Hisashi Kawashima

Summary

Affiliation: Tokyo Medical University
Country: Japan

Publications

  1. doi Extreme efficiency of airway pressure release ventilation (APRV) in a patient suffering from acute lung injury with pandemic influenza A (H1N1) 2009 and high cytokines
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Indian J Pediatr 78:348-50. 2011
  2. pmc Clinical application of rapid assay of interleukin-6 in influenza-associated encephalopathy
    Mikage Nakamura
    Department of Paediatrics, Tokyo Medical University, Japan
    Dis Markers 21:199-202. 2005
  3. pmc A boy with non-herpes simplex acute limbic encephalitis and antiglutamate receptor antibodies
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Clin Med Insights Case Rep 4:43-7. 2011
  4. pmc The burden of rotavirus gastroenteritis and hospital-acquired rotavirus gastroenteritis among children aged less than 6 years in Japan: a retrospective, multicenter epidemiological survey
    Hitoshi Tajiri
    Osaka General Medical Center, 3 1 56, Mandai Higashi, Sumiyoshi, Osaka 558 8558, Japan
    BMC Pediatr 13:83. 2013
  5. doi Treatment of pandemic influenza A (H1N1) 2009-associated encephalopathy in children
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Scand J Infect Dis 44:941-7. 2012
  6. doi Production of chemokines in respiratory syncytial virus infection with central nervous system manifestations
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Infect Chemother 18:827-31. 2012
  7. doi National survey of pandemic influenza A (H1N1) 2009-associated encephalopathy in Japanese children
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    J Med Virol 84:1151-6. 2012
  8. doi Transaminase in rotavirus gastroenteritis
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Pediatr Int 54:86-8. 2012
  9. ncbi Therapy of childhood generalized morphea: case reports and reviews of the literature of Japanese cases
    Hisashi Kawashima
    Department of Paediatrics, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Pediatr Int 48:342-5. 2006
  10. ncbi Primary biomarkers in cerebral spinal fluid obtained from patients with influenza-associated encephalopathy analyzed by metabolomics
    Hisashi Kawashima
    Department of Paediatrics, Tokyo Medical University, Japan
    Int J Neurosci 116:927-36. 2006

Detail Information

Publications78

  1. doi Extreme efficiency of airway pressure release ventilation (APRV) in a patient suffering from acute lung injury with pandemic influenza A (H1N1) 2009 and high cytokines
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Indian J Pediatr 78:348-50. 2011
    ..There was no improvement by using any conventional ventilation, however, APRV immediately led to an improvement of his clinical symptoms and laboratory findings...
  2. pmc Clinical application of rapid assay of interleukin-6 in influenza-associated encephalopathy
    Mikage Nakamura
    Department of Paediatrics, Tokyo Medical University, Japan
    Dis Markers 21:199-202. 2005
    ..However the levels of IL-6 in severe cases were significantly higher than those of mild cases with influenza-associated encephalopathy. Consequently the rapid assay of serum IL-6 is useful to evaluate and decide the therapies...
  3. pmc A boy with non-herpes simplex acute limbic encephalitis and antiglutamate receptor antibodies
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Clin Med Insights Case Rep 4:43-7. 2011
    ..After five months he recovered without serious sequelae. Virological studies, including for herpes simplex virus, were all negative. He was transiently positive for antiglutamate receptor antibodies in cerebrospinal fluid and serum...
  4. pmc The burden of rotavirus gastroenteritis and hospital-acquired rotavirus gastroenteritis among children aged less than 6 years in Japan: a retrospective, multicenter epidemiological survey
    Hitoshi Tajiri
    Osaka General Medical Center, 3 1 56, Mandai Higashi, Sumiyoshi, Osaka 558 8558, Japan
    BMC Pediatr 13:83. 2013
    ..Rotavirus is a leading worldwide cause of acute gastroenteritis in young children. This retrospective hospital-based study assessed the burden of rotavirus gastroenteritis in children younger than 6 years in Japan...
