Yoshio Nakagawa

Summary

Affiliation: Tokyo Metropolitan Institute of Public Health
Country: Japan

Publications

  1. doi request reprint Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunction
    Yoshio Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, 3 24 1 Hyakunin cho, Shinjuku ku, Tokyo, Japan
    Arch Toxicol 85:1429-40. 2011
  2. ncbi request reprint Biotransformation of chlorpropham (CIPC) in isolated rat hepatocytes and xenoestrogenic activity of CIPC and its metabolites by in vitro assays
    Y Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Research Laboratory of Public Health, 3 24 1, Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
    Xenobiotica 34:257-72. 2004
  3. ncbi request reprint Chlorpropham induces mitochondrial dysfunction in rat hepatocytes
    Yoshio Nakagawa
    Divisions of Pharmacology, Tokyo Metropolitan Institute of Public Health, 3 24 1 Hyakunin cho, Shinjuku ku, 169 0073, Japan
    Toxicology 200:123-33. 2004
  4. ncbi request reprint N-Nitrosofenfluramine induces cytotoxicity via mitochondrial dysfunction and oxidative stress in isolated rat hepatocytes
    Yoshio Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, 3 24 1, Hyakunin cho, Shinjuku ku, Tokyo, 169 0073, Japan
    Arch Toxicol 79:312-20. 2005
  5. ncbi request reprint Role of mitochondrial membrane permeability transition in N-nitrosofenfluramine-induced cell injury in rat hepatocytes
    Yoshio Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, Shinjuku ku, Tokyo 169 0073, Japan
    Eur J Pharmacol 529:33-9. 2006
  6. ncbi request reprint ATP-generating glycolytic substrates prevent N-nitrosofenfluramine-induced cytotoxicity in isolated rat hepatocytes
    Yoshio Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, 3 24 1, Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
    Chem Biol Interact 164:93-101. 2006
  7. ncbi request reprint Biotransformation and cytotoxicity of a brominated flame retardant, tetrabromobisphenol A, and its analogues in rat hepatocytes
    Y Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, Japan
    Xenobiotica 37:693-708. 2007
  8. doi request reprint Cytotoxic effects of 3,4-methylenedioxy-N-alkylamphetamines, MDMA and its analogues, on isolated rat hepatocytes
    Yoshio Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, 3 24 1, Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
    Arch Toxicol 83:69-80. 2009
  9. doi request reprint Biotransformation and cytotoxic effects of hydroxychavicol, an intermediate of safrole metabolism, in isolated rat hepatocytes
    Yoshio Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan
    Chem Biol Interact 180:89-97. 2009
  10. doi request reprint Mitochondrial dysfunction and biotransformation of β-carboline alkaloids, harmine and harmaline, on isolated rat hepatocytes
    Yoshio Nakagawa
    Tokyo Metropolitan Institute of Public Health, Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
    Chem Biol Interact 188:393-403. 2010

