Yoh Matsumoto

Summary

Affiliation: Tokyo Metropolitan Institute for Neuroscience
Country: Japan

Publications

  1. ncbi Fine T cell receptor repertoire analysis of spinal cord T cells responding to the major and minor epitopes of myelin basic protein during rat autoimmune encephalomyelitis
    Y Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
    J Neurosci Res 59:145-52. 2000
  2. ncbi Complementarity-determining region 3 spectratyping analysis of the TCR repertoire in multiple sclerosis
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Immunol 170:4846-53. 2003
  3. ncbi Characterization of T cells that are activated after depletion of major encephalitogenic T cells in rat autoimmune encephalomyelitis
    Y Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    J Neuroimmunol 114:89-98. 2001
  4. ncbi C protein-induced myocarditis and subsequent dilated cardiomyopathy: rescue from death and prevention of dilated cardiomyopathy by chemokine receptor DNA therapy
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Immunol 173:3535-41. 2004
  5. ncbi Matrix metalloproteinase (MMP)-9, but not MMP-2, is involved in the development and progression of C protein-induced myocarditis and subsequent dilated cardiomyopathy
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2 6, Fuchu, Tokyo 183 8526, Japan
    J Immunol 183:4773-81. 2009
  6. ncbi Characterization of T cell receptor (TCR) of organ-specific autoimmune disease-inducing T cells and TCR-based immunotherapy with DNA vaccines
    Y Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2 6 Fuchu, 183 8526, Tokyo, Japan
    J Neuroimmunol 110:1-12. 2000
  7. ncbi Successful TCR-based immunotherapy for autoimmune myocarditis with DNA vaccines after rapid identification of pathogenic TCR
    Y Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Immunol 164:2248-54. 2000
  8. ncbi Characterization of T cell receptor associated with the development of P2 peptide-induced autoimmune neuritis
    Y Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan
    J Neuroimmunol 102:67-72. 2000
  9. ncbi New approach to immunotherapy against organ-specific autoimmune diseases with T cell receptor and chemokine receptor DNA vaccines
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Curr Drug Targets Immune Endocr Metabol Disord 5:73-7. 2005
  10. ncbi CDR3 spectratyping analysis of the TCR repertoire in myasthenia gravis
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Immunol 176:5100-7. 2006

Collaborators

Detail Information

Publications82

  1. ncbi Fine T cell receptor repertoire analysis of spinal cord T cells responding to the major and minor epitopes of myelin basic protein during rat autoimmune encephalomyelitis
    Y Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
    J Neurosci Res 59:145-52. 2000
    ..Furthermore, the strategy used in this study gives insight into the pathogenesis of autoimmune disease and provides useful information for designing TCR-based immunotherapy...
  2. ncbi Complementarity-determining region 3 spectratyping analysis of the TCR repertoire in multiple sclerosis
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Immunol 170:4846-53. 2003
    ..2 spectratype expansion is associated with the development of MS and that TCR-based immunotherapy can be applicable to MS patients if the TCR activation pattern of each patient is determined at different stages of the disease...
  3. ncbi Characterization of T cells that are activated after depletion of major encephalitogenic T cells in rat autoimmune encephalomyelitis
    Y Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo 183 8526, Japan
    J Neuroimmunol 114:89-98. 2001
    ..These findings suggest that rapid and frequent examination of the TCR repertoire is essential to identify pathogenic TCRs and to establish TCR-based immunotherapy for autoimmune diseases...
  4. ncbi C protein-induced myocarditis and subsequent dilated cardiomyopathy: rescue from death and prevention of dilated cardiomyopathy by chemokine receptor DNA therapy
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Immunol 173:3535-41. 2004
    ..The present study has demonstrated for the first time that gene therapy targeting the chemokine receptor could be a powerful tool for the control of experimental autoimmune myocarditis and DCM...
