K Kikugawa

Summary

Affiliation: Tokyo University of Pharmacy and Life Science
Country: Japan

Publications

  1. ncbi request reprint Effect of beta-carotene on the transformation of tyrosine by nitrogen dioxide and peroxynitrous acid
    K Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Free Radic Res 30:37-43. 1999
  2. ncbi request reprint Effect of supplementation of n-3 polyunsaturated fatty acids on oxidative stress-induced DNA damage of rat hepatocytes
    Kiyomi Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
    Biol Pharm Bull 26:1239-44. 2003
  3. ncbi request reprint Protective effect of supplementation of fish oil with high n-3 polyunsaturated fatty acids against oxidative stress-induced DNA damage of rat liver in vivo
    Kiyomi Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan
    J Agric Food Chem 51:6073-9. 2003
  4. ncbi request reprint Effects of oxygen on the reactivity of nitrogen oxide species including peroxynitrite
    Kiyomi Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Biol Pharm Bull 27:17-23. 2004
  5. ncbi request reprint [Defense of living body against oxidative damage]
    Kiyomi Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 092 0392, Japan
    Yakugaku Zasshi 124:653-66. 2004
  6. ncbi request reprint Prevention of mutagen formation in heated meats and model systems
    Kiyomi Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Mutagenesis 19:431-9. 2004
  7. ncbi request reprint Effect of food reductones on the generation of the pyrazine cation radical and on the formation of the mutagens in the reaction of glucose, glycine and creatinine
    K Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo, Japan
    Mutat Res 465:183-90. 2000
  8. ncbi request reprint Participation of the pyrazine cation radical in the formation of mutagens in the reaction of glucose/glycine/creatinine
    K Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Japan
    Mutat Res 444:133-44. 1999
  9. ncbi request reprint Involvement of free radicals in the formation of heterocyclic amines and prevention by antioxidants
    K Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science Formerly Tokyo College of Pharmacy, Hachioji, Japan
    Cancer Lett 143:123-6. 1999
  10. ncbi request reprint Beta-carotene generates thiobarbituric acid-reactive substances by interaction with nitrogen dioxide in air
    K Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Free Radic Res 31:517-23. 1999

