Hitoshi Nakatogawa

Summary

Affiliation: Tokyo Institute of Technology
Country: Japan

Publications

  1. doi request reprint Autophagy: close contact keeps out the uninvited
    Hitoshi Nakatogawa
    Frontier Research Center, Tokyo Institute of Technology, Yokohama, Japan Electronic address
    Curr Biol 24:R560-2. 2014
  2. pmc The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation
    Hitoshi Nakatogawa
    Frontier Research Center, Tokyo Institute of Technology, Yokohama 226 8503, Japan
    J Biol Chem 287:28503-7. 2012
  3. doi request reprint Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis
    Hitoshi Nakatogawa
    Frontier Research Center, Tokyo Institute of Technology, Yokohama, Japan
    Autophagy 8:177-86. 2012
  4. doi request reprint SDS-PAGE techniques to study ubiquitin-like conjugation systems in yeast autophagy
    Hitoshi Nakatogawa
    Frontier Research Center, Tokyo Institute of Technology, Yokohama, Japan
    Methods Mol Biol 832:519-29. 2012
  5. doi request reprint Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site
    Machiko Sakoh-Nakatogawa
    Frontier Research Center, Tokyo Institute of Technology, Yokohama, Japan
    Nat Struct Mol Biol 20:433-9. 2013
  6. doi request reprint Dynamics and diversity in autophagy mechanisms: lessons from yeast
    Hitoshi Nakatogawa
    Integrated Research Institute, Tokyo Institute of Technology, Yokohama 2268503, Japan
    Nat Rev Mol Cell Biol 10:458-67. 2009
  7. doi request reprint Localization of Atg3 to autophagy-related membranes and its enhancement by the Atg8-family interacting motif to promote expansion of the membranes
    Machiko Sakoh-Nakatogawa
    Frontier Research Center, Tokyo Institute of Technology, Yokohama 226 8503, Japan
    FEBS Lett 589:744-9. 2015
  8. doi request reprint Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of α-mannosidase under nitrogen starvation conditions
    Keisuke Mochida
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan
    FEBS Lett 588:3862-9. 2014
  9. pmc Hrr25 triggers selective autophagy-related pathways by phosphorylating receptor proteins
    Chikara Tanaka
    Frontier Research Center and Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori ku, Yokohama 226 8503, Japan
    J Cell Biol 207:91-105. 2014
  10. doi request reprint Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
    Keisuke Mochida
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226 8503, Japan
    Nature 522:359-62. 2015

Collaborators

  • Fuyuhiko Inagaki
  • Kuninori Suzuki
  • Yoshiaki Kamada
  • Keisuke Mochida
  • Yoshinori Ohsumi
  • Machiko Sakoh-Nakatogawa
  • Hiromi Kirisako
  • Chikara Tanaka
  • Eri Asai
  • Yu Oikawa
  • Hisashi Hirano
  • Yayoi Kimura
  • Michiko Koizumi
  • Li Jing Tan
  • Kazuaki Matoba
  • Nobuo N Noda
  • Junko Ishii

Detail Information

Publications11

  1. doi request reprint Autophagy: close contact keeps out the uninvited
    Hitoshi Nakatogawa
    Frontier Research Center, Tokyo Institute of Technology, Yokohama, Japan Electronic address
    Curr Biol 24:R560-2. 2014
    ..A new study now provides critical insights into the mechanism by which the autophagosomal membrane closely sticks to the target to avoid incorporating material that should not be degraded...
  2. pmc The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation
    Hitoshi Nakatogawa
    Frontier Research Center, Tokyo Institute of Technology, Yokohama 226 8503, Japan
    J Biol Chem 287:28503-7. 2012
    ..We propose that in addition to its essential function in the initial stage, Atg1 also associates with the isolation membrane to promote its maturation into the autophagosome...
  3. doi request reprint Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis
    Hitoshi Nakatogawa
    Frontier Research Center, Tokyo Institute of Technology, Yokohama, Japan
    Autophagy 8:177-86. 2012
    ....
  4. doi request reprint SDS-PAGE techniques to study ubiquitin-like conjugation systems in yeast autophagy
    Hitoshi Nakatogawa
    Frontier Research Center, Tokyo Institute of Technology, Yokohama, Japan
    Methods Mol Biol 832:519-29. 2012
    ..Especially, the latter technique is also ubiquitously applicable for studies on conjugation reactions of ubiquitin (Ub) and other Ubl proteins...
  5. doi request reprint Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site
    Machiko Sakoh-Nakatogawa
    Frontier Research Center, Tokyo Institute of Technology, Yokohama, Japan
    Nat Struct Mol Biol 20:433-9. 2013
    ..Thus, this study reveals the mechanism of the key reaction that drives membrane biogenesis during autophagy...
  6. doi request reprint Dynamics and diversity in autophagy mechanisms: lessons from yeast
    Hitoshi Nakatogawa
    Integrated Research Institute, Tokyo Institute of Technology, Yokohama 2268503, Japan
    Nat Rev Mol Cell Biol 10:458-67. 2009
    ..Analyses of autophagy-related (Atg) proteins have unveiled dynamic and diverse aspects of mechanisms that underlie membrane formation during autophagy...
  7. doi request reprint Localization of Atg3 to autophagy-related membranes and its enhancement by the Atg8-family interacting motif to promote expansion of the membranes
    Machiko Sakoh-Nakatogawa
    Frontier Research Center, Tokyo Institute of Technology, Yokohama 226 8503, Japan
    FEBS Lett 589:744-9. 2015
    ..It is suggested that the AIM-mediated PAS/IM localization of Atg3 facilitates membrane expansion in these structures probably by ensuring active production of Atg8-PE on the membranes. ..
  8. doi request reprint Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of α-mannosidase under nitrogen starvation conditions
    Keisuke Mochida
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan
    FEBS Lett 588:3862-9. 2014
    ..Our findings reveal the regulatory mechanism of a biosynthetic pathway mediated by the autophagy machinery. ..
  9. pmc Hrr25 triggers selective autophagy-related pathways by phosphorylating receptor proteins
    Chikara Tanaka
    Frontier Research Center and Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori ku, Yokohama 226 8503, Japan
    J Cell Biol 207:91-105. 2014
    ....
  10. doi request reprint Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
    Keisuke Mochida
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226 8503, Japan
    Nature 522:359-62. 2015
    ..Our results provide fundamental insight into the pathophysiological roles and mechanisms of 'ER-phagy' and 'nucleophagy' in other organisms. ..
  11. doi request reprint Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy
    Hitoshi Nakatogawa
    Frontier Research Center, Tokyo Institute of Technology, Yokohama 226 8503, Japan
    Essays Biochem 55:39-50. 2013
    ..Thus these two ubiquitin-like systems are intimately involved in driving the biogenesis of the autophagosomal membrane. ..