Nobuyuki Miyasaka

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. pmc Effects of intravenous immunoglobulin therapy in Japanese patients with polymyositis and dermatomyositis resistant to corticosteroids: a randomized double-blind placebo-controlled trial
    Nobuyuki Miyasaka
    Department of Medicine, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mod Rheumatol 22:382-93. 2012
  2. pmc Guidelines for the proper use of etanercept in Japan
    Nobuyuki Miyasaka
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Mod Rheumatol 16:63-7. 2006
  3. ncbi request reprint Adalimumab for the treatment of rheumatoid arthritis
    Nobuyuki Miyasaka
    Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, Japan
    Expert Rev Clin Immunol 5:19-26. 2009
  4. doi request reprint Efficacy and safety of tacrolimus for lupus nephritis: a placebo-controlled double-blind multicenter study
    Nobuyuki Miyasaka
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medicine and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Mod Rheumatol 19:606-15. 2009
  5. pmc Clinical investigation in highly disease-affected rheumatoid arthritis patients in Japan with adalimumab applying standard and general evaluation: the CHANGE study
    Nobuyuki Miyasaka
    Department of Medicine and Rheumatology, Graduate School of Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Mod Rheumatol 18:252-62. 2008
  6. ncbi request reprint Pneumatosis cystoides intestinalis following lupus enteritis and peritonitis
    Fumitaka Mizoguchi
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Intern Med 47:1267-71. 2008
  7. doi request reprint Retinoid ameliorates experimental autoimmune myositis, with modulation of Th cell differentiation and antibody production in vivo
    Naho Ohyanagi
    Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 60:3118-27. 2009
  8. ncbi request reprint Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice
    Fumihito Suzuki
    Department of Medicine and Rheumatology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Immunol 175:6987-96. 2005
  9. ncbi request reprint Inhibition of fractalkine ameliorates murine collagen-induced arthritis
    Toshihiro Nanki
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 173:7010-6. 2004
  10. pmc Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis
    Toshihiro Nanki
    Department of Medicine, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Arthritis Res Ther 11:R149. 2009

Detail Information

Publications87

  1. pmc Effects of intravenous immunoglobulin therapy in Japanese patients with polymyositis and dermatomyositis resistant to corticosteroids: a randomized double-blind placebo-controlled trial
    Nobuyuki Miyasaka
    Department of Medicine, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mod Rheumatol 22:382-93. 2012
    ..These results indicate that GB-0998 can be safely used with the same precautions as other current IVIG therapy...
  2. pmc Guidelines for the proper use of etanercept in Japan
    Nobuyuki Miyasaka
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Mod Rheumatol 16:63-7. 2006
    ....
  3. ncbi request reprint Adalimumab for the treatment of rheumatoid arthritis
    Nobuyuki Miyasaka
    Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, Japan
    Expert Rev Clin Immunol 5:19-26. 2009
    ..6). Adalimumab is even effective in patients with RA treated previously with other biologics. Long-term treatment with adalimumab is safe and well tolerated in patients with RA...
  4. doi request reprint Efficacy and safety of tacrolimus for lupus nephritis: a placebo-controlled double-blind multicenter study
    Nobuyuki Miyasaka
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medicine and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Mod Rheumatol 19:606-15. 2009
    ..In patients on glucocorticoid therapy for lupus nephritis, addition of tacrolimus to basal therapy achieved significant improvement compared with placebo. Tacrolimus may therefore be a useful alternative treatment for lupus nephritis...
  5. pmc Clinical investigation in highly disease-affected rheumatoid arthritis patients in Japan with adalimumab applying standard and general evaluation: the CHANGE study
    Nobuyuki Miyasaka
    Department of Medicine and Rheumatology, Graduate School of Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Mod Rheumatol 18:252-62. 2008
    ..These results and comparable ACR20 responses in Western patients support adalimumab 40 mg every other week as the appropriate dosage to treat RA in Japanese patients...
  6. ncbi request reprint Pneumatosis cystoides intestinalis following lupus enteritis and peritonitis
    Fumitaka Mizoguchi
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Intern Med 47:1267-71. 2008
    ..Although PCI is a rare complication of SLE, the present case suggests that lupus enteritis could be a risk factor for PCI, and that high-dose PSL could cause additional insult to PCI...
