine, Shinjuku, Tokyo, Japan
    Neuron 18:369-82. 1997
    ....
  29. ncbi request reprint Disturbances of the symphysis pubis in rheumatoid arthritis: report of two cases
    So Tsukahara
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 17:344-7. 2007
    ..Both cases had received long-term corticosteroid therapy, including pulse therapy. We recommend reducing the corticosteroid dose to prevent disturbances of the symphysis pubis especially in RA patients on long-term steroid therapy...
  30. ncbi request reprint Vasopressin cell antibodies and central diabetes insipidus in a patient with systemic lupus erythematosus and dermatomyositis
    Hiroshi Kajiyama
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 31:1218-21. 2004
  31. pmc Cytokines and chemokines in neuropsychiatric syndromes of systemic lupus erythematosus
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    J Biomed Biotechnol 2010:268436. 2010
    ..Based on the number of recently published studies, this review overviewed the roles of cytokines and chemokines in NPSLE...
  32. ncbi request reprint Spontaneous multiple insufficiency fractures after pelvic abscess and sepsis in a rheumatoid arthritis patient treated with high-load corticosteroid therapy: a case report
    Takeshi Mochizuki
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada, Shinjuku, Tokyo, 162 0054, Japan
    Clin Rheumatol 26:1925-8. 2007
    ....
  33. ncbi request reprint A role of monocyte chemoattractant protein-4 (MCP-4)/CCL13 from chondrocytes in rheumatoid arthritis
    Takuji Iwamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    FEBS J 274:4904-12. 2007
    ....
  34. ncbi request reprint A case of severe acute pancreatitis, in overlap syndrome of systemic sclerosis and systemic lupus erythematosus, successfully treated with plasmapheresis
    Yukie Suzuki
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 16:172-5. 2006
    ..This is the first case report of severe acute pancreatitis in the setting of overlap syndrome of SLE and SSc. The advantages and disadvantages of the use of corticosteroids are discussed...
  35. doi request reprint Molecular aspects of rheumatoid arthritis: role of environmental factors
    Shu Kobayashi
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    FEBS J 275:4456-62. 2008
    ..have been extensively studied previously. Understanding of how these factors contribute to the development of RA may lead to the better understanding of pathogenesis of RA...
  36. ncbi request reprint Neglected spontaneous rupture of the Achilles' tendon in patients with systemic lupus erythematosus
    Kaoru Murakoshi
    Department of Orthopedic Surgery, Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 16:324-6. 2006
    ..We concluded that careful diagnosis, surgical suture, and careful treatment after operation are necessary for Achilles' tendon rupture in those patients with SLE...
  37. ncbi request reprint Chaperonin 10 for rheumatoid arthritis
    Hiroshi Okamoto
    Lancet 368:1961; author reply 1961-2. 2006
  38. ncbi request reprint Higher serum tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy
    Fumio Terasaki
    Department of Internal Medicine III, Osaka Medical College, Takatsuki, Japan
    Circ J 71:327-30. 2007
    ..Therefore, the expression of TN-C might be useful for detecting the clinical characteristics of, and ventricular remodeling in, dilated cardiomyopathy (DCM)...
  39. ncbi request reprint Tumor necrosis factor inhibitors for rheumatoid arthritis
    Hiroshi Okamoto
    N Engl J Med 355:2047; author reply 2048. 2006
  40. ncbi request reprint Cholesteryl ester transfer protein promotes the formation of cholesterol-rich remnant like lipoprotein particles in human plasma
    Hiroshi Okamoto
    Central Pharmaceutical Research Institute, Japan Tobacco Inc, Takatsuki, Osaka, 569 1125, Japan
    Clin Chim Acta 375:92-8. 2007
    ..Cholesteryl ester transfer protein (CETP) is suggested to be involved in the cholesterol level in remnant like lipoprotein particles (RLP), but there is no direct evidence that CETP increases cholesterol-rich RLP in plasma...
  41. ncbi request reprint Enhancement of cell viability in cryopreserved rat vascular grafts by administration of regenerating gene (REG) inducers
    Tatsuya Kiji
    Department of Surgery III, Nara Medical University, Kashihara, Nara, Japan
    J Vasc Res 40:132-9. 2003
    ..01). We conclude that REG-inductive therapy shows promise as a novel strategy for enhancing the viability of vascular allografts. Moreover, FK506 may be involved in tissue regeneration as well as immunosuppression...
  42. ncbi request reprint Myelodysplastic syndrome associated with low-dose methotrexate in rheumatoid arthritis
    Hiroshi Okamoto
    Ann Pharmacother 38:172-3. 2004
  43. ncbi request reprint Rituximab for rheumatoid arthritis
    Hiroshi Okamoto
    N Engl J Med 351:1909; author reply 1909. 2004
  44. doi request reprint Pravastatin attenuates left ventricular remodeling and diastolic dysfunction in angiotensin II-induced hypertensive mice
    Zhujie Xu
    Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Cardiovasc Pharmacol 51:62-70. 2008
    ..However, the exact mechanisms of statins possibly explaining the decreased cardiovascular morbidity and mortality in patients with DHF have not been elucidated...
