Hiroyoshi Kawakami

Summary

Affiliation: Tokyo Metropolitan University
Country: Japan

Publications

  1. ncbi request reprint Mn-porphyrin derivatives as an antioxidant for medical devices
    T Ohse
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Japan
    J Biomater Sci Polym Ed 10:917-29. 1999
  2. ncbi request reprint Biodegradation and biocompatibility of polyorganophosphazene
    Hiroyoshi Kawakami
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Japan
    Artif Organs 26:883-90. 2002
  3. ncbi request reprint Development of a fluorinated polyimide hollow fiber for medical devices
    Hiroyoshi Kawakami
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
    J Artif Organs 6:124-9. 2003
  4. ncbi request reprint Plasma protein adsorption to nanofabricated fluorinated polyimide surface
    H Kawakami
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
    J Biomater Sci Polym Ed 16:1023-34. 2005
  5. ncbi request reprint Neuronal attachment and outgrowth on a micropatterned fluorinated polyimide surface
    Hiroyoshi Kawakami
    Department of Applied Chemistry, Tokyo Metropolitan University, Tokyo, Hachioji 192 0397, Japan
    J Artif Organs 7:83-90. 2004
  6. doi request reprint Polymeric membrane materials for artificial organs
    Hiroyoshi Kawakami
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
    J Artif Organs 11:177-81. 2008
  7. doi request reprint Zinc-chelated poly(1-vinylimidazole) and a carbohydrate ligand polycation form DNA ternary complexes for gene delivery
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo, Japan
    Bioconjug Chem 22:1864-8. 2011
  8. ncbi request reprint Superoxide dismutase as a target enzyme for Fe-porphyrin-induced cell death
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
    J Inorg Biochem 101:261-6. 2007
  9. ncbi request reprint Biocompatibility of fluorinated poly(organophosphazene)
    Shota Kanezaki
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
    J Biomater Sci Polym Ed 14:469-79. 2003
  10. doi request reprint Carboxymethyl poly(L-histidine) as a new pH-sensitive polypeptide to enhance polyplex gene delivery
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, Hacioji, Tokyo, Japan
    Mol Pharm 5:898-901. 2008