  5. doi Treatment of pandemic influenza A (H1N1) 2009-associated encephalopathy in children
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Scand J Infect Dis 44:941-7. 2012
    ..The novel pandemic influenza A (H1N1) 2009 virus (influenza A(H1N1)pdm09) caused an epidemic of critical illness, with some patients developing fatal encephalopathy as well as pneumonia...
  6. doi Production of chemokines in respiratory syncytial virus infection with central nervous system manifestations
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Infect Chemother 18:827-31. 2012
    ..These data suggest that chemokines in CSF play roles in neurological complications in RSV-infected children...
  7. doi National survey of pandemic influenza A (H1N1) 2009-associated encephalopathy in Japanese children
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    J Med Virol 84:1151-6. 2012
    ..In conclusion, pdm H1N1 2009 infection-associated encephalopathy was a critical disease in children, with rapidly progressive characteristics similar to those of seasonal influenza-associated encephalopathy...
  8. doi Transaminase in rotavirus gastroenteritis
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Pediatr Int 54:86-8. 2012
    ..The aim of the present study was therefore to investigate transaminase and interleukin (IL)-6 levels in rotavirus infection, in order to better understand their clinical significance...
  9. ncbi Therapy of childhood generalized morphea: case reports and reviews of the literature of Japanese cases
    Hisashi Kawashima
    Department of Paediatrics, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Pediatr Int 48:342-5. 2006
  10. ncbi Primary biomarkers in cerebral spinal fluid obtained from patients with influenza-associated encephalopathy analyzed by metabolomics
    Hisashi Kawashima
    Department of Paediatrics, Tokyo Medical University, Japan
    Int J Neurosci 116:927-36. 2006
    ..0247 in all of the patients except one was less than that in other patients. These results indicate that the new metabolites detected in CSF would be primary markers for the diagnosis of influenza-associated encephalopathy...
  11. ncbi Diagnosis and evaluation of febrile infants under 4 months of age in Japan by using RT-PCR for enterovirus
    Hisashi Kawashima
    Department of Paediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Infect 53:16-20. 2006
    ..From February 1998 to January 2001, 263 infants under 4 months of age were admitted to our hospital because of fever (>38.0 degrees C) and enrolled in this study...
  12. ncbi Children Behavior Checklist (CBCL)/2-3 in children with febrile episodes under 3 months of age and enterovirus infection
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Pediatr Int 44:341-3. 2002
  13. doi mRNA expression of T-helper 1, T-helper 2 cytokines in autoimmune hepatitis in childhood
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Pediatr Int 50:284-6. 2008
    ..The purpose of the present study was to measure the mRNA levels in peripheral mononuclear cells and serum cytokines obtained from children with autoimmune hepatitis for a better understanding of the mechanism...
  14. doi Viral loads of cerebrospinal fluid in infants with enterovirus meningitis
    Hisashi Kawashima
    Department of Paediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, Japan
    J Clin Lab Anal 22:216-9. 2008
    ..IL-6 decreased within the short period. Viral loads and free radicals increased simultaneously. IL-6 and free radicals of CSF are helpful for diagnosis and treatment of viral meningitis at an early stage...
  15. ncbi Hydranencephaly with cholestasis and giant hepatitis
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    J Clin Gastroenterol 40:956-8. 2006
    ..Although the anterior pituitary functions (cortisol, thyroid stimulating hormone, free T4, human growth hormone) were normal, the patient revealed massive cholestasis and giant hepatitis...
  16. ncbi Hazards of early BCG vaccination: BCGitis in a patient with chronic granulomatous disease
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Pediatr Int 49:418-9. 2007
  17. ncbi NOx (nitrite/nitrate) in patients with pediatric nephrotic syndrome
    Hisashi Kawashima
    Department of Paediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Pediatr Nephrol 22:840-3. 2007
    ..The studies with immunostaining of iNOS and nitrotyrosine were negative for glomerulus in patients with nephrotic syndrome. Those findings suggest that NOx might indirectly influence disease progression in nephrotic syndrome...
  18. doi Anti-glutamate receptor antibodies in pediatric enteroviral encephalitis
    Hisashi Kawashima
    Department of Peadiatrics, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Int J Neurosci 120:99-103. 2010
    ..Therefore, a specific therapy against immunological status might decrease the sequela; however, further research is necessary to confirm this...
