Shigeru Kotake

Summary

Affiliation: Tokyo Women's Medical University
Country: Japan

Publications

  1. doi request reprint Effect of TNFα on osteoblastogenesis from mesenchymal stem cells
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan Electronic address
    Biochim Biophys Acta 1840:1209-13. 2014
  2. doi request reprint Voltage-dependent anion channels (VDACs, porin) expressed in the plasma membrane regulate the differentiation and function of human osteoclasts
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Cell Biol Int 37:65-77. 2013
  3. doi request reprint Human receptor activator of NF-κB ligand (RANKL) induces osteoclastogenesis of primates in vitro
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, Shinjuku, Tokyo, Japan
    In Vitro Cell Dev Biol Anim 48:593-8. 2012
  4. doi request reprint Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial 'human osteoclastology'
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    J Bone Miner Metab 30:125-35. 2012
  5. ncbi request reprint IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Eur J Immunol 35:3353-63. 2005
  6. doi request reprint T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Bone 45:627-39. 2009
  7. pmc The role of T-cell leukemia translocation-associated gene protein in human tumorigenesis and osteoclastogenesis
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    J Biomed Biotechnol 2012:675317. 2012
  8. ncbi request reprint Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Clin Rheumatol 26:2137-41. 2007
  9. doi request reprint IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-alpha antibody: a novel mechanism of osteoclastogenesis by IL-17
    Toru Yago
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    J Cell Biochem 108:947-55. 2009
  10. doi request reprint Combining effects of polymorphism of tumor necrosis factor alpha 5'-flanking region and HLA-DRB1 on radiological progression in patients with rheumatoid arthritis
    Naomi Ichikawa
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 19:134-9. 2009

