Research Topics
| Motoyoshi NomizuSummaryAffiliation: Tokyo University of Pharmacy and Life Science Country: Japan Publications
| Collaborators
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Detail Information
Publications
[Laminin active peptides as a powerful tool for biomedical materials]Mayumi Mochizuki
Tanpakushitsu Kakusan Koso 50:374-82. 2005- Preparation and characterization of laminin-derived peptide AG73-coated liposomes as a selective gene delivery toolYoichi Negishi
Department of Drug and Gene Delivery Systems, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Japan
Biol Pharm Bull 33:1766-9. 2010..Furthermore, our results suggest that AG73-PEG liposomes can be a useful targeted gene delivery vehicle for syndecan-2 overexpressing cancer cells... - The LG1-3 tandem of laminin alpha5 harbors the binding sites of Lutheran/basal cell adhesion molecule and alpha3beta1/alpha6beta1 integrinsYamato Kikkawa
Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 282:14853-60. 2007..Our results also suggest that the binding site for Lu/B-CAM on laminin alpha5 may overlap with that of integrins alpha3beta1 and alpha6beta1... - The influence of synthetic peptides derived from the laminin alpha1 chain on hepatocyte adhesion and gene expressionYamato Kikkawa
Laboratory of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Hachioji, Tokyo 192 0392, Japan
Biomaterials 30:6888-95. 2009..The amino acid sequence of A13 peptide was required for regulating hepatocyte behavior. The hepatocyte adhesive peptides can be utilized in tailoring synthetic biomaterials in order to achieve a specific cellular response... - Enhanced laminin-derived peptide AG73-mediated liposomal gene transfer by bubble liposomes and ultrasoundYoichi Negishi
Drug and Gene Delivery Systems, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
Mol Pharm 7:217-26. 2010..Thus, the combination of AG73-PEG liposomes with Bubble liposomes and ultrasound exposure may be a promising method to achieve selective and efficient gene delivery for cancer therapy... - Identification of an active site of EMMPRIN for the augmentation of matrix metalloproteinase-1 and -3 expression in a co-culture of human uterine cervical carcinoma cells and fibroblastsTakashi Sato
Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
Gynecol Oncol 114:337-42. 2009..Gynecol Oncol 2004; 92:47-56). The aim of this study was to clarify the active site of EMMPRIN in the augmentation of MMP production in the co-culture of SKG-II cells and HUCF... - The influence of Tribenoside on expression and deposition of epidermal laminins in HaCaT cellsYamato Kikkawa
Laboratory of Clinical Biochemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
Biol Pharm Bull 33:307-10. 2010..These results suggest that tribenoside interacts with epidermal cells and regulates the expression and localization of laminins to help reconstruct BMs in wound healing of hemorrhoids... - Identification of an active site on the laminin alpha5 chain globular domain that binds to CD44 and inhibits malignancySuguru Hibino
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research/NIH, 30 Convent Drive, Bethesda, MD 20892, USA
Cancer Res 64:4810-6. 2004..Our results suggest that A5G27 binds to the CD44 receptor of B16-F10 melanoma cells via the GAGs on CD44 and, thus, inhibits tumor cell migration, invasion, and angiogenesis in a dominant-negative manner... - Localization of the laminin alpha4 chain in the skin and identification of a heparin-dependent cell adhesion site within the laminin alpha4 chain C-terminal LG4 moduleHiroshi Matsuura
Department of Dermatology, Graduate School of Medicine, Chiba University, Chiba, Japan
J Invest Dermatol 122:614-20. 2004..Our study suggests that the laminin alpha4 LG4 module may play an important role in cell adhesion and/or vessel wall formation in the skin by interacting with syndecan-2 and/or -4... - Cyclic peptides from the loop region of the laminin alpha 4 chain LG4 module show enhanced biological activity over linear peptidesFumiharu Yokoyama
Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060 0810, Japan
Biochemistry 43:13590-7. 2004..These results indicate that the activity of A4G82 is highly conformation-dependent, suggesting that the E-F loop structure is crucial for its biological activity... - Cyclic peptide analysis of the biologically active loop region in the laminin alpha3 chain LG4 module demonstrates the importance of peptide conformation on biological activityKozue Kato Takagaki
