Hajime Karasuyama

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi request reprint [B cell development through preB cell receptor signaling]
    Hajime Karasuyama
    Tanpakushitsu Kakusan Koso 47:2182-7. 2002
  2. pmc Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells
    Yumiko Ishikawa
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Respir Res 12:42. 2011
  3. ncbi request reprint Role for basophils in systemic anaphylaxis
    Hajime Karasuyama
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan
    Chem Immunol Allergy 95:85-97. 2010
  4. doi request reprint Newly discovered roles for basophils: a neglected minority gains new respect
    Hajime Karasuyama
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Nat Rev Immunol 9:9-13. 2009
  5. doi request reprint Nonredundant roles of basophils in immunity
    Hajime Karasuyama
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Japan
    Annu Rev Immunol 29:45-69. 2011
  6. doi request reprint Newly appreciated roles for basophils in allergy and protective immunity
    H Karasuyama
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Allergy 66:1133-41. 2011
  7. doi request reprint Emerging roles of basophils in protective immunity against parasites
    Hajime Karasuyama
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Trends Immunol 32:125-30. 2011
  8. pmc Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells
    Masako Saito
    Department of Immune Regulation, Japan Science and Technology Agency, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Exp Med 208:235-49. 2011
  9. doi request reprint Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis
    Yusuke Tsujimura
    Department of Immune Regulation and Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Immunity 28:581-9. 2008
  10. pmc Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks
    Takeshi Wada
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Clin Invest 120:2867-75. 2010

Detail Information

Publications58

  1. ncbi request reprint [B cell development through preB cell receptor signaling]
    Hajime Karasuyama
    Tanpakushitsu Kakusan Koso 47:2182-7. 2002
  2. pmc Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells
    Yumiko Ishikawa
    Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Respir Res 12:42. 2011
    ..The purpose of this study is to clarify the role of inhibitory FcRs and antigen presenting cells (APCs) in pathogenesis of asthma and to evaluate antigen-transporting and presenting capacity by APCs in the tracheobronchial mucosa...
  3. ncbi request reprint Role for basophils in systemic anaphylaxis
    Hajime Karasuyama
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan
    Chem Immunol Allergy 95:85-97. 2010
    ..Thus, there are two major, distinct pathways to allergen-induced systemic anaphylaxis: one mediated by basophils, IgG and platelet-activating factor, and the other 'classical' pathway mediated by mast cells, IgE and histamine...
  4. doi request reprint Newly discovered roles for basophils: a neglected minority gains new respect
    Hajime Karasuyama
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Nat Rev Immunol 9:9-13. 2009
    ..However, recent studies have now defined previously unrecognized roles for basophils in both immune regulation and allergic responses, and have shown that basophils and mast cells have distinct roles in immune responses...
  5. doi request reprint Nonredundant roles of basophils in immunity
    Hajime Karasuyama
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Japan
    Annu Rev Immunol 29:45-69. 2011
    ..We now appreciate that basophils play nonredundant roles in acquired immunity regulation, protective immunity to pathogens, and immunological disorders such as allergy and autoimmunity...
  6. doi request reprint Newly appreciated roles for basophils in allergy and protective immunity
    H Karasuyama
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Allergy 66:1133-41. 2011
    ..Thus, basophils are no longer the neglected minority and are key players in the immune system...
  7. doi request reprint Emerging roles of basophils in protective immunity against parasites
    Hajime Karasuyama
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Trends Immunol 32:125-30. 2011
    ....
  8. pmc Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells
    Masako Saito
    Department of Immune Regulation, Japan Science and Technology Agency, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Exp Med 208:235-49. 2011
    ..These results suggest that the defective generation of IL-10-induced tolerogenic DCs and iT(reg) cells may contribute to inflammatory changes in HIES...
  9. doi request reprint Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis
    Yusuke Tsujimura
    Department of Immune Regulation and Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Immunity 28:581-9. 2008
    ....
  10. pmc Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks
    Takeshi Wada
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Clin Invest 120:2867-75. 2010
    ....
