Takatoshi Koyama

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi request reprint Successful management of massive intraperitoneal bleeding in a hemophilia A patient with inhibitor by surgical debridement of the incomplete hematoma and administration of recombinant factor VIII and activated factor VII
    Takatoshi Koyama
    Department of Hematology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Pathophysiol Haemost Thromb 35:405-7. 2006
  2. ncbi request reprint [Analyses on activation and regulation of blood coagulation]
    Takatoshi Koyama
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Rinsho Byori 58:45-57. 2010
  3. doi request reprint Activation of coagulation by a thalidomide-based regimen
    Asuka Hoshi
    Laboratory Molecular Genetics of Hematology, Graduate School of Healthcare Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Blood Coagul Fibrinolysis 22:532-40. 2011
  4. ncbi request reprint Identification of tissue factor and platelet-derived particles on leukocytes during cardiopulmonary bypass by flow cytometry and immunoelectron microscopy
    Jihwa Chung
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Thromb Haemost 98:368-74. 2007
  5. ncbi request reprint [Bortezomib-induced tumor lysis syndrome with a remarkable elevation of LDH in a case of relapsed and therapy-resistant multiple myeloma]
    Ayako Arai
    Department of Hematology, Tokyo Medical and Dental University
    Rinsho Ketsueki 47:777-80. 2006
  6. ncbi request reprint [Proteasome degradation of protein C and plasmin inhibitor mutants: molecular mechanism of congenital protein deficiency]
    Miwako Nishio
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Rinsho Byori 57:737-45. 2009
  7. pmc Activation of coagulation by lenalidomide-based regimens for the treatment of multiple myeloma
    Yu Isozumi
    Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 8:e64369. 2013
  8. doi request reprint Release of salusin-beta from human monocytes/macrophages
    Kengo Sato
    Laboratory of Molecular Genetics and Hematology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
    Regul Pept 162:68-72. 2010
  9. ncbi request reprint Proteasome degradation of protein C and plasmin inhibitor mutants
    Miwako Nishio
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Thromb Haemost 100:405-12. 2008
  10. ncbi request reprint [Ischemic colitis following the treatment of acute hemorrhage in a patient with acquired hemophilia A]
    Takayuki Suzuki
    Department of Hematology, Tokyo Medical and Dental University
    Rinsho Ketsueki 47:310-4. 2006

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Successful management of massive intraperitoneal bleeding in a hemophilia A patient with inhibitor by surgical debridement of the incomplete hematoma and administration of recombinant factor VIII and activated factor VII
    Takatoshi Koyama
    Department of Hematology, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Pathophysiol Haemost Thromb 35:405-7. 2006
  2. ncbi request reprint [Analyses on activation and regulation of blood coagulation]
    Takatoshi Koyama
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Rinsho Byori 58:45-57. 2010
    ....
  3. doi request reprint Activation of coagulation by a thalidomide-based regimen
    Asuka Hoshi
    Laboratory Molecular Genetics of Hematology, Graduate School of Healthcare Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Blood Coagul Fibrinolysis 22:532-40. 2011
    ..Induction may be protracted by Thal, which has an antiangiogenic activity. Therefore, prophylactic anticoagulant strategies should be considered in Thal-based combination regimens...
  4. ncbi request reprint Identification of tissue factor and platelet-derived particles on leukocytes during cardiopulmonary bypass by flow cytometry and immunoelectron microscopy
    Jihwa Chung
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Thromb Haemost 98:368-74. 2007
    ..These findings may be important for the development of strategies to control procoagulant activities during and after cardiac surgery...
  5. ncbi request reprint [Bortezomib-induced tumor lysis syndrome with a remarkable elevation of LDH in a case of relapsed and therapy-resistant multiple myeloma]
    Ayako Arai
    Department of Hematology, Tokyo Medical and Dental University
    Rinsho Ketsueki 47:777-80. 2006
    ..These findings suggest that a bortezomib-induced rapid reduction in tumor burden led to tumor lysis syndrome, for which caution is needed when treating myeloma patients with this very effective agent...