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Effect of beta-carotene on the transformation of tyrosine by nitrogen dioxide and peroxynitrous acid
    K Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Free Radic Res 30:37-43. 1999
    ....
  2. ncbi request reprint Effect of supplementation of n-3 polyunsaturated fatty acids on oxidative stress-induced DNA damage of rat hepatocytes
    Kiyomi Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
    Biol Pharm Bull 26:1239-44. 2003
    ..It is unlikely that an n-3 PUFA-rich diet enhances oxidative stress-induced hepatocyte DNA damage as compared with the control n-6 PUFA-rich diet...
  3. ncbi request reprint Protective effect of supplementation of fish oil with high n-3 polyunsaturated fatty acids against oxidative stress-induced DNA damage of rat liver in vivo
    Kiyomi Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan
    J Agric Food Chem 51:6073-9. 2003
    ..The above results indicate that fish oil supplementation does not enhance but appears to protect against oxidative stress-induced DNA damage and suggest that lipid peroxidation does not enhance but lowers the DNA damage...
  4. ncbi request reprint Effects of oxygen on the reactivity of nitrogen oxide species including peroxynitrite
    Kiyomi Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Biol Pharm Bull 27:17-23. 2004
    ..Generation of.OH from ONOO(-)/ONOOH was suppressed under anaerobic conditions. The reactivity of ONOO(-)/ONOOH and.OH generation from ONOO(-) were reversibly controlled by the O(2) concentration...
  5. ncbi request reprint [Defense of living body against oxidative damage]
    Kiyomi Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 092 0392, Japan
    Yakugaku Zasshi 124:653-66. 2004
    ..Oxidized protein hydrolase that preferentially hydrolyzes proteins damaged by oxidative stress was newly discovered, which may play an important role in saving cells from oxidative damage...
  6. ncbi request reprint Prevention of mutagen formation in heated meats and model systems
    Kiyomi Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Mutagenesis 19:431-9. 2004
    ..Addition of a small amount of ascorbate or erythorbate is also effective, which may be the result of scavenging the intermediary pyrazine cation radical...
  7. ncbi request reprint Effect of food reductones on the generation of the pyrazine cation radical and on the formation of the mutagens in the reaction of glucose, glycine and creatinine
    K Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo, Japan
    Mutat Res 465:183-90. 2000
    ..On the other hand, ascorbic acid and erythorbic acid were effective to decrease the mutagen formation in the reaction of Glc, Gly and creatinine...
  8. ncbi request reprint Participation of the pyrazine cation radical in the formation of mutagens in the reaction of glucose/glycine/creatinine
    K Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Japan
    Mutat Res 444:133-44. 1999
    ..Thiol antioxidants and unsaturated fatty acids can be evaluated as inhibitors of the pyrazine cation radical-derived formation of the mutagens...
  9. ncbi request reprint Involvement of free radicals in the formation of heterocyclic amines and prevention by antioxidants
    K Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science Formerly Tokyo College of Pharmacy, Hachioji, Japan
    Cancer Lett 143:123-6. 1999
    ..Prevention of the generation of these radical intermediates by phenolic antioxidants effectively inhibited the generation of the heterocyclic amines...
  10. ncbi request reprint Beta-carotene generates thiobarbituric acid-reactive substances by interaction with nitrogen dioxide in air
    K Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Free Radic Res 31:517-23. 1999
    ..TBARS from beta-carotene may interfere the measurement of TBARS from polyunsaturated fatty acids, and may give undesirable effects on biomaterials...
  11. ncbi request reprint Water-soluble antioxidants inhibit macrophage recognition of oxidized erythrocytes
    M Beppu
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Biol Pharm Bull 24:575-8. 2001
    ....
  12. ncbi request reprint Enhanced adhesion of oxidized mouse polymorphonuclear leukocytes to macrophages by a cell-surface sugar-dependent mechanism
    M Beppu
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Biol Pharm Bull 24:19-26. 2001
    ..Clustered sialylated poly-N-acetyllactosaminyl sugar chains on the cell surface may be involved in the increased adhesion of the oxidized PMNs to macrophages...
  13. ncbi request reprint Effect of food reductones, 2,5-dimethyl-4-hydroxy-3(2H)-furanone (DMHF) and hydroxyhydroquinone (HHQ), on lipid peroxidation and type IV and I allergy responses of mouse
    H Mi
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan
    J Agric Food Chem 49:4950-5. 2001
    ..In no cases were additive effects of NO(2) inhalation observable. Allergen-sensitized type IV and I allergy responses of mice may be enhanced by supplementation of food reductones, DMHF or HHQ...
  14. ncbi request reprint Standardization of nitric oxide aqueous solutions by modified Saltzman method
    T Ohkawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan
    Nitric Oxide 5:515-24. 2001
    ..Simultaneous quantification of nitrogen oxide species by the modified Saltzman method was found to be useful for practical standardization of NO aqueous solutions...
  15. ncbi request reprint Release of nitric oxide together with carbon-centered radicals from N-nitrosamines by ultraviolet light irradiation
    K Hiramoto
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Free Radic Res 35:803-13. 2001
    ..Released NO from the N-nitrosamines must be converted into nitrite through intermediary reactive nitrogen oxide species including nitrogen dioxide and dinitrogen trioxide in contact with dissolved oxygen...
  16. ncbi request reprint Decomposition of N-nitrosamines, and concomitant release of nitric oxide by Fenton reagent under physiological conditions
    K Hiramoto
    School of Pharmacy, Tokyo University of Pharmacy, and Life Science, 1432 1 Horinouchi, Hachioji, 192 0392, Tokyo, Japan
    Mutat Res 520:103-11. 2002
    ..Above results indicate that the N-nitrosamines were decomposed accompanying concomitant release of NO on contact with reactive oxygen species...
  17. ncbi request reprint Involvement of calcium signaling in the fibronectin-stimulated macrophage recognition of oxidatively damaged erythrocytes
    M Beppu
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
    Biochim Biophys Acta 1538:119-28. 2001
    ..Involvement of microfilament formation and arachidonate cascade in the fibronectin stimulation was also suggested...
  18. ncbi request reprint Increased release of free Fe ions in human erythrocytes during aging in the circulation
    Ken Ando
