M Nagao

Summary

Affiliation: Tokyo University of Agriculture
Country: Japan

Publications

  1. ncbi request reprint LacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences
    M Nagao
    Biochemistry Division, National Cancer Center Research Institute, Tsukiji 5, Chuo Ku, 104 0045, Tokyo, Japan
    Mutat Res 477:119-24. 2001
  2. ncbi request reprint Single nucleotide instability without microsatellite instability in rat mammary carcinomas
    N Watanabe
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 61:2632-40. 2001
  3. pmc Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals
    M Nagao
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Environ Health Perspect 104:497-501. 1996
  4. ncbi request reprint Genetic determinant and environmental carcinogens
    M Nagao
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Mutat Res 402:85-91. 1998
  5. ncbi request reprint Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing
    Y Ishizaka
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Oncogene 4:789-94. 1989
  6. ncbi request reprint cDNA cloning of the rat APC gene and assignment to chromosome 18
    M Toyota
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Mamm Genome 6:746-8. 1995
  7. ncbi request reprint Molecular cloning of rat phosphoprotein phosphatase 2A beta cDNA and increased expressions of phosphatase 2A alpha and 2A beta in rat liver tumors
    Y Kitagawa
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 157:821-7. 1988
  8. ncbi request reprint Expression of PP2A B regulatory subunit beta isotype in rat testis
    Y Hatano
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    FEBS Lett 324:71-5. 1993
  9. ncbi request reprint High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat
    R H Dashwood
    Division of Carcinogenesis, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 58:1127-9. 1998
  10. ncbi request reprint Cloning of rat Brca2 and linkage mapping to chromosome 12
    S Yamada
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Mamm Genome 8:850-1. 1997