Detail Information

Publications47

  1. doi request reprint Effect of TNFα on osteoblastogenesis from mesenchymal stem cells
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan Electronic address
    Biochim Biophys Acta 1840:1209-13. 2014
    ....
  2. doi request reprint Voltage-dependent anion channels (VDACs, porin) expressed in the plasma membrane regulate the differentiation and function of human osteoclasts
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Cell Biol Int 37:65-77. 2013
    ..Inhibitors of VDACs could be used to treat diseases involving increased resorption, such as osteoporosis, rheumatoid arthritis, and Paget's disease...
  3. doi request reprint Human receptor activator of NF-κB ligand (RANKL) induces osteoclastogenesis of primates in vitro
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, Shinjuku, Tokyo, Japan
    In Vitro Cell Dev Biol Anim 48:593-8. 2012
    ..Thus, these findings clearly demonstrated that human RANKL induces primate osteoclastogenesis in the presence of human M-CSF...
  4. doi request reprint Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial 'human osteoclastology'
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    J Bone Miner Metab 30:125-35. 2012
    ..In this review article, we describe our articles on the roles of osteoclasts and IL-17 in joint destruction in RA, from 1990 to 2011, and highlight a novel term, 'human osteoclastology', which we have used since 2008...
  5. ncbi request reprint IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Eur J Immunol 35:3353-63. 2005
    ..Contrary to our hypothesis, IFN-gamma(+) human T cells induced osteoclastogenesis through the expression of RANKL, suggesting that Th1 cells play a direct role in bone resorption in Th1 dominant diseases such as RA...
  6. doi request reprint T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Bone 45:627-39. 2009
    ..Our novel peptide and polyclonal antibodies against the peptide inhibited human osteoclastogenesis and the function of mature osteoclasts, preventing cellular fusion by TCTA protein and a putative counterpart molecule...
  7. pmc The role of T-cell leukemia translocation-associated gene protein in human tumorigenesis and osteoclastogenesis
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    J Biomed Biotechnol 2012:675317. 2012
    ..In the current paper, we reviewed the roles of TCTA protein in lung cancer cell lines and human osteoclastogenesis...
  8. ncbi request reprint Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Clin Rheumatol 26:2137-41. 2007
    ..In addition, SNPs in RANKL and IL-17 may be associated with radiographic progression in Japanese patients with early RA...
  9. doi request reprint IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-alpha antibody: a novel mechanism of osteoclastogenesis by IL-17
    Toru Yago
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    J Cell Biochem 108:947-55. 2009
    ..The present study clearly demonstrated the novel mechanism by which IL-17 directly induces osteoclastogenesis from human monocytes alone. In addition, infliximab potently inhibits the osteoclastogenesis directly induced by IL-17...
  10. doi request reprint Combining effects of polymorphism of tumor necrosis factor alpha 5'-flanking region and HLA-DRB1 on radiological progression in patients with rheumatoid arthritis
    Naomi Ichikawa
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 19:134-9. 2009
    ..The combination of the polymorphism of the TNFA upstream promoter region and HLA-DRB1 allele was associated with radiological progression in the early stage of RA...
  11. doi request reprint Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients
    Wako Urano
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    J Bone Miner Metab 27:574-83. 2009
    ..Our results suggest that MTX use is associated with a nonvertebral fracture risk, whereas MTHFR polymorphism status does not appear to be a clinically useful marker for predicting fracture risk in Japanese female RA patients...
  12. doi request reprint Risk factors associated with incident fractures in Japanese men with rheumatoid arthritis: a prospective observational cohort study
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, Japan
    J Bone Miner Metab 26:499-505. 2008
    ..High HAQ disability score and baseline doses of daily prednisolone may correlate with incident clinical vertebral fracture in Japanese men with RA...
  13. ncbi request reprint [Serum markers of synovitis and bone metabolism in rheumatoid arthritis]
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University
    Clin Calcium 19:362-71. 2009
    ..In this article, we reviewed the literature on these issues after describing our hypothesis of the pathogenesis of synovitis in RA...
  14. ncbi request reprint [Effects of biologic therapies on systemic osteoporosis in patients with rheumatoid arthritis]
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University
    Nihon Rinsho 67:996-1002. 2009
    ..In this review article, we reviewed the literature on the issue after we described our hypothesis on the pathogenesis of synovitis in patients with RA...
  15. ncbi request reprint Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 19:379-83. 2009
    ..1 or 0.5 microM Fluv was significantly higher than that by the medium alone. In summary, we found that GGA induced cell death in RA FLS, suggesting that GGA may be a potential new therapeutic agent for RA as well as osteoporosis...
  16. pmc IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats
    Toru Yago
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Arthritis Res Ther 9:R96. 2007
    ..Thus, controlling IL-23 production and function could be a strategy for preventing inflammation and bone destruction in patients with rheumatoid arthritis...
