F Kametani

Summary

Affiliation: Tokyo Institute of Psychiatry
Country: Japan

Publications

  1. ncbi request reprint Epsilon-secretase: reduction of amyloid precursor protein epsilon-site cleavage in Alzheimer's disease
    Fuyuki Kametani
    Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Curr Alzheimer Res 5:165-71. 2008
  2. doi request reprint Identification of casein kinase-1 phosphorylation sites on TDP-43
    Fuyuki Kametani
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
    Biochem Biophys Res Commun 382:405-9. 2009
  3. ncbi request reprint Secretion of long Abeta-related peptides processed at epsilon-cleavage site is dependent on the alpha-secretase pre-cutting
    Fuyuki Kametani
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagayaku, Tokyo 156 8585, Japan
    FEBS Lett 570:73-6. 2004
  4. ncbi request reprint Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the processing of Alzheimer's amyloid precursor protein in PC12D cells
    F Kametani
    Department of Molecular Biology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagayaku, 156 8585, Tokyo, Japan
    J Neurol Sci 188:27-31. 2001
  5. ncbi request reprint Mutant presenilin (A260V) affects Rab8 in PC12D cell
    Fuyuki Kametani
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagayaku, Tokyo 156 8585, Japan
    Neurochem Int 44:313-20. 2004
  6. ncbi request reprint Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain
    K Maruyama
    Department of Molecular Biology, Tokyo Institute of Psychiatry, Kamikitazawa, Setagaya, Tokyo 156 8585, Japan
    Int J Mol Med 5:269-73. 2000
  7. doi request reprint Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models
    Makiko Yamashita
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Reearch, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    FEBS Lett 583:2419-24. 2009
  8. ncbi request reprint gamma-Secretase can cleave amyloid precursor protein fragments independent of alpha- and beta-secretase pre-cutting
    Hideaki Kume
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo 156 8585, Japan
    Int J Mol Med 12:57-60. 2003
  9. ncbi request reprint Serum transthyretin monomer in patients with familial amyloid polyneuropathy
    Y Sekijima
    Department of Molecular Biology, Tokyo Institute of Psychiatry, Japan
    Amyloid 8:257-62. 2001
  10. doi request reprint Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43
    Takashi Nonaka
    Department of Molecular Neurobiology, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
    Hum Mol Genet 18:3353-64. 2009