  6. ncbi request reprint [Proteasome degradation of protein C and plasmin inhibitor mutants: molecular mechanism of congenital protein deficiency]
    Miwako Nishio
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Rinsho Byori 57:737-45. 2009
    ..These findings might help to elucidate the molecular mechanisms and potential treatments of congenital deficiencies of proteins in a system of coagulation and fibrinolysis...
  7. pmc Activation of coagulation by lenalidomide-based regimens for the treatment of multiple myeloma
    Yu Isozumi
    Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 8:e64369. 2013
    ..An anti-TF monoclonal antibody almost completely blocked the induced PCA. When Len is given in combination with Dex, PCA may be induced on endothelial cells and monocytes through TF expression and PS exposure...
  8. doi request reprint Release of salusin-beta from human monocytes/macrophages
    Kengo Sato
    Laboratory of Molecular Genetics and Hematology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
    Regul Pept 162:68-72. 2010
    ..These data demonstrate that salusin-beta, which induces macrophage foam cell formation, is secreted in its authentic form from human monocytes/macrophages...
  9. ncbi request reprint Proteasome degradation of protein C and plasmin inhibitor mutants
    Miwako Nishio
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Thromb Haemost 100:405-12. 2008
    ..When the misfolded or truncated mutant proteins are functionally active, proteasome inhibitors such as bortezomib may have therapeutic potential for treatment of protein deficiencies...
  10. ncbi request reprint [Ischemic colitis following the treatment of acute hemorrhage in a patient with acquired hemophilia A]
    Takayuki Suzuki
    Department of Hematology, Tokyo Medical and Dental University
    Rinsho Ketsueki 47:310-4. 2006
    ..We should thus pay attention to the possible occurrence of thrombotic events even in acquired hemophilia patients in the presence of risk factors for thrombosis...
  11. ncbi request reprint IRF4 negatively regulates proliferation of germinal center B cell-derived Burkitt's lymphoma cell lines and induces differentiation toward plasma cells
    Yuou Teng
    Department of Hematology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    Eur J Cell Biol 86:581-9. 2007
    ..These results suggest that IRF4 inhibits cell cycle progression of germinal center B cell-derived Burkitt's lymphoma cells and induces terminal differentiation toward plasma cells through mechanisms independent of BCL6 downregulation...
  12. doi request reprint Serum levels and urinary excretion of salusin-alpha in renal insufficiency
    Shigeaki Kimoto
    Department of Internal Medicine, Ohme Municipal Hospital, Tokyo, Japan
    Regul Pept 162:129-32. 2010
    ..Urinary salusin-alpha may originate from the renal tubules, and may not necessarily represent the peptides filtered at the glomerulus...
  13. ncbi request reprint [Acute promyelocytic leukemia associated with hemophagocytic syndrome]
    Minako Jinta
    Department of Hematology, Tokyo Medical and Dental University
    Rinsho Ketsueki 48:310-4. 2007
    ..After administration of dexamethasone and etoposide, DIC and HPS improved, and complete remission of APL was obtained. ATRA was implicated in the aggravation of APL-induced MAHS in the present case...
  14. doi request reprint Clinical features of adult-onset chronic active Epstein-Barr virus infection: a retrospective analysis
    Ayako Arai
    Department of Hematology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo, 113 8519, Japan
    Int J Hematol 93:602-9. 2011
    ..Patients' disease courses seemed to be rapidly progressive and more aggressive than those of childhood-onset cases. More cases must be studied to clarify clinical features and establish an optimal treatment strategy...
  15. ncbi request reprint Gradually glycosylated protein C mutants (Arg178Gln and Cys331Arg) are degraded by proteasome after mannose trimming
    Masako Nakahara
    Laboratory Molecular Genetics, Graduate School of Health Sciences, Tokyo, Japan
    Thromb Haemost 92:1284-90. 2004
    ..These results indicate that the initiation of mannose trimming by mannosidase I leads to the proteasomemediated degradation of glucose-trimmed or untrimmed PC mutants...
  16. doi request reprint Systemic distribution of salusin expression in the rat
    Noriko Suzuki
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University, Tokyo, Japan
    Hypertens Res 30:1255-62. 2007
    ....
