H Okamoto

Summary

Affiliation: Tokyo Women's Medical University
Country: Japan

Publications

  1. pmc Tyrosine kinases in rheumatoid arthritis
    Hiroshi Okamoto
    Minami Otsuka Institute of Technology, Minami Otsuka Clinic, Tokyo, Japan
    J Inflamm (Lond) 8:21. 2011
  2. pmc Cytokines and chemokines in neuropsychiatric syndromes of systemic lupus erythematosus
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    J Biomed Biotechnol 2010:268436. 2010
  3. ncbi request reprint Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis
    H Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Clin Exp Rheumatol 23:323-30. 2005
  4. doi request reprint A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis
    S Kobayashi
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Rheumatology (Oxford) 47:1317-22. 2008
  5. pmc Raised monocyte chemotactic protein-1 (MCP-1)/CCL2 in cerebrospinal fluid of patients with neuropsychiatric lupus
    N Iikuni
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Ann Rheum Dis 65:253-6. 2006
  6. ncbi request reprint Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis
    T Iwamoto
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Rheumatology (Oxford) 45:421-4. 2006
  7. doi request reprint Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese
    K Nishimoto
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Ann Rheum Dis 69:368-73. 2010
  8. ncbi request reprint What's in season for rheumatoid arthritis patients? Seasonal fluctuations in disease activity
    N Iikuni
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054 Japan
    Rheumatology (Oxford) 46:846-8. 2007
  9. ncbi request reprint Plasma concentration of TARC/CCL17 is elevated in nonepisodic angioedema associated with eosinophilia
    H Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Allergy 60:1091-2. 2005
  10. ncbi request reprint Fate of the asymptomatic contralateral limb after initial intervention for ipsilateral critical limb ischemia
    K Yamamoto
    Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int Angiol 32:526-31. 2013