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
Biochemistry 46:1952-60. 2007..The cyclo-hEF3A peptide may be useful for the development of therapeutic reagents especially for wound healing and nerve regeneration... - Laminin alpha 3 LG4 module induces matrix metalloproteinase-1 through mitogen-activated protein kinase signalingAtsushi Utani
Department of Dermatology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
J Biol Chem 278:34483-90. 2003..Our study suggests that the laminin alpha 3 LG4 module may play an important role in tissue remodeling by inducing MMP-1 expression during wound healing... - Identification of neurite outgrowth active sites on the laminin alpha4 chain G domainNaoki Ichikawa
Research Institute for Diseases of Old Age, Department of Neurology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
Biochemistry 44:5755-62. 2005..Taken together, the data suggest that the peptides from the laminin alpha4 chain G domain promote neurite outgrowth activity via a specific conformation... - Laminin alpha1 chain LG4 module promotes cell attachment through syndecans and cell spreading through integrin alpha2beta1Kentaro Hozumi
Molecular Biology Section, Craniofacial Developmental Biology and Regeneration Branch, NIDCR, National Institutes of Health, Bethesda, MD 20892 4370, USA
J Biol Chem 281:32929-40. 2006..Our findings indicate that LG4 has a unique function distinct from laminin-1 and suggest that laminin alpha1 LG4-5 may also be produced by a proteolytic cleavage in certain tissues where it exerts its activity... - Functional sites in the laminin alpha chainsNobuharu Suzuki
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Connect Tissue Res 46:142-52. 2005..Laminins possess multifunctional sequences and are key molecules that determine cell fate... - Bifunctional peptides derived from homologous loop regions in the laminin alpha chain LG4 modules interact with both alpha 2 beta 1 integrin and syndecan-2Fumiharu Yokoyama
Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan
Biochemistry 44:9581-9. 2005..We conclude that the approach utilizing chimeric peptides is useful for examining cellular mechanisms in dual-receptor systems... - Laminin peptide-conjugated chitosan membrane: Application for keratinocyte delivery in wounded skinShigehiro Ikemoto
Department of Plastic and Aesthetic Surgery, Kitasato University School of Medicine, Sagamihara, Japan
J Biomed Mater Res A 79:716-22. 2006..We suggest that the AG73-chitosan membrane is useful as a therapeutic formulation and is applicable as a cell delivery system such as delivering keratinocytes to a wound bed... - Integrin-dependent cell behavior on ECM peptide-conjugated chitosan membranesMayumi Mochizuki
Laboratory of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
Biopolymers 88:122-30. 2007..These data demonstrate that peptide-chitosan membranes can regulate specific integrin-mediated cell responses and are useful constructs as ECM mimetics... - Identification of cell binding sites in the laminin alpha5-chain G domainMasayoshi Makino
Graduate School of Environmental Earth Science, Hokkaido University, Kita 10 Nishi 5, Kita ku, Sapporo 060 0810, Japan
Exp Cell Res 277:95-106. 2002..Therefore, these peptides may be useful in the investigation of laminin-receptor interactions and possibly mechanisms of laminin signal transduction... - Identification of neurite outgrowth promoting sites on the laminin alpha 3 chain G domainKozue Kato
Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060 0810, Japan
Biochemistry 41:10747-53. 2002..These results suggest that the A3G75- and A3G83-conjugated chitosan membranes are applicable as bio-medical materials for neural tissue repair and engineering... - Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion moleculeYamato Kikkawa
Laboratory of Clinical Biochemistry, Tokyo University of Pharmacy and Life Sciences, Hachioji 192 0392, Japan
Exp Cell Res 314:2579-90. 2008..These results suggest that laminins containing alpha 5 serve as functional substrates regulating progression of HCC... - Laminin-1 peptide-conjugated chitosan membranes as a novel approach for cell engineeringMayumi Mochizuki
Laboratory of Bio Material Chemistry, Division of Bioscience, Graduate School of Environmental Earth Science Hokkaido University, Kita 10 Nishi 5, Kita ku, Sapporo 060 0810, Japan