  17. doi request reprint Presence of immunoreactive salusin-beta in human plasma and urine
    Kengo Sato
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
    Regul Pept 158:63-7. 2009
    ..16+/-0.84 nmol/l, n=10). These data present the first evidence that salusin-beta circulates and is excreted in its authentic form, thereby verifying the initially predicted processing sites for salusin-beta in humans...
  18. ncbi request reprint [Physicochemical characteristics of salusin-beta and establishment of the radioimmunoassay]
    Kengo Sato
    Unit of Clinical Anatomy, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Rinsho Byori 59:121-7. 2011
    ..Successful establishment of a specific radioimmunoassay suitable for detection of immunoreactive human salusin-beta allowed to characterize the molecular form of salusin-beta released from a human-derived cultured cell line...
  19. ncbi request reprint Non-viral in vivo thrombomodulin gene transfer prevents early loss of thromboresistance of grafted veins
    Noriyuki Tabuchi
    Department of Cardio Thoracic Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Eur J Cardiothorac Surg 26:995-1001. 2004
    ....
  20. ncbi request reprint 1,25(OH)(2)D(3) blocks TNF-induced monocytic tissue factor expression by inhibition of transcription factors AP-1 and NF-kappaB
    Jihwa Chung
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Lab Invest 87:540-7. 2007
    ....
  21. doi request reprint Biosynthesis and secretion of salusin-alpha from human cells
    Kengo Sato
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Peptides 29:2203-7. 2008
    ..These results present the first evidence that salusin-alpha is biosynthesized and released from human-derived cells...
  22. doi request reprint A variant-type MLL/SEPT9 fusion transcript in adult de novo acute monocytic leukemia (M5b) with t(11;17)(q23;q25)
    Tetsuya Kurosu
    Department of Hematology, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo, 113 8519, Japan
    Int J Hematol 88:192-6. 2008
    ..It is thus suggested that, in common with the original MLL/SEPT9 cases, monocytic differentiation and a poor prognosis may also be associated with acute myeloid leukemia with the variant MLL/SEPT9 fusion transcript...
  23. doi request reprint Serum salusin-alpha levels are decreased and correlated negatively with carotid atherosclerosis in essential hypertensive patients
    Takuya Watanabe
    Department of Biochemistry, Showa University School of Medicine, Tokyo, Japan
    Hypertens Res 31:463-8. 2008
    ..Our results suggest that the decrease in serum salusin-alpha, an anti-atherogenic peptide, may be associated with carotid atherosclerosis in hypertensive patients...
  24. ncbi request reprint Gamma-secretase inhibitors suppress the growth of leukemia and lymphoma cells
    Hanae Kogoshi
    Department of Laboratory Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Oncol Rep 18:77-80. 2007
    ..The mechanism behind the effects remains to be clarified. Our investigations lead to a novel molecular target therapy for chemotherapy-resistant leukemia and lymphomas...
  25. ncbi request reprint [Acquired hemophilia developing after treatment of idiopathic interstitial pneumonia]
    Toshikage Nagao
    Department of Hematology, Tokyo Medical and Dental University
    Rinsho Ketsueki 46:1156-9. 2005
    ..After 41 days, APTT decreased to 33.4 seconds and the factor VIII inhibitor disappeared. This is the first reported case of acquired hemophilia which developed during treatment of IIP...
  26. ncbi request reprint Effect of notch ligands on in vitro sensitivity to chemo-therapeutic drugs in leukemia and lymphoma cells
    Hanae Kogoshi
    Department of Laboratory Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Oncol Rep 14:723-6. 2005
    ..However, the ligand-coated culture-plates are more similar to the microenvironment in human bone marrow than ordinary plates. We will further examine the clinical usefulness of the drug-sensitivity test using the ligand-coated plates...
  27. ncbi request reprint Activated leukocytes adsorbed on the surface of an extracorporeal circuit
    Noriyuki Tabuchi
    Department of Cardio Thoracic Surgery, Graduate School of Medicine, and Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Artif Organs 27:591-4. 2003
    ..Although our data is limited, this elution procedure appears useful to investigate the biocompatibility of extracorporeal circuits...