  19. ncbi A case report of neonatal onset multisystemic inflammatory disease in Japan treated with continuous hemodiafiltration and steroid pulse therapy
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Ther Apher Dial 11:232-4. 2007
    ..The patient showed repeated flare ups of fever, arthralgia and meningitis accompanied with high levels of cytokines. The effect was temporary, but useful in recovery from such a serious condition...
  20. ncbi High concentration of serum nitrite/nitrate obtained from patients with influenza-associated encephalopathy
    Hisashi Kawashima
    Department of Paediatrics, Tokyo Medical University, Tokyo, Japan
    Pediatr Int 44:705-7. 2002
  21. ncbi NOx (nitrite/nitrate) in cerebral spinal fluids obtained from patients with influenza-associated encephalopathy
    H Kawashima
    Department of Paediatrics, Tokyo Medical University, Tokyo, Japan
    Neuropediatrics 34:137-40. 2003
    ..One case having normal levels in NO 2 and NO 3 showed that NH 3 was high. These results revealed that NO plays a role in influenza-associated encephalopathy through indirect effects of NO...
  22. ncbi Efficacy of plasma exchange and methylprednisolone pulse therapy on influenza-associated encephalopathy
    Hisashi Kawashima
    Department of Paediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Infect 51:E53-6. 2005
    ..Therefore when influenza-associated encephalopathy is actually diagnosed, steroid pulse therapy should be started at an early stage, and when signs of DIC and/or MOF appear, plasma exchange is recommended to remove the cytokines and NOx...
  23. ncbi Enterovirus-related type 1 diabetes mellitus and antibodies to glutamic acid decarboxylase in Japan
    Hisashi Kawashima
    Department of Peadiatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Infect 49:147-51. 2004
    ..In order to clarify the relationship between enteroviruses and type 1 diabetes mellitus in Japan we investigated enteroviral RNA in serum from children with type 1 diabetes mellitus...
  24. ncbi Extraordinary changes in excitatory amino acid levels in cerebrospinal fluid of influenza-associated encephalopathy of children
    Hisashi Kawashima
    Department of Paediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Neurochem Res 29:1537-40. 2004
    ..The high mortality in the disease may correlate with the hyperactivity of supra-spinal glutamate neurons and the subsequent high activity levels of NOx in CNS...
  25. doi Myopathy and neurogenic muscular atrophy in unexpected cardiopulmonary arrest
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Pediatr Int 53:159-61. 2011
    ..Neuromuscular disorders can be the cause of sudden death of infants because of their weakness and gastroesophageal reflux (GER)...
  26. doi New treatment of free-radical scavenger in adrenoleukodystrophy
    H Kawashima
    Department of Paediatrics, Tokyo Medical University, Tokyo, Japan
    J Clin Pharm Ther 36:412-5. 2011
    ..Treatment is still unsatisfactory. Our objective is to report on the effect of the free-radical scavenger, edaravone, in a patient with ALD...
  27. ncbi Nitrite/nitrate (NOx) and zinc concentrations in influenza-associated encephalopathy in children with different sequela
    Hisashi Kawashima
    Department of Paediatrics, Tokyo Medical University, Tokyo, Japan
    Neurochem Res 30:311-4. 2005
    ..These results indicate that the increase of NOx levels detected in influenza-associated encephalopathy relates to the low zinc levels, and both low molecules might play an important role for the cause of encephalopathy...
  28. ncbi Virological and immunological characteristics of fatal virus-associated haemophagocytic syndrome (VAHS)
    Yasuyo Kashiwagi
    Department of Pediatrics, Tokyo Medical University, Japan
    Microbiol Immunol 51:53-62. 2007
    ..Although aggressive therapies were performed in all cases, the outcome was fatal. Further investigation would be needed to clarify the mechanism of VAHS and an effective therapeutic regimen is needed...
  29. ncbi Serum and cerebrospinal fluid nitrite/nitrate levels in patients with rotavirus gastroenteritis induced convulsion
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishi shinjuku, Tokyo 160 0023, Japan
    Life Sci 74:1397-405. 2004
    ..Consequently, NOx inhibitors might be helpful for the treatment of rotavirus encephalopathy...