  17. ncbi request reprint [Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis]
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University
    Nihon Rinsho Meneki Gakkai Kaishi 32:466-71. 2009
    ..Only a few studies on the role of TCTA protein have been reported, including our report published in 2009. In the current review paper, we summarized papers on TCTA protein before 2009 and our recent findings...
  18. doi request reprint Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet's disease before ocular attack: a possible predictive marker of ocular attack
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 18:354-8. 2008
    ..In addition, decreased percentages of Treg cells may be a predictive marker of ocular attack in BD patients allowing treatment of BD patients before an ocular attack...
  19. doi request reprint A1330V polymorphism of low-density lipoprotein receptor-related protein 5 gene and self-reported incident fractures in Japanese female patients with rheumatoid arthritis
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 19:140-6. 2009
    ..Our results suggest that this LPR5 polymorphism does not appear to be a clinically useful marker for the prediction of fracture risk in Japanese female RA patients, although it is associated with increased serum total cholesterol levels...
  20. ncbi request reprint Risk factors associated with incident clinical vertebral and nonvertebral fractures in Japanese women with rheumatoid arthritis: a prospective 54-month observational study
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 34:303-10. 2007
    ..To evaluate the association between potential risk factors and incident clinical fractures in Japanese patients with rheumatoid arthritis (RA)...
  21. ncbi request reprint [Association of polymorphisms in genes of osteoclastogenesis-related cytokines with severity in patients with rheumatoid arthritis]
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University
    Nihon Rinsho 63:1574-8. 2005
    ..In this article, we review recent findings, including ours, indicating that polymorphisms in genes of osteoclastogenesis-related cytokines may account for the severity of RA...
  22. doi request reprint Tacrolimus potently inhibits human osteoclastogenesis induced by IL-17 from human monocytes alone and suppresses human Th17 differentiation
    Toru Yago
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Cytokine 59:252-7. 2012
    ....
  23. doi request reprint Radiographic repair in three Japanese patients with rheumatoid arthritis treated with bucillamine
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 19:681-6. 2009
    ..However, it remains unclear whether Bc repairs bone erosion in patients with RA. Here, we treated three RA patients with Bc who subsequently showed radiographic repair of erosions and cysts...
  24. ncbi request reprint A case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated by corticosteroid and mizoribine, followed by mizoribine alone
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Intern Med 49:1449-53. 2010
    ..Thus, this case may be associated with IgG4. The present case is the first case in which mizoribine was effective for Mikulicz's disease and IgG4-related plasmacytic syndrome...
  25. ncbi request reprint [A case of Sjögren syndrome suspected, rheumatoid arthritis and Behcet's disease complicated with cochlear nerve and trigeminal nerve disorders]
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University
    Nihon Rinsho Meneki Gakkai Kaishi 35:429-32. 2012
    ..In 2001, she was also diagnosed with Sjögren's syndrome suspected. Afterward, abducent and trigeminal neuropathies and uveites occurred. This case is important to insight into the cranial neuropathy with Sjögren's syndrome...
  26. ncbi request reprint Granzyme B induces apoptosis of chondrocytes with natural killer cell-like cytotoxicity in rheumatoid arthritis
    Seiji Saito
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 35:1932-43. 2008
    ..We have now investigated whether granzyme B directly induces apoptosis in chondrocytes and whether chondrocytes possess NK cell-like function...
  27. ncbi request reprint Case of Chlamydia-associated arthritis
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University
    Nihon Rinsho Meneki Gakkai Kaishi 32:511-4. 2009
    ..During the course, the levels of Th1, Th17 and regulatory T cells in the peripheral blood were increased on flowcytometry. Thus, we speculate that Th17 may play, at least in part, an important role of the pathogenesis in this case...
  28. ncbi request reprint Immunogenetic features in 120 Japanese patients with idiopathic inflammatory myopathy
    Takefumi Furuya
    Institute of Rheumatology and Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 31:1768-74. 2004
    ..To examine the role of HLA-DRB1 and tumor necrosis factor (TNF) promoter genotypes in the development and the autoantibody profiles of idiopathic inflammatory myopathy (IIM) in Japanese patients...
  29. ncbi request reprint [Geranylgeranylacetone, an antiulcer drug, potently inhibits formation and function of human osteoclasts in vitro and bone loss in ovariectomized rats]
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University
    Nihon Rinsho 62:575-9. 2004
  30. ncbi request reprint The effects of disease modifying anti-rheumatic drugs on osteoclastogenesis and bone destruction in rheumatoid arthritis
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 34:493-500. 2011
    ..Here, we review the effects of disease modifying anti-rheumatic drugs (DMRAD) on the amelioration of bone destruction and osteoclastogenesis...
  31. ncbi request reprint Efficacy of methotrexate in the treatment of a HLA-B27-positive Japanease patient with reactive arthritis
