Affiliation: Tokyo Institute of Technology
Kubo F, Ariestanti D, Oki S, Fukuzawa T, Demizu R, Sato T, et al
. Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells. Respir Res. 2019;20:11 pubmed publisher
..ADGRF5 also has a potential role in the regulation of genes encoding CCL2 in lung ECs, thereby maintaining immune homeostasis. ..
..Ever since the discovery of ubiquitin in 1975[...]. ..
Nakamura N. The Role of the Transmembrane RING Finger Proteins in Cellular and Organelle Function. Membranes (Basel). 2011;1:354-93 pubmed publisher
..This review summarizes the current knowledge of mammalian transmembrane RNF proteins, focusing on their roles and significance. ..
Nakamura N, Hirose S. Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane. Mol Biol Cell. 2008;19:1903-11 pubmed publisher
..Our findings reveal that USP30 participates in the maintenance of mitochondrial morphology, a finding that provides new insight into the cellular function of deubiquitination. ..
Nakamura N, Harada K, Kato M, Hirose S. Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6. Exp Cell Res. 2014;328:207-16 pubmed publisher
..However, elimination of this processing had no evident effect on MARCH6 stabilization. These results suggest that USP19 is involved in the regulation of ERAD by controlling the stability of MARCH6 via deubiquitination...
Ariestanti D, Ando H, Hirose S, Nakamura N. Targeted Disruption of Ig-Hepta/Gpr116 Causes Emphysema-like Symptoms That Are Associated with Alveolar Macrophage Activation. J Biol Chem. 2015;290:11032-40 pubmed publisher
Miyagi H, Nag K, Sultana N, Munakata K, Hirose S, Nakamura N. Characterization of the zebrafish cx36.7 gene promoter: Its regulation of cardiac-specific expression and skeletal muscle-specific repression. Gene. 2016;577:265-74 pubmed publisher
..These results suggest that cx36.7 expression is directed by cardiac promoter activation via the two proximal GATA elements as well as by skeletal muscle-specific promoter repression via the two distal GATA elements. ..
Harada K, Kato M, Nakamura N. USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase. Int J Mol Sci. 2016;17: pubmed
..In addition, the altered expression of USP19 affects the steady-state levels of HRD1. These results suggest that USP19 regulates the stability of HRD1 and provide insight into the regulatory mechanism of the ERAD ubiquitin ligases. ..