  30. ncbi [Successful treatment of congenital cytomegalovirus infection with valganciclovir]
    Yu Ishida
    Department of Pediatrics, Tokyo Medical University, Tokyo
    No To Hattatsu 44:55-9. 2012
    ..Further investigation is needed to establish a screening test and treatment for congenital CMV infection in Japan...
  31. ncbi Diagnostic and predictive value of CSF d-ROM level in influenza virus-associated encephalopathy
    Gaku Yamanaka
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku, Tokyo, 160 0023, Japan
    J Neurol Sci 243:71-5. 2006
    ..In patients with IE, the CSF d-ROM levels could be a valid predictive biomarker of the severity, and oxidative stress may be related to the pathogenesis of IE...
  32. ncbi A case of Reye syndrome with rotavirus infection accompanied with high cytokines
    Hiroaki Ioi
    Department of Paediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Infect 52:e124-8. 2006
    ..The liver pathology also revealed mild infiltration and fatty changes. He was suspected to be suffering from a cytokine storm followed by Reye syndrome...
  33. doi Classification of acute encephalopathy in respiratory syncytial virus infection
    Shinichiro Morichi
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Infect Chemother 17:776-81. 2011
    ..Strategies to treat each type of encephalopathy, targeting cytokines and free radicals, should be established...
  34. ncbi Discordant endocrinopathy in a sibling with shwachman-diamond syndrome
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Nishisinjuku, Tokyo, Japan
    J Trop Pediatr 52:445-7. 2006
  35. doi Cerebrospinal fluid Diacron-Reactive Oxygen Metabolite levels in pediatric patients with central nervous system diseases
    Gaku Yamanaka
    Department of Pediatrics, Tokyo Medical University, Shinjuku, Tokyo, Japan
    Pediatr Neurol 39:80-4. 2008
    ..Oxidative stress may be associated with the pathogenesis of various pediatric central nervous system diseases. Cerebrospinal fluid Diacron-Reactive Oxygen Metabolite levels may correlate with clinical status in these diseases...
  36. ncbi Efficacy of prolonged valganciclovir therapy for congenital cytomegalovirus infection
    Yasuyo Kashiwagi
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, Japan
    J Infect Chemother 17:538-40. 2011
    ..It is crucial to gather information from as many cases as possible treated with VGCV to establish a standard protocol for VGCV treatment...
  37. doi Severe form of encephalopathy associated with 2009 pandemic influenza A (H1N1) in Japan
    Akihisa Okumura
    Department of Pediatrics, Juntendo University Faculty of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Clin Virol 56:25-30. 2013
    ..Every year, an estimated 200-500 children in Japan develop influenza-associated encephalopathy (IAE), and 10-30% of these children die...
  38. ncbi Rapid diagnosis of bacterial meningitis by using multiplex PCR and real time PCR
    Rina Uzuka
    Department of Pediatrics and Central Clinical Laboratory, Tokyo Medical University, Japan
    Pediatr Int 46:551-4. 2004
    ..The purpose of the present study was to improve a method for a rapid identification of bacteria in bacterial meningitis by using multiplex polymerase chain reaction (PCR)...
  39. ncbi Biliary atresia with cartilage formation
    Yasuyo Kashiwagi
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Pediatr Int 49:683-5. 2007
  40. ncbi Enteroviral hepatitis in children
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Pediatr Int 46:130-4. 2004
    ..The pathogen causing enteroviral hepatitis is often not found despite careful examination...
  41. ncbi Determination of enterovirus serotype inferred from sequence analysis of PCR products
    Takeshi Takami
    Department of Pediatrics, Tokyo Medical University, 6 7 1, Nishi Shinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    J Clin Virol 26:355-9. 2003
    ..Enterovirus infections are common in neonates. Virus isolation is the only diagnostic method to confirm enterovirus serotype infections, however, is not always successful...