  7. doi request reprint Retinoid ameliorates experimental autoimmune myositis, with modulation of Th cell differentiation and antibody production in vivo
    Naho Ohyanagi
    Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 60:3118-27. 2009
    ..The present study was undertaken to examine the effects of a synthetic retinoid, Am80, on experimental autoimmune myositis as well as on Th phenotype development and antibody production...
  8. ncbi request reprint Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice
    Fumihito Suzuki
    Department of Medicine and Rheumatology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Immunol 175:6987-96. 2005
    ..The results also point to the potential therapeutic usefulness of CX3CL1 inhibition and/or blockade of CX3CL1-CX3CR1 interaction in idiopathic inflammatory myopathy...
  9. ncbi request reprint Inhibition of fractalkine ameliorates murine collagen-induced arthritis
    Toshihiro Nanki
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 173:7010-6. 2004
    ..Our results suggest that anti-FKN mAb ameliorates arthritis by inhibiting infiltration of inflammatory cells into the synovium. Thus, FKN can be a new target molecule for the treatment of RA...
  10. pmc Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis
    Toshihiro Nanki
    Department of Medicine, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Arthritis Res Ther 11:R149. 2009
    ..The aims of this study were to determine chemokine receptor expression by B cells both in the peripheral blood of normal donors and subjects with RA, and at the inflammatory site in RA, and the effects of chemokines on B cell activation...
  11. ncbi request reprint Anti-tumor necrosis factor therapy does not diminish the immune response to influenza vaccine in Japanese patients with rheumatoid arthritis
    Tetsuo Kubota
    Tokyo Medical and Dental University Graduate School of Health Sciences, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Mod Rheumatol 17:531-3. 2007
  12. ncbi request reprint Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis
    Hideyuki Iwai
    Department of Molecular Immunology, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 171:2848-54. 2003
    ..Our results demonstrated the involvement of the ICOS-B7h costimulatory pathway in the pathogenesis of lupus nephritis, and the blockade of this pathway may be beneficial for the treatment of human systemic lupus erythematosus...
  13. doi request reprint Drug retention rates and relevant risk factors for drug discontinuation due to adverse events in rheumatoid arthritis patients receiving anticytokine therapy with different target molecules
    Ryoko Sakai
    Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Ann Rheum Dis 71:1820-6. 2012
    ....
  14. pmc NF-kappaB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor
    Tetsuo Kubota
    Department of Microbiology and Immunology, Tokyo Medical and Dental University Graduate School of Health Sciences, Tokyo, Japan
    Arthritis Res Ther 9:R97. 2007
    ....
  15. doi request reprint Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis
    Yousuke Murakami
    Tokyo Medical and Dental University, Department of Medicine and Rheumatology, Graduate School, Tokyo, Japan
    Arthritis Rheum 60:1615-23. 2009
    ..Its blockade rescues the hosts in murine models of sepsis, to clear the bacteria without impairing the host defense. The aim of this study was to investigate the involvement of TREM-1 in an autoimmune, noninfectious disease...
  16. ncbi request reprint Pathogenic role of the CXCL16-CXCR6 pathway in rheumatoid arthritis
    Toshihiro Nanki
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Yushima, Tokyo, Japan
    Arthritis Rheum 52:3004-14. 2005
    ..It is thought that chemokines contribute to T cell accumulation in the synovium. In this study, we examined the role of CXCL16 and CXCR6 in T cell migration and stimulation in RA synovium...
  17. ncbi request reprint A case report of rheumatoid arthritis complicated with rapidly progressive interstitial pneumonia, multiple bullae and pneumomediastinum, which was successfully treated with tacrolimus
    Sae Ochi
    Department of Medicine and Rheumatology, Tokyo Medical and Dental University
    Nihon Rinsho Meneki Gakkai Kaishi 31:62-7. 2008
    ..Although the efficacy of tacrolimus on IP complicated with polymyositis / dermatomyositis and other autoimmune diseases has been reported, this case first suggests its efficacy on IP associated with RA...
  18. doi request reprint Time-dependent increased risk for serious infection from continuous use of tumor necrosis factor antagonists over three years in patients with rheumatoid arthritis
    Ryoko Sakai
    Tokyo Medical and Dental University, Japan
    Arthritis Care Res (Hoboken) 64:1125-34. 2012
    ....