FASEB J 17:875-7. 2003.... - Biological activities of homologous loop regions in the laminin alpha chain G domainsNobuharu Suzuki
Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan
J Biol Chem 278:45697-705. 2003..The homologous peptides, which promote either integrin- or syndecan-mediated cell attachment, may be useful for understanding the cell type- and chain-specific biological activities of the laminins... - Identification of a potent peptide antagonist to an active laminin-1 sequence that blocks angiogenesis and tumor growthM Lourdes Ponce
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Cancer Res 63:5060-4. 2003..These results indicate that we have identified a more potent antiangiogenesis inhibitor peptide that may be used as a therapeutic to treat cancer... - Role for laminin-alpha5 chain LG4 module in epithelial branching morphogenesisYuichi Kadoya
Department of Anatomy, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
Dev Biol 263:153-64. 2003..A5G77f also perturbed in vitro development of lung and kidney. These results suggest a crucial role for the LG4 module of laminin-alpha5 in epithelial morphogenesis that is distinct from that of the laminin-alpha1 LG4... - Syndecan binding sites in the laminin alpha1 chain G domainNobuharu Suzuki
Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060 0810, Japan
Biochemistry 42:12625-33. 2003..These sites may play a critical role in the diverse biological activities involving heparin and syndecan-4 binding... - Preparation and biological activities of a bivalent poly(ethylene glycol) hybrid containing an active site and its synergistic site of fibronectinYuichi Susuki
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University, Japan
Chem Pharm Bull (Tokyo) 50:1229-32. 2002..PEG may serve as a spacer for maintaining the desired spatial array... - Angiogenic activity of syndecan-binding laminin peptide AG73 (RKRLQVQLSIRT)Mayumi Mochizuki
Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
Arch Biochem Biophys 459:249-55. 2007..These results indicate that the AG73 peptide is a potent syndecan-binding angiogenesis stimulator and may be useful for therapeutic application to treat ischemic injuries... - Interaction of arginine-rich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosisIkuhiko Nakase
Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
Biochemistry 46:492-501. 2007..These data strongly suggest the possibility that the interaction of the arginine-rich peptides with the membrane-associated proteoglycans quickly activates the intracellular signals and induces actin organization and macropinocytotis... - Identification of multiple amyloidogenic sequences in laminin-1Shingo Kasai
Tokyo University of Pharmacy and Life Science, Tokyo 192 0392, Japan
Biochemistry 46:3966-74. 2007..We conclude that the laminin-derived amyloidogenic peptides have the potential to form amyloid-like fibrils in vivo, possibly when laminin-1 is degraded... - Laminin alpha5 chain metastasis- and angiogenesis-inhibiting peptide blocks fibroblast growth factor 2 activity by binding to the heparan sulfate chains of CD44Suguru Hibino
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892-4370, USA
Cancer Res 65:10494-501. 2005..We conclude that peptide A5G27 inhibits metastasis and angiogenesis by blocking FGF2 binding to the heparan sulfate side chains of CD44 variant 3, thus decreasing FGF2 bioactivity... - Identification of biologically active sequences in the laminin alpha 4 chain G domainIkuko Okazaki
Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060 0810, Japan
J Biol Chem 277:37070-8. 2002..These active peptides may be useful for defining of the molecular mechanism laminin-receptor interactions and laminin-mediated cellular signaling pathways... - Ile-Lys-Val-Ala-Val (IKVAV)-containing laminin alpha1 chain peptides form amyloid-like fibrilsMasanori Yamada
Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Kita 10 Nishi 5, Kita-ku, Sapporo 060-0810, Japan
FEBS Lett 530:48-52. 2002..We also examined amyloid-like fibril formation of LAM-L analogs. The neurite outgrowth activity of the LAM-L analogs was closely related to their amyloid-like fibril formation... - An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patientsJunko Inagaki
Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