  5. ncbi Matrix metalloproteinase (MMP)-9, but not MMP-2, is involved in the development and progression of C protein-induced myocarditis and subsequent dilated cardiomyopathy
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2 6, Fuchu, Tokyo 183 8526, Japan
    J Immunol 183:4773-81. 2009
    ..These findings indicate that MMP-9, but not MMP-2, is involved in the pathogenesis of the acute phase of EAC, and further suggest that MMP-9 inhibitors, minocycline and its derivatives, may be useful therapies for EAC and DCM...
  6. ncbi Characterization of T cell receptor (TCR) of organ-specific autoimmune disease-inducing T cells and TCR-based immunotherapy with DNA vaccines
    Y Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2 6 Fuchu, 183 8526, Tokyo, Japan
    J Neuroimmunol 110:1-12. 2000
    ..TCR-based immunotherapy after rapid identification of autoimmune disease-associated TCR by CDR3 spectratyping can be applicable, not only to animal, but also to human autoimmune diseases whose pathomechanism is poorly understood...
  7. ncbi Successful TCR-based immunotherapy for autoimmune myocarditis with DNA vaccines after rapid identification of pathogenic TCR
    Y Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Immunol 164:2248-54. 2000
    ..TCR-based immunotherapy after rapid identification of autoimmune disease-associated TCRs by CDR3 spectratyping can be applicable, not only to animal, but also to human autoimmune diseases whose pathomechanism is poorly understood...
  8. ncbi Characterization of T cell receptor associated with the development of P2 peptide-induced autoimmune neuritis
    Y Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan
    J Neuroimmunol 102:67-72. 2000
    ..Collectively, these findings indicate that determination of autoimmune disease-associated TCR by CDR3 spectratyping provides useful information for designing TCR-based immunotherapy for the disease...
  9. ncbi New approach to immunotherapy against organ-specific autoimmune diseases with T cell receptor and chemokine receptor DNA vaccines
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Curr Drug Targets Immune Endocr Metabol Disord 5:73-7. 2005
    ..These findings clearly indicate that DNA vaccination can be a powerful tool for treatment of organ-specific autoimmune diseases...
  10. ncbi CDR3 spectratyping analysis of the TCR repertoire in myasthenia gravis
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Immunol 176:5100-7. 2006
    ..Close examination of pathogenic T cells in MG provides useful information to elucidate the pathogenesis and to estimate the disease status...
  11. ncbi Paralysis of CD4(+)CD25(+) regulatory T cell response in chronic autoimmune encephalomyelitis
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Neuroimmunol 187:44-54. 2007
    ..These findings suggest that impairment of the CD4(+)CD25(+) Treg response is critical for development of chronic autoimmune diseases, and can be adjustable by autologous Treg transplantation...
  12. ncbi Characterization of relapsing autoimmune encephalomyelitis and its treatment with decoy chemokine receptor genes
    Yoh Matsumo
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2 6, Fuchu, Tokyo 183 8526, Japan
    J Neuroimmunol 170:49-61. 2005
    ..Taken together, these findings demonstrated that neutralization therapy with decoy chemokine receptor DNAs is effective to control autoimmune diseases...
  13. ncbi Role of natural killer cells and TCR gamma delta T cells in acute autoimmune encephalomyelitis
    Y Matsumoto
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu City, Japan
    Eur J Immunol 28:1681-8. 1998
    ..These findings suggest that NK cells play a suppressive role in acute EAE whereas TCR gamma delta+ T cells are not involved in the development of or recovery from the disease...
  14. ncbi B-cell epitope spreading is a critical step for the switch from C-protein-induced myocarditis to dilated cardiomyopathy
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2 6, Fuchu, Tokyo 183 8526, Japan
    Am J Pathol 170:43-51. 2007
    ..These findings suggest that T-cell activation and B-cell epitope spreading in the CC2 molecule is a key step for the switch from myocarditis to the development of DCM...
  15. ncbi Characterization of pathogenic T cells and autoantibodies in C-protein-induced autoimmune polymyositis
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2 6, Fuchu, Tokyo, Japan
    J Neuroimmunol 190:90-100. 2007
    ..Further analysis of C-protein-induced EAM will provide useful information to elucidate the pathomechanisms of human polymyositis...