  19. doi request reprint Efficacy and safety of additional use of tacrolimus in patients with early rheumatoid arthritis with inadequate response to DMARDs--a multicenter, double-blind, parallel-group trial
    Shinichi Kawai
    Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, Tokyo, 143 8541, Japan
    Mod Rheumatol 21:458-68. 2011
    ....
  20. ncbi request reprint A new murine model to define the critical pathologic and therapeutic mediators of polymyositis
    Takahiko Sugihara
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 56:1304-14. 2007
    ..To establish a new murine model of polymyositis (PM) for the understanding of its pathologic mechanisms and the development of new treatment strategies...
  21. doi request reprint Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption
    Fumitaka Mizoguchi
    Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3 10 Kanda Surugadai 2 Chome, Chiyoda ku, Tokyo 101 0062, Japan
    J Cell Biochem 109:866-75. 2010
    ..On the other hand, conditional Dicer deletion in osteoblasts by using 2.3 kb type I collagen-Cre did not affect bone mass. These results indicate that Dicer in osteoclasts controls activity of bone resorption in vivo...
  22. doi request reprint Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A
    Naoko Okiyama
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 60:2505-12. 2009
    ..To explore new molecular targets in the treatment of polymyositis (PM) by examining a recently established murine model of PM, C protein-induced myositis (CIM), for involvement of an interleukin-6 (IL-6)/IL-17A pathway...
  23. pmc Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity
    Fumihito Suzuki
    Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arthritis Res Ther 14:R48. 2012
    ....
  24. pmc Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts
    Yukiko Komano
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Arthritis Res Ther 8:R152. 2006
    ..Blockade of accumulation and activation of CD16- monocytes could therefore be a beneficial approach as an anti-bone resorptive therapy, especially for RA...
  25. doi request reprint Expression of CD45 isoforms correlates with differential proliferative responses of peripheral CD4+ and CD8+ T cells
    Iwao Seki
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Immunol Lett 129:39-46. 2010
    ..Thus, the expression of specific CD45 isoforms on T cells correlates with their proliferative response to IL-2, suggesting that controlling cells expressing specific CD45 isoforms could correct excessive or insufficient immune responses...
  26. ncbi request reprint Update on the Japanese guidelines for the use of infliximab and etanercept in rheumatoid arthritis
    Ryuji Koike
    Department of Pharmacovigilance, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Mod Rheumatol 17:451-8. 2007
    ..It is stressed that secondary-care rheumatologists should be better familiarized with the proper use of TNF-alpha blocking agents and be alert to any adverse events for a better management of RA patients...
  27. doi request reprint The effect of synthetic retinoid, Am80, on T helper cell development and antibody production in murine collagen-induced arthritis
    Aya Sato
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mod Rheumatol 20:244-51. 2010
    ..Am80 exhibits inhibitory effects on CIA and might regulate both Th development and Ab production in vivo. Decreased Th17 by treatment with Am80 might be responsible for the attenuation of arthritis...
  28. doi request reprint Pathogenic role of CXCR7 in rheumatoid arthritis
    Kaori Watanabe
    Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 62:3211-20. 2010
    ..CXCR7 was recently identified as an alternative receptor for CXCL12. We undertook this study to analyze the expression of CXCR7 in RA synovium and the pathogenic role of the CXCL12/CXCR7 pathway in RA...
  29. pmc Pathological role of osteoclast costimulation in arthritis-induced bone loss
    Sae Ochi
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8549, Japan
    Proc Natl Acad Sci U S A 104:11394-9. 2007
    ..These results establish the pathological role of costimulatory receptors for RANK in bone loss in arthritis and may provide a molecular basis for the future therapy of inflammatory diseases...
  30. doi request reprint Definitive engagement of cytotoxic CD8 T cells in C protein-induced myositis, a murine model of polymyositis
    Takahiko Sugihara
    Tokyo Medical and Dental University, Tokyo, and Yokohama Institute, RIKEN, Yokohama, Japan
    Arthritis Rheum 62:3088-92. 2010
    ..To substantiate a pathogenic role of cytotoxic CD8 T cells in the development of a murine polymyositis model, C protein-induced myositis (CIM)...
