M Miyaki

Summary

Affiliation: Tokyo Metropolitan Komagome Hospital
Country: Japan

Publications

  1. pmc Molecular evidence for multicentric development of thyroid carcinomas in patients with familial adenomatous polyposis
    M Miyaki
    Hereditary Tumor Research Project, Department of Pathology, Tokyo Metropolitan Komagome Hospital Institute of Molecular Oncology Showa University Sasaki Institute, Tokyo, Japan
    Am J Pathol 157:1825-7. 2000
  2. ncbi request reprint Mutations of the PIK3CA gene in hereditary colorectal cancers
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Int J Cancer 121:1627-30. 2007
  3. ncbi request reprint Both BRAF and KRAS mutations are rare in colorectal carcinomas from patients with hereditary nonpolyposis colorectal cancer
    Michiko Miyaki
    Department Surgery, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8677, Japan
    Cancer Lett 211:105-9. 2004
  4. ncbi request reprint Novel germline hMSH2 genomic deletion and somatic hMSH2 mutations in a hereditary nonpolyposis colorectal cancer family
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, and Institute of Molecular Oncology, Showa University, Tokyo, Japan
    Mutat Res 548:19-25. 2004
  5. ncbi request reprint Germline mutations of the MYH gene in Japanese patients with multiple colorectal adenomas
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Tokyo 113 8677, Japan
    Mutat Res 578:430-3. 2005
  6. ncbi request reprint High incidence of protein-truncating mutations of the p53 gene in liver metastases of colorectal carcinomas
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo 113 8677, Japan
    Oncogene 21:6689-93. 2002
  7. ncbi request reprint Increased frequency of p53 mutation in sporadic colorectal cancer from cigarette smokers
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Japan
    Jpn J Clin Oncol 32:196-201. 2002
  8. doi request reprint Difference in characteristics of APC mutations between colonic and extracolonic tumors of FAP patients: variations with phenotype
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Tokyo, Japan
    Int J Cancer 122:2491-7. 2008
  9. ncbi request reprint Alterations of repeated sequences in 5' upstream and coding regions in colorectal tumors from patients with hereditary nonpolyposis colorectal cancer and Turcot syndrome
    M Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo 113 8677, Japan
    Oncogene 20:5215-8. 2001
  10. ncbi request reprint Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome
    M Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Japan
    Cancer Res 60:6311-3. 2000