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 33:283-5. 2010
    ..Finally, methtrexate was added ; thereafter, polyarthritis and elevated CRP were resolved. HLA-B270502 was positive. Methotrexate could be one of the choices for sulphasalazine-resistant reactive arthritis...
  32. ncbi request reprint Bone erosion of the sternocostal joint in a patient with Behcet's disease
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University
    Nihon Rinsho Meneki Gakkai Kaishi 32:186-8. 2009
    ..Erosive arthropathy is extremely rare. We report a 52-year-old female patient with BD demonstrating bone erosion of the sternocostal joint...
  33. ncbi request reprint [Prospective cohort studies of incident fractures in patients with rheumatoid arthritis]
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University
    Nihon Rinsho 65:125-9. 2007
  34. ncbi request reprint [Isolated pulmonary hypertension in overlap syndrome: successful treatment by methylprednisolone pulse therapy]
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University
    Nihon Rinsho Meneki Gakkai Kaishi 26:28-33. 2003
    ..Since PH in this case responded favorably to methylprednisolone pulse therapy, this therapy may be effective for PH associated with overlap syndrome...
  35. ncbi request reprint [Secondary osteoporosis. Fractures in patients with rheumatoid arthritis]
    Takefumi Furuya
    Tokyo Women s Medical University, Institute of Rheumatology, Japan
    Clin Calcium 17:1429-34. 2007
    ..This article reviews the epidemiology and associated risk factors with the development of fractures in patients with RA...
  36. doi request reprint Irsogladine is effective for recurrent oral ulcers in patients with Behçet's disease : an open-label, single-centre study
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Drugs R D 9:455-9. 2008
    ..We investigated whether irsogladine, a drug for the treatment of gastritis and peptic ulcers, reduced aphthous stomatitis lesions in patients with BD...
  37. doi request reprint Therapeutic effects of hyaluronate injections in patients with chronic painful shoulder: a meta-analysis of randomized controlled trials
    Seiji Saito
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    Arthritis Care Res (Hoboken) 62:1009-18. 2010
    ..To elucidate the therapeutic efficacy and safety of injection of hyaluronate (HA) for chronic painful shoulder...
  38. doi request reprint A Japanese case of Behçet's disease complicated by recurrent optic neuropathy involving both eyes: a third case in the English literature
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 19:334-7. 2009
    ..However, optic neuropathy in BD is very rare. This case suggests that optic neuropathy can affect both eyes and be recurrent. This case provides clinical insight into optic nerve involvement in BD...
  39. ncbi request reprint A case of Weber-Christian disease with later development of rheumatoid arthritis
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 34:49-52. 2011
    ..This is the second case of WCD showing the subsequent development of RA, successfully treated with MTX, in the English literature. This case may provide clinical insight into WCD and RA...
  40. ncbi request reprint [Chlamydia-associated arthritis and enteropathic arthritis--two important spondyloarthritides]
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 34:121-30. 2011
    ..Sacroiliac joint tests need to be performed to diagnose sacroiliac arthritis. Rheumatologists should be aware of the pathogenesis of Chl-AA and EA and diagnose and treat these diseases appropriately...
  41. ncbi request reprint [An asymptomatic mother of cutaneous neonatal lupus child was diagnosed with Sjögren's syndrome suspected]
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 33:154-6. 2010
    ..Serum IgG was elevated (2918 mg/dl). Finally, this case was suspected as Sjögren's syndrome. Continuoues follow-up of asymptomatic mothers of a neonatal lupus child is warranted...
  42. ncbi request reprint Is there evidence in support of the use of intra-articular hyaluronate in treating rheumatoid arthritis of the knee? A meta-analysis of the published literature
    Seiji Saito
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 19:493-501. 2009
    ..98, p = 0.32). The results indicated that intra-articular HA is an effective and safe alternative therapy for the rheumatoid knee...
  43. ncbi request reprint Association of IL1A gene polymorphisms with susceptibility to and severity of systemic sclerosis in the Japanese population
    Yasushi Kawaguchi
    Institute of Radiology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Arthritis Rheum 48:186-92. 2003
    ....
  44. ncbi request reprint Effect of bone marrow grafting on the titanium porous-coated implant in bilateral total knee arthroplasty
    Kang Jung Kim
    Department of Orthopaedic Surgery, Tokyo Women s Medical College, Tokyo, Japan
    Acta Orthop 78:116-22. 2007
    ..The second aim was to compare the clinical and radiographic results after bilateral total knee arthroplasty (TKA) with and without autologous bone marrow transplantation to the bone-implant interface...
  45. ncbi request reprint [Possible roles of TNF family cytokines in bone destruction of rheumatoid arthritis]
    Nobuyuki Udagawa
    Ryumachi 42:3-12. 2002
  46. pmc The molecular mechanism of osteoclastogenesis in rheumatoid arthritis
    Nobuyuki Udagawa
    Department of Biochemistry, Matsumoto Dental University, Nagano, Japan
    Arthritis Res 4:281-9. 2002
    ..The possible roles of RANKL and other cytokines produced by T lymphocytes in bone destruction are described...
  47. ncbi request reprint [Rheumatoid arthritis and osteoporosis]
    Shigeru Kotake
    Nihon Naika Gakkai Zasshi 94:649-55. 2005