  16. ncbi Role of pathogenic T cells and autoantibodies in relapse and progression of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis in LEW.1AV1 rats
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Immunology 128:e250-61. 2009
    ..Relapses and the progression of MS-mimicking EAE are differently immunoregulated so immunotherapy should be designed appropriately on the basis of precise information...
  17. ncbi Differential effects of decoy chemokine (7ND) gene therapy on acute, biphasic and chronic autoimmune encephalomyelitis: implication for pathomechanisms of lesion formation
    Il Kwon Park
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Neuroimmunol 194:34-43. 2008
    ..Thus, the mechanisms of lesion formation are not uniform and immunotherapy should be performed on the basis of information about the pathomechanisms of autoimmune diseases...
  18. ncbi Characterization of CD8-positive macrophages infiltrating the central nervous system of rats with chronic autoimmune encephalomyelitis
    Keiko Hiraki
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Neurosci Res 87:1175-84. 2009
    ..Analysis of CD8+ monocytes/macrophages may provide useful information to permit further dissect the pathomechanisms of multiple sclerosis and to develop effective immunotherapies against autoimmune diseases in the CNS...
  19. ncbi Tracking of V beta 8.2-positive encephalitogenic T cells by complementarity-determining region 3 spectratyping and subsequent Southern blot hybridization in Lewis rats after neuroantigen sensitization
    Hiroshi Sakuma
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Immunol 173:4516-22. 2004
    ..Analysis of pathogenic T cells at the clonal level provides useful information for designing effective immunotherapy...
  20. ncbi Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient mice
    Kazuhiko Namekata
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    Neurosci Lett 465:160-4. 2009
    ..Our findings suggest that the use of IL-1 for enhancing the function of glutamate transporters may be useful for neuroprotection in retinal degenerative disorders including NTG...
  21. ncbi Quantitation of myelin oligodendrocyte glycoprotein and myelin basic protein in the thymus and central nervous system and its relationship to the clinicopathologic features of autoimmune encephalomyelitis
    Hiroshi Sakuma
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Neurosci Res 84:606-13. 2006
    ..Furthermore, the lesion distribution, but not the clinical course, of EAE is related to the neuroantigen expression in the CNS...
  22. ncbi Clinicopathological study of a myelin oligodendrocyte glycoprotein-induced demyelinating disease in LEW.1AV1 rats
    Hiroshi Sakuma
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Brain 127:2201-13. 2004
    ..Further analysis will provide useful information to elucidate the pathogenesis and to develop immunotherapy for neuromyelitis optica and multiple sclerosis...
  23. ncbi Attenuation of experimental autoimmune myositis by blocking ICOS-ICOS ligand interaction
    Yasuhiro Katsumata
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Immunol 179:3772-9. 2007
    ..ICOS-ICOS ligand interaction would be a novel therapeutic target for PM...
  24. ncbi Characterization of the antigen specificity and TCR repertoire, and TCR-based DNA vaccine therapy in myelin basic protein-induced autoimmune encephalomyelitis in DA rats
    Akira Miyakoshi
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Immunol 170:6371-8. 2003
    ..Analyses of the Ag specificity and T cell repertoire of pathogenic T cells performed in this study provide useful information for designing specific immunotherapies against autoimmune diseases...
  25. ncbi Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats
    Youngheun Jee
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2-6 Fuchu, Tokyo 183-8526, Japan
    J Neuroimmunol 128:49-57. 2002
    ..Collectively, these findings suggest that high expression of MCP-1 and its receptor, CCR2, in the CNS play important roles in relapse of EAE...
  26. ncbi Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis
    Xiaoli Guo
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:2696-703. 2011
    ..To assess the effects of spermidine on the severity of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), with a focus on optic neuritis often associated with MS and EAE...
  27. ncbi Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis
    Xiaoli Guo
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo, Japan
    Neurosci Res 59:457-66. 2007
    ..Taken together, our results indicate that treatments that suppress the activation of microglia and astrocytes should be pursued in future research for their potential as avenues for the treatment of MS...