  31. doi request reprint Incidence and risk factors for serious infection in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors: a report from the Registry of Japanese Rheumatoid Arthritis Patients for Longterm Safety
    Yukiko Komano
    Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, and the Clinical Research Center, Tokyo Medical and Dental University, Tokyo, Japan
    J Rheumatol 38:1258-64. 2011
    ..To compare tumor necrosis factor-α (TNF-α) inhibitors to nonbiological disease-modifying antirheumatic drugs (DMARD) for the risk of serious infection in Japanese patients with rheumatoid arthritis (RA)...
  32. doi request reprint Anti-arthritic effect of E3 ubiquitin ligase, c-MIR, expression in the joints
    Masayasu Toyomoto
    Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Int Immunol 23:177-83. 2011
    ..These results have disclosed a new function of c-MIR, inhibition of inflammatory cytokine production. Induction of c-MIR in the joints could be a new therapeutic approach to the treatment of RA...
  33. ncbi request reprint Direct modulation of rheumatoid inflammatory mediator expression in retinoblastoma protein-dependent and -independent pathways by cyclin-dependent kinase 4/6
    Yoshinori Nonomura
    Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 54:2074-83. 2006
    ..The purpose of this study was to determine whether CDK activity directly modulates the production of inflammatory molecules in patients with rheumatoid arthritis (RA)...
  34. ncbi request reprint [A case report of hypertrophic pachymeningitis associated with systemic lupus erythematosus, showing a headache and hearing loss resembling intracranial hypotension]
    Sae Ochi
    Department of Medicine and Rheumatology, Tokyo Medical and Dental University
    Nihon Rinsho Meneki Gakkai Kaishi 30:55-60. 2007
    ..Although hypertrophic pachymeningitis is a rare complication with SLE, it should be considered in SLE patients with severe headache...
  35. doi request reprint Pneumocystis jirovecii pneumonia associated with etanercept treatment in patients with rheumatoid arthritis: a retrospective review of 15 cases and analysis of risk factors
    Michi Tanaka
    Department of Pharmacovigilance, Tokyo Medical and Dental University, Tokyo, Japan
    Mod Rheumatol 22:849-58. 2012
    ..The goal of this study was to clarify the clinical characteristics and the risk factors of RA patients who developed Pneumocystis jirovecii pneumonia (PCP) during etanercept therapy...
  36. doi request reprint Elevation of KL-6 serum levels in clinical trials of tumor necrosis factor inhibitors in patients with rheumatoid arthritis: a report from the Japan College of Rheumatology Ad Hoc Committee for Safety of Biological DMARDs
    Masayoshi Harigai
    The Ad Hoc Committee for the Safety of Biological DMARDs, Japan College of Rheumatology, 1 1 24 Toranomon, Minato ku, Tokyo 105 0001, Japan
    Mod Rheumatol 23:284-96. 2013
    ..The associations between elevated levels of serum Krebs von den Lungen-6 (KL-6) and treatment of rheumatoid arthritis (RA) with tumor necrosis factor (TNF) inhibitors were investigated in five Japanese clinical trials...
  37. ncbi request reprint Leflunomide-related acute interstitial pneumonia in two patients with rheumatoid arthritis: autopsy findings with a mosaic pattern of acute and organizing diffuse alveolar damage
    Sae Ochi
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University Hospital, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Mod Rheumatol 16:316-20. 2006
    ..Methylprednisolone pulse therapy and cholestyramine ameliorated her IP. The implication of leflunomide in the pathogenesis of IP was suggested...
  38. doi request reprint Pneumocystis jiroveci pneumonia in patients with rheumatoid arthritis treated with infliximab: a retrospective review and case-control study of 21 patients
    Yukiko Komano
    Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 61:305-12. 2009
    ..To establish proper management of Pneumocystis jiroveci pneumonia (PCP) in rheumatoid arthritis (RA) patients treated with infliximab. PCP has been observed in 0.4% of patients with RA treated with infliximab in Japan...
  39. doi request reprint Infected abdominal aortic aneurysm caused by nontyphoid Salmonella in an immunocompromised patient with rheumatoid arthritis
    Kayoko Kaneko
    Department of Medicine and Rheumatology, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Infect Chemother 15:312-5. 2009
    ....
