Osamu Kitagawa

Summary

Affiliation: Tokyo University of Pharmacy and Life Science
Country: Japan

Publications

  1. ncbi request reprint Catalytic asymmetric desymmetrization of meso-diamide derivatives through enantioselective N-allylation with a chiral pi-allyl Pd catalyst: improvement and reversal of the enantioselectivity
    Osamu Kitagawa
    Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Org Chem 71:2524-7. 2006
  2. ncbi request reprint Highly enantioselective synthesis of atropisomeric anilide derivatives through catalytic asymmetric N-arylation: conformational analysis and application to asymmetric enolate chemistry
    Osamu Kitagawa
    Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Am Chem Soc 128:12923-31. 2006
  3. doi request reprint Highly selective stereodivergent synthesis of separable amide rotamers, by using Pd chemistry, and their thermodynamic behavior
    Nobutaka Ototake
    School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Chemistry 15:5090-5. 2009
  4. ncbi request reprint Catalytic asymmetric synthesis of vicinal diamine derivatives through enantioselective N-allylation using chiral pi-allyl Pd-catalyst
    Osamu Kitagawa
    Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Org Lett 6:3605-7. 2004

Collaborators

  • Takeo Taguchi
  • Nobutaka Ototake
  • Haruhiko Fukaya
  • Masashi Nakamura
  • Yasuo Dobashi

Detail Information

Publications4

  1. ncbi request reprint Catalytic asymmetric desymmetrization of meso-diamide derivatives through enantioselective N-allylation with a chiral pi-allyl Pd catalyst: improvement and reversal of the enantioselectivity
    Osamu Kitagawa
    Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Org Chem 71:2524-7. 2006
    ..Under the same conditions, in the reaction with meso-bistolunesulfonylamide derivatives, reversal of the enantioselectivity is observed...
  2. ncbi request reprint Highly enantioselective synthesis of atropisomeric anilide derivatives through catalytic asymmetric N-arylation: conformational analysis and application to asymmetric enolate chemistry
    Osamu Kitagawa
    Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    J Am Chem Soc 128:12923-31. 2006
    ..The reaction of the lithium enolate prepared from the atropisomeric anilide and lactam products with various alkyl halides gives alpha-alkylated products with high diastereoselectivity (diastereomer ratio = 13:1 to 46:1)...
  3. doi request reprint Highly selective stereodivergent synthesis of separable amide rotamers, by using Pd chemistry, and their thermodynamic behavior
    Nobutaka Ototake
    School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Chemistry 15:5090-5. 2009
    ..The prepared anilide rotamers changed to equilibrium mixtures in which the E rotamer was the major isomer when heated in toluene...
  4. ncbi request reprint Catalytic asymmetric synthesis of vicinal diamine derivatives through enantioselective N-allylation using chiral pi-allyl Pd-catalyst
    Osamu Kitagawa
    Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Org Lett 6:3605-7. 2004
    ..The product was converted to the known sigma-receptor agonist in short steps. In addition, the present catalytic asymmetric N-allylation was applied to kinetic resolution of racemic-diamide...