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Epsilon-secretase: reduction of amyloid precursor protein epsilon-site cleavage in Alzheimer's disease
    Fuyuki Kametani
    Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Curr Alzheimer Res 5:165-71. 2008
    ..Recent findings indicate that gamma- and epsilon-site cleavage are regulated independently. In this review, the reduction of epsilon-site cleavage in AD and the importance of epsilon-site cleavage are discussed...
  2. doi request reprint Identification of casein kinase-1 phosphorylation sites on TDP-43
    Fuyuki Kametani
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
    Biochem Biophys Res Commun 382:405-9. 2009
    ..Interestingly, 18 of them were located in the C-terminal glycine-rich region of TDP-43. Our results indicate that CK1-mediated phosphorylation may play a role in the pathogenesis of these diseases...
  3. ncbi request reprint Secretion of long Abeta-related peptides processed at epsilon-cleavage site is dependent on the alpha-secretase pre-cutting
    Fuyuki Kametani
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagayaku, Tokyo 156 8585, Japan
    FEBS Lett 570:73-6. 2004
    ..These results indicated that longer Abeta-related peptides cleaved at epsilon-cleavage site were secreted under normal conditions and were dependent on the alpha-secretase cleavage products...
  4. ncbi request reprint Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the processing of Alzheimer's amyloid precursor protein in PC12D cells
    F Kametani
    Department of Molecular Biology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagayaku, 156 8585, Tokyo, Japan
    J Neurol Sci 188:27-31. 2001
    ..These results suggest that APP metabolism is physiologically regulated by the PS1 and that loss of normal PS1 affects gamma-secretase activity...
  5. ncbi request reprint Mutant presenilin (A260V) affects Rab8 in PC12D cell
    Fuyuki Kametani
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagayaku, Tokyo 156 8585, Japan
    Neurochem Int 44:313-20. 2004
    ..Therefore, it is highly likely that reduction of Abeta is closely related to the retention of APP CTF during TGN-to-PM transport...
  6. ncbi request reprint Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain
    K Maruyama
    Department of Molecular Biology, Tokyo Institute of Psychiatry, Kamikitazawa, Setagaya, Tokyo 156 8585, Japan
    Int J Mol Med 5:269-73. 2000
    ..These results suggest a regulatory function of presenilin on the calpain system...
  7. doi request reprint Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models
    Makiko Yamashita
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Reearch, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    FEBS Lett 583:2419-24. 2009
    ..These findings were confirmed by immunoblot analysis. The results indicate that MB and dimebon may be useful for the treatment of ALS, FTLD-U and other TDP-43 proteinopathies...
  8. ncbi request reprint gamma-Secretase can cleave amyloid precursor protein fragments independent of alpha- and beta-secretase pre-cutting
    Hideaki Kume
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo 156 8585, Japan
    Int J Mol Med 12:57-60. 2003
    ..This suggests that gamma-secretase cleavage occurs independently and is not dependent on alpha- and beta-secretase cleavage...
  9. ncbi request reprint Serum transthyretin monomer in patients with familial amyloid polyneuropathy
    Y Sekijima
    Department of Molecular Biology, Tokyo Institute of Psychiatry, Japan
    Amyloid 8:257-62. 2001
    ..These findings suggest that the free variant TTR monomer is unstable in serum, and that it aggregates in deposits in various organs or is adsorbed by preexisting amyloid fibrils before it is degraded..
  10. doi request reprint Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43
    Takashi Nonaka
    Department of Molecular Neurobiology, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
    Hum Mol Genet 18:3353-64. 2009
    ....
  11. pmc Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Masato Hasegawa
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Kamikitazawa, Setagaya Ku, Tokyo, Japan
    Ann Neurol 64:60-70. 2008
    ..The aim of this study was to identify the phosphorylation sites and responsible kinases, and to clarify the pathological significance of phosphorylation of TDP-43...
  12. ncbi request reprint Alzheimer amyloid beta/A4 peptide binding sites and a possible 'APP-secretase' activity associated with rat brain cortical membranes
    D Allsop
    Department of Molecular Biology, Psychiatric Research Institute of Tokyo, Japan
    Brain Res 551:1-9. 1991
    ....
  13. pmc Expression of reticulon 3 in Alzheimer's disease brain
    H Kume
    Department of Demyelinating Disease and Ageing, National Institute of Neuroscience, NCNP, Tokyo, Japan
    Neuropathol Appl Neurobiol 35:178-88. 2009
    ..The aim of the present study was to clarify the biological role of RTN3 in the brain and its potential involvement in the neuropathology of Alzheimer's disease (AD)...
  14. ncbi request reprint The amino-terminally truncated forms of amyloid beta-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients
    H Akiyama
    Tokyo Institute of Psychiatry, Japan
    Neurosci Lett 219:115-8. 1996
    ..These data suggest that appropriately stimulated macrophages can phagocytose A beta deposits and that digestion of the N-terminal region is an early consequence of this phagocytosis...
  15. ncbi request reprint [Frontotemporal dementia (FTD) and genetic mutations including progranulin gene]
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research
    Rinsho Shinkeigaku 48:990-3. 2008
    ..Taken together, these results suggest that elucidating the mechanism of C-terminal fragment origination may shed light on the pathogenesis of several neurodegenerative disorders involving TDP-43 proteinopathy and tauopathy...