Detail Information

Publications31

  1. ncbi request reprint LacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences
    M Nagao
    Biochemistry Division, National Cancer Center Research Institute, Tsukiji 5, Chuo Ku, 104 0045, Tokyo, Japan
    Mutat Res 477:119-24. 2001
    ..However, there was no direct correlation between MFs and cancer incidences. Possible mechanisms involved in the discordance between DNA damage markers and cancer incidences are discussed...
  2. ncbi request reprint Single nucleotide instability without microsatellite instability in rat mammary carcinomas
    N Watanabe
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 61:2632-40. 2001
    ....
  3. pmc Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals
    M Nagao
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Environ Health Perspect 104:497-501. 1996
    ..The mechanisms involved in this development of microsatellite instability in PhlP. The mechanisms involved in this development of microsatellite instability in PhlP-induced cancers remain to be elucidated...
  4. ncbi request reprint Genetic determinant and environmental carcinogens
    M Nagao
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Mutat Res 402:85-91. 1998
    ..By mapping the gene, we will be able to identify humans who might belong to high risk group in general population, and cancer can be prevented more efficiently by attaining early diagnosis...
  5. ncbi request reprint Activation of the ret-II oncogene without a sequence encoding a transmembrane domain and transforming activity of two ret-II oncogene products differing in carboxy-termini due to alternative splicing
    Y Ishizaka
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Oncogene 4:789-94. 1989
    ..In addition, differences in the carboxy-terminal amino acid residues in the two types of ret-II oncogene products have no influence on the transforming activity of the ret-II oncogene...
  6. ncbi request reprint cDNA cloning of the rat APC gene and assignment to chromosome 18
    M Toyota
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Mamm Genome 6:746-8. 1995
  7. ncbi request reprint Molecular cloning of rat phosphoprotein phosphatase 2A beta cDNA and increased expressions of phosphatase 2A alpha and 2A beta in rat liver tumors
    Y Kitagawa
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 157:821-7. 1988
    ..0 kb mRNA transcript and a minor 1.4 kb mRNA transcript. These transcripts were both greatly increased in rat liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) regardless of the carcinoma or hyperplastic nodule...
  8. ncbi request reprint Expression of PP2A B regulatory subunit beta isotype in rat testis
    Y Hatano
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    FEBS Lett 324:71-5. 1993
    ..After meiosis, round spermatids change morphologically to elongated spermatids. BR beta may regulate the activity of the PP2A catalytic subunit in spermatids, and be involved in spermatogenic maturation, especially spermatid elongation...
  9. ncbi request reprint High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat
    R H Dashwood
    Division of Carcinogenesis, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 58:1127-9. 1998
    ..In contrast, Ctnnb1 mutations were completely absent in 23 PhIP-induced mammary tumors, in accordance with recent work showing that human breast carcinomas lack mutations in CTNNB1...
  10. ncbi request reprint Cloning of rat Brca2 and linkage mapping to chromosome 12
    S Yamada
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Mamm Genome 8:850-1. 1997
  11. pmc Marked increases of two kinds of two-exon-skipped albumin mRNAs with aging and their further increase by treatment with 3'-methyl-4-dimethylaminoazobenzene in Nagase analbuminemic rats
    T Kaneko
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Proc Natl Acad Sci U S A 88:2707-11. 1991
    ..The 60-kDa protein could be a translation product of mRNAs lacking two exons, the amount of which increases in aged NARs and 3'-MeDAB-treated NARs...
  12. ncbi request reprint Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice
    T Suzuki
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan
    Mutat Res 369:45-9. 1996
    ..8 times higher in the bone marrow, 4.6 times higher in the liver, and 2.6 times higher in the forestomach. No increase in MF was detected in the heart, where no tumors develop...
  13. ncbi request reprint Linkage mapping of the rat Tp53 gene on chromosome 10
    F Canzian
    Carcinogenesis Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104, Japan
    Mamm Genome 7:630. 1996
  14. ncbi request reprint p53 mutations in MeIQ-induced mouse forestomach tumors
    H Makino
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Nihon Ika Daigaku Zasshi 64:39-44. 1997
    ..These results thus indicate that p53 mutations may occur relatively early but do not confer any predisposition for lymph node metastasis...
  15. ncbi request reprint A new modification of the 32P-post-labeling method to recover IQ-DNA adducts as mononucleotides
    M Ochiai
    Biochemistry Division, National Cancer Center Research Institute, Tokyo, Japan
    Mutagenesis 14:239-42. 1999
    ..The third spot, of which the structure is unknown, was minor. The new method is called modified method II. Modified method II could be applicable to a wide variety of chemicals...
  16. pmc Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system
    T Kuramoto
    Carcinogenesis Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Proc Natl Acad Sci U S A 98:559-64. 2001
    ..We conclude from these results that the membrane Atrn has a critical role in normal myelination in the CNS and would provide insights into the physiology of myelination as well as the etiology of myelin diseases...
  17. ncbi request reprint Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas
    T Ushijima
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 60:1092-6. 2000
    ....
  18. ncbi request reprint Population-based mapping of pulmonary adenoma susceptibility 1 locus
    T A Dragani
    National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 60:5017-20. 2000
    ..001) and survival rate (log rank = 0.0014), confirming the mapping of PAS1 and pointing to the role of this locus in human lung cancer...
  19. pmc Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
    H Kakiuchi
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Proc Natl Acad Sci U S A 92:910-4. 1995
    ..PhIP-induced tumors are characterized by their specific and unique mutation, which may be useful for mutational fingerprinting of human cancers...
  20. ncbi request reprint The complete primary structure of the rat A-raf cDNA coding region: conservation of the putative regulatory regions present in rat c-raf
    F Ishikawa
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Oncogene Res 1:243-53. 1987
    ..A-raf was expressed in several tissues and cell line at various amounts...
  21. pmc Carcinogenicity of food mutagens
    T Sugimura
    National Cancer Center, Tokyo, Japan
    Environ Health Perspect 104:429-33. 1996
    ..Carcinogenic risk and anticarcinogenic efficacy are hard to express quantitatively; however, holistic approaches that are designed to improve lifestyle are realistic for cancer prevention...
  22. ncbi request reprint Genetic mapping of the RET protooncogene on rat chromosome 4
    F Canzian
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Mamm Genome 6:433-5. 1995
  23. ncbi request reprint Genetic alterations of androgen receptor gene in Japanese human prostate cancer
    M Watanabe
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Jpn J Clin Oncol 27:389-93. 1997
    ..This study indicates that AR gene mutations play a role, in only a subset of prostate cancer patients, in a treatment-refractory state...
  24. ncbi request reprint cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line
    Y Ishizaka
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 168:402-8. 1990
    ..The aberrant tyrosine kinase activity induced by the rearrangement of ret proto-oncogene could be involved in the development of papillary thyroid carcinoma...
  25. ncbi request reprint Human ret proto-oncogene mapped to chromosome 10q11.2
    Y Ishizaka
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Oncogene 4:1519-21. 1989
    ..These findings suggest that ret proto-oncogene might be a suitable probe for approaching the MEN2A locus...
  26. ncbi request reprint cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase
    N Akiyama
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Eur J Biochem 230:766-72. 1995
    ..Thus BR gamma is though to be a brain-specific isoform of the B regulatory subunit...
  27. ncbi request reprint Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons
    R Mizuguchi
    Department of Neurobioloy, The University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, 113 0033, Tokyo, Japan
    Neuron 31:757-71. 2001
    ..We suggest that distinct classes of transcription factors collaborate to generate motoneurons in the ventral neural tube...
  28. ncbi request reprint Detection and isolation of minisatellite Pc-1 binding proteins
    H Fukuda
    Biochemistry Division, National Cancer Center Research Institute, Tsukiji 5, Chuo-ku, 104, Tokyo, Japan
    Biochim Biophys Acta 1528:152-8. 2001
    ..Sequence specificities for DNA binding were revealed and one base substitution and insertion into the Pc-1 repeat unit dramatically changed the affinity of each protein, suggesting that they bind to Pc-1 and Pc-1-like MNs in vivo...
  29. ncbi request reprint No genetic association between alpha-2 macroglobulin I1000V polymorphism and Japanese sporadic Alzheimer's disease
    N Shibata
    Department of Psychiatry, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, 113 8421, Tokyo, Japan
    Neurosci Lett 290:154-6. 2000
    ..8% in the control and AD groups, respectively. Our results failed to demonstrate an association between this polymorphism and Japanese sporadic AD, and the A2M I1000V mutation does not seem to be a risk factor per se for sporadic AD...
  30. ncbi request reprint Molecular cloning of cDNA for the catalytic subunit of rat liver type 2A protein phosphatase, and detection of high levels of expression of the gene in normal and cancer cells
    Y Kitagawa
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochim Biophys Acta 951:123-9. 1988
    ..High levels of expression of the gene were also detected in mouse NIH3T3 cells and their transformants, and in human cancer cell lines as well as a human immortalized cell line...
  31. ncbi request reprint Sézary syndrome treated with narrowband ultraviolet B: time-course measurement of serum levels of CCL17/CCL27
    Y Masui
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Clin Exp Dermatol 32:57-9. 2007
    ..Sézary cells in peripheral blood correlated with severity of skin lesions. In addition, serum levels of CCL17 and CCL27 decreased as disease activity improved. These chemokines may be important for the pathogenesis of SS...