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Mn-porphyrin derivatives as an antioxidant for medical devices
    T Ohse
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Japan
    J Biomater Sci Polym Ed 10:917-29. 1999
    ..As a result, it has been found that Mn-porphyrin derivatives may be a vastly better scavenger of reactive oxygen species in vivo...
  2. ncbi request reprint Biodegradation and biocompatibility of polyorganophosphazene
    Hiroyoshi Kawakami
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Japan
    Artif Organs 26:883-90. 2002
    ..On the other hand, the proliferation of HeLa cells cultured on poly(organophosphazene) was reduced compared with that on the control tissue culture polystyrene...
  3. ncbi request reprint Development of a fluorinated polyimide hollow fiber for medical devices
    Hiroyoshi Kawakami
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
    J Artif Organs 6:124-9. 2003
    ..Additionally, we fabricated a novel porous membrane with three-dimensional fine structure from cylindrical microscale pores and examined possibility of a porous membrane for use in hemodialysis...
  4. ncbi request reprint Plasma protein adsorption to nanofabricated fluorinated polyimide surface
    H Kawakami
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
    J Biomater Sci Polym Ed 16:1023-34. 2005
    ..We proposed that the nano-ordered hydrophilic and hydrophobic patternings formed on the top and bottom surfaces on the rubbed fluorinated polyimide film might have a significant influence on the plasma protein adsorption...
  5. ncbi request reprint Neuronal attachment and outgrowth on a micropatterned fluorinated polyimide surface
    Hiroyoshi Kawakami
    Department of Applied Chemistry, Tokyo Metropolitan University, Tokyo, Hachioji 192 0397, Japan
    J Artif Organs 7:83-90. 2004
    ..This initial study indicated enhanced neurite outgrowth and differentiation of PC12 cells on fluorinated polyimide film micropatterned by ion irradiation...
  6. doi request reprint Polymeric membrane materials for artificial organs
    Hiroyoshi Kawakami
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
    J Artif Organs 11:177-81. 2008
    ..This review will describe current issues regarding polymeric membrane materials for use in artificial organs...
  7. doi request reprint Zinc-chelated poly(1-vinylimidazole) and a carbohydrate ligand polycation form DNA ternary complexes for gene delivery
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo, Japan
    Bioconjug Chem 22:1864-8. 2011
    ....
  8. ncbi request reprint Superoxide dismutase as a target enzyme for Fe-porphyrin-induced cell death
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
    J Inorg Biochem 101:261-6. 2007
    ..These results suggest that SOD is a target enzyme for the cell death induced by cis-FeMPy(2)P(2)P as a new class of anticancer agents...
  9. ncbi request reprint Biocompatibility of fluorinated poly(organophosphazene)
    Shota Kanezaki
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
    J Biomater Sci Polym Ed 14:469-79. 2003
    ....
  10. doi request reprint Carboxymethyl poly(L-histidine) as a new pH-sensitive polypeptide to enhance polyplex gene delivery
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, Hacioji, Tokyo, Japan
    Mol Pharm 5:898-901. 2008
    ..These results suggest that the synergistic effect of the pH-sensitive imidazole groups at endosomal pH and the anionic carboxymethyl groups at physiological pH in the CM-PLH enhanced polyplex gene delivery...
  11. doi request reprint New water-soluble Mn-porphyrin with catalytic activity for superoxide dismutation and peroxynitrite decomposition
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo, Japan
    Metallomics 3:744-8. 2011
    ..Furthermore, the new porphyrin recovered the viability of lipopolysaccharide-stimulated macrophage RAW 264.7 cells but the control Mn-porphyrin did not...
  12. doi request reprint Synthesis and characterization of alkylated poly(1-vinylimidazole) to control the stability of its DNA polyion complexes for gene delivery
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
    Bioconjug Chem 21:646-52. 2010
    ..These results suggest that pH-sensitive PVIm-R's control of the stability of DNA polyion complexes enhanced noncytotoxic gene delivery by the optimized alkylated imidazole groups...
  13. doi request reprint Highly amphiphilic manganese porphyrin for the mitochondrial targeting antioxidant
    Takayuki Haruyama
    Department of Applied Chemistry, Tokyo Metropolitan University, and 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
    J Biochem 147:153-6. 2010
    ..As a result, the MnMImP(3)P rescued the cell death under oxidative stress concerned with mitochondrial damage...
  14. ncbi request reprint Design of the complex between manganese porphyrins and catalase-poly(ethylene glycol) conjugates for a new antioxidant
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
    Mol Pharm 4:484-6. 2007
    ..These results suggest that the Mn-porphyrin/catalase-PEG complex with dual enzymatic activity, i.e., SOD and catalase, is promising for a new class of antioxidants...
  15. doi request reprint Protective effects of the complex between manganese porphyrins and catalase-poly(ethylene glycol) conjugates against hepatic ischemia/reperfusion injury in vivo
    Tomochika Hanawa
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo, Japan
    J Control Release 135:60-4. 2009
    ..These results suggest that the Mn-porphyrin/catalase-PEG complex exhibited the antioxidative activity to protect hepatic ischemia/reperfusion injury in vivo...
  16. doi request reprint Preparation of pH-sensitive liposomes retaining SOD mimic and their anticancer effect
    Kazue Hiraka
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
    Colloids Surf B Biointerfaces 67:54-8. 2008
    ..These findings suggest that the pH-sensitive liposome retaining the Fe-porphyrin as an SOD mimic promises to be a novel anticancer drug for endosomal escape...
  17. ncbi request reprint Double-stranded RNA homopolymer poly(rC).poly(rG) for a new pH-sensitive drug carrier
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