  28. ncbi Characterization of fibrosis-promoting factors and siRNA-mediated therapies in C-protein-induced experimental autoimmune myocarditis
    Yoh Matsumoto
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Cell Immunol 279:70-7. 2012
    ..These findings suggest that in case of diseases characterized by initial inflammation and subsequent fibrosis, immunotherapies should target inflammation, not fibrosis, because the latter therapies exacerbate inflammation...
  29. ncbi Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production
    Lin Xie
    Laboratory of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    Int Immunopharmacol 9:575-81. 2009
    ....
  30. ncbi Interferon beta-1b exacerbates multiple sclerosis with severe optic nerve and spinal cord demyelination
    Yoko Warabi
    Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan
    J Neurol Sci 252:57-61. 2007
    ..The present study strongly suggests that these patients should be diagnosed as having NMO...
  31. ncbi Nonviral DNA vaccination augments microglial phagocytosis of beta-amyloid deposits as a major clearance pathway in an Alzheimer disease mouse model
    Yoshio Okura
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Neuropathol Exp Neurol 67:1063-71. 2008
    ..Collectively, these data suggest that phagocytosis of Abeta deposits by microglia plays a central role in Abeta reduction after DNA vaccination...
  32. ncbi Definitive engagement of cytotoxic CD8 T cells in C protein-induced myositis, a murine model of polymyositis
    Takahiko Sugihara
    Tokyo Medical and Dental University, Tokyo, and Yokohama Institute, RIKEN, Yokohama, Japan
    Arthritis Rheum 62:3088-92. 2010
    ..To substantiate a pathogenic role of cytotoxic CD8 T cells in the development of a murine polymyositis model, C protein-induced myositis (CIM)...
  33. ncbi Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: long-term effects and safety
    Yoshio Okura
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2-6, Fuchu, Tokyo 183-8526, Japan
    Proc Natl Acad Sci U S A 103:9619-24. 2006
    ..Although it is reported that other anti-Abeta therapies have pharmacological and/or technical difficulties, nonviral DNA vaccines are highly secure and easily controllable and are promising for the treatment of Alzheimer's disease...
  34. ncbi A new murine model to define the critical pathologic and therapeutic mediators of polymyositis
    Takahiko Sugihara
    Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 56:1304-14. 2007
    ..To establish a new murine model of polymyositis (PM) for the understanding of its pathologic mechanisms and the development of new treatment strategies...
  35. ncbi [Novel vaccine therapy for Alzheimer's disease--recent progress and our approach]
    Yoshio Okura
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    Brain Nerve 60:931-40. 2008
    ..Finally, we will present data regarding the mechanisms of Abeta reduction after DNA vaccination. DNA vaccination for AD may open up new avenues in vaccine therapy for the treatment of AD...
  36. ncbi Effect of geranylgeranylacetone on optic neuritis in experimental autoimmune encephalomyelitis
    Xiaoli Guo
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    Neurosci Lett 462:281-5. 2009
    ..These results suggest that oral GGA administration has beneficial effect on the treatment for optic neuritis in the EAE mouse model of MS...
  37. ncbi Chemokine expression by astrocytes plays a role in microglia/macrophage activation and subsequent neurodegeneration in secondary progressive multiple sclerosis
    Naoyuki Tanuma
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, 183 8526, Japan
    Acta Neuropathol 112:195-204. 2006
    ..Targeting chemokines in SPMS may therefore be a powerful therapeutic approach to inhibit lesional expansion...
  38. ncbi Identification of autoimmune encephalomyelitis-associated common CDR3 sequences by CDR3 spectratyping and subsequent DNA hybridization
    Youngheun Jee
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2-6 Fuchu, 183-8526, Japan
    J Neuroimmunol 126:37-49. 2002
    ..Characterization of the CDR3 region of pathogenic TCR by this approach may be of value for the screening of autoimmune disease-associated TCR and for the development of TCR-based specific immunotherapy...