  40. doi request reprint Possible involvement of chemokine-induced platelet activation in thrombophilic diathesis of antiphospholipid syndrome
    Tetsuo Kubota
    Tokyo Medical and Dental University Graduate School of Health Care Sciences, Department of Microbiology and Immunology, Tokyo, Japan
    Ann N Y Acad Sci 1173:137-45. 2009
    ..These results suggest that the NF-kappaB pathway may be a potential therapeutic target relating to both the coagulation pathway and platelet activity...
  41. doi request reprint Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients
    Naomi Takahashi
    Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 182:5515-27. 2009
    ..Our study suggests that extensive T cell dysfunction, decreased memory T cell compartment, and imbalance between effector and regulatory cells in ICOS-deficient patients may underlie their immunodeficiency and/or autoimmunity...
  42. pmc Japan College of Rheumatology 2009 guidelines for the use of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, in rheumatoid arthritis
    Ryuji Koike
    Department of Pharmacovigilance, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mod Rheumatol 19:351-7. 2009
    ..The guidelines are intended as a guide for postmarketing surveillance and clinical practice, and will be revised periodically based on the surveillance...
  43. ncbi request reprint Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation
    Hideyuki Iwai
    Department of Molecular Immunology, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    J Immunol 169:4332-9. 2002
    ....
  44. doi request reprint Am80, a retinoic acid receptor agonist, ameliorates murine vasculitis through the suppression of neutrophil migration and activation
    Chie Miyabe
    Tokyo Medical and Dental University and Tokyo Medical University, Tokyo, Japan
    Arthritis Rheum 65:503-12. 2013
    ..This study was undertaken to examine the therapeutic effects of a synthetic retinoid, Am80, in a murine model of vasculitis induced by Candida albicans water-soluble fraction (CAWS)...
  45. doi request reprint p16(INK4a) exerts an anti-inflammatory effect through accelerated IRAK1 degradation in macrophages
    Yousuke Murakami
    Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Immunol 189:5066-72. 2012
    ..Thus, p16(INK4a) senescence gene upregulation inhibits inflammatory cytokine production in macrophages in a different way than in RSF...
  46. doi request reprint T lymphocytes and muscle condition act like seeds and soil in a murine polymyositis model
    Naoko Okiyama
    Tokyo Medical and Dental University, Japan
    Arthritis Rheum 64:3741-9. 2012
    ..We undertook the present study to delineate the roles of innate and acquired immunity in myositis...
  47. ncbi request reprint [Treatment guidelines for the use of biologics in rheumatoid arthritis; present and future]
    Nobuyuki Miyasaka
    Department of Medicine and Rheumatology, Tokyo Medical and Dental University
    Nihon Rinsho 65:1169-78. 2007
    ..We introduce the revised guidelines for the use of biologics in Japanese RA patients in this article...
  48. doi request reprint Hypoxia-induced abrogation of contact-dependent inhibition of rheumatoid arthritis synovial fibroblast proliferation
    Yoshinori Nonomura
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, 113 8519, Tokyo, Japan
    J Rheumatol 36:698-705. 2009
    ..Since synovial tissues in the rheumatoid joints are hypoxic, we investigated how hypoxia affects RA synovial fibroblast (RASF) proliferation...
  49. doi request reprint A retrospective study of serum KL-6 levels during treatment with biological disease-modifying antirheumatic drugs in rheumatoid arthritis patients: a report from the Ad Hoc Committee for Safety of Biological DMARDs of the Japan College of Rheumatology
    Akito Takamura
    Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Mod Rheumatol 23:297-303. 2013
    ....
  50. pmc Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis
    Kayoko Kaneko
    Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Arthritis Res Ther 13:R158. 2011
    ..In this study, we analyzed the expression of chemerin and ChemR23 in the synovium of rheumatoid arthritis (RA) patients and the stimulatory effects of chemerin on fibroblast-like synoviocytes (FLSs) from RA patients...
