Yoshiyuki Minegishi

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Nature 448:1058-62. 2007
  2. pmc Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells
    Masako Saito
    Department of Immune Regulation, Japan Science and Technology Agency, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Exp Med 208:235-49. 2011
  3. doi Cutaneous manifestations of Hyper IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Allergol Int 61:191-6. 2012
  4. doi Molecular mechanisms of the immunological abnormalities in hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University, Tokyo, Japan
    Ann N Y Acad Sci 1246:34-40. 2011
  5. ncbi Hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, 1 5 45 Bunkyo Ku, Yushima, Tokyo 113 8519, Japan
    Curr Opin Immunol 21:487-92. 2009
  6. pmc Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Exp Med 206:1291-301. 2009
  7. doi Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int Immunol 21:105-12. 2009
  8. ncbi Genetic origins of hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Curr Allergy Asthma Rep 8:386-91. 2008
  9. ncbi Hyperimmunoglobulin E syndrome and tyrosine kinase 2 deficiency
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Curr Opin Allergy Clin Immunol 7:506-9. 2007
  10. ncbi Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, Yushima, Tokyo, Japan
    Immunity 25:745-55. 2006

Collaborators

Detail Information

Publications29

  1. ncbi Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Nature 448:1058-62. 2007
    ..These results highlight the multiple roles played by STAT3 in humans, and underline the critical involvement of multiple cytokine pathways in the pathogenesis of HIES...
  2. pmc Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells
    Masako Saito
    Department of Immune Regulation, Japan Science and Technology Agency, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Exp Med 208:235-49. 2011
    ..These results suggest that the defective generation of IL-10-induced tolerogenic DCs and iT(reg) cells may contribute to inflammatory changes in HIES...
  3. doi Cutaneous manifestations of Hyper IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Allergol Int 61:191-6. 2012
    ....
  4. doi Molecular mechanisms of the immunological abnormalities in hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University, Tokyo, Japan
    Ann N Y Acad Sci 1246:34-40. 2011
    ..These findings open up possibilities for exploring new approaches to the treatment of HIES patients...
  5. ncbi Hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, 1 5 45 Bunkyo Ku, Yushima, Tokyo 113 8519, Japan
    Curr Opin Immunol 21:487-92. 2009
    ..These findings suggest that the defect in cytokine signaling constitutes the molecular basis for the immunological and nonimmunological abnormalities observed in HIES...
  6. pmc Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Exp Med 206:1291-301. 2009
    ..These results appear to explain, at least in part, why HIES patients suffer from recurrent staphylococcal infections confined to the skin and lung in contrast to more systemic infections in neutrophil-deficient patients...
  7. doi Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int Immunol 21:105-12. 2009
    ....
  8. ncbi Genetic origins of hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Curr Allergy Asthma Rep 8:386-91. 2008
    ..These findings suggest that HIES is caused by the defects in multiple cytokine signals and that the susceptibility to various infections in HIES is associated with the T-helper type 17 defect...
  9. ncbi Hyperimmunoglobulin E syndrome and tyrosine kinase 2 deficiency
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Curr Opin Allergy Clin Immunol 7:506-9. 2007
    ..The purpose of the review is to provide recent insight into the pathogenesis and pathophysiology of hyperimmunoglobulin E syndrome...
  10. ncbi Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, Yushima, Tokyo, Japan
    Immunity 25:745-55. 2006
    ..This study identifies human Tyk2 deficiency and demonstrates that Tyk2 plays obligatory roles in multiple cytokine signals involved in innate and acquired immunity of humans, which differs substantially from Tyk2 function in mice...
  11. doi Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4
    Mayumi Egawa
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo 113 8519, Japan
    Immunity 38:570-80. 2013
    ..Thus, inflammatory monocytes can be converted from being proinflammatory to anti-inflammatory under the influence of basophils in allergic reactions...
  12. pmc Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks
    Takeshi Wada
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Clin Invest 120:2867-75. 2010
    ....
  13. doi Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis
    Yusuke Tsujimura
    Department of Immune Regulation and Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Immunity 28:581-9. 2008
    ....
  14. ncbi Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner
    Toshiyuki Kojima
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Immunol 179:7093-100. 2007
    ....
  15. ncbi Basophils are essential initiators of a novel type of chronic allergic inflammation