  39. ncbi Therapeutic gene silencing with siRNA for IL-23 but not for IL-17 suppresses the development of experimental autoimmune encephalomyelitis in rats
    Naoko Niimi
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Neuroimmunol 254:39-45. 2013
    ..Consistent with this finding, siRNA-IL-23 treatment downregulated IL-12, IL-17 and IL-23 mRNAs. These findings indicate that IL-23, but not IL-17, play an important role in the development of EAE...
  40. ncbi Characterization of the T cell receptor repertoire in the Japanese neuromyelitis optica: T cell activity is up-regulated compared to multiple sclerosis
    Yoko Warabi
    Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan
    J Neurol Sci 249:145-52. 2006
    ..Detailed TCR investigations will provide useful information to evaluate the clinical and immunological status of NMO and MS and to develop effective immunotherapies...
  41. ncbi Development of anti-Abeta vaccination as a promising therapy for Alzheimer's disease
    Yoshio Okura
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Drug News Perspect 20:379-86. 2007
    ..In this article, we will review conventional vaccine therapies and newly developed vaccine therapies, mainly DNA vaccines, for possible clinical application in the near future...
  42. ncbi Recent advance in immunotherapies for Alzheimer disease: with special reference to DNA vaccination
    Yoshio Okura
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Hum Vaccin 5:373-80. 2009
    ..DNA vaccines were developed by several groups including our laboratory, which induced Abeta reduction in AD model mice without side effects. DNA vaccination may be open up new avenue of vaccine therapies for AD in the near future...
  43. ncbi Acquired thymic tolerance to autoimmune encephalomyelitis is associated with activation of peripheral IL-10-producing macrophages/dendritic cells
    Yoshio Okura
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Musashidai 2-6 Fuchu, Tokyo 183-8526, Japan
    Int Immunol 15:437-46. 2003
    ..Taken together, IL-10-secreting Mø/DC in peripheral lymphoid organs activated by MBP i.t. injection may play a critical role in the induction and maintenance of tolerance...
  44. ncbi Two-step activation of T cells, clonal expansion and subsequent Th1 cytokine production, is essential for the development of clinical autoimmune encephalomyelitis
    Y Jee
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Eur J Immunol 31:1800-12. 2001
    ....
  45. ncbi Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway
    Xiaoli Guo
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo, Japan
    EMBO Mol Med 2:504-15. 2010
    ..These results suggest that the TLR-ASK1-p38 pathway in glial cells may serve as a valid therapeutic target for autoimmune demyelinating disorders including multiple sclerosis...
  46. ncbi Interleukin-1 stimulates glutamate uptake in glial cells by accelerating membrane trafficking of Na+/K+-ATPase via actin depolymerization
    Kazuhiko Namekata
    Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    Mol Cell Biol 28:3273-80. 2008
    ..Our observations suggested that IL-1 acts as a potential neuroprotective agent by modulating the functions of the glia-neuron network...
  47. ncbi Autoantibodies recognizing native MOG are closely associated with active demyelination but not with neuroinflammation in chronic EAE
    Shin Ohtani
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Neuropathology 31:101-11. 2011
    ..These findings suggest that autoantibodies reacting with native and glycosylated MOG play an important role in the progression of demyelinating diseases and could be biomarkers for monitoring the status of patients with MS...
  48. ncbi DNA vaccine therapy for Alzheimer's disease: present status and future direction
    Yoshio Okura
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    Rejuvenation Res 11:301-8. 2008
    ..Finally, we show some data regarding the mechanisms of Abeta reduction after administration of DNA vaccines. DNA vaccination may open up new avenues of vaccine therapy for AD...
  49. ncbi Intravenous immunoglobulin therapy prevents development of autoimmune encephalomyelitis and suppresses activation of matrix metalloproteinases
    Naoko Niimi
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Neuropathology 31:392-400. 2011
    ..These findings provide useful information to set optimal conditions for IVIG treatment of MS and to obtain more beneficial effects...