Detail Information

Publications29

  1. pmc Molecular evidence for multicentric development of thyroid carcinomas in patients with familial adenomatous polyposis
    M Miyaki
    Hereditary Tumor Research Project, Department of Pathology, Tokyo Metropolitan Komagome Hospital Institute of Molecular Oncology Showa University Sasaki Institute, Tokyo, Japan
    Am J Pathol 157:1825-7. 2000
    ..This is molecular confirmation for the multicentric development of thyroid carcinomas in familial adenomatous polyposis through biallelic inactivation of the APC gene...
  2. ncbi request reprint Mutations of the PIK3CA gene in hereditary colorectal cancers
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Int J Cancer 121:1627-30. 2007
    ..Our data suggest that PIK3CA mutations contribute to the invasion step from intramucosal carcinoma to invasive carcinoma in colorectal carcinogenesis in FAP and HNPCC patients at a similar extent to that seen in sporadic patients...
  3. ncbi request reprint Both BRAF and KRAS mutations are rare in colorectal carcinomas from patients with hereditary nonpolyposis colorectal cancer
    Michiko Miyaki
    Department Surgery, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8677, Japan
    Cancer Lett 211:105-9. 2004
    ....
  4. ncbi request reprint Novel germline hMSH2 genomic deletion and somatic hMSH2 mutations in a hereditary nonpolyposis colorectal cancer family
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, and Institute of Molecular Oncology, Showa University, Tokyo, Japan
    Mutat Res 548:19-25. 2004
    ..RT-PCR-sequencing revealed that the deleted region encompassed exon 5. This novel genomic deletion of the hMSH2 gene was confirmed to be pathogenic, and the Southern hybridization pattern was applied to the pre-symptomatic diagnosis...
  5. ncbi request reprint Germline mutations of the MYH gene in Japanese patients with multiple colorectal adenomas
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Tokyo 113 8677, Japan
    Mutat Res 578:430-3. 2005
    ..The MYH mutations detected in Japanese patients were novel and different from those detected among Caucasian, Indian and Pakistani patients, which suggests the existence of ethnic differentiation in MYH mutations...
  6. ncbi request reprint High incidence of protein-truncating mutations of the p53 gene in liver metastases of colorectal carcinomas
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo 113 8677, Japan
    Oncogene 21:6689-93. 2002
    ..0005). The present results suggest that protein-truncating mutations of the p53 gene are more relevant than missense mutations as one of the prognostic factors in liver metastasis of colorectal carcinomas...
  7. ncbi request reprint Increased frequency of p53 mutation in sporadic colorectal cancer from cigarette smokers
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Japan
    Jpn J Clin Oncol 32:196-201. 2002
    ..Cigarette smoking has been shown to increase the risk of colorectal cancer. However, the relation between smoking and genetic alterations has not been clarified in this type of cancer...
  8. doi request reprint Difference in characteristics of APC mutations between colonic and extracolonic tumors of FAP patients: variations with phenotype
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Bunkyo ku, Tokyo, Japan
    Int J Cancer 122:2491-7. 2008
    ....
  9. ncbi request reprint Alterations of repeated sequences in 5' upstream and coding regions in colorectal tumors from patients with hereditary nonpolyposis colorectal cancer and Turcot syndrome
    M Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo 113 8677, Japan
    Oncogene 20:5215-8. 2001
    ....
  10. ncbi request reprint Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome
    M Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Japan
    Cancer Res 60:6311-3. 2000
    ....
  11. ncbi request reprint Malignant transformation and EGFR activation of immortalized mouse liver epithelial cells caused by HBV enhancer-X from a human hepatocellular carcinoma
    M Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Int J Cancer 85:518-22. 2000
    ..Our data provide evidence that the Enhancer-X region alone is the key contributor to the malignant change of pre-malignant liver cells in HBV carriers through activation of some specific genes, such as EGFR...
  12. ncbi request reprint Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer
    M Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Japan
    Cancer Res 59:4506-9. 1999
    ..These and previous data from our laboratory suggest that activation of the beta-catenin-Tcf signaling pathway, through either beta-catenin or APC mutation, contributes to HNPCC colorectal carcinogenesis in approximately 65% of cases...
  13. pmc A novel case with germline p53 gene mutation having concurrent multiple primary colon tumours
    M Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Gut 52:304-6. 2003
    ..It is also suggested that in such a patient, a somatic APC mutation is involved in tumour formation and that an additional somatic p53 mutation contributes to tumour progression...
  14. ncbi request reprint Difference in the role of loss of heterozygosity at 10p15 (KLF6 locus) in colorectal carcinogenesis between sporadic and familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer patients
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Oncology 71:131-5. 2006
    ....
  15. pmc A novel case of a sporadic desmoid tumour with mutation of the beta catenin gene
    K Shitoh
    Hereditary Tumour Research Project, Tokyo Metropolitan Komagome Hospital, Japan
    J Clin Pathol 52:695-6. 1999