Collaborators

Detail Information

Publications27

  1. doi request reprint Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunction
    Yoshio Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, 3 24 1 Hyakunin cho, Shinjuku ku, Tokyo, Japan
    Arch Toxicol 85:1429-40. 2011
    ....
  2. ncbi request reprint Biotransformation of chlorpropham (CIPC) in isolated rat hepatocytes and xenoestrogenic activity of CIPC and its metabolites by in vitro assays
    Y Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Research Laboratory of Public Health, 3 24 1, Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
    Xenobiotica 34:257-72. 2004
    ....
  3. ncbi request reprint Chlorpropham induces mitochondrial dysfunction in rat hepatocytes
    Yoshio Nakagawa
    Divisions of Pharmacology, Tokyo Metropolitan Institute of Public Health, 3 24 1 Hyakunin cho, Shinjuku ku, 169 0073, Japan
    Toxicology 200:123-33. 2004
    ....
  4. ncbi request reprint N-Nitrosofenfluramine induces cytotoxicity via mitochondrial dysfunction and oxidative stress in isolated rat hepatocytes
    Yoshio Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, 3 24 1, Hyakunin cho, Shinjuku ku, Tokyo, 169 0073, Japan
    Arch Toxicol 79:312-20. 2005
    ....
  5. ncbi request reprint Role of mitochondrial membrane permeability transition in N-nitrosofenfluramine-induced cell injury in rat hepatocytes
    Yoshio Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, Shinjuku ku, Tokyo 169 0073, Japan
    Eur J Pharmacol 529:33-9. 2006
    ....
  6. ncbi request reprint ATP-generating glycolytic substrates prevent N-nitrosofenfluramine-induced cytotoxicity in isolated rat hepatocytes
    Yoshio Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, 3 24 1, Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
    Chem Biol Interact 164:93-101. 2006
    ....
  7. ncbi request reprint Biotransformation and cytotoxicity of a brominated flame retardant, tetrabromobisphenol A, and its analogues in rat hepatocytes
    Y Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, Japan
    Xenobiotica 37:693-708. 2007
    ....
  8. doi request reprint Cytotoxic effects of 3,4-methylenedioxy-N-alkylamphetamines, MDMA and its analogues, on isolated rat hepatocytes
    Yoshio Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, 3 24 1, Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
    Arch Toxicol 83:69-80. 2009
    ....
  9. doi request reprint Biotransformation and cytotoxic effects of hydroxychavicol, an intermediate of safrole metabolism, in isolated rat hepatocytes
    Yoshio Nakagawa
    Division of Pharmacology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan
    Chem Biol Interact 180:89-97. 2009
    ....
  10. doi request reprint Mitochondrial dysfunction and biotransformation of β-carboline alkaloids, harmine and harmaline, on isolated rat hepatocytes
    Yoshio Nakagawa
    Tokyo Metropolitan Institute of Public Health, Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
    Chem Biol Interact 188:393-403. 2010
    ....
  11. ncbi request reprint Cytotoxic and xenoestrogenic effects via biotransformation of trans-anethole on isolated rat hepatocytes and cultured MCF-7 human breast cancer cells
    Yoshio Nakagawa
    Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, 3 24 1 Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
    Biochem Pharmacol 66:63-73. 2003
    ....
  12. ncbi request reprint Metabolism of 2-hydroxy-4-methoxybenzophenone in isolated rat hepatocytes and xenoestrogenic effects of its metabolites on MCF-7 human breast cancer cells
    Yoshio Nakagawa
    Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, 3 24 1, Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
    Chem Biol Interact 139:115-28. 2002
    ..These results indicate that some hydroxylated intermediates such as DHB rather than the parent compound act as a xenoestrogen via biotransformation...
  13. ncbi request reprint Genotoxic effects of environmental estrogen-like compounds in CHO-K1 cells
    Sumiko Tayama
    Department of Toxicology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan
    Mutat Res 649:114-25. 2008
    ..Our findings also suggest that E2, DES and BPA have aneuploidogenic properties, and that the former two of chemicals also are polyploidy-inducing agents...
  14. ncbi request reprint Environmental fate of bisphenol A and its biological metabolites in river water and their xeno-estrogenic activity
    Toshinari Suzuki
    Tama Branch Laboratory, Tokyo Metropolitan Institute of Public Health, 3 16 25, Shibazaki cho, Tachikawa shi, Tokyo 190 0023, Japan
    Environ Sci Technol 38:2389-96. 2004
    ..The presence of the bisphenols having the xeno-estrogenic effect suggests the necessity of monitoring those in river water, in the effluent waters from sewage plants, or in landfill leachate...
