Kunio Ohyama


Affiliation: Tokyo University of Pharmacy and Life Science
Country: Japan


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    Ohyama K, Nishina M, Yuan B, Bessho T, Yamakawa T. Apoptosis induced by influenza virus-hemagglutinin stimulation may be related to fluctuation of cellular oxidative condition. Biol Pharm Bull. 2003;26:141-7 pubmed
    ..It is concluded that IV-HA induces apoptosis in Amnion-cells, and that this apoptotic induction may be facilitated by certain sialoglycoproteins on the cell surface, and is related to changes in the intracellular redox condition. ..
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    Ohyama K, Akaike T, Hirobe C, Yamakawa T. Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth. Biol Pharm Bull. 2003;26:10-8 pubmed
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    Ohyama K, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T. Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress. Int J Biochem Cell Biol. 2005;37:1496-510 pubmed
    ..Our results demonstrate that intracellular oxidative stress and mitochondrial membrane damage is responsible for Vitex-induced apoptosis, which may be mediated by a diminution of reduced type glutathione within the cell...