  50. ncbi Assessment of non-viral amyloid-β DNA vaccines on amyloid-β reduction and safety in rhesus monkeys
    Yoriko Tokita
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Alzheimers Dis 22:1351-61. 2010
    ..Taken together, DNA vaccination to monkeys is safe and effective in Aβ reduction and provides useful information for performing preclinical and clinical trials...
  51. ncbi Differential role of TNF-alpha and IFN-gamma in the brain of rats with chronic relapsing autoimmune encephalomyelitis
    N Tanuma
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan
    J Neuroimmunol 96:73-9. 1999
    ..Taken together, differential involvement of TNF-alpha and IFN-gamma is closely associated with the clinical features of CR-EAE...
  52. ncbi The subarachnoid space as a site for precursor T cell proliferation and effector T cell selection in experimental autoimmune encephalomyelitis
    T Shin
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
    J Neuroimmunol 56:171-8. 1995
    ..Double staining for V beta 8.2 TCR and microglia demonstrated an increase in the number of microglia together with morphological changes into rod-shape cells in the vicinity of infiltrating T cells.(ABSTRACT TRUNCATED AT 250 WORDS)..
  53. ncbi Microsomal prostaglandin E synthase-1 aggravates inflammation and demyelination in a mouse model of multiple sclerosis
    Chisen Takeuchi
    Medical Research Institute, Tokyo Women s Medical University, Tokyo, Japan
    Neurochem Int 62:271-80. 2013
    ..The inhibition of mPGES-1 may be useful for the treatment of human MS...
  54. ncbi A rapid and quantitative detection system for Streptococcus mutans in saliva using monoclonal antibodies
    Y Matsumoto
    GC Corporation, Research and Developmental Department, Oral Health Care Group, Tokyo, Japan
    Caries Res 40:15-9. 2006
    ..01). The results generated from the system were consistent with the data generated from two culture-based commercial products...
  55. ncbi STAT expression and localization in the central nervous system during autoimmune encephalomyelitis in Lewis rats
    Y Jee
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Neuroimmunol 114:40-7. 2001
    ..Taken together, these findings suggest that STAT3 and STAT4 play an important role in the formation of, and recovery from, autoimmune inflammation in the CNS...
  56. ncbi Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1
    S Ozawa
    Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
    Xenobiotica 30:1005-17. 2000
    ..7. The results thus indicate the involvement of rat CYP2C11/CYP2E1 and human CYP1A2 in the hepatic p-hydroxylation of o-phenylphenol...
  57. ncbi Distribution of cellular isoform of prion protein in T lymphocytes and bone marrow, analyzed by wild-type and prion protein gene-deficient mice
    A Kubosaki
    Department of Molecular Immunology, University of Tokyo, Bunkyo-ku, Tokyo, 113-8657, Japan
    Biochem Biophys Res Commun 282:103-7. 2001
    ..In fetuses, PrP(C+) cells were observed in the liver and thymus at day 16.0 and 15.0 of gestation, respectively. These results demonstrated that PrP(C) is expressed on immature immunocytes...
  58. ncbi Topical tranilast for treatment of the early stage of mild dry eye associated with chronic GVHD
    Y Ogawa
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Bone Marrow Transplant 45:565-9. 2010
    ..5%) did; the rest still had mild dry eye (P<0.05). These results suggest the hypothesis that topical tranilast may effectively retard the progression of mild dry eye associated with cGVHD...
  59. ncbi Uterine macrophages express the gp49B inhibitory receptor in midgestation
    Y Matsumoto
    Department of Obstetrics and Gynecology, Faculty of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    J Immunol 166:781-6. 2001
    ..Thus, our data provide evidence that gp49B is an endogenous negative regulator of macrophage activation and may regulate the function of macrophages during pregnancy...
  60. ncbi Diagnosis of kala-azar by nested PCR based on amplification of the Leishmania mini-exon gene
    K Katakura
    Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
    J Clin Microbiol 36:2173-7. 1998
    ..Thus, this nested PCR method represents a new tool for the diagnosis of kala-azar with patient blood samples instead of bone marrow or spleen aspirates obtained by more invasive procedures...
