S Okabe

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi request reprint Molecular anatomy of the postsynaptic density
    Shigeo Okabe
    Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Mol Cell Neurosci 34:503-18. 2007
  2. ncbi request reprint Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    Hirofumi Nakatomi
    Department of Neurobiology, The University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Japan
    Cell 110:429-41. 2002
  3. ncbi request reprint Rapid redistribution of the postsynaptic density protein PSD-Zip45 (Homer 1c) and its differential regulation by NMDA receptors and calcium channels
    S Okabe
    Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, 113 8519, Japan
    J Neurosci 21:9561-71. 2001
  4. ncbi request reprint Birth, growth and elimination of a single synapse
    Shigeo Okabe
    Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Anat Sci Int 77:203-10. 2002
  5. ncbi request reprint Spine formation and correlated assembly of presynaptic and postsynaptic molecules
    S Okabe
    Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, 113 8519, Japan
    J Neurosci 21:6105-14. 2001
  6. ncbi request reprint Continual remodeling of postsynaptic density and its regulation by synaptic activity
    S Okabe
    Department of Anatomy, School of Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Nat Neurosci 2:804-11. 1999
  7. ncbi request reprint Visualizing synapse formation and remodeling: recent advances in real-time imaging of CNS synapses
    T Umeda
    Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan
    Neurosci Res 40:291-300. 2001
  8. pmc Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking
    Yumi Noda
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    J Cell Biol 182:587-601. 2008
  9. ncbi request reprint [NMDA receptors and their interacting proteins in the postsynaptic density]
    S Okabe
    Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
    Kaibogaku Zasshi 76:185-91. 2001
  10. ncbi request reprint Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanisms
    Toshihiko Kuriu
    Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    J Neurosci 26:7693-706. 2006

Collaborators

  • A Miwa
  • Haruhiko Bito
  • T Ohshima
  • Y Takei
  • N Hirokawa
  • K Sobue
  • Hisashi Umemori
  • Sei Sasaki
  • Yumi Noda
  • Yutaka Yoshida
  • Toru Takumi
  • S Terada
  • Toshiya Manabe
  • Masahiro Yamaguchi
  • Michio Kuwahara
  • Akihiro Inoue
  • Hideko Nishida
  • Takanobu Nakazawa
  • Toshihiko Kuriu
  • Izumi Kawabata
  • Atsushi Yoshimura
  • Ritsuko Fujii
  • Tatsuya Umeda
  • Kazuhiro Yamamoto
  • Tatsuhiko Ebihara
  • Shinichi Usui
  • Tohru Tezuka
  • Tadashi Yamamoto
  • Junko Iki
  • Yoshiko Sugiyama
  • Tanja Schmandt
  • Mitsuhiro Enomoto
  • Hirofumi Nakatomi
  • T Umeda
  • Yasuhito Watanabe
  • Kenji Fukui
  • Oliver Brüstle
  • Kiyoshi Inoue
  • Toru Nishikawa
  • Tomoe Urushido
  • Gudrun Gossrau
  • Eybe Meents
  • Geoffrey G Hicks
  • Taro Tachibana
  • Volker Gornik
  • Daijiro Konno
  • Kenichi Shinomiya
  • Kazumasa Yokoyama
  • Takashi Fujikado
  • Hisato Maruoka
  • Kei Hori
  • Yasuo Tano
  • Ayako M Watabe
  • Akira Tamura
  • Shin Ichi Yamamoto
  • Masato Nakafuku
  • Takaaki Kirino
  • Nobutaka Kawahara
  • Osamu Hatano
  • A Harada
  • R Sato-Yoshitake
  • J Kuno
  • K Oguchi
  • T Noda