  16. ncbi request reprint [Significance of the TDP-43 deposition in FTLD-U and ALS]
    Masato Hasegawa
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research
    Rinsho Shinkeigaku 48:994-7. 2008
    ..These findings together with recent discovery of mutations in the TDP-43 gene in ALS strongly suggest that TDP-43 is the..
  17. doi request reprint Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy
    Tetsuaki Arai
    Department of Psychogeriatrics, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
    Neuropathology 30:170-81. 2010
    ..Understanding the mechanism of phosphorylation and truncation of TDP-43 and aggregate formation may be crucial for clarifying the pathogenesis of TDP-43 proteinopathy and for developing useful therapeutics...
  18. ncbi request reprint [TDP-43 proteinopathies, toward understanding of the molecular pathogenesis]
    Masato Hasegawa
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry
    Rinsho Shinkeigaku 49:783-5. 2009
    ....
  19. ncbi request reprint Characterization of a transthyretin-related amyloid fibril protein from cerebral amyloid angiopathy in type I familial amyloid polyneuropathy
    F Kametani
    Department of Molecular Biology, Psychiatric Research Institute of Tokyo, Japan
    J Neurol Sci 108:178-83. 1992
    ..Furthermore, the patients with type I FAP are well known to have the variant TTR in the serum. These suggest that cerebrovascular amyloid fibril protein in type I FAP may derive from a serum precursor...
  20. ncbi request reprint Abeta 11-40/42 production without gamma-secretase epsilon-site cleavage
    Hideaki Kume
    Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Tokyo 156 8585, Japan
    Biochem Biophys Res Commun 349:1356-60. 2006
    ....
  21. ncbi request reprint Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage
    Hideaki Kume
    Department of Moleculr Neurobiology, Tohoku University Graduate School of Medicine, Tokyo 156 8585, Japan
    Int J Mol Med 13:121-5. 2004
    ..Furthermore, elevated alpha-secretase levels induced an increase of AICD. The results suggest that generation of AICD by epsilon-cleavage depends on CTFalpha and that gamma- and epsilon-cleavage are differentially regulated...
  22. ncbi request reprint Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase
    Yue Qi-Takahara
    Department of Neuropathology, Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 25:436-45. 2005
    ..We therefore propose an alpha-helical model in which longer Abeta species generated by epsilon-cleavage is cleaved at every three residues in its carboxyl portion...
  23. ncbi request reprint Extracellular release of BACE1 holoproteins from human neuronal cells
    Kiyoko S Murayama
    Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 338:800-7. 2005
    ..These findings suggest that the release of BACE1 holoproteins may be a physiologically relevant cellular process...
  24. ncbi request reprint Beta-site APP cleaving enzyme 1 (BACE1) is increased in remaining neurons in Alzheimer's disease brains
    Hirotsugu Harada
    Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Neurosci Res 54:24-9. 2006
    ..This could justify the development of anti-BACE1 drugs for AD treatment...
  25. ncbi request reprint Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein
    Kiyoko S Murayama
    Department of Demyelinating Disease and Ageing, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Eur J Neurosci 24:1237-44. 2006
    ..Because RTN3 and RTN4-B/C are substantially expressed in neural tissues, our findings suggest that they play important roles in the regulation of BACE1 function and Abeta production in the brain...
  26. ncbi request reprint A novel monoclonal antibody specific for the amino-truncated beta-amyloid Abeta5-40/42 produced from caspase-cleaved amyloid precursor protein
    Kiyoko S Murayama
    Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Neurosci Methods 161:244-9. 2007
    ..The antibody reacted weakly with Abeta derived from AD brains. These results suggest that our novel monoclonal antibody is useful for detecting the N-terminally truncated Abeta produced in conjunction with caspase activation...
  27. doi request reprint Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro
    Takashi Kasai
    Department of Neurology, Research Institute for Geriatrics, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
    Neurosci Lett 436:52-6. 2008
    ....
  28. ncbi request reprint Cerebral vascular accumulation of Dutch-type Abeta42, but not wild-type Abeta42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type
    Kazuchika Nishitsuji
    Department of Neuroscience, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Neurosci Res 85:2917-23. 2007
    ..Moreover, we detected peaks corresponding to Dutch-type Abeta42 but not to wild-type Abeta42. These results suggest a pathogenic role for the mutant Abeta42 in addition to the mutant Abeta40 in the cerebral amyloid angiopathy of HCHWA-D...
  29. ncbi request reprint Glial fibrillary acidic protein is greatly modified by oxidative stress in aceruloplasminemia brain
    Kazuma Kaneko
    Third Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Free Radic Res 36:303-6. 2002
    ..We speculate that the dysfunction of astrocytes may be causatively related to neuronal cell loss in aceruloplasminemia...
  30. ncbi request reprint A family of membrane proteins associated with presenilin expression and gamma-secretase function
    Wataru Araki
    Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    FASEB J 22:819-27. 2008
    ..Our data collectively indicate that adoplins are unique molecules with PS-related expression and functions that may play important role(s) in the maturation and activity of the gamma-secretase complex...