  61. ncbi TATA-less mouse vitronectin gene promoter: characterization of the transcriptional regulatory elements and a nuclear protein binding site on the promoter
    Y Miyamoto
    Department of Biology, Ochanomizu University, Tokyo, Japan
    Cell Struct Funct 23:23-32. 1998
    ..The nuclear protein is a putative trans-acting factor involved in transcription initiation...
  62. ncbi Contrasting effects of carbachol, McN-A-343 and AHR-602 on Ca(2+)-mobilization and Ca(2+)-influx pathways in taenia caeci
    S Hishinuma
    Department of Pharmacology, Meiji College of Pharmacy, Tokyo, Japan
    Br J Pharmacol 122:985-92. 1997
    ..The compounds McN-A-343 and AHR-602 are agonists of the Ca2+ influx pathway, but do not appear to stimulate the Ca2+ release pathway...
  63. ncbi Isolation and characterization of cytotoxic diterpenoid isomers from propolis
    T Matsuno
    National Institute of Health, Tokyo, Japan
    Z Naturforsch C 52:702-4. 1997
    ..46) were isolated. The structures of these colorless compounds were determined as clerodane diterpenoids (I, 15-oxo-3, 13Z-kolavadien-17-oic acid; II, 15-oxo-3Z, 13E-kolavadien-17-oic acid)...
  64. ncbi Novel regulation of muscarinic receptors and their coupling with G proteins in smooth muscle: transient resensitization during desensitizing process
    S Hishinuma
    Department of Pharmacology, Meiji College of Pharmacy, Tanashi, Tokyo, Japan
    Br J Pharmacol 109:330-5. 1993
    ..This novel resensitization mechanism may have some physiological significance for cellular homoeostasis by modulating cellular responsiveness transiently or even in an oscillatory manner during the process of desensitization...
  65. ncbi Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity
    Y Hosoi
    Department of Radiation Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Br J Cancer 86:1143-9. 2002
    ..Our present observations suggest that suramin may possibly result in sensitisation of cells to ionising radiation by inactivation of DNA-dependent protein kinase and the impairment of double-stranded breaks repair...
  66. ncbi Tear function and lipid layer alterations in dry eye patients with chronic graft-vs-host disease
    Y Ban
    Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan
    Eye (Lond) 23:202-8. 2009
    ..To investigate the changes in the tear film lipid layer in haematopoietic stem cell transplantation (HSCT) patients with dry eye (DE) associated with chronic graft-vs-host disease (cGVHD) and compare with HSCT recipients without DE...
  67. ncbi CDR3 spectratyping analysis of the T cell receptor repertoire in Guillain-Barré and Fisher syndromes
    Michiaki Koga
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    J Neuroimmunol 141:112-7. 2003
    ..The predominant phenotypes vary, even within subgroups of patients with a syndrome of single etiological origin or those with uniform serological features...
  68. ncbi Increased expression of phospholipase D in the heart with experimental autoimmune myocarditis in Lewis rats
    Meejung Ahn
    Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University, Jeju, South Korea
    Immunol Invest 33:95-105. 2004
    ....
  69. ncbi Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis: possible role of the netrin-1/DCC binding pathway in an autoimmune PNS disorder
    Changjong Moon
    Department of Veterinary Medicine, Cheju National University, Ara 1 Dong, Jeju 690 756, South Korea
    J Neuroimmunol 172:66-72. 2006
    ..We suggest that a significant increase in netrin-1 expression contributes to host cell survival and axon regeneration to counter autoimmune injury and inflammation, which may play a role in recovery from EAN-induced paralysis...
  70. ncbi Increased expression of osteopontin in the heart tissue of Lewis rats with experimental autoimmune myocarditis
    Taekyun Shin
    Department of Veterinary Medicine, Cheju National University, Jeju, Republic of Korea
    J Vet Med Sci 68:379-82. 2006
    ..These findings suggest that OPN is significantly increased in EAM lesions and that OPN mediates the inflammatory process in the course of rat EAM model...
