Research Topics
| Hiroyoshi KawakamiSummaryAffiliation: Tokyo Metropolitan University Country: Japan Publications
| Collaborators
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Detail Information
Publications
Mn-porphyrin derivatives as an antioxidant for medical devicesT Ohse
Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Japan
J Biomater Sci Polym Ed 10:917-29. 1999..As a result, it has been found that Mn-porphyrin derivatives may be a vastly better scavenger of reactive oxygen species in vivo...- Biodegradation and biocompatibility of polyorganophosphazeneHiroyoshi Kawakami
Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Japan
Artif Organs 26:883-90. 2002..On the other hand, the proliferation of HeLa cells cultured on poly(organophosphazene) was reduced compared with that on the control tissue culture polystyrene... - Development of a fluorinated polyimide hollow fiber for medical devicesHiroyoshi Kawakami
Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
J Artif Organs 6:124-9. 2003..Additionally, we fabricated a novel porous membrane with three-dimensional fine structure from cylindrical microscale pores and examined possibility of a porous membrane for use in hemodialysis... 
Polymeric membrane materials for artificial organsHiroyoshi Kawakami
Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
J Artif Organs 11:177-81. 2008..This review will describe current issues regarding polymeric membrane materials for use in artificial organs...- Neuronal attachment and outgrowth on a micropatterned fluorinated polyimide surfaceHiroyoshi Kawakami
Department of Applied Chemistry, Tokyo Metropolitan University, Tokyo, Hachioji 192 0397, Japan
J Artif Organs 7:83-90. 2004..This initial study indicated enhanced neurite outgrowth and differentiation of PC12 cells on fluorinated polyimide film micropatterned by ion irradiation... - Plasma protein adsorption to nanofabricated fluorinated polyimide surfaceH Kawakami
Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
J Biomater Sci Polym Ed 16:1023-34. 2005..We proposed that the nano-ordered hydrophilic and hydrophobic patternings formed on the top and bottom surfaces on the rubbed fluorinated polyimide film might have a significant influence on the plasma protein adsorption... - Zinc-chelated poly(1-vinylimidazole) and a carbohydrate ligand polycation form DNA ternary complexes for gene deliveryShoichiro Asayama
Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo, Japan
Bioconjug Chem 22:1864-8. 2011.... - Superoxide dismutase as a target enzyme for Fe-porphyrin-induced cell deathShoichiro Asayama
Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
J Inorg Biochem 101:261-6. 2007..These results suggest that SOD is a target enzyme for the cell death induced by cis-FeMPy(2)P(2)P as a new class of anticancer agents... - Biocompatibility of fluorinated poly(organophosphazene)Shota Kanezaki
Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan
J Biomater Sci Polym Ed 14:469-79. 2003.... - Carboxymethyl poly(L-histidine) as a new pH-sensitive polypeptide to enhance polyplex gene deliveryShoichiro Asayama
Department of Applied Chemistry, Tokyo Metropolitan University, Hacioji, Tokyo, Japan
Mol Pharm 5:898-901. 2008..These results suggest that the synergistic effect of the pH-sensitive imidazole groups at endosomal pH and the anionic carboxymethyl groups at physiological pH in the CM-PLH enhanced polyplex gene delivery... - New water-soluble Mn-porphyrin with catalytic activity for superoxide dismutation and peroxynitrite decompositionShoichiro Asayama
Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo, Japan
Metallomics 3:744-8. 2011..Furthermore, the new porphyrin recovered the viability of lipopolysaccharide-stimulated macrophage RAW 264.7 cells but the control Mn-porphyrin did not... - Highly amphiphilic manganese porphyrin for the mitochondrial targeting antioxidantTakayuki Haruyama
Department of Applied Chemistry, Tokyo Metropolitan University, and 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
J Biochem 147:153-6. 2010..As a result, the MnMImP(3)P rescued the cell death under oxidative stress concerned with mitochondrial damage... - Synthesis and characterization of alkylated poly(1-vinylimidazole) to control the stability of its DNA polyion complexes for gene deliveryShoichiro Asayama
Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
Bioconjug Chem 21:646-52. 2010..These results suggest that pH-sensitive PVIm-R's control of the stability of DNA polyion complexes enhanced noncytotoxic gene delivery by the optimized alkylated imidazole groups... - Design of the complex between manganese porphyrins and catalase-poly(ethylene glycol) conjugates for a new antioxidantShoichiro Asayama
Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
Mol Pharm 4:484-6. 2007..These results suggest that the Mn-porphyrin/catalase-PEG complex with dual enzymatic activity, i.e., SOD and catalase, is promising for a new class of antioxidants... - Development of a novel polyimide hollow-fiber oxygenatorMotohiro Niwa
Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo, Japan
Artif Organs 28:487-95. 2004..It is found that the polyimide hollow-fiber oxygenator can enhance the gas transfer rates of O(2) and CO(2), and that the hollow fiber provides excellent blood compatibility in vitro and in vivo... - Biomedical properties of nanofabricated fluorinated polyimide surfaceShoji Nagaoka
Department of Applied Chemistry, Tokyo Metropolitan Unversity, Tokyo, Japan