  51. ncbi request reprint [CTLA4-Ig]
    Nobuyuki Miyasaka
    Department of Medicine and Rheumatology, Tokyo Medical and Dental University
    Nihon Rinsho 63:751-5. 2005
  52. doi request reprint Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis
    Eizo Saito
    Department of Rheumatology, Toho University Ohashi Medical Center, Tokyo, Japan
    Mod Rheumatol 18:34-44. 2008
    ..8%) during the study period, but none of the adverse reactions were considered to be serious or required emergency treatment. In conclusion, the present study indicates that IVIG therapy is effective for steroid-resistant PM/DM...
  53. pmc Effect of a small molecule inhibitor of nuclear factor-kappaB nuclear translocation in a murine model of arthritis and cultured human synovial cells
    Kyoko Wakamatsu
    Department of Microbiology and Immunology, Tokyo Medical and Dental University Graduate School of Health Sciences, Tokyo, Japan
    Arthritis Res Ther 7:R1348-59. 2005
    ....
  54. doi request reprint Therapeutic effect of D1-like dopamine receptor antagonist on collagen-induced arthritis of mice
    Hiroki Nakashioya
    Global Center of Excellence GCOE Program, Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mod Rheumatol 21:260-6. 2011
    ..Our results argue that D1R blockade is potentially a new approach to the treatment of RA. Its effect could be partly attributable to the inhibition of osteoclastogenesis...
  55. ncbi request reprint SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit
    Koh Yamamoto
    Department of Hematology and Oncology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 310:1188-93. 2003
    ....
  56. doi request reprint Varicella-zoster virus hepatitis in polymyositis
    Fumitaka Mizoguchi
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Mod Rheumatol 18:301-5. 2008
    ..Physicians should be aware that VZV infection could complicate severe hepatitis in immuno-suppressed patients...
  57. ncbi request reprint Excessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B
    Masayoshi Harigai
    Department of Pharmacovigilance, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
    J Immunol 181:2211-9. 2008
    ....
  58. pmc Golimumab monotherapy in Japanese patients with active rheumatoid arthritis despite prior treatment with disease-modifying antirheumatic drugs: results of the phase 2/3, multicentre, randomised, double-blind, placebo-controlled GO-MONO study through 24 we
    Tsutomu Takeuchi
    Division of Rheumatology, Keio University, Shinjuku ku, Tokyo, Japan
    Ann Rheum Dis 72:1488-95. 2013
    ..To evaluate the efficacy and safety of golimumab 50 and 100 mg monotherapy in Japanese patients with active rheumatoid arthritis (RA) despite treatment with disease-modifying antirheumatic drugs (DMARDs)...
  59. doi request reprint Discontinuation of adalimumab treatment in rheumatoid arthritis patients after achieving low disease activity
    Masayoshi Harigai
    Department of Pharmacovigilance, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
    Mod Rheumatol 22:814-22. 2012
    ..We implemented a retrospective study to explore discontinuation of therapy with adalimumab (ADA) without exacerbation in rheumatoid arthritis (RA) patients who had achieved low disease activity (LDA) with the biological agent...
  60. doi request reprint Interleukin-1 and tumor necrosis factor α blockade treatment of experimental polymyositis in mice
    Takahiko Sugihara
    Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 64:2655-62. 2012
    ....
  61. ncbi request reprint Cognitive dysfunction in systemic lupus erythematosus
    Asako Emori
    Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan
    Psychiatry Clin Neurosci 59:584-9. 2005
    ..The results suggest that verbal memory and psychomotor speed underlie the neuropsychiatric symptoms seen in SLE patients...
  62. doi request reprint A case of Behçet's disease with widespread perforating enteric ulcers preceded by a long history of peripheral gangrene
    Kyoko Honne
    Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Mod Rheumatol 21:651-4. 2011
    ..Thus, the disease course of this patient was characterized by the reappearance of peripheral gangrene after a long interval that preceded the devastating intestinal lesions...
  63. ncbi request reprint A multicenter phase I/II trial of rituximab for refractory systemic lupus erythematosus
    Yoshiya Tanaka
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahata Nishi, Kitakyushu 807 8555, Japan
    Mod Rheumatol 17:191-7. 2007
    ..Rituximab therapy appears to be safe for the treatment of active SLE patients and holds significant therapeutic promise, at least for the majority of patients experiencing profound B-cell depletion...