Hum Reprod 18:544-9. 2003..The present study assessed the clinical significance of anti-laminin-1 Abs with infertility, accompanied with or without endometriosis... - Blood compatible aspects of DNA-modified polysulfone membrane-protein adsorption and platelet adhesionChangsheng Zhao
Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Kita-ku, 060-0810, Sapporo, Japan
Biomaterials 24:3747-55. 2003..This suggested that DNA can be regarded as a biopolymer to modify PSf, and contributes to the hydrophilic and hemocompatible wipers on the surface of the hydrophobic PSf membranes... - UV-irradiated DNA matrixes selectively bind endocrine disruptors with a planar structureMasanori Yamada
Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan
Environ Sci Technol 36:949-54. 2002..DNA-immobilized glass beads and DNA-films prepared by UV irradiation have the potential to serve as useful biomaterials for medical, engineering, and environmental applications... - Immunization of naïve mice with mouse laminin-1 affected pregnancy outcome in a mouse modelShelly Tartakover Matalon
Research Center for Autoimmune Diseases, Department of Medicine B Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Am J Reprod Immunol 50:159-65. 2003..CONCLUSIONS: Active immunization with laminin-1 followed by elevated circulating anti-laminin-1 antibodies results in reproductive failure manifested by a higher fetal resorption rate... - Multifunctional peptide fibrils for biomedical materialsShingo Kasai
Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan
Biopolymers 76:27-33. 2004..We conclude that multifunctional peptide fibrils can be designed by conjugation of active peptides on A208 and that this construct has potential to serve as a bioadhesive for tissue regeneration and engineering... - Active sites in the carboxyl-terminal region of the laminin alpha chain in Drosophila neuronal cell spreadingYasumitsu Takagi
Hirohashi Cell Configuration Project, Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Corporation JSTC, Tsukuba Research Consortium, Tsukuba, Japan
Arch Insect Biochem Physiol 56:162-9. 2004..Furthermore, laminin-dependent BG2-c6 cell spreading was inhibited by heparin. This observation suggests that cell surface glycoproteins participate in the interaction of laminin and BG2-c6 cells... - Characterization of a murine anti-laminin-1 monoclonal antibody (AK8) produced by immunization with mouse-derived laminin-1Akane Kondo
Department of Obstetrics and Gynecology, Center for Specialized Clinical Science, Tokai University, School of Medicine, Ishehara, Japan
Clin Dev Immunol 12:67-73. 2005..The passive immunization of mice with AK8 mAb may represent a suitable animal model for anti-laminin-1 Ab-mediated reproductive failure... - Effect of DNA structure on the formation of collagen-DNA complexMichiko Kaya
Graduate School of Environmental Earth Science, Hokkaido University, Kita-ku, Sapporo 060-0810, Japan
Int J Biol Macromol 35:39-46. 2005..DNA and ss.DNA complexes with collagen. Spatial distribution of the DNA and collagen in the complexes suggests that the characteristic collagen-DNA interaction depends on the DNA forms... - Laminin alpha3 LG4 module induces keratinocyte migration: involvement of matrix metalloproteinase-9Yutaka Momota
Department of Dermatology, Graduate School of Medicine, Chiba University, Chiba, Japan
J Recept Signal Transduct Res 25:1-17. 2005..Taken these together, laminin-5 alpha3 LG4 module may play an important role in re-epithelialization at tissue remodeling... - Characterization of a fasciclin I-like protein with cell attachment activity from sea urchin (Strongylocentrotus intermedius) ovariesKoji Sato
Division of Bio-Science, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan
Arch Biochem Biophys 424:1-10. 2004..The protein has a potential to be involved in biological functions in sea urchin as a cell adhesive molecule... - Inhibition of hair follicle growth by a laminin-1 G-domain peptide, RKRLQVQLSIRT, in an organ culture of isolated vibrissa rudimentKazuhiro Hayashi
Department of Plastic and Reconstructive Surgery, Kitasato University School of Medicine, Kitasato, Sagamihara, Japan
J Invest Dermatol 118:712-8. 2002..We also found a region-specific loss of the laminin-alpha1 chain in the basement membrane at the distal region of the invading hair follicle epithelium, indicating that laminins play a part in hair morphogenesis...