  42. doi A case of recurrent acute encephalopathy with febrile convulsive status epilepticus with carnitine palmitoyltransferase II variation
    Eiko Sakai
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Neuropediatrics 44:218-21. 2013
    ..This report presents the first case of recurrent encephalopathy with CPT II variations that may partially associate with pathogenesis of recurrent AEFCSE. ..
  43. doi Inflammatory cytokines as predictors of resistance to intravenous immunoglobulin therapy in Kawasaki disease patients
    Satoshi Sato
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Int J Rheum Dis 16:168-72. 2013
    ..Activation of the immune system is a central feature of KD. Some KD patients are resistant to initial high-dose intravenous immunoglobulin (IVIG) treatment. The study aimed to determine the predictors of IVIG resistance...
  44. ncbi [Rotavirus infection]
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University
    Nihon Rinsho 70:1376-80. 2012
    ..Two safety and effective vaccinations were implemented to prevent infections. According to the overseas guideline management for estimations for the severity and treatment by oral rehydration solution are recommended...
  45. ncbi Extreme efficiency of anti-interleukin 1 agent (anakinra) in a Japanese case of CINCA syndrome
    Yasuyo Kashiwagi
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Clin Rheumatol 27:277-9. 2008
    ..We describe a case of severe CINCA syndrome in a Japanese male infant. We recently managed with anti-interleukin 1 agent (anakinra). Anakinra immediately led to improvement of both the clinical symptoms and the laboratory findings...
  46. ncbi Absence of associations between influenza-associated encephalopathy and human herpesvirus 6 or human herpesvirus 7
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    Pediatr Infect Dis J 22:115-9. 2003
    ..AIM To confirm or refute the association between influenza-associated encephalopathy and HHV-6 or HHV-7...
  47. ncbi Cerebrospinal fluid analysis in children with seizures from respiratory syncytial virus infection
    Hisashi Kawashima
    Departments of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Scand J Infect Dis 41:228-31. 2009
    ..These data revealed that neurological involvement might be caused by a direct invasion...
  48. ncbi A case report of Kabuki make-up syndrome with cytomegalovirus infection
    Yasuyo Kashiwagi
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Infect 48:278-82. 2004
    ..According to the correlation between the number of CMV DNA copies and his platelet count, it is speculated that ITP would occur when the number of CMV DNA copies was elevated...
  49. doi A case of juvenile idiopathic polyarticular arthritis complicated by IgA deficiency in 22q11 deletion syndrome
    Satoshi Sato
    Department of Pediatrics, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Rheumatol Int 31:1089-92. 2011
    ..And the presence of IL-10 and IL-5 might suggest that the synovitis is associated with JIA and IgA deficiency...
  50. doi Increased level of serum interleukin-1 receptor antagonist subsequent to resolution of clinical symptoms in patients with West syndrome
    Gaku Yamanaka
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku, Tokyo, Japan
    J Neurol Sci 298:106-9. 2010
    ..Serum IL-1Ra levels were elevated subsequent to resolution of clinical and EEG findings in WS patients. A larger study should be conducted to clarify whether an immunological processes are concerned with the pathophysiology of WS...
  51. doi Association of mannose-binding lectin gene polymorphisms with Kawasaki disease in the Japanese
    Satoshi Sato
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Int J Rheum Dis 12:307-10. 2009
    ..Here, we investigate the relationship between the MBL gene polymorphisms and the occurrence of KD in the Japanese population...
  52. ncbi Combined treatment of steroids and cyclosporine in Kimura disease
    Satoshi Sato
    Department of Pediatrics, Tokyo Medical University, Nishishinjuku, Tokyo, Japan
    Pediatrics 118:e921-3. 2006
    ....
  53. ncbi [Prevalence of chlamydia-pneumoniae-specific immunoglobulin M antibody and acute exacerbations of asthma in childhood]
    Satoshi Sato
    Department of Pediatrics, Tokyo Medical University
    Arerugi 56:1378-83. 2007
    ..We investigated the prevalence of C. pneumoniae infections in childhood patients with acute exacerbations of asthma...