    ..This is the first example of a sporadic desmoid tumour in which a mutation of the beta catenin gene was revealed...
  16. ncbi request reprint Expression of CD44 variants in gastric carcinoma with or without Epstein-Barr virus
    J M Chong
    Department of Pathology, Tokyo Metropolitan Komagome Hospital, Japan
    Int J Cancer 74:450-4. 1997
    ..Thus, the mechanism and significance of CD44 variant-expression are different in gastric carcinomas with or without EBV. EBVaGC is a distinct type of gastric carcinoma which should be considered separately from EBV-negative carcinoma...
  17. ncbi request reprint Role of Smad4 (DPC4) inactivation in human cancer
    Michiko Miyaki
    Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8677, Japan
    Biochem Biophys Res Commun 306:799-804. 2003
    ....
  18. ncbi request reprint p300 gene alterations in intestinal and diffuse types of gastric carcinoma
    Naoki Koshiishi
    Department of Pathology, Jichi Medical School, Tochigi, Japan
    Gastric Cancer 7:85-90. 2004
    ..p300 is a transcriptional coactivator, and bi-allelic mutations of the p300 gene have been demonstrated in human cancers...
  19. ncbi request reprint [Microsatellite instability in hereditary gastrointestinal polyposis]
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital
    Nihon Shokakibyo Gakkai Zasshi 99:1057-62. 2002
  20. doi request reprint Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumors
    Michiko Miyaki
    Hereditary Tumor Research Project, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Oncology 76:430-4. 2009
    ..CDC4 mutations were investigated in 194 colorectal carcinomas and adenomas for comparison between sporadic and hereditary cancers...
  21. ncbi request reprint Association of K-ras mutations with liver metastases from colorectal carcinoma
    Akira Tsunoda
    Second Department of Surgery, School of Medicine, Showa University, Tokyo, Japan
    Anticancer Res 24:2471-6. 2004
    ..Colorectal carcinomas were studied regarding early proof of liver metastases through determination of K-ras mutations...
  22. ncbi request reprint Accumulation profile of frameshift mutations during development and progression of colorectal cancer from patients with hereditary nonpolyposis colorectal cancer
    Tatsuro Yamaguchi
    Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Dis Colon Rectum 49:399-406. 2006
    ..This study was designed to clarify the relationship between frameshift mutations and clinicopathologic features in colorectal cancer from patients with hereditary nonpolyposis colorectal cancer...
  23. ncbi request reprint A historical perspective on familial cancer: results and vision of the Polyposis Center Project
    Joji Utsunomiya
    Familial Cancer Center, The Cancer Institute Hospital, Tokyo, Japan
    Int J Clin Oncol 9:215-31. 2004
  24. ncbi request reprint Germline mutation of the LKB1/STK11 gene with loss of the normal allele in an aggressive breast cancer of Peutz-Jeghers syndrome
    Chikashi Nakanishi
    Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Oncology 67:476-9. 2004
    ..To our knowledge, we are the first to show that a germline mutation causing PJS is combined with the loss of the homologous normal allele of LKB1/STK11 in breast cancer...
  25. ncbi request reprint Suspected HNPCC and Amsterdam criteria II: evaluation of mutation detection rate, an international collaborative study
    Jae Gahb Park
    Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Korea
    Int J Colorectal Dis 17:109-14. 2002
    ..The original Amsterdam criteria have recently been revised, including some extracolonic cancers. This study compared the mutation detection rates between the revised and previous Amsterdam and S-HNPCC criteria...
  26. ncbi request reprint APC gene mutations in a jejunal adenoma causing intussusception in a patient with familial adenomatous polyposis
    Hideyuki Ishida
    Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda Tsujidocho, Kawagoe 350 8550, Japan
    J Gastroenterol 37:1057-61. 2002
    ..This is the first evidence that the coexistence of somatic and germline alterations in the APC gene is involved in the development of a jejunal adenoma causing small-bowel intussusception...
  27. ncbi request reprint Intratumoral heterogeneity of genetic changes in primary colorectal carcinomas with metastasis
    Hiroyuki Fukunari
    Department of Digestive Surgery, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Surg Today 33:408-13. 2003
    ..To elucidate the intratumoral distribution of genetic changes, surgically resected colorectal carcinomas were investigated regarding their loss of heterozygosity in the regions of tumor suppressor genes and the mutation of ras genes...
  28. ncbi request reprint Extended lymphadenectomy and preoperative radiotherapy for lower rectal cancers
    Toshiaki Watanabe
    Department of Surgery, University of Tokyo Hospital, The Cancer Institute Hospital, Japan
    Surgery 132:27-33. 2002
    ..However, EXT-L is frequently associated with impairment of sexual and urinary function. We therefore compared the effectiveness of preoperative radiotherapy with that of EXT-L...
  29. ncbi request reprint Immunohistochemistry and c-kit gene analysis in determining malignancy in gastrointestinal stromal tumors
    Masahiko Yamaguchi
    Department of Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan
    Hepatogastroenterology 50:1431-5. 2003
    ..Usefulness of immunohistochemistry and c-kit proto-oncogene mutation was examined for determining malignancy in 24 cases of gastrointestinal stromal tumors...