Hidehito Kuroyanagi

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi request reprint Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo
    Hidehito Kuroyanagi
    School of Biomedical Science, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Nat Methods 3:909-15. 2006
  2. pmc Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans
    Genta Ohno
    Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS Genet 8:e1002991. 2012
  3. pmc Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans
    Hidehito Kuroyanagi
    Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Nucleic Acids Res 41:4015-25. 2013
  4. pmc CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans
    Hidehito Kuroyanagi
    Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS Genet 9:e1003337. 2013
  5. doi request reprint Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans
    Hidehito Kuroyanagi
    Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Nat Protoc 5:1495-517. 2010
  6. pmc Fox-1 family of RNA-binding proteins
    Hidehito Kuroyanagi
    Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Cell Mol Life Sci 66:3895-907. 2009
  7. pmc The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo
    Hidehito Kuroyanagi
    School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Mol Cell Biol 27:8612-21. 2007
  8. doi request reprint Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans
    Hiroaki Iwasa
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Exp Cell Res 319:931-45. 2013
  9. pmc STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo
    Genta Ohno
    Laboratory of Gene Expression, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Genes Dev 22:360-74. 2008
  10. doi request reprint Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1
    Hiroaki Iwasa
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Exp Cell Res 319:1-11. 2013

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo
    Hidehito Kuroyanagi
    School of Biomedical Science, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Nat Methods 3:909-15. 2006
    ..This transgenic reporter system can be a powerful experimental tool for the comprehensive study of expression profiles and regulation mechanisms of alternative splicing in metazoans...
  2. pmc Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans
    Genta Ohno
    Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS Genet 8:e1002991. 2012
    ....
  3. pmc Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans
    Hidehito Kuroyanagi
    Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Nucleic Acids Res 41:4015-25. 2013
    ..elegans. This study thus reveals the repertoire of target events for the CELF family in the living organism...
  4. pmc CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans
    Hidehito Kuroyanagi
    Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS Genet 9:e1003337. 2013
    ..Taken together, UNC-75 is the neuron-specific splicing factor and regulates both sets of the mutually exclusive exons of the unc-32 gene...
  5. doi request reprint Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans
    Hidehito Kuroyanagi
    Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Nat Protoc 5:1495-517. 2010
    ..The fluorescence-reporter construction described here can also be applied to the vertebrate cell culture system...
  6. pmc Fox-1 family of RNA-binding proteins
    Hidehito Kuroyanagi
    Laboratory of Gene Expression, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Cell Mol Life Sci 66:3895-907. 2009
    ..Further systematic elucidation of target genes of the Fox-1 family and other splicing regulators in various tissues will lead to a comprehensive understanding of splicing regulatory networks...
  7. pmc The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo
    Hidehito Kuroyanagi
    School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Mol Cell Biol 27:8612-21. 2007
    ..These results establish an in vivo model that coordination of the two families of RNA-binding proteins regulates tissue-specific alternative splicing of a specific target gene...
  8. doi request reprint Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans
    Hiroaki Iwasa
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Exp Cell Res 319:931-45. 2013
    ..In short, YAP-1 partially shares basal characters with mammalian YAP and plays a role in thermal stress response and healthy aging...
  9. pmc STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo
    Genta Ohno
    Laboratory of Gene Expression, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Genes Dev 22:360-74. 2008
    ..We propose that the developmental switching between alternative sequences of intron removal determines the ratio between the mature let-2 mRNA isoforms...
  10. doi request reprint Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1
    Hiroaki Iwasa
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Exp Cell Res 319:1-11. 2013
    ..Although we could not detect the direct physical interaction of LET-60 with RSF-1, rsf-1 mutants suppress the multivulva phenotype of the active let-60 mutants, suggesting that rsf-1 genetically interacts with the Ras signaling...
  11. doi request reprint Dual role of the carboxyl-terminal region of pig liver L-kynurenine 3-monooxygenase: mitochondrial-targeting signal and enzymatic activity
    Kumiko Hirai
    Neuronal Signaling Research Team, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo, Japan
    J Biochem 148:639-50. 2010
    ....
  12. pmc The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans
    Keiko Gengyo-Ando
    Department of Physiology, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    EMBO Rep 8:152-7. 2007
    ..Our results indicate that VPS-45 is a key molecule that functions downstream from RAB-5, cooperating with RABS-5, to regulate the dynamics of the endocytic system in multicellular organisms...