  71. ncbi Increased expression of caveolin-1 and -2 in the hearts of Lewis rats with experimental autoimmune myocarditis
    Meejung Ahn
    Department of Veterinary Medicine, Graduate School, Cheju National University, Jeju City, 690 756, South Korea
    Autoimmunity 39:489-95. 2006
    ....
  72. ncbi Increased phosphorylation of caveolin-1 in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis
    Heechul Kim
    Department of Veterinary Medicine, Cheju National University, Jeju 690-756, South Korea
    Neurosci Lett 402:76-80. 2006
    ....
  73. ncbi Increased phosphorylation of cyclic AMP response element-binding protein in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis
    Heechul Kim
    Department of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju 690 756, South Korea
    Brain Res 1162:113-20. 2007
    ....
  74. ncbi Expression of caveolin-1, -2, and -3 in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis
    Taekyun Shin
    Department of Veterinary Medicine, Cheju National University, Jeju 690 756, South Korea
    J Neuroimmunol 165:11-20. 2005
    ..Taking all the findings into consideration, we postulate that the expression levels of each caveolin begin to increase when EAE is initiated, possibly contributing to the modulation of signal transduction pathways in the affected cells...
  75. ncbi Activation of p38 mitogen-activated protein kinase in the early and peak phases of autoimmune neuritis in rat sciatic nerves
    Changjong Moon
    Department of Veterinary Medicine, Cheju National University, Jeju 690-756, South Korea
    Brain Res 1040:208-13. 2005
    ....
  76. ncbi Immunohistochemical study of caveolin-1 in the sciatic nerves of Lewis rats with experimental autoimmune neuritis
    Meejung Ahn
    Department of Veterinary Medicine, Cheju National University, Jeju, South Korea
    Brain Res 1102:86-91. 2006
    ....
  77. ncbi Phospholipase D1 is up-regulated in the retina of Lewis rats with experimental autoimmune uveoretinitis
    JongChul Kang
    Department of Veterinary Medicine, College of Agriculture and Life Science, Cheju National University, Jeju, Republic of Korea
    Immunol Invest 34:27-36. 2005
    ....
  78. ncbi Increased phosphorylation of caveolin-1 in the sciatic nerves of Lewis rats with experimental autoimmune neuritis
    Heechul Kim
    Department of Veterinary Medicine, Cheju National University, Jeju 690 756, South Korea
    Brain Res 1137:153-60. 2007
    ....
  79. ncbi Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes
    Changjong Moon
    Department of Veterinary Medicine, Aradong 1, Cheju National University, Jeju 690-756, South Korea
    Brain Res 1035:206-10. 2005
    ..Overall, these findings suggest that COX-1/-2 and 5-LOX are important inflammatory mediators in the pathogenesis of EAE, and that the inhibition of both COX and LOX ameliorates the autoimmune disorder of the central nervous system...
  80. ncbi Upregulation of osteopontin in Schwann cells of the sciatic nerves of Lewis rats with experimental autoimmune neuritis
    Meejung Ahn
    Department of Veterinary Medicine, Cheju National University, Jeju 690 756, South Korea
    Neurosci Lett 372:137-41. 2004
    ..Continued elevation of OPN after recovery may represent a functional recovery after a transient inflammatory insult...
  81. ncbi Activation of extracellular signal-regulated kinases in the sciatic nerves of rats with experimental autoimmune neuritis
    Meejung Ahn
    Department of Veterinary Medicine, Cheju National University, Aradong 1, Jeju 690-756, South Korea
    Neurosci Lett 372:57-61. 2004
    ..Specifically, the activation of ERK in the recovery phase of EAN paralysis seems to be related in the survival of Schwann cells...
  82. ncbi Immunohistochemical study of flotillin-1 in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis
    Heechul Kim
    Department of Veterinary Medicine, Cheju National University, Jeju 690-756, South Korea
    Brain Res 1114:204-11. 2006
    ..Taking all these findings into consideration, we postulate that expression of flotillin-1 begins to increase when EAE is initiated and that flotillin-1 contributes to the formation of phagosomes in affected cells in EAE...