S Nakamura

Summary

Affiliation: Tokyo Institute of Psychiatry
Country: Japan

Publications

  1. ncbi request reprint Fibroblast growth factor (FGF)-9 immunoreactivity in senile plaques
    S Nakamura
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya, Tokyo 156 8585, Japan
    Brain Res 814:222-5. 1998
  2. ncbi request reprint Motor neurons in human and rat spinal cord synthesize fibroblast growth factor-9
    S Nakamura
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Kamikitazawa, Setagaya, Japan
    Neurosci Lett 221:181-4. 1997
  3. ncbi request reprint Glial expression of fibroblast growth factor-9 in rat central nervous system
    S Nakamura
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Kamikitazawa, Setagaya, Tokyo, Japan
    Glia 28:53-65. 1999
  4. ncbi request reprint Neuronal localization of a novel mosaic apolipoprotein E receptor, LR11, in rat and human brain
    Y Motoi
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Brain Res 833:209-15. 1999
  5. ncbi request reprint Neuronal localization of fibroblast growth factor-9 immunoreactivity in human and rat brain
    T Todo
    Department of Neurosurgery, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    Brain Res 783:179-87. 1998
  6. ncbi request reprint P39 immunoreactivity in glial cytoplasmic inclusions in brains with multiple system atrophy
    Y Honjyo
    Department of Neurology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan
    Acta Neuropathol 101:190-4. 2001
  7. ncbi request reprint Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system
    M a Torii
    Division of Neurobiology, The University of Tokyo Graduate School of Medicine, Bunkyo ku, Tokyo, 113 0033 Japan
    Development 126:443-56. 1999
  8. ncbi request reprint Neurons in the lateral paragigantocellular nucleus projecting to the infralimbic cortex in rats: electrical activity and response to changes in blood pressure
    A Ishikawa
    Department of Neuroscience, Yamaguchi University School of Medicine, Ube, 755-8505, Yamaguchi, Japan
    Neurosci Lett 311:57-60. 2001
  9. ncbi request reprint Requirement of Ras for the activation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons
    N Iida
    Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan
    J Neurosci 21:6459-66. 2001
  10. ncbi request reprint The relationship between alphaB-crystallin and neurofibrillary tangles in Alzheimer's disease
    J J Mao
    Third Department of Internal Medicine, Institute of Health Sciences, Hiroshima, University School of Medicine, Hiroshima, Japan
    Neuropathol Appl Neurobiol 27:180-8. 2001

Detail Information

Publications64

  1. ncbi request reprint Fibroblast growth factor (FGF)-9 immunoreactivity in senile plaques
    S Nakamura
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya, Tokyo 156 8585, Japan
    Brain Res 814:222-5. 1998
    ..The amyloid core and neurofibrillary tangles lacked immunoreactivity. FGF-9 immunoreactive astrocytes were conspicuous in AD brains. FGF-9 may be involved in the neuropathology of AD...
  2. ncbi request reprint Motor neurons in human and rat spinal cord synthesize fibroblast growth factor-9
    S Nakamura
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Kamikitazawa, Setagaya, Japan
    Neurosci Lett 221:181-4. 1997
    ..Our results indicate that these neurons synthesize FGF-9...
  3. ncbi request reprint Glial expression of fibroblast growth factor-9 in rat central nervous system
    S Nakamura
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, Kamikitazawa, Setagaya, Tokyo, Japan
    Glia 28:53-65. 1999
    ..In the present study, we demonstrated that FGF-9 was expressed not only in neurons but also in glial cells in the CNS. FGF-9 was considered to have important functions in adult and developing CNS...
  4. ncbi request reprint Neuronal localization of a novel mosaic apolipoprotein E receptor, LR11, in rat and human brain
    Y Motoi
    Department of Ultrastructure and Histochemistry, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Brain Res 833:209-15. 1999
    ....
  5. ncbi request reprint Neuronal localization of fibroblast growth factor-9 immunoreactivity in human and rat brain
    T Todo
    Department of Neurosurgery, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    Brain Res 783:179-87. 1998
    ..These findings suggest that FGF-9 plays an important role in the central nervous system and may have a potential function closely connected to neurons in the normal brain...
  6. ncbi request reprint P39 immunoreactivity in glial cytoplasmic inclusions in brains with multiple system atrophy
    Y Honjyo
    Department of Neurology, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan
    Acta Neuropathol 101:190-4. 2001
    ..These results suggest that p39 and Cdk5 are up-regulated in oligodendrocytes and may be involved in the formation of GCIs through phosphorylation of cytoskeletal proteins in oligodendrocytes in MSA...