  11. ncbi request reprint Basophils are essential initiators of a novel type of chronic allergic inflammation
    Kazushige Obata
    Department of Immune Regulation, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Blood 110:913-20. 2007
    ..Thus, basophils play a pivotal role in the development of IgE-mediated chronic allergic inflammation, as an initiator rather than as an effector...
  12. doi request reprint Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4
    Mayumi Egawa
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo 113 8519, Japan
    Immunity 38:570-80. 2013
    ..Thus, inflammatory monocytes can be converted from being proinflammatory to anti-inflammatory under the influence of basophils in allergic reactions...
  13. pmc The skin is an important bulwark of acquired immunity against intestinal helminths
    Kazushige Obata-Ninomiya
    Department of Immune Regulation, 2 Department of Environmental Parasitology, 3 Department of Integrated Pulmonology, and 4 Japan Science and Technology Agency Core Research for Evolutional Science and Technology, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Bunkyo ku, Tokyo 113 8519, Japan
    J Exp Med 210:2583-95. 2013
    ..This study thus reveals a novel mode of acquired antihelminth immunity, in which IgE-armed basophils mediate skin trapping of larvae, thereby limiting lung injury caused by larval migration. ..
  14. ncbi request reprint New insights into the roles for basophils in acute and chronic allergy
    Kaori Mukai
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Allergol Int 58:11-9. 2009
    ..Accumulating evidence suggests that basophils function as initiators rather than effectors of the chronic allergic inflammation. Thus, basophils and their products seem to be promising therapeutic targets for allergic disorders...
  15. ncbi request reprint Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner
    Toshiyuki Kojima
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Immunol 179:7093-100. 2007
    ....
  16. doi request reprint Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner
    Hirofumi Yamagishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 415:709-13. 2011
    ..Thus, basophil-derived mMCP-11 can induce microvascular leakage via prostaglandins in a mast cell-independent manner, and may contribute to the development of basophil-mediated inflammatory responses...
  17. ncbi request reprint Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils
    Maki Watanabe
    Department of Dermatology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Immunol 181:5653-9. 2008
    ..Thus, IgE appears to be capable of stimulating basophils to produce MDC in the absence of a specific Ag, which may contribute to IgE-mediated and/or Th2-predominant allergic inflammation...
  18. doi request reprint Basophils preferentially express mouse Mast Cell Protease 11 among the mast cell tryptase family in contrast to mast cells
    Tsukasa Ugajin
    Department of Dermatology, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Tokyo, Japan
    J Leukoc Biol 86:1417-25. 2009
    ..Thus, basophils rather than mast cells are the major source of mMCP-11. This is the first study to demonstrate that mouse basophils produce a trypsin-like protease...
  19. pmc Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Exp Med 206:1291-301. 2009
    ..These results appear to explain, at least in part, why HIES patients suffer from recurrent staphylococcal infections confined to the skin and lung in contrast to more systemic infections in neutrophil-deficient patients...
  20. ncbi request reprint Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Nature 448:1058-62. 2007
    ..These results highlight the multiple roles played by STAT3 in humans, and underline the critical involvement of multiple cytokine pathways in the pathogenesis of HIES...
  21. doi request reprint IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen
    Ryosuke Ishikawa
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Biochem Biophys Res Commun 402:742-6. 2010
    ....
  22. ncbi request reprint Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells
    Kaori Mukai
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Japan
    Immunity 23:191-202. 2005
    ..These findings indicate a novel mechanism of development of chronic allergic inflammation that is induced by basophils through the interaction of antigen, IgE, and FcRI...
  23. ncbi request reprint [Novel role of basophils in chronic allergic inflammation]
    Hajime Karasuyama
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bukyo ku, Tokyo 113 8519, Japan
    Seikagaku 79:761-8. 2007
  24. doi request reprint The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver
    Soichiro Yoshikawa
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bukyo ku, Tokyo, Japan
    Int Immunol 21:43-52. 2009
    ....
