Masayuki Nagasawa

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. pmc A pediatric case of systemic lupus erythematosus developed 10 years after cord blood transplantation for juvenile myelomonocytic leukemia
    Masayuki Nagasawa
    Department of Developmental Biology, Post Graduate School, Tokyo Medical and Dental University, 5 45, Yushima 1 chome, Bunkyo ku, Tokyo 113 8519, Japan
    Case Rep Transplant 2012:619126. 2012
  2. pmc Epstein-Barr-Virus-Positive B-Cell Lymphoma of Recipient Origin Despite of the Elimination of Clonally EBV-Infected T Cells by Allogeneic Stem Cell Transplantation in a Patient with Chronic Active EBV Infection
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 5 45, Yushima 1 chome, Bunkyo ku, Tokyo 113 8519, Japan
    Case Rep Transplant 2012:164824. 2012
  3. doi request reprint Early coagulation disorder after allogeneic stem cell transplantation is a strong prognostic factor for transplantation-related mortality, and intervention with recombinant human thrombomodulin improves the outcome: a single-center experience
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Post Graduate School, Tokyo Medical and Dental University, 5 45 Yushima 1 chome, Bunkyo ku, Tokyo, 113 8519, Japan
    Int J Hematol 98:533-42. 2013
  4. pmc Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors
    David H Dreyfus
    Division of Basic Sciences, Department of Pediatrics, National Jewish Medical Research Center, Denver, CO 80262 USA
    BMC Immunol 6:12. 2005
  5. ncbi request reprint Analysis of serum soluble CD40 ligand (sCD40L) in the patients undergoing allogeneic stem cell transplantation: platelet is a major source of serum sCD40L
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Postgraduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Haematol 74:54-60. 2005
  6. ncbi request reprint Pancytopenia presenting with monosomy 7 which disappeared after immunosuppressive therapy
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, 5 45, Yushima 1 chome, Bunkyo ku, Tokyo 113 8519, Japan
    Leuk Res 28:315-9. 2004
  7. ncbi request reprint Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Postgraduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Hematol 83:222-5. 2008
  8. ncbi request reprint Analysis of serum granulysin in patients with hematopoietic stem-cell transplantation: its usefulness as a marker of graft-versus-host reaction
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Hematol 81:340-8. 2006
  9. pmc Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells
    Masako Saito
    Department of Immune Regulation, Japan Science and Technology Agency, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Exp Med 208:235-49. 2011
  10. ncbi request reprint Novel adopted immunotherapy for mixed chimerism after unrelated cord blood transplantation in Omenn syndrome
    Daisuke Tomizawa
    Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Eur J Haematol 75:441-4. 2005