    Kazushige Obata
    Department of Immune Regulation, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Blood 110:913-20. 2007
    ..Thus, basophils play a pivotal role in the development of IgE-mediated chronic allergic inflammation, as an initiator rather than as an effector...
  16. doi Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner
    Hirofumi Yamagishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 415:709-13. 2011
    ..Thus, basophil-derived mMCP-11 can induce microvascular leakage via prostaglandins in a mast cell-independent manner, and may contribute to the development of basophil-mediated inflammatory responses...
  17. ncbi Basophils preferentially express mouse Mast Cell Protease 11 among the mast cell tryptase family in contrast to mast cells
    Tsukasa Ugajin
    Department of Dermatology, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Tokyo, Japan
    J Leukoc Biol 86:1417-25. 2009
    ..Thus, basophils rather than mast cells are the major source of mMCP-11. This is the first study to demonstrate that mouse basophils produce a trypsin-like protease...
  18. pmc The skin is an important bulwark of acquired immunity against intestinal helminths
    Kazushige Obata-Ninomiya
    Department of Immune Regulation, 2 Department of Environmental Parasitology, 3 Department of Integrated Pulmonology, and 4 Japan Science and Technology Agency Core Research for Evolutional Science and Technology, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Bunkyo ku, Tokyo 113 8519, Japan
    J Exp Med 210:2583-95. 2013
    ..This study thus reveals a novel mode of acquired antihelminth immunity, in which IgE-armed basophils mediate skin trapping of larvae, thereby limiting lung injury caused by larval migration. ..
  19. doi IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen
    Ryosuke Ishikawa
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Biochem Biophys Res Commun 402:742-6. 2010
    ....
  20. doi The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver
    Soichiro Yoshikawa
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bukyo ku, Tokyo, Japan
    Int Immunol 21:43-52. 2009
    ....
  21. doi NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivo
    Hideto Nishikado
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    J Immunol 186:5766-71. 2011
    ....
  22. doi Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-α on macrophages through the autocrine action of IL-6
    Hiromi Ogawa
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 420:114-8. 2012
    ..Thus, IL-4 and IL-33 synergistically elicit the tmTNF-α expression on macrophages through the autocrine action of IL-6...
  23. ncbi Different stabilities of the structurally related receptors for IgE and IgG on the cell surface are determined by length of the stalk region in their alpha-chains
    Toshiyuki Kubota
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Immunol 176:7008-14. 2006
    ..This finding provides new insights into the mechanism regulating surface FcepsilonRI expression...
  24. ncbi Pre-B cell receptor assesses the quality of IgH chains and tunes the pre-B cell repertoire by delivering differential signals
    Yohei Kawano
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Immunol 177:2242-9. 2006
    ..These results indicate that the pre-BCR assesses the quality of muH chains and tunes the pre-B cell repertoire by driving the preferential expansion and differentiation of cells with the higher quality of muH chains...
  25. ncbi Selection of stereotyped VH81X-{micro}H chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells
    Yohei Kawano
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Int Immunol 17:857-67. 2005
    ..This strongly suggests that neonatally generated and selected B cells expressing the stereotyped V(H)81X-muH chains are maintained in the adult MZ and could function as innate-like lymphocytes...
  26. ncbi Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells
    Kaori Mukai
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Japan
    Immunity 23:191-202. 2005
    ..These findings indicate a novel mechanism of development of chronic allergic inflammation that is induced by basophils through the interaction of antigen, IgE, and FcRI...
  27. ncbi Allogeneic hematopoietic stem cell transplantation for seven children with X-linked hyper-IgM syndrome: a single center experience
    Daisuke Tomizawa
    Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Hematol 76:33-9. 2004
    ..For the high-risk patients, an alternative approach including nonmyeloablative HSCT may be more feasible...
  28. ncbi [Molecular mechanisms of antibody generation]
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University
    Nihon Rinsho 63:248-53. 2005
  29. ncbi Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage
    Ling Chen
    Department of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical and Dental Univesrity, Tokyo, Japan
    Cancer Sci 96:134-41. 2005
    ..Since deficiency of either DNA-Pkcs or ATM leads to defective repair of IR-induced DSB, our finding places Artemis at the signaling crossroads downstream of DNA-PKcs and ATM in IR-induced DSB repair...