  25. ncbi request reprint [The roles for basophils in allergy]
    Kaori Mukai
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School
    Nihon Rinsho 67:2095-9. 2009
    ..Thus, basophils are a key player in both immune regulation and allergic responses. Basophils and their products seem to be promising therapeutic targets for allergic disorders...
  26. doi request reprint NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivo
    Hideto Nishikado
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    J Immunol 186:5766-71. 2011
    ....
  27. pmc A novel mechanism for the autonomous termination of pre-B cell receptor expression via induction of lysosome-associated protein transmembrane 5
    Yohei Kawano
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Mol Cell Biol 32:4462-71. 2012
    ....
  28. doi request reprint Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-α on macrophages through the autocrine action of IL-6
    Hiromi Ogawa
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 420:114-8. 2012
    ..Thus, IL-4 and IL-33 synergistically elicit the tmTNF-α expression on macrophages through the autocrine action of IL-6...
  29. doi request reprint Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int Immunol 21:105-12. 2009
    ....
  30. doi request reprint A novel hairless mouse model on an atopic dermatitis-prone genetic background generated by receptor-mediated transgenesis
    Toyoyuki Takada
    Department of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science Rinshoken, 3 18 22, Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    Transgenic Res 17:1155-62. 2008
    ..NCN24 mice, which we have newly developed, will be useful to assess drugs for AD therapy, being able to monitor skin inflammation without shaving...
  31. pmc GATA-1 regulates the generation and function of basophils
    Yuichiro Nei
    Departments of Immune Regulation and Integrated Pulmonology and Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Proc Natl Acad Sci U S A 110:18620-5. 2013
    ..Our findings demonstrate that GATA-1 plays a key role in the generation and function of basophils and underscore the need for careful distinction of the cell lineage responsible for each phenotype observed in ΔdblGATA mice. ..
  32. ncbi request reprint Genetic origins of hyper-IgE syndrome
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Curr Allergy Asthma Rep 8:386-91. 2008
    ..These findings suggest that HIES is caused by the defects in multiple cytokine signals and that the susceptibility to various infections in HIES is associated with the T-helper type 17 defect...
  33. ncbi request reprint Pre-B cell receptor assesses the quality of IgH chains and tunes the pre-B cell repertoire by delivering differential signals
    Yohei Kawano
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Immunol 177:2242-9. 2006
    ..These results indicate that the pre-BCR assesses the quality of muH chains and tunes the pre-B cell repertoire by driving the preferential expansion and differentiation of cells with the higher quality of muH chains...
  34. ncbi request reprint Different stabilities of the structurally related receptors for IgE and IgG on the cell surface are determined by length of the stalk region in their alpha-chains
    Toshiyuki Kubota
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    J Immunol 176:7008-14. 2006
    ..This finding provides new insights into the mechanism regulating surface FcepsilonRI expression...
  35. pmc Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture
    Noriko Toyama-Sorimachi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Proc Natl Acad Sci U S A 101:1016-21. 2004
    ..Thus, Ly49Q has unique features different from other known Ly49 family members and appears to be involved in regulation of cytoskeletal architecture of macrophages through ITIM-mediated signaling...
  36. ncbi request reprint [B cells]
    Hajime Karasuyama
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School
    Nihon Rinsho 63:130-5. 2005
  37. ncbi request reprint Selection of stereotyped VH81X-{micro}H chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells
    Yohei Kawano
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Int Immunol 17:857-67. 2005
    ..This strongly suggests that neonatally generated and selected B cells expressing the stereotyped V(H)81X-muH chains are maintained in the adult MZ and could function as innate-like lymphocytes...
  38. ncbi request reprint Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity
    Yoshiyuki Minegishi
    Department of Immune Regulation, Graduate School, Tokyo Medical and Dental University, Yushima, Tokyo, Japan
    Immunity 25:745-55. 2006
    ..This study identifies human Tyk2 deficiency and demonstrates that Tyk2 plays obligatory roles in multiple cytokine signals involved in innate and acquired immunity of humans, which differs substantially from Tyk2 function in mice...