  7. ncbi request reprint Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system
    M a Torii
    Division of Neurobiology, The University of Tokyo Graduate School of Medicine, Bunkyo ku, Tokyo, 113 0033 Japan
    Development 126:443-56. 1999
    ..Thus, we propose that induction of Mash-1 and Prox-1 is one of the critical molecular events that control early development of the CNS...
  8. ncbi request reprint Neurons in the lateral paragigantocellular nucleus projecting to the infralimbic cortex in rats: electrical activity and response to changes in blood pressure
    A Ishikawa
    Department of Neuroscience, Yamaguchi University School of Medicine, Ube, 755-8505, Yamaguchi, Japan
    Neurosci Lett 311:57-60. 2001
    ..These results suggest that the LPGi neurons in a very restricted location influence the IL in response to changes in BP...
  9. ncbi request reprint Requirement of Ras for the activation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons
    N Iida
    Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan
    J Neurosci 21:6459-66. 2001
    ..These results demonstrate that Ras transduces signals elicited by a broad range of stimuli to MAP kinase in hippocampal neurons and further suggest that CREB phosphorylation depends on multiple pathways...
  10. ncbi request reprint The relationship between alphaB-crystallin and neurofibrillary tangles in Alzheimer's disease
    J J Mao
    Third Department of Internal Medicine, Institute of Health Sciences, Hiroshima, University School of Medicine, Hiroshima, Japan
    Neuropathol Appl Neurobiol 27:180-8. 2001
    ..These data suggest that a close relationship exists between the appearance of alphaB-crystallin in neurones, extracellular NFTs, and neurofibrillary formation in alphaB-crystallin positive neurones in Alzheimer brain...
  11. ncbi request reprint The formation of capsule and septum in human hepatocellular carcinoma
    M Ishizaki
    The First Department of Internal Medicine, Okayama University Medical School, Japan
    Virchows Arch 438:574-80. 2001
    ..g., cancer nodule vs non-cancerous liver or another cancer nodule). The wound healing occurs even in HCC. The capsule formation may result from interaction between tumor and host liver and interfere the growth and invasion of HCC...
  12. ncbi request reprint Lack of an association between cystatin C gene polymorphisms in Japanese patients with Alzheimer's disease
    H Maruyama
    Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Neurology 57:337-9. 2001
    ..The authors could not confirm the previously reported association between CST3 polymorphisms and AD in Japan. Age had no effect on the CST3 genotype...
  13. ncbi request reprint Sebaceous gland metaplasia in intraductal papilloma of the breast
    Y F Jiao
    Division of Pathology, School of Medicine, Iwate Medical University, Morioka, Japan
    Virchows Arch 438:505-8. 2001
    ..Immunohistochemically, the cells of the lobules and nests stained positively for monoclonal antibodies anti-cytokeratin 14 and epithelial membrane antigen. This study confirms a novel type of metaplasia of the breast...
  14. ncbi request reprint A novel series of thromboxane A2 synthetase inhibitors with free radical scavenging and anti-peroxidative activities
    S Kamiya
    Research Laboratories, Kyoto Pharmaceutical Industries, Ltd, Japan
    Chem Pharm Bull (Tokyo) 49:563-71. 2001
    ..Compound 13 showed in vivo anti-thrombotic effect in mice and ex vivo anti-peroxidative activity in rats...
  15. ncbi request reprint Improved data processing for optical imaging of developing neuronal connectivity in the neonatal mouse barrel cortex
    C Itami
    National Institute of Neuroscience, NCNP, 187-8502, Tokyo, Japan
    Brain Res Brain Res Protoc 7:103-14. 2001
    ..Successful application of this method has been published on the analysis of thalamocortical glutamatergic connectivity [8]...
  16. ncbi request reprint Evaluation of the expression of NADPH oxidase components during maturation of HL-60 clone 15 cells to eosinophilic lineage
    J Hua
    Department of Biochemistry, Juntendo University, School of Medicine, Tokyo, Japan
    Inflamm Res 50:156-67. 2001
    ..CONCLUSIONS: Together these observations indicate that all the components for NADPH oxidase are expressed, and the superoxide-producing activity is obtained after myelocyte stages during eosinophilic maturation...