  45. ncbi request reprint Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome accompanied by Parkinson's disease
    Eiichi Ito
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University
    Intern Med 46:1139-42. 2007
    ....
  46. ncbi request reprint Lipopolysaccharide injection into the cerebral ventricle evokes kininogen induction in the rat brain
    Masaoki Takano
    Department of Pharmacology, Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University, Ikawadani cho, Nishi ku, Kobe 651 2180, Japan
    Brain Res 978:72-82. 2003
    ..These results suggest that LPS stimulates the induction of kininogens in the brain, especially the choroid plexus, by stimulating the production of arachidonic metabolites such as prostaglandin E(2)...
  47. doi request reprint Lipopolysaccharide activates the kallikrein-kinin system in mouse choroid plexus cell line ECPC4
    Masaoki Takano
    Department of Life Sciences Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, 1 1 3 Minatojima, Chuo Ku, Kobe 650 8586, Japan
    Neurosci Lett 434:310-4. 2008
    ..These results suggest that LPS activates the kallikrein-kinin system in the choroid plexus via autocrine induction of IL-1beta and TNF-alpha...
  48. ncbi request reprint Antibodies to bovine serum albumin do not affect the results of enzyme-linked immunosorbent assays for IgG anti-NR2 glutamate receptor antibodies: reply to the letter by Hirohata et al
    Taku Yoshio
    Arthritis Rheum 56:2813-4. 2007
  49. ncbi request reprint Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death
    Asuka Iwanaga
    Division of Molecular Cell Signaling, Department of Molecular and Cellular Biology, Cancer Research Institute, Kanazawa University, Ishikawa 920 0934, Japan
    Neurosci Lett 429:43-8. 2007
    ..These results strongly suggest that the neonatal death of jsap1-deficient mice is caused by defects in the nervous system...
  50. pmc Protective effect of A at position - 168 in the type III promoter of the MHCIITA gene in systemic lupus erythematosus
    Hiroshi Okamoto
    Ann Rheum Dis 66:1263-4. 2007
  51. ncbi request reprint Interleukin-12/23 monoclonal antibody for psoriasis
    Hiroshi Okamoto
    N Engl J Med 356:2003; author reply 2003. 2007
  52. ncbi request reprint An angiotensin receptor blocker suppresses monocyte chemoattractant protein 1 production from rheumatoid synovial fibroblasts: comment on the article by Sagawa et al
    Noriko Iikuni
    Arthritis Rheum 52:4047-8. 2005
  53. ncbi request reprint Transgenic overexpression of Reg protein caused gastric cell proliferation and differentiation along parietal cell and chief cell lineages
    Youichi Miyaoka
    Second Department of Internal Medicine, Shimane Medical University, Izumo 693 8501, Japan
    Oncogene 23:3572-9. 2004
    ..In the injured gastric mucosa, Reg may play a unique and important part in the reconstruction of the properly organized mucosal architecture...
  54. ncbi request reprint S-(2-(acylamino)phenyl) 2,2-dimethylpropanethioates as CETP inhibitors
    Kimiya Maeda
    Central Pharmaceutical Research Institute, JT Inc, 1 1 Murasaki cho, Takatsuki, Osaka 569 1125, Japan
    Bioorg Med Chem Lett 14:2589-91. 2004
    ..The most potent compound showed 50% inhibition of CETP activity in human plasma at a concentration of 2 microM...
  55. ncbi request reprint Rationale for the use of combination angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker therapy in heart failure
    Yoshio Yasumura
    Division of Cardiology, Department of Medicine, University of Tsukuba, Japan
    Circ J 68:361-6. 2004
    ....
  56. ncbi request reprint A newly developed angiotensin II type 1 receptor antagonist, CS866, promotes regression of cardiac hypertrophy by reducing integrin beta1 expression
    Nan Jia
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Hypertens Res 26:737-42. 2003
    ..The correlation between the expression of integrin beta1 and AT1 receptor was significant. Our results also suggest that integrin expression by myocytes might be modulated by angiotensin II via AT1 receptor...
  57. ncbi request reprint REG gene expression is associated with the infiltrating growth of gastric carcinoma
    Yutaka Yonemura
    Gastric Surgery Division, Shizuoka Cancer Center, Shizuoka, Japan
    Cancer 98:1394-400. 2003
    ..The Reg gene is known to be involved in the growth of not only pancreatic B-cells, but also epithelial cells of the gastrointestinal tract and carcinoma of its lineage...
  58. ncbi request reprint Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model
    Hitoshi Ogawa
    Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Inflamm Bowel Dis 9:162-70. 2003
    ..Epithelial expression of Reg III or HIP/PAP was induced under mucosal inflammation initiated by exposure to commensal bacteria or DSS as well as inflamed IBD colon...
  59. ncbi request reprint Effect of JTT-705 on cholesteryl ester transfer protein and plasma lipid levels in normolipidemic animals
    Hiroshi Okamoto
    Central Pharmaceutical Research Institute, Japan Tobacco Inc, 1 1 Murasaki cho, Takatsuki, 569 1125, Osaka, Japan
    Eur J Pharmacol 466:147-54. 2003
    ..These results indicate that JTT-705 can be expected to inhibit plasma CETP activity and improve plasma lipoprotein profiles in a wide range of animal species, including humans...