  64. ncbi request reprint Gene transfer of a cell cycle modulator exerts anti-inflammatory effects in the treatment of arthritis
    Yoshinori Nonomura
    Department of Bioregulatory Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Immunol 171:4913-9. 2003
    ....
  65. doi request reprint A case of IgG4-related disease with features of Mikulicz's disease, and retroperitoneal fibrosis and lymphadenopathy mimicking Castleman's disease
    Kenchi Takenaka
    Department of Medicine and Rheumatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Mod Rheumatol 21:410-4. 2011
    ....
  66. ncbi request reprint Step-up versus primary intensive approach to the treatment of interstitial pneumonia associated with dermatomyositis/polymyositis: a retrospective study
    Kazuki Takada
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mod Rheumatol 17:123-30. 2007
    ..Prospective clinical investigation of this approach is now needed, but the limited clinical utility of CS as an initial treatment might ethically challenge clinical-trial designing...
  67. doi request reprint Arthritic joint-targeting small interfering RNA-encapsulated liposome: implication for treatment strategy for rheumatoid arthritis
    Yukiko Komano
    Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    J Pharmacol Exp Ther 340:109-13. 2012
    ....
  68. ncbi request reprint Development of TCRB CDR3 length repertoire of human T lymphocytes
    Junko Nishio
    Department of Bioregulatory Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Int Immunol 16:423-31. 2004
    ..Thus, the TCRB CDR3 length repertoires are finely tuned in the thymus before the lymphocytes emigrate into the peripheral blood...
  69. ncbi request reprint [An autopsy case of intestinal Behcet's disease with sacroiliitis accompanied by myelodysplastic syndrome with trisomy 8. ]
    Rieko Tsubata
    Department of Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 28:48-55. 2005
    ..We reviewed similar cases reported and investigated the association of intestinal Behcet's disease with trisomy 8. The association of sacroiliitis with Behcet's disease is also studied...
  70. ncbi request reprint [Etanercept for therapy of rheumatoid arthritis]
    Nobuyuki Miyasaka
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University
    Nihon Rinsho 63:521-5. 2005
  71. pmc Baseline tumour necrosis factor alpha levels predict the necessity for dose escalation of infliximab therapy in patients with rheumatoid arthritis
    Tsutomu Takeuchi
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Ann Rheum Dis 70:1208-15. 2011
    ..To investigate the possible role of baseline plasma tumour necrosis factor alpha levels (baseline-TNF) on the clinical response to infliximab in patients with rheumatoid arthritis (RA)...
  72. doi request reprint Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss
    Fumitaka Mizoguchi
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Cell Physiol 216:47-53. 2008
    ..TRPV4 protein is expressed in both osteoblasts and osteoclasts. These results indicated that TRPV4 plays a critical role in unloading-induced bone loss...
  73. doi request reprint Tacrolimus-induced pulmonary injury in rheumatoid arthritis patients
    Ryuji Koike
    Tokyo Medical and Dental University, Tokyo, Japan
    Pulm Pharmacol Ther 24:401-6. 2011
    ..As of May 2007, spontaneous reports identified twenty-seven cases of exacerbation or new development of interstitial pneumonia among RA patients given TAC in Japan...
  74. doi request reprint Etanercept-induced necrotizing crescentic glomerulonephritis in two patients with rheumatoid arthritis
    Kayoko Kaneko
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Mod Rheumatol 20:632-6. 2010
    ..In both patients, nephritis improved following discontinuation of etanercept and administration of prednisolone. Physicians should be aware of etanercept-induced GN in patients with RA on anti-tumor necrosis factor therapy...
  75. ncbi request reprint The gene delivery system for rheumatoid synovium
    Makoto Nakasato
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University
    Nihon Rinsho Meneki Gakkai Kaishi 31:17-22. 2008
    ..We hope that it will be applied to RA therapy in near future...
  76. ncbi request reprint [A case of progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus]
    Hideki Kaneko
    Department of Medicine and Rheumatology, Tokyo Medical and Dental University
    Nihon Rinsho Meneki Gakkai Kaishi 31:465-9. 2008
    ..In patients with SLE presenting with subacute neurological abnormalities and white matter lesions in the brain, PML should be considered in the differential diagnosis...