Collaborators

Detail Information

Publications27

  1. pmc A pediatric case of systemic lupus erythematosus developed 10 years after cord blood transplantation for juvenile myelomonocytic leukemia
    Masayuki Nagasawa
    Department of Developmental Biology, Post Graduate School, Tokyo Medical and Dental University, 5 45, Yushima 1 chome, Bunkyo ku, Tokyo 113 8519, Japan
    Case Rep Transplant 2012:619126. 2012
    ..Significance of persistent mixed chimera as a cause of SLE is discussed...
  2. pmc Epstein-Barr-Virus-Positive B-Cell Lymphoma of Recipient Origin Despite of the Elimination of Clonally EBV-Infected T Cells by Allogeneic Stem Cell Transplantation in a Patient with Chronic Active EBV Infection
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 5 45, Yushima 1 chome, Bunkyo ku, Tokyo 113 8519, Japan
    Case Rep Transplant 2012:164824. 2012
    ..EBV-DNA was persistently negative after PBSCT in the peripheral blood. This case is suggestive in management of EBV reactivation after SCT and understanding alloimmune response to EBV...
  3. doi request reprint Early coagulation disorder after allogeneic stem cell transplantation is a strong prognostic factor for transplantation-related mortality, and intervention with recombinant human thrombomodulin improves the outcome: a single-center experience
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Post Graduate School, Tokyo Medical and Dental University, 5 45 Yushima 1 chome, Bunkyo ku, Tokyo, 113 8519, Japan
    Int J Hematol 98:533-42. 2013
    ....
  4. pmc Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors
    David H Dreyfus
    Division of Basic Sciences, Department of Pediatrics, National Jewish Medical Research Center, Denver, CO 80262 USA
    BMC Immunol 6:12. 2005
    ..Interactions between the two proteins, both direct and indirect, have been noted previously and the two proteins play central roles in the control of proliferation and apoptosis...
  5. ncbi request reprint Analysis of serum soluble CD40 ligand (sCD40L) in the patients undergoing allogeneic stem cell transplantation: platelet is a major source of serum sCD40L
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Postgraduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Haematol 74:54-60. 2005
    ..host disease with markedly increased sIL2R, sCD40L was not increased in vivo. These results indicate that sCD40L in vivo is released mainly from the platelets or in the process of platelet production but not from the activated T cells...
  6. ncbi request reprint Pancytopenia presenting with monosomy 7 which disappeared after immunosuppressive therapy
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, 5 45, Yushima 1 chome, Bunkyo ku, Tokyo 113 8519, Japan
    Leuk Res 28:315-9. 2004
    ..Immunosuppressive therapy was effective along with the disappearance of monosomy 7 clone. WT1 mRNA expression was not increased in monosomy 7 clone. Pathogenesis of monosomy 7 and its relation to aplastic anemia is discussed...
  7. ncbi request reprint Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Postgraduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Hematol 83:222-5. 2008
    ..Ksp37 was only slightly increased in HLH patients. These results indicate that TWEAK may be involved in pathogenesis of HLH and is useful as a clinical marker...
  8. ncbi request reprint Analysis of serum granulysin in patients with hematopoietic stem-cell transplantation: its usefulness as a marker of graft-versus-host reaction
    Masayuki Nagasawa
    Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Hematol 81:340-8. 2006
    ..These results indicate that increased release of granulysin presents alloreactivity and serum granulysin is useful as a marker of GVHD in SCT...
  9. pmc Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells
    Masako Saito
    Department of Immune Regulation, Japan Science and Technology Agency, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Exp Med 208:235-49. 2011
    ..These results suggest that the defective generation of IL-10-induced tolerogenic DCs and iT(reg) cells may contribute to inflammatory changes in HIES...
  10. ncbi request reprint Novel adopted immunotherapy for mixed chimerism after unrelated cord blood transplantation in Omenn syndrome
    Daisuke Tomizawa
    Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Eur J Haematol 75:441-4. 2005
    ..host disease, especially in the UCBT setting...
  11. doi request reprint Irreversible leukoencephalopathy after reduced-intensity stem cell transplantation in a dyskeratosis congenita patient with TINF2 mutation
    Takeshi Isoda
    Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan
    J Pediatr Hematol Oncol 35:e178-82. 2013
    ..Therefore, to decrease risk in DC cases after HSCT, strict control of hypertension, graft-versus-host disease, and thrombotic microangiopathy is required...
  12. doi request reprint Successful treatment of diffuse large B-cell lymphoma in a patient with ataxia telangiectasia using rituximab
    Shizuka Machida