  39. ncbi request reprint Hyperimmunoglobulin E syndrome and tyrosine kinase 2 deficiency
    Yoshiyuki Minegishi
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Curr Opin Allergy Clin Immunol 7:506-9. 2007
    ..The purpose of the review is to provide recent insight into the pathogenesis and pathophysiology of hyperimmunoglobulin E syndrome...
  40. ncbi request reprint Inhibitory NK receptor Ly49Q is expressed on subsets of dendritic cells in a cellular maturation- and cytokine stimulation-dependent manner
    Noriko Toyama-Sorimachi
    Department of Gastroenterology, Research Institute, International Medical Center of Japan, Toyama, Tokyo, Japan
    J Immunol 174:4621-9. 2005
    ..Therefore, depending on IFN-alpha, our results imply that Ly49Q serves a role for the biological functions of certain DC subsets through recognition of MHC class I or related molecules...
  41. ncbi request reprint Chronic inflammation of the skin can be induced in IgE transgenic mice by means of a single challenge of multivalent antigen
    Eiichiro Sato
    Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    J Allergy Clin Immunol 111:143-8. 2003
    ..It is now widely accepted that IgE mediates immediate-type allergic response. However, the pathologic role of IgE is controversial in the chronic allergic inflammation observed in atopic diseases, such as asthma and atopic dermatitis...
  42. ncbi request reprint Pre-B cell antigen receptor-mediated signal inhibits CD24-induced apoptosis in human pre-B cells
    Tomoko Taguchi
    Department of Developmental Biology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Immunol 170:252-60. 2003
    ..Our findings should be important to understanding the role of CD24-mediated cell signaling in early B cell development...
  43. ncbi request reprint Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase
    Kiichiro Tsuchiya
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University Graduate School, Japan
    FEBS Lett 537:203-9. 2003
    ..Thus, TPP36/32 appear to be novel substrates of Abl tyrosine kinase...
  44. ncbi request reprint Diagnostic importance of CD179a/b as markers of precursor B-cell lymphoblastic lymphoma
    Nobutaka Kiyokawa
    Department of Developmental Biology, National Research Institute for Child Health and Development, Japan
    Mod Pathol 17:423-9. 2004
    ..Our data indicate that CD179a and CD179b may be important markers for the immunophenotypic diagnosis of precursor B-cell lymphoblastic lymphomas...
  45. ncbi request reprint Differential surrogate light chain expression governs B-cell differentiation
    Yui Hsi Wang
    Department of Medicine, Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, 1824 6th Avenue S, Birmingham, AL 35294 3300, USA
    Blood 99:2459-67. 2002
    ....
  46. ncbi request reprint Ovalbumin-specific IgE modulates ovalbumin-specific T-cell response after repetitive oral antigen administration
    Nemuko Omata
    Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, 2303 Shimoaizuki, Matsuoka cho, Yoshida gun, Fukui 910 1193, USA
    J Allergy Clin Immunol 115:822-7. 2005
    ..Some patients outgrow their food allergies even though their serum antigen-specific IgE levels remain high...
  47. ncbi request reprint Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells
    Eijiro Jimi
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Int Immunol 17:815-25. 2005
    ..These data therefore indicate that activation of NF-kappaB in CD43(+) pre-B cells, as a result of signaling by the pre-B-cell receptor, facilitates the continued development of large, CD43(+) pre-B cells into small CD43(-) pre-B cells...
  48. ncbi request reprint Long term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE
    Shuichi Kubo
    Department of Laboratory Animal Science, Tokyo Metropolitan Organization for Medical Science, Tokyo Metropolitan Institute of Medical Science, Japan
    J Immunol 170:775-80. 2003
    ..These results suggest that IgE-mediated stabilization and up-regulation of FcepsilonRI enables mast cells and basophils not only to acquire Ag specificity, but also to maintain memory in vivo for lengthy periods of time...