  77. ncbi request reprint Polymyositis/dermatomyositis and interstitial lung disease: a new therapeutic approach with T-cell-specific immunosuppressants
    Kazuki Takada
    Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Autoimmunity 38:383-92. 2005
    ..FK506 may be advantageous even in refractory cases to CsA. These findings indicate that further investigation is warranted. Currently, prospective investigation of FK506 is underway...
  78. ncbi request reprint Migration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis
    Toshihiro Nanki
    Department of Bioregulatory Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arthritis Rheum 46:2878-83. 2002
    ..In this study, we examined the role of CX3CL1/fractalkine and its receptor CX3C chemokine receptor 1 (CX3CR1) in the T cell migration into RA synovium...
  79. ncbi request reprint Complete cDNA coding sequence of the HLA-DRB1*1405 allele
    Hitoshi Kohsaka
    Department of Bioregulatory Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    DNA Seq 13:359-61. 2002
    ..Functional analyses would discern if these allelic differences in the cytoplasmic domain are of functional significance...
  80. ncbi request reprint A case of Muckle-Wells syndrome caused by a novel H312P mutation in NALP3 (cryopyrin)
    Ryuji Koike
    Department of Pharmacovigilance, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Mod Rheumatol 17:496-9. 2007
    ..The diagnosis was established on the basis of a typical clinical picture together with a missense mutation, which replaced an amino acid adjacent to one in an earlier reported case of MWS resembling this one...
  81. ncbi request reprint [False-positive reaction of urinary ketone bodies caused by bucillamine]
    Hiroko Ogasawara
    Department of Clinical Laboratory, Tokyo Medical and Dental University, Bunkyo ku, Tokyo
    Rinsho Byori 56:584-8. 2008
    ..In the evaluation of ketone findings on urinary dipstick, the physician must ascertain whether the patient is taking bucillamine...
  82. ncbi request reprint Usefulness of cyclosporine A on rapidly progressive interstitial pneumonia in dermatomyositis
    Shuji Miyake
    Pulmonary Medicine, Tokyo Medical and Dental University, Japan
    Sarcoidosis Vasc Diffuse Lung Dis 19:128-33. 2002
    ..Recently cyclosporine A (CyA) has emerged as an available treatment for interstitial pneumonia in PM/DM, but its efficacy on RPIP is unclear...
  83. ncbi request reprint [An autopsied case of chronic active Epstein-Barr virus infection complicated in systemic lupus erythematosus and antiphospholipid antibody syndrome]
    Jun Ogawa
    Department of Bioregulatory Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University
    Nihon Rinsho Meneki Gakkai Kaishi 25:458-65. 2002
    ..Final pathological diagnosis was CAEBV with hemophagocytic syndrome in association with lupus nephritis, pulmonary hemorrhage and pulmonary infarction...
  84. ncbi request reprint Abnormal regional cerebral blood flow in systemic lupus erythematosus patients with psychiatric symptoms
    Kenji Oda
    Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan
    J Clin Psychiatry 66:907-13. 2005
    ..Using L,L-ethyl cysteinate dimer (99mTc ECD) SPECT and SPM, we aimed to clarify the association of rCBF changes with psychiatric symptoms in SLE patients whose magnetic resonance imaging (MRI) showed no morphological abnormalities...
  85. ncbi request reprint [Introduction: Cytokine receptors and their classification]
    Nobuyuki Miyasaka
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University
    Nihon Rinsho 63:5-9. 2005
  86. ncbi request reprint The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells
    Koh Yamamoto
    Department of Hematology and Oncology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8519, Tokyo, Japan
    Biochem Biophys Res Commun 297:1245-52. 2002
    ..These results indicate that the IL-12-induced expression of the perforin gene in NK cells is directly regulated by STAT4, which binds, most likely as a homo-tetramer, to the tandem STAT-binding sequences in the perforin gene promoter...
  87. doi request reprint Expression and tyrosine phosphorylation of Crk-associated substrate lymphocyte type (Cas-L) protein in human neutrophils
    Tetsuya Nakamoto
    21st Century Center of Excellence COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Tokyo, Japan
    J Cell Biochem 105:121-8. 2008
    ..These findings suggest that Cas-L is one of the targets of inflammatory cytokines and is also modulated by cell adhesion process in neutrophils...