  60. pmc RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions
    Norio Takada
    Department of Molecular Genetics, Nagoya City University Medical School, Japan
    J Virol 76:8019-30. 2002
    ..These findings indicate that RAI acts as an efficient inhibitor of HIV-1 gene expression in which both NF-kappaB and Sp1 play major roles...
  61. ncbi request reprint Development of atherosclerosis in osteopontin transgenic mice
    Satoru Chiba
    Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Heart Vessels 16:111-7. 2002
    ..Thus, these results suggest that OPN is atherogenic and that macrophages expressing OPN can be easily activated and thus promote atheromatous lesions if a high fat diet is consumed...
  62. ncbi request reprint Effect of HDL, from Japanese white rabbit administered a new cholesteryl ester transfer protein inhibitor JTT-705, on cholesteryl ester accumulation induced by acetylated low density lipoprotein in J774 macrophage
    Junji Kobayashi
    Second Department of Internal Medicine, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Atherosclerosis 162:131-5. 2002
    ....
  63. ncbi request reprint Blockade of macrophage migration inhibitory factor ameliorates experimental autoimmune myocarditis
    Yutaka Matsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Mol Cell Cardiol 37:557-66. 2004
    ..These results demonstrate an important role of MIF in the pathogenesis of EAM and suggest that MIF blockade may be a promising new strategy for the treatment of myocarditis...
  64. ncbi request reprint Matrix metalloproteinase 28/epilysin expression in cartilage from patients with rheumatoid arthritis and osteoarthritis: comment on the article by Kevorkian et al
    Shigeki Momohara
    Arthritis Rheum 50:4074-5; author reply 4075. 2004
  65. ncbi request reprint Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells
    Haruhiro Higashida
    Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Neurosci Res 57:339-46. 2007
    ..These results indicate that cADPR is an intracellular messenger of Ca(2+) signalling, suggesting that CD38 can contribute to mAChR-cADPR signalling...
  66. pmc MHC2TA is associated with rheumatoid arthritis in Japanese patients
    Noriko Iikuni
    Ann Rheum Dis 66:274-5. 2007
  67. ncbi request reprint Stimulatory autoantibodies to the PDGF receptor in scleroderma
    Hiroshi Okamoto
    N Engl J Med 355:1278; author reply 1279. 2006
  68. pmc Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis
    Martin H Bluth
    Department of Surgery, State University of New York Downstate Medical Center, Brooklyn, New York, USA
    World J Gastroenterol 12:4511-6. 2006
    ..This suggests that reg I and its receptor may play a role in recovery after pancreatic injury. We hypothesized that reg I and its receptor are induced in acute pancreatitis...
  69. ncbi request reprint Corticosteroids in ARDS
    Hiroshi Okamoto
    N Engl J Med 355:317; author reply 318-9. 2006
  70. ncbi request reprint Development of a human mammary epithelial cell culture model for evaluation of drug transfer into milk
    Soichiro Kimura
    Hospital Pharmacy, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    Arch Pharm Res 29:424-9. 2006
    ..These results indicate that the 3-t-HMEC monolayer is potentially useful for the evaluation of carrier-mediated secretion of drugs including organic cations into human milk...
  71. ncbi request reprint Mouse monoclonal anti-human thrombomodulin antibodies bind to and activate endothelial cells through NF-kappaB activation in vitro
    Hiroyuki Nara
    Jichi Medical School, Tochigi ken, Japan
    Arthritis Rheum 54:1629-37. 2006
    ....
  72. pmc Identification of mouse orthologue of endogenous secretory receptor for advanced glycation end-products: structure, function and expression
    Ai Harashima
    Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science, Kanazawa 920 8640, Japan
    Biochem J 396:109-15. 2006
    ..The esRAGE expression was increased in the kidney of diabetic wild-type mice. The present study has thus provided an animal orthologue of esRAGE for clarification of its roles in health and disease...
  73. ncbi request reprint Activation of regenerating gene Reg in rat and human hearts in response to acute stress
    Tatsuya Kiji
    Dept of Thoracic and Cardiovascular Surgery, Nara Medical Univ School of Medicine, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Am J Physiol Heart Circ Physiol 289:H277-84. 2005
    ..In view of emerging evidence of Reg for tissue regeneration in a variety of tissues/organs, it is proposed that the damaged heart may be a target for Reg action and that Reg may protect against acute heart stress...
  74. ncbi request reprint REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer
    Akira Sekikawa
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Gastroenterology 128:642-53. 2005
    ....
  75. ncbi request reprint Blockade of T cell costimulatory signals using adenovirus vectors prevents both the induction and the progression of experimental autoimmune myocarditis
    Yutaka Matsui
    Division of Molecular Immunology, Institute for Genetic Medicine, Sapporo 060 0815, Japan
    J Mol Cell Cardiol 34:279-95. 2002
    ..This study indicates the therapeutic potential of costimulatory pathway blockade by gene-transfer in myocarditis...