  17. ncbi request reprint Plasma thrombin-antithrombin III complex is associated with the severity of experimental autoimmune encephalomyelitis
    Y Inaba
    Department of Pediatrics, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan
    J Neurol Sci 185:89-93. 2001
    ..These results suggest that plasma TAT levels are sensitive markers of the severity of EAE, and may be useful clinical indicators for the severity of human autoimmune demyelinating disorders...
  18. ncbi request reprint Mutation of the doublecortin gene in male patients with double cortex syndrome: somatic mosaicism detected by hair root analysis
    M Kato
    Department of Pediatrics, Yamagata University School of Medicine, Japan
    Ann Neurol 50:547-51. 2001
    ..We conclude that somatic mosaic mutations in the doublecortin gene in male patients can cause subcortical band heterotopia, and that molecular analysis using hair roots is a useful method for detecting somatic mosaicism...
  19. ncbi request reprint Expression of tumor-associated antigen RCAS1 and its possible involvement in immune evasion in oral squamous cell carcinoma
    T Toyoshima
    Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Oral Pathol Med 35:361-8. 2006
    ..The authors investigated RCAS1 expression in oral squamous cell carcinoma (SCC) and its association with the apoptosis of tumor-infiltrating lymphocytes (TILs)...
  20. pmc Blood vessel density correlates with the effects of targeted intra-arterial carboplatin infusion with concurrent radiotherapy for squamous cell carcinomas of the oral cavity and oropharynx
    S Takagi
    Department of Oral and Maxillofacial Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Br J Cancer 94:1580-5. 2006
    ..Therefore, BVD is a valid predictor of the effects of i.a. targeted carboplatin chemotherapy and concurrent radiotherapy for treating human oral and oropharyngeal squamous cell carcinomas...
  21. ncbi request reprint Biological behavior of myoepithelial cells in the regeneration of rat atrophied sublingual glands following release from duct ligation
    S Takahashi
    Department of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, 060 8586, Japan
    J Mol Histol 36:373-9. 2005
    ....
  22. ncbi request reprint Lymphomatous polyposis of the gastrointestinal tract, including mantle cell lymphoma, follicular lymphoma and mucosa-associated lymphoid tissue lymphoma
    T Kodama
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Histopathology 47:467-78. 2005
    ..However, a few reports have suggested that some are follicular lymphoma (FL) or mucosa-associated lymphoid tissue (MALT) lymphomas. In this study, we analysed 35 patients and clarified the clinicopathological features of LP...
  23. ncbi request reprint Active participation of apoptosis and mitosis in sublingual gland regeneration of the rat following release from duct ligation
    S Takahashi
    Department of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo 060 8586, Japan
    J Mol Histol 36:199-205. 2005
    ..These observations suggest that apoptosis as well as mitosis of duct and acinar cells actively participate in and play important roles in sublingual gland regeneration...
  24. ncbi request reprint Cell death and cell proliferation in the regeneration of atrophied rat submandibular glands after duct ligation
    S Takahashi
    Department of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo
    J Oral Pathol Med 33:23-9. 2004
    ..The present study aimed to clarify the proliferation and apoptosis of parenchymal cells during regeneration of rat submandibular glands following atrophy...
  25. ncbi request reprint Characterization of the development of ectopic chondroid/bone matrix and chondrogenic/osteogenic cells during osteoinduction by rhBMP-2: a histochemical and ultrastructural study
    T Nakagawa
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Mie University, Tsu, Mie, Japan
    Oral Dis 9:255-63. 2003
    ..To investigate the characteristics of ectopic chondroid/bone matrix and chondrogenic/osteogenic cells induced by recombinant human bone morphogenetic protein-2 (rhBMP-2)...
  26. ncbi request reprint Piroxicam-induced regression of intestinal adenomatous polyps in APC(delta474) mice
    Z F Qiu
    Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Invest Surg 16:71-81. 2003
    ..In conclusion, piroxicam suppressed the development of large polyps in APC(delta474) mice by inducing apoptosis and inhibiting VEGF expression in interstitial cells of polyps...
  27. ncbi request reprint Materno-fetal coordination of stress-induced Fos expression in the hypothalamic paraventricular nucleus during pregnancy
    T Fujioka
    Department of Neuroscience, Yamaguchi University School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Neuroscience 118:409-15. 2003
    ..In addition, BDNF may play a role in protecting fetal brain neurons from damage caused by severe stress...
  28. ncbi request reprint Endogenous GABA in the commissural subnucleus of the NTS inhibits the carotid chemoreceptor reflex via GABA A receptors in rats
    M Suzuki
    Department of Pharmacology, Saitama Medical School, Saitama, Japan
    J Neural Transm 110:211-8. 2003
    ..These findings suggest that endogenous GABA mainly acts on GABA(A) receptors, and inhibits the chemoreceptor reflex in the commNTS in rats...
