Y Nanke

Summary

Affiliation: Tokyo Women's Medical University
Country: Japan

Publications

  1. ncbi IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats
    Toru Yago
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Arthritis Res Ther 9:R96. 2007
  2. ncbi Radiographic repair in three Japanese patients with rheumatoid arthritis treated with bucillamine
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 19:681-6. 2009
  3. ncbi Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 19:379-83. 2009
  4. ncbi A Japanese case of Behçet's disease complicated by recurrent optic neuropathy involving both eyes: a third case in the English literature
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 19:334-7. 2009
  5. ncbi Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet's disease before ocular attack: a possible predictive marker of ocular attack
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 18:354-8. 2008
  6. ncbi Cryptogenic organizing pneumonia in two patients with Behçet's disease
    Y Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Clin Exp Rheumatol 25:S103-6. 2007
  7. ncbi A case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated by corticosteroid and mizoribine, followed by mizoribine alone
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Intern Med 49:1449-53. 2010
  8. ncbi Two Japanese cases with MAGIC syndrome (mouth and genital ulcers with inflamed cartilage)
    Y Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Clin Exp Rheumatol 24:S113-4. 2006
  9. ncbi Geranylgeranylacetone inhibits formation and function of human osteoclasts and prevents bone loss in tail-suspended rats and ovariectomized rats
    Y Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Calcif Tissue Int 77:376-85. 2005
  10. ncbi Rapidly progressive glomerulonephritis with D-penicillamine
    Y Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Am J Med Sci 320:398-402. 2000