Detail Information

Publications28

  1. ncbi request reprint Molecular anatomy of the postsynaptic density
    Shigeo Okabe
    Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Mol Cell Neurosci 34:503-18. 2007
    ..This information will be combined with recent quantitative analyses of the PSD protein contents per synapse, in order to provide a current view of the PSD molecular architecture and its dynamics...
  2. ncbi request reprint Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors
    Hirofumi Nakatomi
    Department of Neurobiology, The University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Japan
    Cell 110:429-41. 2002
    ..These results expand the possibility of novel neuronal cell regeneration therapies for stroke and other neurological diseases...
  3. ncbi request reprint Rapid redistribution of the postsynaptic density protein PSD-Zip45 (Homer 1c) and its differential regulation by NMDA receptors and calcium channels
    S Okabe
    Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, 113 8519, Japan
    J Neurosci 21:9561-71. 2001
    ..Thus, neuronal activity differentially redistributes a specific subset of PSD proteins, which are important for localization of both surface receptors and intracellular signaling complexes...
  4. ncbi request reprint Birth, growth and elimination of a single synapse
    Shigeo Okabe
    Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Anat Sci Int 77:203-10. 2002
    ..Information regarding birth, maturation and elimination of a single synapse is accumulating and will influence our concepts about how neuronal circuits are organized and maintained...
  5. ncbi request reprint Spine formation and correlated assembly of presynaptic and postsynaptic molecules
    S Okabe
    Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, 113 8519, Japan
    J Neurosci 21:6105-14. 2001
    ..The local and stepwise assembly of synaptic components at the contact sites between dendritic protrusions and axons explains the developmental remodeling of excitatory synapses...
  6. ncbi request reprint Continual remodeling of postsynaptic density and its regulation by synaptic activity
    S Okabe
    Department of Anatomy, School of Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Nat Neurosci 2:804-11. 1999
    ..Dynamics of PSD-95 clusters were also inhibited by blockers of excitatory synaptic transmission. Continual PSD turnover and its regulation by synaptic activity may be important in activity-dependent remodeling of neuronal connections...
  7. ncbi request reprint Visualizing synapse formation and remodeling: recent advances in real-time imaging of CNS synapses
    T Umeda
    Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan
    Neurosci Res 40:291-300. 2001
    ....
  8. pmc Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking
    Yumi Noda
    Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    J Cell Biol 182:587-601. 2008
    ..These findings indicate a novel mechanism of channel protein trafficking, in which the channel protein itself critically regulates local actin reorganization to initiate its movement...
  9. ncbi request reprint [NMDA receptors and their interacting proteins in the postsynaptic density]
    S Okabe
    Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
    Kaibogaku Zasshi 76:185-91. 2001
    ..In the second part, implications obtained from our recent analyses on the structural remodeling of the postsynaptic density are presented...
  10. ncbi request reprint Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanisms
    Toshihiko Kuriu
    Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    J Neurosci 26:7693-706. 2006
    ..These results collectively indicate a critical role of filamentous actin in determining the extent of dynamic reorganization in PSD molecular composition...
  11. ncbi request reprint Simultaneous observation of stably associated presynaptic varicosities and postsynaptic spines: morphological alterations of CA3-CA1 synapses in hippocampal slice cultures
    Tatsuya Umeda
    Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Mol Cell Neurosci 28:264-74. 2005
    ..These results indicate the presence of local regulatory mechanisms to coordinate presynaptic and postsynaptic motility...
  12. ncbi request reprint Altered microtubule organization in small-calibre axons of mice lacking tau protein
    A Harada
    Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan
    Nature 369:488-91. 1994
    ..Our results argue against the suggested role of tau in axonal elongation but confirm that it is crucial in the stabilization and organization of axonal microtubules in a certain type of axon...
  13. ncbi request reprint The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function
    Akihiro Inoue
    Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Curr Opin Neurobiol 13:332-40. 2003
    ..These emerging dynamic properties of synaptic specializations add another layer of complexity to the signaling mechanisms of CNS synapses...
  14. ncbi request reprint Bi-directional regulation of postsynaptic cortactin distribution by BDNF and NMDA receptor activity
    Junko Iki
    Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, 113 8519, Japan
    Eur J Neurosci 22:2985-94. 2005
    ..These results indicate the importance of counterbalance between BDNF and NMDA receptor-mediated signalling in the reorganization of the postsynaptic actin cytoskeleton during neuronal development...
  15. ncbi request reprint Determination of absolute protein numbers in single synapses by a GFP-based calibration technique