  54. doi Clinical application of rapid assay of serum interleukin-6 in Kawasaki disease
    Yusuke Suganami
    Department of Pediatrics, Tokyo Medical University, Shinjuku, Tokyo, Japan
    Pediatr Int 50:264-6. 2008
  55. ncbi A novel homozygous YARS2 mutation causes severe myopathy, lactic acidosis, and sideroblastic anemia 2
    Junya Nakajima
    1 Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan 2 Department of Pediatrics, Tokyo Medical University, Shinjuku, Japan
    J Hum Genet 59:229-32. 2014
    ..Interestingly, the proband showed more severe symptoms and an earlier onset than previously reported patients, suggesting the functional importance of the S4-like domain in tyrosyl-tRNA synthetase...
  56. doi Detection of MCP-1 and IL-8 in the serum and cerebrospinal fluid of a child with Miller Fisher syndrome
    Satoshi Sato
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Clin Neurosci 16:1698-9. 2009
    ..The cause of MFS in this patient was suggested by the localized chemokine production in the CSF. The high expression of MCP-1 and IL-8 chemokines suggest that macrophages and T cells may stimulate inflammation of the CNS in MFS...
  57. ncbi Sudden infant death syndrome due to parainfluenza virus 2 associated with hemophagocytic syndrome
    Yasuyo Kashiwagi
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Infect 49:329-32. 2004
    ..His laboratory data of elevated level of ferritin and IL-6 suggested hemophagocytic syndrome (HPS). It is suspected that PIV2 infection in infants is a risk factor for SIDS...
  58. doi Alum-adjuvanted H5N1 whole virion inactivated vaccine (WIV) enhanced inflammatory cytokine productions
    Tetsuo Nakayama
    Kitasato Institute for Life Sciences, Laboratory of Viral Infection, Tokyo, Japan
    Vaccine 30:3885-90. 2012
    ....
  59. doi High production of interleukin-10 and interferon-γ in influenza-associated MERS in the early phase
    Shinichiro Morichi
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Pediatr Int 54:536-8. 2012
    ..Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL-10 and IFN-γ might work to localize the lesion and to prevent sequelae...
  60. ncbi [Mumps virus]
    Hisashi Kawashima
    Department of Pediatrics, Tokyo Medical University
    Nihon Rinsho 61:513-7. 2003
  61. ncbi Clinical characteristics and gB genotype of cytomegalovirus infection in Japan
    Yasuyo Kashiwagi
    Department of Pediatrics, Tokyo Medical University, Tokyo, 160 0023, Japan
    In Vivo 16:447-50. 2002
    ..The distribution of CMV gB genotypes in clinical specimens was as follows: gB 1-17 out of 19 (89.5%) and gB 3-2 out of 19 (10.5%). Our data revealed that gB genotype 3 CMV did not show symptomatic infection...
  62. ncbi Virological and immunological characteristics of a 19-year-old Japanese female with fatal outcome with Epstein-Barr virus-associated hemophagocytic syndrome
    Satoshi Sato
    Department of Paediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Clin Virol 31:235-8. 2004
    ..These results suggest that EBV-infected CD8+ T-cells in each organ (peripheral blood lymphocytes, lung, kidney, brain and liver) may have an integral role in the pathophysiology of the HPS...
  63. pmc Increased nitric oxide production and GFAP expression in the brains of influenza A/NWS virus infected mice
    Chiako Watanabe
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Neurochem Res 33:1017-23. 2008
    ..These results indicate that the NWS enhances the activation of astrocytes and NOS-2 expression which in turn enhances NO production and the expansion of capillary blood vessels...
  64. doi Case of localized scleroderma successfully treated with bath psoralen and ultraviolet A therapy
    Masaki Uchiyama
    Department of Dermatology, Tokyo Medical University, Tokyo, Japan
    J Dermatol 37:75-80. 2010
    ..The successful results of bath-PUVA therapy in this case suggest its utility for localized scleroderma...
  65. doi Expressions of brain-derived neurotrophic factor (BDNF) in cerebrospinal fluid and plasma of children with meningitis and encephalitis/encephalopathy
    Shinichiro Morichi
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Int J Neurosci 123:17-23. 2013
    ..Monitoring the changes in serum and CSF levels of BDNF may facilitate the diagnosis of acute meningitis and acute encephalopathy and allow the differential diagnosis of specific CNS infections...
