Affiliation: Tokyo University of Pharmacy and Life Science
Ohyama K, Nishina M, Yuan B, Bessho T, Yamakawa T. Apoptosis induced by influenza virus-hemagglutinin stimulation may be related to fluctuation of cellular oxidative condition. Biol Pharm Bull. 2003;26:141-7 pubmed
..It is concluded that IV-HA induces apoptosis in Amnion-cells, and that this apoptotic induction may be facilitated by certain sialoglycoproteins on the cell surface, and is related to changes in the intracellular redox condition. ..
Ohyama K, Akaike T, Hirobe C, Yamakawa T. Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth. Biol Pharm Bull. 2003;26:10-8 pubmed
Ohyama K, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T. Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress. Int J Biochem Cell Biol. 2005;37:1496-510 pubmed
..Our results demonstrate that intracellular oxidative stress and mitochondrial membrane damage is responsible for Vitex-induced apoptosis, which may be mediated by a diminution of reduced type glutathione within the cell...