  29. ncbi request reprint P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are induced by arsenic trioxide (As(2)O(3)), but are not the main mechanism of As(2)O(3)-resistance in acute promyelocytic leukemia cells
    A Takeshita
    Leukemia 17:648-50. 2003
  30. ncbi request reprint The roles of apoptosis and mitosis in atrophy of the rat sublingual gland
    S Takahashi
    Department of Oral Health Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
    Tissue Cell 34:297-304. 2002
    ..In addition, it appears that the transition from acinar to duct cell and the necrosis of acinar cells play important roles in the atrophy of the sublingual gland...
  31. ncbi request reprint Re-expression of the cadherin-catenin complex in lymph nodes with metastasis in advanced gastric cancer: the relationship with patient survival
    J Liu
    First Dept of Surgery, Faculty of Medicine, Tottori University, Yonago, Japan
    J Exp Clin Cancer Res 21:65-71. 2002
    ..A comparison of the expression patterns of adhesion molecules between the primary tumor and metastatic lymph nodes may provide new prognostic information for patients with advanced gastric cancer...
  32. ncbi request reprint Morphological spectrum of cyclin D1-positive mantle cell lymphoma: study of 168 cases
    Y Yatabe
    Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital, Nagoya, Japan
    Pathol Int 51:747-61. 2001
    ..MCL can be diagnosed with the application of cyclin D1 immunostaining, if careful attention is given to architectural and cytological features...
  33. ncbi request reprint Repair of articular cartilage on the surface of heat-treated bone by transplantation of cultured chondrocytes
    S Nakamura
    Department of Orthopaedic Surgery, Hiroshima University Faculty of Medicine, Japan
    Hiroshima J Med Sci 50:87-96. 2001
    ..We believe that this modality of heat-treated joints will contribute to limb salvage reconstruction after resection of malignant bone tumors adjacent to the joints...
  34. ncbi request reprint Lack of binding observed between human alpha-synuclein and Bcl-2 protein family
    Y Nagano
    Third Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima 734 8551, Japan
    Neurosci Lett 316:103-7. 2001
    ..In contrast, alpha-synuclein was observed to bind to synphilin-1. Although alpha-synuclein has been reported to bind to BAD, modification of alpha-synuclein might be required for such binding to occur...
  35. ncbi request reprint Establishment of a follicular lymphoma cell line (FLK-1) dependent on follicular dendritic cell-like cell line HK
    Y Kagami
    Department of Hematology and Chemotherapy, Aichi Cancer Center Hospital, Nagoya, Japan
    Leukemia 15:148-56. 2001
    ..The FLK-1 cell line may thus prove to be useful for studying the growth mechanism of follicular lymphoma and provide new insights into the pathogenesis of follicular lymphoma...
  36. ncbi request reprint Genetic studies in Parkinson's disease with an alpha-synuclein/NACP gene polymorphism in Japan
    Y Izumi
    Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Neurosci Lett 300:125-7. 2001
    ..In this study, we genotyped the same alpha-SYN/NACP polymorphism in Japanese sPD patients and healthy controls, but found that any aliele showed no significant difference between the two groups...
  37. ncbi request reprint Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma
    K Kitamura
    Department of First Internal Medicine, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 192:553-60. 1993
    ..These data suggest that adrenomedullin is a new hormone participating in blood pressure control. Occurrence of adrenomedullin indicates the possible existence of a novel system for circulation control...
  38. ncbi request reprint Purification of a novel ras GTPase-activating protein from rat brain
    M Maekawa
    Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Biol Chem 268:22948-52. 1993
    ..These results clearly indicate that p100GAPras is a novel ras GAP molecule...
  39. ncbi request reprint Expression and myristoylation of NAP-22 using a baculovirus transfer vector system
    S Maekawa
    Graduate School, Division of Science, University of Tokyo, Japan
    Biochim Biophys Acta 1218:119-22. 1994
    ..In this study, we showed the myristoylation of NAP-22 using a Baculovirus expression system and also showed a liposome binding ability of the expressed protein in Escherichia coli...
  40. ncbi request reprint Differential expression of bovine adseverin in adrenal gland revealed by in situ hybridization. Cloning of a cDNA for adseverin
    S Nakamura
    Department of Pharmacology, Faculty of Medicine, University of Tokyo, Japan
    J Biol Chem 269:5890-6. 1994
    ..The observation strongly suggested that adseverin is not involved in secretory processes in general but is specifically involved in exocytosis...