Collaborators

Detail Information

Publications22

  1. pmc Tyrosine kinases in rheumatoid arthritis
    Hiroshi Okamoto
    Minami Otsuka Institute of Technology, Minami Otsuka Clinic, Tokyo, Japan
    J Inflamm (Lond) 8:21. 2011
    ..Based on the number of recently published studies, this manuscript reviews the role of tyrosine kinases in the pathogenesis of RA and the potential role of kinase inhibitors as new therapeutic strategies of RA...
  2. pmc Cytokines and chemokines in neuropsychiatric syndromes of systemic lupus erythematosus
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    J Biomed Biotechnol 2010:268436. 2010
    ..Based on the number of recently published studies, this review overviewed the roles of cytokines and chemokines in NPSLE...
  3. ncbi request reprint Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis
    H Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Clin Exp Rheumatol 23:323-30. 2005
    ..Ligands for peroxisome proliferator-activated receptor (PPAR) -gamma have recently been reported to inhibit the development of RA. In this study, we investigated the role of PPARalpha in RA...
  4. doi request reprint A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis
    S Kobayashi
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Rheumatology (Oxford) 47:1317-22. 2008
    ..The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is one of the major toxic components in cigarettes. To clarify the biological effects of smoking in RA, we investigated the role of TCDD in RA pathogenesis...
  5. pmc Raised monocyte chemotactic protein-1 (MCP-1)/CCL2 in cerebrospinal fluid of patients with neuropsychiatric lupus
    N Iikuni
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Ann Rheum Dis 65:253-6. 2006
    ..An imbalance in cytokine homoeostasis is thought to have a key role in the neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE), and recently, a role for chemokines has been noted...
  6. ncbi request reprint Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis
    T Iwamoto
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Rheumatology (Oxford) 45:421-4. 2006
    ....
  7. doi request reprint Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese
    K Nishimoto
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Ann Rheum Dis 69:368-73. 2010
    ..Gene expression levels of TRAF1 and C5 to assess the functional significance of genotypes were also analysed...
  8. ncbi request reprint What's in season for rheumatoid arthritis patients? Seasonal fluctuations in disease activity
    N Iikuni
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054 Japan
    Rheumatology (Oxford) 46:846-8. 2007
    ..To examine whether a seasonal fluctuation exists with rheumatoid arthritis (RA) activity and to analyse seasonal effects of varying components that express disease activity in RA patients...
  9. ncbi request reprint Plasma concentration of TARC/CCL17 is elevated in nonepisodic angioedema associated with eosinophilia
    H Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Allergy 60:1091-2. 2005
  10. ncbi request reprint Fate of the asymptomatic contralateral limb after initial intervention for ipsilateral critical limb ischemia
    K Yamamoto
    Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int Angiol 32:526-31. 2013
    ..Information on the contralateral limb at initial surgery may help to speculate the fate of the asymptomatic contralateral limb. ..
  11. pmc Single nucleotide polymorphisms in the gene encoding the major histocompatibility complex class II transactivator (CIITA) in systemic lupus erythematosus
    K Koizumi
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Ann Rheum Dis 64:947-50. 2005
    ..Insufficient up regulation of MHC class II molecules is reported to be one of the major immunological mechanisms in systemic lupus erythematosus (SLE)...
  12. ncbi request reprint A CCR-5 antagonist inhibits the development of adjuvant arthritis in rats
    H Okamoto
    Rheumatology (Oxford) 45:230-2. 2006
  13. ncbi request reprint Differential in vitro effects of IL-4, IL-10, and IL-13 on proinflammatory cytokine production and fibroblast proliferation in rheumatoid synovium
    Y Morita
    Department of Medicine III, Okayama University Medical School, Japan
    Rheumatol Int 20:49-54. 2001
    ..These results suggest that IL-4, IL-10, and IL-13 all have the therapeutic potential to regulate the disease activity mediated by proinflammatory cytokines in RA, but each cytokine may have different potencies...
  14. pmc Successful treatment with fenofibrate, a peroxisome proliferator activated receptor alpha ligand, for a patient with rheumatoid arthritis
    H Okamoto
    Ann Rheum Dis 63:1002-3. 2004
  15. ncbi request reprint Successful gene therapy via intraarticular injection of adenovirus vector containing CTLA4IgG in a murine model of type II collagen-induced arthritis
    K Ijima
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, 060-0815 Sapporo, Japan
    Hum Gene Ther 12:1063-77. 2001
    ....
  16. ncbi request reprint Induction of collagenase-2 (matrix metalloproteinase-8) gene expression by interleukin-1beta in human gingival fibroblasts
    M Abe
    Department of Biochemistry, Ohu University School of Dentistry, Koriyama, Japan
    J Periodontal Res 36:153-9. 2001
    ..The findings also suggest that enhancement of collagenase-2 mRNA expression by IL-1beta involves both protein synthesis and suppression of mRNA degradation...
  17. doi request reprint Promoter activity of A/G at position -168 in the type III promoter of MHCIITA gene
    H Okamoto
    Rheumatology (Oxford) 47:547-8. 2008
  18. ncbi request reprint Successful treatment with fenofibrate of autoimmune hepatitis in a patient with rheumatoid arthritis
    H Okamoto
    Scand J Rheumatol 36:235-6. 2007
  19. ncbi request reprint The occurrence of Japanese cedar pollinosis with rheumatoid arthritis
    K Koizumi
    Clin Exp Rheumatol 25:505-6. 2007
  20. ncbi request reprint Adenovirus-mediated CTLA4 immunoglobulin G gene therapy in cardiac xenotransplantation
    T Watanabe
    Department of Cardiovascular Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Transplant Proc 36:2478-9. 2004
    ..We hypothesized that the combination therapy of DSG and adenovirus-mediated CTLA4IgG might induce long-term, survival or tolerance in cardiac xenotransplantation...
  21. ncbi request reprint Rapidly destructive knee arthropathy associated with hepatitis B
    S Momohara
    Clin Exp Rheumatol 24:111-2. 2006
  22. pmc Mucopolysaccharidosis type VII: characterization of mutations and molecular heterogeneity
    S Tomatsu
    Department of Pediatrics, Gifu University School of Medicine, Japan
    Am J Hum Genet 48:89-96. 1991
    ..Each of these two amino acid changes reduced the beta G1 activity of the corresponding mutant beta G1 expressed following transfection of COS cells with expression vectors harboring the mutated cDNAs...