    Yoshiko Sugiyama
    Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Nat Methods 2:677-84. 2005
    ..The EGFP-based calibration technique provides an unprecedented general method for estimating the amounts of proteins in macromolecular complexes...
  16. ncbi request reprint Gene expression in transgenic mice using neural promoters
    S Okabe
    Tokyo Medical and Dental University, Tokyo, Japan
    Curr Protoc Neurosci . 2001
    ..This information is useful both as a guide for carrying out the analysis of cis-acting elements and as a reference for selection of promoter/enhancer elements for designing an appropriate transgenic construct...
  17. ncbi request reprint Migration and differentiation of neural progenitor cells from two different regions of embryonic central nervous system after transplantation into the intact spinal cord
    Mitsuhiro Enomoto
    Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, 113 8519, Japan
    Eur J Neurosci 17:1223-32. 2003
    ....
  18. ncbi request reprint [Visualization of synapse-glia dynamics]
    Hideko Nishida
    Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Brain Nerve 59:755-61. 2007
    ..Furthermore, in vivo time-lapse imaging of synapseastrocyte pairs will soon be accomplished, as techniques of in vivo two-photon imaging showed remarkable progress recently...
  19. ncbi request reprint Electroporation-mediated gene transfer system applied to cultured CNS neurons
    Izumi Kawabata
    Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Neuroreport 15:971-5. 2004
    ..The system described here is useful in analyzing biological roles of multiple genes in specific stages of neuronal development...
  20. doi request reprint Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP
    Takanobu Nakazawa
    Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    J Neurochem 105:1384-93. 2008
    ..Thus, these data suggest that p250GAP plays an important role in NMDA receptor-mediated regulation of RhoA activity leading to spine morphological plasticity...
  21. ncbi request reprint Direct astrocytic contacts regulate local maturation of dendritic spines
    Hideko Nishida
    Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Neurosci 27:331-40. 2007
    ..Our data support a model in which astrocytic protrusive activity in development acts as a key local regulator for stabilization of individual dendritic protrusions and subsequent maturation into spines...
  22. ncbi request reprint Synchronized formation and remodeling of postsynaptic densities: long-term visualization of hippocampal neurons expressing postsynaptic density proteins tagged with green fluorescent protein
    Tatsuhiko Ebihara
    Molecular Neurophysiology Group, Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki 305 8566, Japan
    J Neurosci 23:2170-81. 2003
    ..These observations suggest the presence of signaling mechanisms that can induce synchronized addition or elimination of PSD proteins throughout dendritic arborization of a single neuron...
  23. ncbi request reprint The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology
    Ritsuko Fujii
    Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Curr Biol 15:587-93. 2005
    ..Our results indicate that TLS participates in mRNA sorting to the dendritic spines induced by mGluR5 activation and regulates spine morphology to stabilize the synaptic structure...
  24. ncbi request reprint Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines
    Atsushi Yoshimura
    Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Curr Biol 16:2345-51. 2006
    ..Our results demonstrate that myosin-Va facilitates the transport of TLS-containing mRNP complexes in spines and may function in synaptic plasticity through Ca2+ signaling...
  25. ncbi request reprint Synaptic targeting of PSD-Zip45 (Homer 1c) and its involvement in the synaptic accumulation of F-actin
    Shinichi Usui
    Department of Neuroscience D13, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Japan
    J Biol Chem 278:10619-28. 2003
    ..Thus, these data suggest that the PSD-Zip45-shank and PSD-95-GKAP complexes form different synaptic compartments, and PSD-Zip45 alone or PSD-Zip45-shank is involved in the synaptic accumulation of F-actin...
  26. pmc p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling
    Takanobu Nakazawa
    Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Mol Biol Cell 14:2921-34. 2003
    ..Finally, NMDA receptor stimulation led to dephosphorylation and redistribution of p250GAP in hippocampal slices. Together, p250GAP is likely to be involved in NMDA receptor activity-dependent actin reorganization in dendritic spines...
  27. ncbi request reprint High-purity lineage selection of embryonic stem cell-derived neurons
    Tanja Schmandt
    Institute of Reconstructive Neurobiology, University of Bonn Medical Center and Hertie Foundation, Bonn, Germany
    Stem Cells Dev 14:55-64. 2005
    ..6% and 96.9%, respectively. These findings depict Talpha1-EGFP and PSA-NCAM as suitable markers for high-purity selection of early ES cell-derived neurons...
  28. ncbi request reprint Direct visualization of cell movement in the embryonic olfactory bulb using green fluorescent protein transgenic mice: evidence for rapid tangential migration of neural cell precursors
    Kazuhiro Yamamoto
    Molecular Neurophysiology Group, Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    Neurosci Res 51:199-214. 2005
    ..These results indicate the presence of a specific form of precursor cell migration in the embryonic olfactory bulb...