  66. ncbi Marked elevation of interferon-γ in acute focal bacterial nephritis
    Yasuyo Kashiwagi
    Department of Pediatrics, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Clin Exp Nephrol 16:656-7. 2012
    ..The current results suggest that the bacterial kidney infection in the AFBN group is localized and that interferon-γ may be produced locally in response to the infection...
  67. ncbi Clinical and genetic analyses of presumed Shwachman-Diamond syndrome in Japan
    Hiromichi Taneichi
    Department of Pediatrics, Faculty of Medicine, University of Toyama, Toyama, Japan
    Int J Hematol 84:60-2. 2006
    ..In addition, presumed SDS patients without SBDS mutations may be included in other disorders...
  68. ncbi A mutation in the IL-2 receptor gamma chain gene associated with X-linked severe combined immunodeficiency accompanying opisthotonus
    Yasuyo Kashiwagi
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Tohoku J Exp Med 218:1-3. 2009
    ..In conclusion, we have identified the novel mutation in the IL-2 receptor gamma chain gene, which is associated with X-SCID. Furthermore, this is the first report that describes the patient with X-SCID accompanying opisthotonus...
  69. ncbi Characteristics of 11 neonates with atrial septal defects detected by heart murmurs
    Takeshi Takami
    Department of Paediatrics, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Am J Perinatol 20:195-9. 2003
    ..We concluded that the absence of a flap sign (valve-like openings of the defects) affects the development of the heart murmur of ASD found in the neonatal period...
  70. ncbi A new proposal for a clinical-oriented subclassification of baboon syndrome and a review of baboon syndrome
    Atsushi Miyahara
    Department of Pediatrics, Tokyo Medical University
    Asian Pac J Allergy Immunol 29:150-60. 2011
    ..To review baboon syndrome (BS). Data Sources: Date sources were obtained from PubMed and Google Scholar: Photographs of baboon syndrome were obtained from our patient...
  71. ncbi Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing
    Satoshi Sato
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 129:1225-36. 2005
    ..In this study, we used a proteomics approach to obtain further insight into the functional properties of nuclear beta-catenin...
  72. ncbi [Rota virus encephalopathy]
    Yasuyo Kashiwagi
    Department of Pediatrics, Tokyo Medical University
    Nihon Rinsho 69:429-34. 2011
    ..Here, we review the recent advances regarding its causative agent, prognosis, pathogenesis, and treatment...
  73. ncbi Increased microorganisms DNA levels in peripheral blood monocytes from psoriatic patients using PCR with universal ribosomal RNA primers
    Yukari Okubo
    Department of Dermatology, Tokyo Medical University, Japan
    J Dermatol 29:547-55. 2002
    ..Our study suggests that monocytes in psoriatic patients engulf more bacteria than there in controls, causing an activation of monocytes and triggering the formation of new lesions in the initial stages of psoriasis...
  74. ncbi Changes in serum lactate dehydrogenase activity in children with atopic dermatitis
    Yasuyuki Morishima
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Pediatr Int 52:171-4. 2010
    ..Some markers indicating the severity of the disease and symptom changes are very useful, and therefore the purpose of the present study was to investigate serum lactate dehydrogenase (LDH) as such a marker...
  75. doi Nationwide survey of severe respiratory syncytial virus infection in children who do not meet indications for palivizumab in Japan
    Masaaki Mori
    Department of Pediatrics, Yokohama City University Medical Center, 4 57 Urafune cho, Minami Ku, Yokohama, 232 0024, Japan
    J Infect Chemother 17:254-63. 2011
    ....
  76. ncbi Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients
    Megumu Saito
    Departments of Pediatrics, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto, Japan
    Blood 111:2132-41. 2008
    ..Our findings reveal a novel effect of CIAS1 mutations in promoting necrosis-like cell death, and demonstrate that CIAS1 mosaicism plays an important role in mutation-negative CAPS patients...
  77. ncbi Klebsiella oxytoca septicemia complicating rotavirus-associated acute diarrhea
    Yasuyo Kashiwagi
    Pediatr Infect Dis J 26:191-2. 2007