Hiroaki Miyaoka

Summary

Affiliation: Tokyo University of Pharmacy and Life Science
Country: Japan

Publications

  1. ncbi request reprint PLA2 inhibitory activity of marine sesterterpenoids cladocorans, their diastereomers and analogues
    Hiroaki Miyaoka
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan
    Chem Pharm Bull (Tokyo) 54:268-70. 2006
  2. ncbi request reprint Terpene isocyanides, isocyanates, and isothiocyanates from the Okinawan marine sponge Stylissa sp
    Hidemichi Mitome
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Nat Prod 67:833-7. 2004
  3. ncbi request reprint 8,17-Epoxybriarane diterpenoids, briaranolides A-J, from an Okinawan Gorgonian Briareum sp
    Ayako Hoshino
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Nat Prod 68:1328-35. 2005
  4. ncbi request reprint New polyhydroxylated sterols stylisterols A-C and a novel 5,19-cyclosterol hatomasterol from the Okinawan marine sponge Stylissa sp
    Hidemichi Mitome
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Steroids 70:63-70. 2005
  5. ncbi request reprint New strongylophorines from the Okinawan marine sponge Petrosia (Strongylophora) corticata
    Ayako Hoshino
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Nat Prod 66:1600-5. 2003
  6. ncbi request reprint Practical synthesis of a key intermediate for lactacystin from (R)-4-hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate
    Hiroaki Miyaoka
    School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 56:738-41. 2008
  7. ncbi request reprint Synthesis of marine diterpene isocyanide (-)-kalihinol Y and diterpene isothiocyanate (-)-10-epi-kalihinol I
    Hiroaki Miyaoka
    School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Chem Pharm Bull (Tokyo) 60:1224-6. 2012
  8. doi request reprint Total synthesis of antimalarial diterpenoid (+)-kalihinol A
    Hiroaki Miyaoka
    School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Chem Commun (Camb) 48:901-3. 2012
  9. ncbi request reprint Total synthesis of cladocorans A and B: a structural revision
    Hiroaki Miyaoka
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Org Chem 68:3476-9. 2003
  10. pmc Total synthesis and absolute configuration of the marine norditerpenoid xestenone
    Koichiro Ota
    School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo, Japan
    Mar Drugs 7:654-71. 2009

Collaborators

Detail Information

Publications14

  1. ncbi request reprint PLA2 inhibitory activity of marine sesterterpenoids cladocorans, their diastereomers and analogues
    Hiroaki Miyaoka
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan
    Chem Pharm Bull (Tokyo) 54:268-70. 2006
    ..Inhibition of secretory phospholipase A(2) (sPLA(2)) by cladocorans A and B and their diastereomers almost equaled that of manoalide...
  2. ncbi request reprint Terpene isocyanides, isocyanates, and isothiocyanates from the Okinawan marine sponge Stylissa sp
    Hidemichi Mitome
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Nat Prod 67:833-7. 2004
    ..along with 12 known related compounds. Structural determinations of these compounds were made by spectroscopic analysis, and assessment was made of their cytotoxicity toward HeLa cells...
  3. ncbi request reprint 8,17-Epoxybriarane diterpenoids, briaranolides A-J, from an Okinawan Gorgonian Briareum sp
    Ayako Hoshino
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Nat Prod 68:1328-35. 2005
    ..The structure of the diterpenoids was determined on the basis of spectroscopic analysis, chemical conversions, and X-ray analysis...
  4. ncbi request reprint New polyhydroxylated sterols stylisterols A-C and a novel 5,19-cyclosterol hatomasterol from the Okinawan marine sponge Stylissa sp
    Hidemichi Mitome
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Steroids 70:63-70. 2005
    ..Structural determinations of these compounds were made by spectroscopic analysis and chemical conversion. Assessment of cytotoxicity toward HeLa cells was also determined...
  5. ncbi request reprint New strongylophorines from the Okinawan marine sponge Petrosia (Strongylophora) corticata
    Ayako Hoshino
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Nat Prod 66:1600-5. 2003
    ..Assessment was also made of the cytotoxicity of strongylophorines-1, -2, -3, -4, -22 (1), -23 (2), and -24 (3) toward HeLa cells...
  6. ncbi request reprint Practical synthesis of a key intermediate for lactacystin from (R)-4-hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate
    Hiroaki Miyaoka
    School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 56:738-41. 2008
    ..R)-4-Hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate is a useful chiral building block for the synthesis of biologically active compounds containing alpha-substituted alpha-amino acid moieties...
  7. ncbi request reprint Synthesis of marine diterpene isocyanide (-)-kalihinol Y and diterpene isothiocyanate (-)-10-epi-kalihinol I
    Hiroaki Miyaoka
    School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Chem Pharm Bull (Tokyo) 60:1224-6. 2012
    ..The absolute structures of these compounds were confirmed by these syntheses...
  8. doi request reprint Total synthesis of antimalarial diterpenoid (+)-kalihinol A
    Hiroaki Miyaoka
    School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Chem Commun (Camb) 48:901-3. 2012
    ....
  9. ncbi request reprint Total synthesis of cladocorans A and B: a structural revision
    Hiroaki Miyaoka
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Org Chem 68:3476-9. 2003
    ..Cladocoran B is thus clearly shown to be an olefinic regioisomer of dysidiolide and cladocoran A as its acetate...
  10. pmc Total synthesis and absolute configuration of the marine norditerpenoid xestenone
    Koichiro Ota
    School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo, Japan
    Mar Drugs 7:654-71. 2009
    ..The relative and absolute configurations of xestenone were thus successfully determined by this synthesis...
  11. doi request reprint Total synthesis of marine eicosanoid (-)-hybridalactone
    Koichiro Ota
    School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Chemistry 18:13531-7. 2012
    ..Further elaboration of the latter compounds through desulfonylation, epoxidation, oxidation, Wittig olefination and Shiina macrolactonization afforded (-)-hybridalactone...
  12. ncbi request reprint Synthesis and anti-tumor activity of new steroidal nuclear analogues of aragusterol A
    Hidemichi Mitome
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 51:640-5. 2003
    ..The in vitro anti-proliferative activity of each of these analogues toward KB cells as well as in vivo anti-tumor activity of 5-epiaragusterol A (2) previously synthesized by the authors and 3 were assessed...
  13. doi request reprint First total synthesis of (-)-sinularianin B
    Koichiro Ota
    School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Chem Commun (Camb) 49:8148-50. 2013
    ..5% overall yield. Key transformations include formation of a cyclopentane possessing a tertiary hydroxy group via a tandem intermolecular-intramolecular alkylation involving a -endo cyclization. ..
  14. ncbi request reprint A new sesquiterpenoid quinone and other related compounds from the Okinawan marine sponge Dactylospongia elegans
    Hidemichi Mitome
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Nat Prod 66:46-50. 2003
    ..The new sesquiterpenoid quinone, neodactyloquinone (1), and dactylolactones A-D (2-5) were isolated from the Okinawan sponge Dactylospongia elegans. The structures of these compounds were determined by spectroscopic analysis...