Detail Information

Publications37

  1. ncbi IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats
    Toru Yago
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Arthritis Res Ther 9:R96. 2007
    ..Thus, controlling IL-23 production and function could be a strategy for preventing inflammation and bone destruction in patients with rheumatoid arthritis...
  2. ncbi Radiographic repair in three Japanese patients with rheumatoid arthritis treated with bucillamine
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 19:681-6. 2009
    ..However, it remains unclear whether Bc repairs bone erosion in patients with RA. Here, we treated three RA patients with Bc who subsequently showed radiographic repair of erosions and cysts...
  3. ncbi Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 19:379-83. 2009
    ..1 or 0.5 microM Fluv was significantly higher than that by the medium alone. In summary, we found that GGA induced cell death in RA FLS, suggesting that GGA may be a potential new therapeutic agent for RA as well as osteoporosis...
  4. ncbi A Japanese case of Behçet's disease complicated by recurrent optic neuropathy involving both eyes: a third case in the English literature
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 19:334-7. 2009
    ..However, optic neuropathy in BD is very rare. This case suggests that optic neuropathy can affect both eyes and be recurrent. This case provides clinical insight into optic nerve involvement in BD...
  5. ncbi Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet's disease before ocular attack: a possible predictive marker of ocular attack
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 18:354-8. 2008
    ..In addition, decreased percentages of Treg cells may be a predictive marker of ocular attack in BD patients allowing treatment of BD patients before an ocular attack...
  6. ncbi Cryptogenic organizing pneumonia in two patients with Behçet's disease
    Y Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Clin Exp Rheumatol 25:S103-6. 2007
    ..The pulmonary parenchymal involvement still needs to be explored fully to diagnose early and start proper treatment. These two rare cases provide clinical insight into lung involvement in Behçet's disease...
  7. ncbi A case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated by corticosteroid and mizoribine, followed by mizoribine alone
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Intern Med 49:1449-53. 2010
    ..Thus, this case may be associated with IgG4. The present case is the first case in which mizoribine was effective for Mikulicz's disease and IgG4-related plasmacytic syndrome...
  8. ncbi Two Japanese cases with MAGIC syndrome (mouth and genital ulcers with inflamed cartilage)
    Y Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Clin Exp Rheumatol 24:S113-4. 2006
    ..The conditions of both patients were resolved by treatment with corticosteroid and colchicine. We also review the English literature related to this rare syndrome...
  9. ncbi Geranylgeranylacetone inhibits formation and function of human osteoclasts and prevents bone loss in tail-suspended rats and ovariectomized rats
    Y Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Calcif Tissue Int 77:376-85. 2005
    ..These results indicate that GGA prevents bone loss by maintaining a positive balance of bone turnover through suppression of both the formation and the activity of osteoclasts. Thus, GGA could be used to prevent and improve osteoporosis...
  10. ncbi Rapidly progressive glomerulonephritis with D-penicillamine
    Y Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Am J Med Sci 320:398-402. 2000
    ..Their renal function improved gradually and MPO-ANCA disappeared after immunosuppressive treatment...
  11. ncbi Pancytopenia and colitis with Clostridium difficile in a rheumatoid arthritis patient taking methotrexate, antibiotics and non-steroidal anti-inflammatory drugs
    Y Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Clin Rheumatol 20:73-5. 2001
    ..Our case suggests that low-dose MTX may seriously interact with antibiotics and that these side-effects should always be considered when RA patients are treated with MTX and antibiotics...
  12. ncbi Alkaline phosphatase in rheumatoid arthritis patients: possible contribution of bone-type ALP to the raised activities of ALP in rheumatoid arthritis patients
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Clin Rheumatol 21:198-202. 2002
    ..In conclusion, ALP levels were elevated in both serum and synovial fluid from RA patients. Bone-type ALP derived from the synovial tissue may contribute to the raised activities of ALP in RA patients...
  13. ncbi Synovial histology in three Behçet's disease patients with orthopedic surgery
    Y Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Clin Exp Rheumatol 20:S35-9. 2002
    ..These findings suggest that the histopathological characteristics of synovial tissue in Behçet's disease may have a wide range, some of which may even resemble the synovial tissue of rheumatoid arthritis...
  14. ncbi Adrenomedullin in synovial fluids from patients with rheumatoid arthritis inhibits interleukin 6 production from synoviocytes
    Y Nanke
    Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan
    Ann Rheum Dis 62:82-3. 2003
  15. ncbi Anti-glucose-6-phosphate isomerase, anti-cyclic citrullinated peptide antibodies and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis
    T Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Clin Exp Rheumatol 26:918-21. 2008
    ..Our goal was to evaluate the associations of antibodies (Abs) to glucose-6-phosphate isomerase (GPI) with Abs to cyclic citrullinated peptide (CCP) and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis (RA)...
  16. ncbi Progressive appearance of overlap syndrome together with autoantibodies in a patient with fatal thrombotic microangiopathy
    Y Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Am J Med Sci 320:348-51. 2000
    ..The clinical presentations of the case support the concept of strong associations between disease-specific autoantibodies and clinical features...
  17. ncbi Differential association of HLA-DRB1 alleles in Japanese patients with early rheumatoid arthritis in relationship to autoantibodies to cyclic citrullinated peptide
    T Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Clin Exp Rheumatol 25:219-24. 2007
    ..To evaluate the role of HLA-DRB1 genotypes and antibodies to cyclic citrullinated peptides (anti-CCP antibodies) in the development and radiographic progression of Japanese patients with rheumatoid arthritis (RA)...
  18. ncbi [Serum markers of synovitis and bone metabolism in rheumatoid arthritis]
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University
    Clin Calcium 19:362-71. 2009
    ..In this article, we reviewed the literature on these issues after describing our hypothesis of the pathogenesis of synovitis in RA...