  49. pmc Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling
    Hisaaki Shinohara
    Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    J Exp Med 201:333-9. 2005
    ..Thus, Dok-1 and Dok-2 are essential negative regulators downstream of TLR4, implying a novel PTK-dependent pathway in innate immunity...
  50. ncbi request reprint Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development
    Kaoru Saijo
    Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, NY 10021, USA
    Nat Immunol 4:274-9. 2003
    ..Our data show the existence of a functionally distinct SFK signaling module responsible for pre-BCR-mediated NF-kappaB activation and B cell development...
  51. ncbi request reprint BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces kappa gene rearrangement
    Mutsumi Yamamoto
    Division of Molecular Biology, Research Institute for Biological Sciences, Tokyo University of Science, Yamazaki 2669, Noda, Chiba 278 0022, Japan
    Blood 108:2703-11. 2006
    ..These data make evident that the Ras-independent BASH-nPKC-Raf-1 pathway of pre-BCR signaling induces the L-chain gene rearrangement and expression...
  52. ncbi request reprint Expansion of natural killer cells in mice transgenic for IgM antibody to ganglioside GD2: demonstration of prolonged survival after challenge with syngeneic tumor cells
    Ikuo Kawashima
    Department of Tumor Immunology, Tokyo Metropolitan Organization for Medical Research, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113 8613, Japan
    Int J Oncol 23:381-8. 2003
    ..Taking these results together, our studies demonstrate that the TG mice have significant anti-tumor characteristics, probably due to CDC and NK cell expansion and activation with anti-ganglioside GD2 antibody...
  53. ncbi request reprint Role of IgE in Th2 cell-mediated allergic airway inflammation
    Yuko Maezawa
    Department of Internal Medicine II, Chiba University School of Medicine, Chiba, Japan
    Int Arch Allergy Immunol 131:2-6. 2003
    ..These findings suggest that IgE-dependent mast cell activation plays an important role in allergic airway inflammation by recruiting Th2 cells into the site of allergic inflammation...
  54. ncbi request reprint Pulmonary granulomas caused experimentally in mice by a recombinant trigger-factor protein of Propionibacterium acnes
    Junko Minami
    Department of Human Pathology, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 50:265-74. 2003
    ..acnes caused pulmonary granulomas in primed and unprimed mice sensitized with the protein and adjuvant. Sarcoid granulomas may form during hypersensitivity to antigens of P. acnes indigenous to the affected organ...
  55. ncbi request reprint Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells
    Kyoko Ochiai
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Seiryo machi 2 1, Sendai 980 8575, Japan
    J Biol Chem 281:38226-34. 2006
    ..Therefore, the Prdm1 regulation in B cells involves the repression by Bach2, which may be cancelled upon terminal plasma cell differentiation...
  56. pmc Placental extravillous cytotrophoblasts persistently express class I major histocompatibility complex molecules after human cytomegalovirus infection
    Masakazu Terauchi
    Department of Comprehensive Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, Bunkyo, Tokyo 113 8510, Japan
    J Virol 77:8187-95. 2003
    ..In fibroblasts, these US proteins were localized at the ER before and after HCMV infection. These results suggest that the US gene products are not integrated into ER of HCMV-infected EVT and fail to downregulate class I MHC molecules...
  57. doi request reprint Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion
    Tomoharu Yasuda
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Immunity 28:499-508. 2008
    ..Together, our results identify a crucial role for Erk kinases in regulating B cell development by initiating transcriptional regulatory network and thereby pre-BCR-mediated cell expansion...
  58. pmc Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells
    Tomoko Taguchi
    Department of Developmental Biology, National Research Institute for Child Health and Development, 3 35 31 Taishido, Setagaya Ku, Tokyo 154 8567, Japan
    Immunology 112:575-82. 2004
    ..Human pre-B cell lines expressing and not expressing BLNK should provide an in vitro model for investigation of the role of BLNK in the pre-BCR-mediated signalling mechanism...