  28. ncbi request reprint [Drug-induced disseminated intravascular coagulation (DIC)]
    Takatoshi Koyama
    Laboratory Molecular Genetics of Hematology, Graduate School of Health Sciences, Tokyo Medical and Dental University
    Nihon Rinsho 65:493-6. 2007
  29. ncbi request reprint Matrix metalloproteinase inhibitor (ONO-4817) attenuates ischemia-reperfusion injury in rat lung
    Takehiko Shimoyama
    Department of Cardio Thoracic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Med Sci Monit 12:BR51-6. 2006
    ..Therefore, we used a novel MMP inhibitor (ONO-4817) with high affinities for MMP-2 and MMP-9 to investigate the roles of MMPs in reperfusion injury of the lungs...
  30. pmc Circulating Levels of Human salusin-β,a Potent Hemodynamic and Atherogenesis Regulator
    Kazumi Fujimoto
    Laboratory of Molecular Genetics of Hematology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan Department of Endocrinology, Diabetes and Metabolism, Kitasato University School of Medicine, Kanagawa, Japan
    PLoS ONE 8:e76714. 2013
    ..The obtained results suggest a limited contribution of the neuroendocrine system to peripheral total salusin-β concentrations and a role for plasma total salusin-β concentrations as an indicator of systemic vascular diseases. ..
  31. pmc CD137 is induced by the CD40 signal on chronic lymphocytic leukemia B cells and transduces the survival signal via NF-κB activation
    Yukana Nakaima
    Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 8:e64425. 2013
    ..Consequently, the CD137 signal augmented the survival of CD154-stimulated CLL B cells in vitro. This unexpected induction of CD137 on B cells by CD40 signal may influence the clinical course of CLL...
  32. doi request reprint Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents
    Yuko Kageyama
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Hepatology 56:1427-38. 2012
    ..Conclusion: S1P may play an important role in the pathophysiology of portal hypertension with Rho kinase activation by way of S1P(2) . The S1P(2) antagonist merits consideration as a novel therapeutic agent for portal hypertension...
  33. ncbi request reprint Formation of tissue factor-bearing leukocytes during and after cardiopulmonary bypass
    Aya Shibamiya
    Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Thromb Haemost 92:124-31. 2004
    ....
  34. pmc Extracellular RNA is a natural cofactor for the (auto-)activation of Factor VII-activating protease (FSAP)
    Fumie Nakazawa
    Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem J 385:831-8. 2005
    ....
  35. ncbi request reprint Presence of immunoreactive salusin-alpha in human serum and urine
    Kengo Sato
    Graduate School of Health Sciences, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Peptides 27:2561-6. 2006
    ..These data indicate the presence of salusin-alpha in human serum and urine, thereby verifying the initially predicted processing sites for salusin-alpha in humans...
  36. ncbi request reprint Induction of tissue factor expression in human monocytic cells by protease inhibitors through activating activator protein-1 (AP-1) with phosphorylation of Jun-N-terminal kinase and p38
    Mai Ohsawa
    Laboratory Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Thromb Res 112:313-20. 2003
    ..In addition to phosphorylation of JNK and p38, an unknown signal pathway needs to be clarified for TF induction...
  37. ncbi request reprint Acquired von Willebrand syndrome associated with Hashimoto's thyroiditis and subcutaneous mucosa-associated lymphoid tissue lymphoma
    Takatoshi Koyama
    Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Japan
    Intern Med 52:2661-3. 2013
    ..VWF-containing concentrates stopped the bleeding. Even if such a complication is rare, for AVWS patients, prompt recognition of the underlying mechanism can save lives. ..
  38. ncbi request reprint Identification of putative metabolites of docosahexaenoic acid as potent PPARgamma agonists and antidiabetic agents
    Keiko Yamamoto
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Bioorg Med Chem Lett 15:517-22. 2005
    ..Furthermore, the 4-keto derivative (10b) showed antidiabetic activity in animal models without producing undesirable effects such as obesity and hepatotoxicity...