  19. ncbi [Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis]
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University
    Nihon Rinsho Meneki Gakkai Kaishi 32:466-71. 2009
    ..Only a few studies on the role of TCTA protein have been reported, including our report published in 2009. In the current review paper, we summarized papers on TCTA protein before 2009 and our recent findings...
  20. ncbi [Effects of biologic therapies on systemic osteoporosis in patients with rheumatoid arthritis]
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University
    Nihon Rinsho 67:996-1002. 2009
    ..In this review article, we reviewed the literature on the issue after we described our hypothesis on the pathogenesis of synovitis in patients with RA...
  21. ncbi Cricoarytenoid arthritis with rheumatoid arthritis and systemic lupus erythematosus
    Y Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    J Rheumatol 28:624-6. 2001
    ..She was given high dose corticosteroids that improved her clinical symptoms and laryngoscopic findings. She represents the first patient with overlap syndrome who developed an acute airway obstruction due to cricoarytenoid arthritis...
  22. ncbi Systemic lupus erythematosus with myocardial dysfunction due to microvasculopathy
    Y Nanke
    The Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Lupus 9:464-7. 2000
    ..In support of this speculation, corticosteroid therapy without any thrombolytic agents was effective. This report represents the first live patient with SLE in whom myocardial dysfunction due to microvasculopathy has been demonstrated...
  23. ncbi Immunogenetic features in 120 Japanese patients with idiopathic inflammatory myopathy
    Takefumi Furuya
    Institute of Rheumatology and Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 31:1768-74. 2004
    ..To examine the role of HLA-DRB1 and tumor necrosis factor (TNF) promoter genotypes in the development and the autoantibody profiles of idiopathic inflammatory myopathy (IIM) in Japanese patients...
  24. ncbi Combining effects of polymorphism of tumor necrosis factor alpha 5'-flanking region and HLA-DRB1 on radiological progression in patients with rheumatoid arthritis
    Naomi Ichikawa
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 19:134-9. 2009
    ..The combination of the polymorphism of the TNFA upstream promoter region and HLA-DRB1 allele was associated with radiological progression in the early stage of RA...
  25. ncbi T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Bone 45:627-39. 2009
    ..Our novel peptide and polyclonal antibodies against the peptide inhibited human osteoclastogenesis and the function of mature osteoclasts, preventing cellular fusion by TCTA protein and a putative counterpart molecule...
  26. ncbi Risk factors associated with incident fractures in Japanese men with rheumatoid arthritis: a prospective observational cohort study
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, Japan
    J Bone Miner Metab 26:499-505. 2008
    ..High HAQ disability score and baseline doses of daily prednisolone may correlate with incident clinical vertebral fracture in Japanese men with RA...
  27. ncbi IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Eur J Immunol 35:3353-63. 2005
    ..Contrary to our hypothesis, IFN-gamma(+) human T cells induced osteoclastogenesis through the expression of RANKL, suggesting that Th1 cells play a direct role in bone resorption in Th1 dominant diseases such as RA...
  28. ncbi Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Clin Rheumatol 26:2137-41. 2007
    ..In addition, SNPs in RANKL and IL-17 may be associated with radiographic progression in Japanese patients with early RA...
  29. ncbi IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-alpha antibody: a novel mechanism of osteoclastogenesis by IL-17
    Toru Yago
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    J Cell Biochem 108:947-55. 2009
    ..The present study clearly demonstrated the novel mechanism by which IL-17 directly induces osteoclastogenesis from human monocytes alone. In addition, infliximab potently inhibits the osteoclastogenesis directly induced by IL-17...
  30. ncbi Risk factors associated with incident clinical vertebral and nonvertebral fractures in Japanese women with rheumatoid arthritis: a prospective 54-month observational study
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 34:303-10. 2007
    ..To evaluate the association between potential risk factors and incident clinical fractures in Japanese patients with rheumatoid arthritis (RA)...
  31. ncbi [Geranylgeranylacetone, an antiulcer drug, potently inhibits formation and function of human osteoclasts in vitro and bone loss in ovariectomized rats]
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women's Medical University
    Nippon Rinsho 62:575-9. 2004
  32. ncbi Bone erosion of the sternocostal joint in a patient with Behcet's disease
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University
    Nihon Rinsho Meneki Gakkai Kaishi 32:186-8. 2009
    ..Erosive arthropathy is extremely rare. We report a 52-year-old female patient with BD demonstrating bone erosion of the sternocostal joint...
  33. ncbi [Prospective cohort studies of incident fractures in patients with rheumatoid arthritis]
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women's Medical University
    Nippon Rinsho 65:125-9. 2007
  34. ncbi Irsogladine is effective for recurrent oral ulcers in patients with Behçet's disease : an open-label, single-centre study
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Drugs R D 9:455-9. 2008
    ..We investigated whether irsogladine, a drug for the treatment of gastritis and peptic ulcers, reduced aphthous stomatitis lesions in patients with BD...
  35. ncbi [Secondary osteoporosis. Fractures in patients with rheumatoid arthritis]
    Takefumi Furuya
    Tokyo Women s Medical University, Institute of Rheumatology, Japan
    Clin Calcium 17:1429-34. 2007
    ..This article reviews the epidemiology and associated risk factors with the development of fractures in patients with RA...
  36. ncbi Case of Chlamydia-associated arthritis
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University
    Nihon Rinsho Meneki Gakkai Kaishi 32:511-4. 2009
    ..During the course, the levels of Th1, Th17 and regulatory T cells in the peripheral blood were increased on flowcytometry. Thus, we speculate that Th17 may play, at least in part, an important role of the pathogenesis in this case...
  37. ncbi [Isolated pulmonary hypertension in overlap syndrome: successful treatment by methylprednisolone pulse therapy]
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women's Medical University
    Nihon Rinsho Meneki Gakkai Kaishi 26:28-33. 2003
    ..Since PH in this case responded favorably to methylprednisolone pulse therapy, this therapy may be effective for PH associated with overlap syndrome...