    Mol Pharm 5:162-4. 2008
    ..The resulting complex exhibited higher anticancer activity than the Dox alone. These results result suggest that the poly(rC).poly(rG) is a promising biopolymer for a new class of pH-sensitive drug carriers...
  18. ncbi request reprint Development of a novel polyimide hollow-fiber oxygenator
    Motohiro Niwa
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo, Japan
    Artif Organs 28:487-95. 2004
    ..It is found that the polyimide hollow-fiber oxygenator can enhance the gas transfer rates of O(2) and CO(2), and that the hollow fiber provides excellent blood compatibility in vitro and in vivo...
  19. ncbi request reprint Biomedical properties of nanofabricated fluorinated polyimide surface
    Shoji Nagaoka
    Department of Applied Chemistry, Tokyo Metropolitan Unversity, Tokyo, Japan
    Artif Organs 26:670-5. 2002
    ....
  20. ncbi request reprint Pharmaceutical effect of manganese porphyrins on manganese superoxide dismutase deficient mice
    Natsumi Hayakawa
    Department of Applied Chemistry, Tokyo Metropolitan University, Minami Osawa, Hachioji, Tokyo, Japan
    Mol Pharm 9:2956-9. 2012
    ..The treatment of a Mn-porphyrin, MnM2Py(2)P, suppressed the progression of cardiac dilation. These results suggest that the Mn-porphyrin MnM2Py(2)P treatment is proposed as a potential therapy for DCM...
  21. doi request reprint Synthesis and characterization of methylated poly(L-histidine) to control the stability of its siRNA polyion complexes for RNAi
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
    Bioconjug Chem 23:1437-42. 2012
    ..These results suggest that PLH-Me controls the stability of siRNA polyion complexes by enhancing noncytotoxic siRNA delivery by optimizing the content balance of dimethyl, τ/π-methyl, and unmodified imidazole groups...
  22. doi request reprint Porphyrin-containing electrospun nanofibers: positional control of porphyrin molecules in nanofibers and their catalytic application
    Takuma Arai
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
    ACS Appl Mater Interfaces 4:5453-7. 2012
    ..The positional control of functional molecules in nanofibers demonstrated a new possibility of nanofiber applications...
  23. ncbi request reprint Design of aminated poly(1-vinylimidazole) for a new pH-sensitive polycation to enhance cell-specific gene delivery
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
    Bioconjug Chem 18:1662-7. 2007
    ..These results suggest that the cell-specific gene delivery mediated by PLL-Lac was enhanced by PVIm-NH2 as a new pH-sensitive polycation...
  24. ncbi request reprint Design of manganese porphyrin modified with mitochondrial signal peptide for a new antioxidant
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
    Mol Pharm 3:468-70. 2006
    ..7 cells. These results suggest that the Mn-porphyrin modified with signal peptide for mitochondrial targeting is promising for a new class of antioxidants...
  25. doi request reprint Zinc-chelated imidazole groups for DNA polyion complex formation
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, Japan
    Metallomics 3:680-2. 2011
    ..The resulting PVIm-Zn/DNA complexes exhibit no significant cytotoxicity and show outstanding gene expression...
  26. ncbi request reprint Selective cell death by water-soluble Fe-porphyrins with superoxide dismutase (SOD) activity
    Nobuyoshi Kasugai
    Department of Applied Chemistry, Tokyo Metropolitan University, Minami Ogsawa, Hachioji, Tokyo 192 0397, Japan
    J Inorg Biochem 91:349-55. 2002
    ..This result suggests that for the SOD mimic, O(2)(*-) may be useful as a target molecule to induce selective cell death between cancer and normal cells and that a metalloporphyrin having SOD activity is a new class of anticancer agents...
  27. ncbi request reprint Design of metalloporphyrin-carbohydrate conjugates for a new superoxide dismutase mimic with cellular recognition
    Shoichiro Asayama
    Department of Applied Chemistry, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji, Tokyo 192 0397, Japan
    Bioconjug Chem 15:1360-3. 2004
    ..The cellular recognition was inhibited by competitors of beta-galactose. These results suggest that the Mn-porphyrin-lactose conjugates recognized the hepatic lectin on the cell surface...
  28. doi request reprint Nickel nanoparticle chains inside carbonized polymer nanofibers: preparation by electrospinning and ion-beam irradiation
    Katsuya Sode
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan
    Nanoscale 5:8235-41. 2013
    ..5 S cm(-1) for the 6FDA-6FAP nanofibrous membrane containing 5.0 wt% Ni(acac)2 after ion-beam irradiation at an ion fluence of 1 × 10(16) ions per cm(2). ..
  29. doi request reprint Aligned electrospun nanofiber composite membranes for fuel cell electrolytes
    Takuya Tamura
    Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo, Japan
    Nano Lett 10:1324-8. 2010
    ..Consequently, nanofibers proved to be promising materials as a proton exchange membrane and the composite membrane containing nanofibers may have potential application for use in fuel cells...
  30. ncbi request reprint Surface modification of poly(L: -lactic acid) affects initial cell attachment, cell morphology, and cell growth
    Manae Yamaguchi
    Bio Nanomaterials Team, Research Center of Advanced Bionics, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba Central 5, 1 1 1 Higashi, Tsukuba, Ibaraki, 305 8565, Japan
    J Artif Organs 7:187-93. 2004
    ....
  31. ncbi request reprint Liposomal surface-loading of water-soluble cationic iron(III) porphyrins as anticancer drugs
    Makoto Yuasa
    Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, Noda 278 8510, Japan
    Mol Pharm 1:387-9. 2004
    ....
  32. doi request reprint Effect of polyethylene glycol on preparation of rifampicin-loaded PLGA microspheres with membrane emulsification technique
    Fuminori Ito
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Colloids Surf B Biointerfaces 66:65-70. 2008
    ..The yield of RFP/PLGA microspheres was 100%. The initial burst observed in the release of RFP from RFP/PLGA microspheres was suppressed by the addition of PEG...