  15. ncbi request reprint Benzophenone-induced estrogenic potency in ovariectomized rats
    Yoshio Nakagawa
    Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, 3 24 1, Hyakunin cho, Shinjuku ku, Japan
    Arch Toxicol 76:727-31. 2002
    ..Based on these findings, it is apparent that the pro-estrogenic compound benzophenone requires biotransformation to p-hydroxybenzophenone, a metabolite with intrinsic hormonal activity...
  16. ncbi request reprint Metabolism and cytotoxicity of bisphenol A and other bisphenols in isolated rat hepatocytes
    Y Nakagawa
    Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan
    Arch Toxicol 74:99-105. 2000
    ..In addition, the toxic potency of bisphenols to hepatocytes and mitochondria depends on the relative elongation and/or molecular size of the hydrocarbon bridge between the phenolic groups...
  17. ncbi request reprint Metabolism of bisphenol A in isolated rat hepatocytes and oestrogenic activity of a hydroxylated metabolite in MCF-7 human breast cancer cells
    Y Nakagawa
    Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan
    Xenobiotica 31:113-23. 2001
    ....
  18. ncbi request reprint Role of mitochondrial membrane permeability transition in p-hydroxybenzoate ester-induced cytotoxicity in rat hepatocytes
    Y Nakagawa
    Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan
    Biochem Pharmacol 58:811-6. 1999
    ....
  19. ncbi request reprint Mechanism of mitochondrial dysfunction and cytotoxicity induced by tropolones in isolated rat hepatocytes
    Y Nakagawa
    Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan
    Chem Biol Interact 116:45-60. 1998
    ....
  20. ncbi request reprint Metabolism and toxicity of benzophenone in isolated rat hepatocytes and estrogenic activity of its metabolites in MCF-7 cells
    Y Nakagawa
    Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, 3 24 1, Hyakunin cho, Shinjuku ku, 169 0073 Tokyo, Japan
    Toxicology 156:27-36. 2000
    ..Even if there is less free p-hydroxybenzophenone than benzhydrol and sulfate conjugate in hepatocyte suspensions, p-hydroxybenzophenone itself acts as a weak xeno-estrogen on MCF-7 cells...
  21. ncbi request reprint Estrogenic potency of benzophenone and its metabolites in juvenile female rats
    Y Nakagawa
    Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, 3 24 1, Hyakunin cho, Shinjuku ku, Tokyo 169 0073, Japan
    Arch Toxicol 75:74-9. 2001
    ..These results indicate that p-hydroxybenzophenone, a metabolite of benzophenone, exhibits intrinsic xeno-estrogenic activity in the female reproductive tract...
  22. ncbi request reprint Toxicity and effects of 2,6-di-tert-butyl-4-methylphenyl N-methylcarbamate (terbutol) on hepatic cytochrome P450 in F344 rats
    T Suzuki
    Tama Branch Laboratory, Tokyo Metropolitan Research Laboratory of Public Health, 3 16 25, Shibazaki cho, Tachikawa, Tokyo 190 0023, Japan
    Arch Toxicol 75:555-61. 2001
    ..These results indicate that terbutol increased CYP2B subfamily in rat liver microsomes, and that the compound did not cause serious hepatic damage...
  23. ncbi request reprint Effects of dicoumarol on cytotoxicity caused by tert-butylhydroquinone in isolated rat hepatocytes
    Y Nakagawa
    Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan
    Toxicol Lett 84:63-8. 1996
    ....
  24. ncbi request reprint Involvement of mitochondrial phospholipid hydroperoxide glutathione peroxidase as an antiapoptotic factor
    K Nomura
    School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Biol Signals Recept 10:81-92. 2001
    ..A model for the release of cytochrome c by lipid hydroperoxide has also been proposed...
  25. ncbi request reprint Immunohistochemical detection of human gastrointestinal glutathione peroxidase in normal tissues and cultured cells with novel mouse monoclonal antibodies
    H Komatsu
    Department of Immunology, School of Allied Health Sciences, Kitasato University, Minato, Tokyo, Japan
    J Histochem Cytochem 49:759-66. 2001
    ....
  26. ncbi request reprint Inhibitory effects of S-nitrosoglutathione on cell proliferation and DNA synthesis: possible role of glyoxalase I inactivation
    A Mitsumoto
    School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Tokyo, 108-8641, Minato-ku, Japan
    Chem Biol Interact 137:105-21. 2001
    ....
  27. ncbi request reprint Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat
    A Mitsumoto
    School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    Free Radic Res 35:301-10. 2001
    ..We consider that the response of Prxs and DJ-1 on 2D gels could reflect endogenous production of ROS in PQ(2+)-treated cells, and might be a sensitive indicator of oxidative stress status...