  41. pmc CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells
    M Matsuda
    Department of Pathology, National Institute of Health, Tokyo, Japan
    Mol Cell Biol 14:5495-500. 1994
    ..The results demonstrate that, in addition to Grb2, CRK participates in signaling from the NGF receptor and that two GNRPs appear to transmit signals from these adaptor molecules to Ras...
  42. ncbi request reprint CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1
    Y Kawaguchi
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    Nat Genet 8:221-8. 1994
    ..Southern blot analyses and genomic cloning demonstrates the existence of related genes. These results raise the possibility that similar abnormalities in related genes may give rise to diseases similar to MJD...
  43. ncbi request reprint Identification and characterization of a sperm peptide antigen recognized by a monoclonal antisperm autoantibody derived from a vasectomized mouse
    S Nakamura
    Department of Obstetrics and Gynecology, Hyogo College of Medicine, Nishinomiya, Japan
    Biochem Biophys Res Commun 205:1503-9. 1994
    ..The rabbit antisera raised to the recombinant protein of the 4A11 cDNA gene showed reaction to mouse, rat, hamster and guinea-pig sperm...
  44. ncbi request reprint Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide
    J Sakata
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 195:921-7. 1993
    ..Synthetic rat adrenomedullin elicits a potent and long-lasting hypotensive activity in anesthetized rats...
  45. ncbi request reprint Regional and subcellular distribution of cyanide metabolizing enzymes in the central nervous system
    Y Mimori
    J Neurochem 43:540-5. 1984
    ..A significant decrease in rhodanese was observed in the posterior column of the cervical or thoracic cord, but the activity in the anterior horn did not differ significantly between the two groups...
  46. pmc Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6
    T Satoh
    Institute of Medical Science, University of Tokyo, Japan
    Mol Cell Biol 8:3546-9. 1988
    ..The BSF-2-stimulated PC12 cells expressed the c-fos proto-oncogene transiently, and they began to change morphologically to neurite-extending cells after several days. The number of voltage-dependent Na+ channels was also increased...
  47. pmc Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor
    Y Furutani
    Nucleic Acids Res 13:5869-82. 1985
    ..The difference in number of amino acid residues results from the carboxy-terminal extention of 4 amino acid residues in human preIL-1. Expression of the cloned human cDNA in E. coli yielded biologically active IL-1...
  48. ncbi request reprint Atrial natriuretic peptide and brain natriuretic peptide coexist in the secretory granules of human cardiac myocytes
    S Nakamura
    Biological Laboratory, Kanagawa Dental College, Yokosuka, Japan
    Am J Hypertens 4:909-12. 1991
    ..No immunoreactive products were found in the control studies. These results suggest that secretion of BNP is under a regulatory mechanism similar to that of ANP...
  49. ncbi request reprint Purification and molecular cloning of a novel acidic calmodulin binding protein from rat brain
    S Maekawa
    Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan
    J Biol Chem 268:13703-9. 1993
    ..Immunoblotting of several tissue extracts using a monoclonal antibody against this protein showed its specific expression in brain...
  50. ncbi request reprint Cloning and expression of a rat brain basic helix-loop-helix factor
    H Kawakami
    Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Biochem Biophys Res Commun 221:199-204. 1996
    ..6 kb and 1.8 kb) were also detected in the mouse embryo, and these decreased in the developmental process. These results suggest that BHF1 may play important roles in cerebellum-specific functions and development of neurons...
  51. ncbi request reprint Structure and organization of the gene encoding human dopamine transporter
    T Kawarai
    Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan
    Gene 195:11-8. 1997
    ..The transcription start site was determined by both 5'-RACE and RNase protection assay. We determined the 5' end of the mRNA by identifying the 5'-terminal cap-G residue in 5'-RACE and RNase protection assay...
  52. ncbi request reprint Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125
    T Nakamura
    Third Department of Internal Medicine, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minamiku, Hiroshima, 734 8551, Japan
    Biochem Biophys Res Commun 280:1085-92. 2001
    ....
  53. pmc Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination
    S Nakamura
    Section of Thoracic Molecular Oncology, Departments of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 20:9391-8. 2000
    ..Taken together, the data suggest that mutations in the putative acetylation sites of the p53 C-terminal domain interfere with ubiquitination, thereby regulating p53 degradation...