Artif Organs 26:670-5. 2002.... - Protective effects of the complex between manganese porphyrins and catalase-poly(ethylene glycol) conjugates against hepatic ischemia/reperfusion injury in vivoTomochika Hanawa
Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo, Japan
J Control Release 135:60-4. 2009..These results suggest that the Mn-porphyrin/catalase-PEG complex exhibited the antioxidative activity to protect hepatic ischemia/reperfusion injury in vivo... - Double-stranded RNA homopolymer poly(rC).poly(rG) for a new pH-sensitive drug carrierShoichiro Asayama
Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
Mol Pharm 5:162-4. 2008..The resulting complex exhibited higher anticancer activity than the Dox alone. These results result suggest that the poly(rC).poly(rG) is a promising biopolymer for a new class of pH-sensitive drug carriers... - Preparation of pH-sensitive liposomes retaining SOD mimic and their anticancer effectKazue Hiraka
Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
Colloids Surf B Biointerfaces 67:54-8. 2008..These findings suggest that the pH-sensitive liposome retaining the Fe-porphyrin as an SOD mimic promises to be a novel anticancer drug for endosomal escape... - Porphyrin-containing electrospun nanofibers: positional control of porphyrin molecules in nanofibers and their catalytic applicationTakuma Arai
Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
ACS Appl Mater Interfaces 4:5453-7. 2012..The positional control of functional molecules in nanofibers demonstrated a new possibility of nanofiber applications... - Design of aminated poly(1-vinylimidazole) for a new pH-sensitive polycation to enhance cell-specific gene deliveryShoichiro Asayama
Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
Bioconjug Chem 18:1662-7. 2007..These results suggest that the cell-specific gene delivery mediated by PLL-Lac was enhanced by PVIm-NH2 as a new pH-sensitive polycation... - Design of manganese porphyrin modified with mitochondrial signal peptide for a new antioxidantShoichiro Asayama
Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
Mol Pharm 3:468-70. 2006..7 cells. These results suggest that the Mn-porphyrin modified with signal peptide for mitochondrial targeting is promising for a new class of antioxidants... - Selective cell death by water-soluble Fe-porphyrins with superoxide dismutase (SOD) activityNobuyoshi Kasugai
Department of Applied Chemistry, Tokyo Metropolitan University, Minami-Ogsawa, Hachioji, Tokyo 192-0397, Japan
J Inorg Biochem 91:349-55. 2002..This result suggests that for the SOD mimic, O(2)(*-) may be useful as a target molecule to induce selective cell death between cancer and normal cells and that a metalloporphyrin having SOD activity is a new class of anticancer agents... - Zinc-chelated imidazole groups for DNA polyion complex formationShoichiro Asayama
Department of Applied Chemistry, Tokyo Metropolitan University, Japan
Metallomics 3:680-2. 2011..The resulting PVIm-Zn/DNA complexes exhibit no significant cytotoxicity and show outstanding gene expression... - Design of metalloporphyrin-carbohydrate conjugates for a new superoxide dismutase mimic with cellular recognitionShoichiro Asayama
Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
Bioconjug Chem 15:1360-3. 2004..The cellular recognition was inhibited by competitors of beta-galactose. These results suggest that the Mn-porphyrin-lactose conjugates recognized the hepatic lectin on the cell surface... - Aligned electrospun nanofiber composite membranes for fuel cell electrolytesTakuya Tamura
Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo, Japan
Nano Lett 10:1324-8. 2010..Consequently, nanofibers proved to be promising materials as a proton exchange membrane and the composite membrane containing nanofibers may have potential application for use in fuel cells... - Pharmaceutical effect of manganese porphyrins on manganese superoxide dismutase deficient miceNatsumi Hayakawa
Department of Applied Chemistry, Tokyo Metropolitan University, Minami Osawa, Hachioji, Tokyo, Japan
Mol Pharm 9:2956-9. 2012..The treatment of a Mn-porphyrin, MnM2Py(2)P, suppressed the progression of cardiac dilation. These results suggest that the Mn-porphyrin MnM2Py(2)P treatment is proposed as a potential therapy for DCM... - Synthesis and characterization of methylated poly(L-histidine) to control the stability of its siRNA polyion complexes for RNAiShoichiro Asayama
Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
Bioconjug Chem 23:1437-42. 2012..These results suggest that PLH-Me controls the stability of siRNA polyion complexes by enhancing noncytotoxic siRNA delivery by optimizing the content balance of dimethyl, τ/π-methyl, and unmodified imidazole groups... - Surface modification of poly(L: -lactic acid) affects initial cell attachment, cell morphology, and cell growthManae Yamaguchi
Bio-Nanomaterials Team, Research Center of Advanced Bionics, National Institute of Advanced Industrial Science and Technology (AIST, Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8565, Japan
J Artif Organs 7:187-93. 2004.... - Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugsMakoto Yuasa
Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, Noda 278 8510, Japan
Mol Pharm 1:387-9. 2004.... - Effect of polyethylene glycol on preparation of rifampicin-loaded PLGA microspheres with membrane emulsification techniqueFuminori Ito
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
Colloids Surf B Biointerfaces 66:65-70. 2008..The yield of RFP/PLGA microspheres was 100%. The initial burst observed in the release of RFP from RFP/PLGA microspheres was suppressed by the addition of PEG...