Affiliation: Tokyo Institute of Technology
Kawaguchi K, Endo A, Fukushima T, Madoka Y, Tanaka T, Komada M. Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion. Biochem Biophys Res Commun. 2018;499:635-641 pubmed publisher
..We concluded that USP8 deubiquitinates Sec31A and inhibits the formation of large COPII carriers, thereby suppressing collagen IV secretion. ..
Burana D, Yoshihara H, Tanno H, Yamamoto A, Saeki Y, Tanaka K, et al
. The Ankrd13 Family of Ubiquitin-interacting Motif-bearing Proteins Regulates Valosin-containing Protein/p97 Protein-mediated Lysosomal Trafficking of Caveolin 1. J Biol Chem. 2016;291:6218-31 pubmed publisher
..The interaction with Ankrd13 was abrogated in IMBPFD-associated VCP mutants. Collectively, our results suggest that Ankrd13 proteins cooperate with VCP to regulate the lysosomal trafficking of ubiquitinated Cav-1. ..
Yanagawa T, Denda K, Inatani T, Fukushima T, Tanaka T, Kumaki N, et al
. Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice. Am J Pathol. 2016;186:2751-60 pubmed publisher
..We suggest that Nrk suppresses the excessive proliferation of mammary epithelial cells during pregnancy, and the impairment of this regulatory system leads to frequent occurrence of breast tumor in Nrk mutant mice. ..
Komada M, Soriano P. [Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. J Cell Biol. 2002;156:337-48 pubmed
..These results indicate that betaIV-spectrin and ankyrin-G mutually stabilize the membrane protein cluster and the linked membrane cytoskeleton at AIS and NR. ..
Mizuno E, Kawahata K, Kato M, Kitamura N, Komada M. STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif. Mol Biol Cell. 2003;14:3675-89 pubmed