  54. ncbi request reprint Differential expression of two glucuronyltransferases synthesizing HNK-1 carbohydrate epitope in the sublineages of the rat myogenic progenitors
    T Nagase
    Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, 187 8502, Tokyo, Japan
    Mech Dev 98:145-9. 2000
    ..Sul-T gene expression was ubiquitously observed in all these myogenic populations. Thus, differential expression of GlcAT genes may relate to the epaxial/hypaxial or migrating/non-migrating myoblast lineages...
  55. ncbi request reprint Neocortical origin and tangential migration of guidepost neurons in the lateral olfactory tract
    N Tomioka
    Division of Biological Science, Nagoya University Graduate School of Science, Japan
    J Neurosci 20:5802-12. 2000
    ..These results reveal a new type of neuronal migration in the telencephalon and introduce an unexpected dramatic feature of the earliest regionalization of the telencephalon...
  56. ncbi request reprint Tissue factor and cancer procoagulant expressed by glioma cells participate in their thrombin-mediated proliferation
    T Ogiichi
    Department of Neurosurgery, Toyama Medical and Pharmaceutical University, Japan
    J Neurooncol 46:1-9. 2000
    ..In the presence of coagulation factors, these glioma cells can generate thrombin and this thrombin generation is capable of inducing glioma cell proliferation in vitro...
  57. ncbi request reprint Cloning of rabbit alpha(1b)-adrenoceptor and pharmacological comparison of alpha(1a)-, alpha(1b)- and alpha(1d)-adrenoceptors in rabbit
    H Piao
    Department of Pharmacology, School of Medicine, Fukui Medical University, Matsuoka, 910 1193, Fukui, Japan
    Eur J Pharmacol 396:9-17. 2000
    ..These results indicate a high identity of structural and pharmacological profiles of three distinct alpha(1)-adrenoceptor subtypes between rabbit and other species, but there are species differences in their distribution...
  58. ncbi request reprint Characterization of phospholipase D activation by GM2 activator in a cell-free system
    H Jinnai
    Department of Biochemistry, Kobe University School of Medicine
    Kobe J Med Sci 45:181-90. 1999
    ..These results facilitate the understanding how the metabolism of both phospholipids and gangliosides is regulated by the same protein...
  59. ncbi request reprint Brain-derived neurotrophic factor requirement for activity-dependent maturation of glutamatergic synapse in developing mouse somatosensory cortex
    C Itami
    Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, 4 1 1, Ogawahigashi, Kodaira, Japan
    Brain Res 857:141-50. 2000
    ..Therefore, we would propose that BDNF is a critical mediator for the maturation of glutamatergic synapse in developing mouse somatosensory cortex...
  60. ncbi request reprint Demarcation of early mammalian cortical development by differential expression of fringe genes
    Y Ishii
    Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, 4 1 1 Ogawa Higashi, Kodaira, Tokyo, Japan
    Brain Res Dev Brain Res 119:307-20. 2000
    ..These observations suggest that a significant number of proliferative cells exist outside the VZ, which supply neurons during early cortical development...
  61. ncbi request reprint Structure and regulation of the human NeuroD (BETA2/BHF1) gene
    T Miyachi
    Third Department of Internal Medicine, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Brain Res Mol Brain Res 69:223-31. 1999
    ..These results raised the possibility that the NeuroD gene expression is positively regulated through the E box sequence, not only by NeuroD itself but also by another E box binding protein...
  62. ncbi request reprint Monkey hepatocytes efficiently express tissue factor pathway inhibitor (TFPI), in contrast with human and rat hepatocytes
    C Hine
    National Cardiovascular Center Research Institute, Suita, Osaka, 565 8565, Japan
    J Biochem 125:1039-47. 1999
    ..The present study indicates that the expression of the monkey TFPI gene is regulated by different mechanisms from the human TFPI gene...
  63. ncbi request reprint Malformation of trachea and pelvic region in goosecoid mutant mice
    C C Zhu
    Forschungszentrum Karlsruhe, Institute of Genetics, Germany
    Dev Dyn 211:374-81. 1998
    ..In addition, we discuss evidence for the existence of at least three goosecoid genes in vertebrates, which may account for the lack of a defect of axial patterning in goosecoid mutant mice...
  64. ncbi request reprint Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells
    S A Miles
    UCLA AIDS Center 90024
    Science 255:1432-4. 1992
    ..Oncostatin M RNA and immunoreactive Oncostatin M protein were found in AIDS-KS-derived cell isolates. These results suggest that Oncostatin M may play a role in the pathogenesis of AIDS-KS...