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Affiliation: Tokyo Denki University
Kawaii S, Ishikawa Y, Yoshizawa Y. Relationship Between the Structure of Methoxylated and Hydroxylated Flavones and Their Antiproliferative Activity in HL60 Cells. Anticancer Res. 2018;38:5679-5684 pubmed publisher
..The correlation between the methoxylation/hydroxylation pattern and antiproliferative activity revealed the importance of the 5,4'- and 3',4'-dihydroxyl moieties in flavone nucleus. ..
Saito Y, Kishimoto M, Yoshizawa Y, Kawaii S. Synthesis and structure-activity relationship studies of furan-ring fused chalcones as antiproliferative agents. Anticancer Res. 2015;35:811-7 pubmed
..In comparison with 2',4'-dihydroxychalcone, attachment of a furan moiety on the A-ring enhanced activity by more than twofold. Benzofurans may be useful in the design of biologically active flavonoids. ..