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Free Radic Res 36:1079-84. 2002
    ..The results indicated that free Fe ions were released from erythrocytes during aging process in the circulation. Released free Fe ions would promote oxidative damages of the cells during aging process...
  19. ncbi request reprint Is nitrotyrosine generated in human erythrocytes in circulation?
    K Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Biol Pharm Bull 23:379-85. 2000
    ..However, this does not conclude that erythrocytes are not exposed to reactive nitrogen species in the circulation...
  20. ncbi request reprint Novel lectin-like proteins on the surface of human monocytic leukemia cell line THP-1 cells that recognize oxidized cells
    S Eda
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Arch Biochem Biophys 385:186-93. 2001
    ....
  21. ncbi request reprint Is nitric oxide (NO) an antioxidant or a prooxidant for lipid peroxidation?
    Kazuyuki Hiramoto
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Chem Pharm Bull (Tokyo) 51:1046-50. 2003
    ..Hence, NO showed both antioxidant and prooxidant effects on lipid peroxidation depending on the solvents...
  22. ncbi request reprint The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange factor, FGD1
    Makio Hayakawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Genes Cells 10:241-51. 2005
    ..FGD1(SA)-expressing cells show a higher level of cell motility than FGD1(WT)-expressing cells. We present a novel 'turning off' mechanism for the inactivation of FGD1, an upstream regulator for Cdc42...
  23. doi request reprint Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1
    Makio Hayakawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan
    Genes Cells 13:329-42. 2008
    ....
  24. ncbi request reprint Substrate-bound fibronectin enhances scavenger receptor activity of macrophages by calcium signaling
    M Beppu
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan
    Arch Biochem Biophys 390:243-52. 2001
    ....
  25. ncbi request reprint Overexpression of oxidized protein hydrolase protects COS-7 cells from oxidative stress-induced inhibition of cell growth and survival
    Kei Shimizu
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Biochem Biophys Res Commun 304:766-71. 2003
    ..Above results indicate that OPH in intact cells plays a preventive role against oxidative stress and suggest that OPH relieves cells from accumulation of oxidatively damaged proteins...
  26. ncbi request reprint Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase
    T Fujino
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo, Japan
    Biochim Biophys Acta 1478:102-12. 2000
    ..The results clearly demonstrate that ACPH, whose physiological function has not yet been well characterized, can play an important role as OPH in destroying oxidatively damaged proteins in living cells...
  27. ncbi request reprint Coordination of oxidized protein hydrolase and the proteasome in the clearance of cytotoxic denatured proteins
    Kei Shimizu
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Biochem Biophys Res Commun 324:140-6. 2004
    ..Thus, OPH and the proteasome coordinately contribute to the clearance of cytotoxic denatured proteins...
  28. ncbi request reprint Interaction of nitric oxide with glutathione or cysteine generates reactive oxygen species causing DNA single strand breaks
    Kiyomi Kikugawa
    Tokyo University of Pharmacy and Life Science, School of Pharmacy, Japan
    Biol Pharm Bull 28:998-1003. 2005
    ..The results indicate that the interaction of NO with thiols in the presence of O2 generates ROS that caused DNA single-strand breaks...
  29. ncbi request reprint [Nitrosamine formation from vegetables produced in Japan]
    Rimiko Ohtsuki
    School of Pharmacy, Tokyo University of Pharmacy and Life Science 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Shokuhin Eiseigaku Zasshi 46:58-61. 2005
    ..Addition of a large amount of ascorbate was required to decrease nitrosamine formation from the extract. The results indicated that nitrosamine formation from these vegetables could not be prevented by other components in the vegetables...
  30. ncbi request reprint Participation of the arachidonic acid cascade pathway in macrophage binding/uptake of oxidized low density lipoprotein
    Masatoshi Beppu
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Biol Pharm Bull 25:710-7. 2002
    ..These results indicate that, as well as the fibronectin-stimulated Ca influx pathway and protein phosphorylation pathway, the arachidonic acid pathway participated in the activation of macrophages to bind and take up oxidized LDL...
  31. ncbi request reprint Macrophage binding and the uptake of oxidized low density lipoprotein are regulated by intracellular protein phosphorylation
    Masatoshi Beppu
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, 192 0392, Japan
    J Biochem 131:547-55. 2002
    ..The above results indicate that intracellular protein phosphorylation maintains and enhances macrophage binding and the uptake of oxLDL...
  32. ncbi request reprint Measurement of blue fluorescence as a protein marker for oxidized membranes
    Kiyomi Kikugawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo
    Methods Mol Biol 196:63-8. 2002
  33. ncbi request reprint Suppression of free radical-induced DNA strand breaks by linoleic acid and low density lipoprotein in vitro
    Kazuyuki Hiramoto
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
    Biol Pharm Bull 26:1129-34. 2003
    ..LDL oxidized with Cu(II) ion did not cause DNA strand breaks. The results indicate that the potency of the free radicals to cause DNA strand breaks was attenuated by the fatty acid and the lipoprotein through lipid peroxidation...
  34. pmc Evidence that reactive oxygen species do not mediate NF-kappaB activation
    Makio Hayakawa
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Tokyo 192 0392, Japan
    EMBO J 22:3356-66. 2003
    ..Furthermore, we present evidence that endogenous ROS produced through Rac/NADPH oxidase do not mediate NF-kappaB signaling, but instead lower the magnitude of its activation...
  35. doi request reprint Hypoxia downregulates farnesoid X receptor via a hypoxia-inducible factor-independent but p38 mitogen-activated protein kinase-dependent pathway
    Tomofumi Fujino
    School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
    FEBS J 276:1319-32. 2009
    ..e. ischemia, a condition accompanying hypoxia, and cholestasis, a condition with intrahepatic accumulation of cytotoxic bile acids...
  36. ncbi request reprint Cholesterol synthesis in mice is suppressed but lipofuscin formation is not affected by long-term feeding of n-3 fatty acid-enriched oils compared with lard and n-6 fatty acid-enriched oils
    Chunyan Du
    Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
    Biol Pharm Bull 26:766-70. 2003
    ....