    Department of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo, Japan
    J Pediatr Hematol Oncol 35:482-5. 2013
    ....
  13. ncbi request reprint Allogeneic hematopoietic stem cell transplantation for seven children with X-linked hyper-IgM syndrome: a single center experience
    Daisuke Tomizawa
    Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Hematol 76:33-9. 2004
    ..For the high-risk patients, an alternative approach including nonmyeloablative HSCT may be more feasible...
  14. ncbi request reprint Successful nonmyeloablative cord blood transplantation for an infant with malignant infantile osteopetrosis
    Yoichiro Tsuji
    Department of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Pediatr Hematol Oncol 27:495-8. 2005
    ..Because of the urgent need, CBT can be considered as one of the SCT sources for MIOP, especially in a severe, life-threatening setting...
  15. doi request reprint Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes
    Yoko Katsuki
    Department of Pediatrics and Developmental Biology, Graduate Medical School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Sci 99:1539-45. 2008
    ..Most of these cells survived and underwent DNA synthesis. Our findings reveal a novel pharmacological effect of a high concentration of caffeine on genomic stability in dividing cells...
  16. doi request reprint Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation
    Masatoshi Takagi
    Department of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Blood 117:2887-90. 2011
    ..These patients did not satisfy the diagnostic criteria for ALPS or juvenile myelomonocytic leukemia and are probably defined as a new disease entity of RAS-associated ALPS-like disease (RALD)...
  17. ncbi request reprint Successful high-dose methotrexate chemotherapy in a patient with acute lymphocytic leukemia who developed acute renal failure during the initial treatment
    Takeshi Isoda
    Department of Pediatrics and Developmental Biology, Postgraduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Pediatr Int 49:1018-9. 2007
    ..To prevent these nephrotoxicities, hydration and alkalinization of the urine are performed to accelerate the urinary excretion and avoid the precipitation of MTX...
  18. ncbi request reprint Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage
    Ling Chen
    Department of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical and Dental Univesrity, Tokyo, Japan
    Cancer Sci 96:134-41. 2005
    ..Since deficiency of either DNA-Pkcs or ATM leads to defective repair of IR-induced DSB, our finding places Artemis at the signaling crossroads downstream of DNA-PKcs and ATM in IR-induced DSB repair...
  19. ncbi request reprint Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells
    Kumiko Ohnuma-Ishikawa
    Department of Pediatrics, Graduate Medical School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 11308519, Japan
    Cancer Res 67:1019-29. 2007
    ....
  20. pmc Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations
    Shinichiro Nakada
    Department of Pediatrics and Developmental Biology, Graduate Medical School, and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Clin Invest 116:80-9. 2006
    ....
  21. pmc Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Exp Med 206:1291-301. 2009
    ..These results appear to explain, at least in part, why HIES patients suffer from recurrent staphylococcal infections confined to the skin and lung in contrast to more systemic infections in neutrophil-deficient patients...
  22. doi request reprint Allogeneic hematopoietic stem cell transplantation for Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative disease in Japan
    Emiko Sato
    Department of Pediatrics, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo cho, Izumi, Osaka, Japan
    Am J Hematol 83:721-7. 2008
    ..563 +/- 0.124. Thus, in a substantial number of cases, EBV-associated T/NK-LPD can be cured by either allogeneic conventional stem cell transplantation or reduced-intensity stem cell transplantation...
  23. doi request reprint Serum granulysin is elevated in patients with hemophagocytic lymphohistiocytosis
    Masayuki Nagasawa
    Int J Hematol 86:470-3. 2007
  24. ncbi request reprint Selective effect of imatinib on serum IgM in a patient with CML
    Masayuki Nagasawa
    Int J Hematol 80:381-2. 2004
  25. ncbi request reprint Unrelated donor marrow transplantation for congenital immunodeficiency and metabolic disease: an update of the experience of the Japan Marrow Donor Program
    Naoki Sakata
    Department of Pediatrics, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan
    Int J Hematol 80:174-82. 2004
    ....
  26. ncbi request reprint Coagulopathy in a patient with X-linked hyper-IgM syndrome who developed Kaposi's sarcoma
    Masayuki Nagasawa
    Am J Hematol 75:116-7. 2004
  27. ncbi request reprint Granulysin in human serum as a marker of cell-mediated immunity
    Kazuyuki Ogawa
    R and D Center, BML, 1361 1 Matoba, Kawagoe, Saitama 350 1101, Japan
    Eur J Immunol 33:1925-33. 2003
    ....