Naoyuki Kamatani

Summary

Affiliation: Tokyo Women's Medical University
Country: Japan

Publications

  1. pmc IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats
    Toru Yago
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Arthritis Res Ther 9:R96. 2007
  2. pmc Replication of association of the D-repeat polymorphism in asporin with osteoarthritis
    Shiro Ikegawa
    Arthritis Res Ther 8:403; author reply 403. 2006
  3. pmc A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population
    Tomoko Sugiura
    Institute of Rheumatology, Tokyo Women s Medical University School of Medicine, 10 22 Kawada cho, Shinjuku ku, Tokyo, Japan
    Arthritis Res Ther 8:R60. 2006
  4. pmc Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus
    Makoto Soejima
    Institute of Rheumatology, Tokyo Women s Medical University School of Medicine, Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Arthritis Res Ther 9:R23. 2007
  5. pmc Large-scale single-nucleotide polymorphism (SNP) and haplotype analyses, using dense SNP Maps, of 199 drug-related genes in 752 subjects: the analysis of the association between uncommon SNPs within haplotype blocks and the haplotypes constructed with hap
    Naoyuki Kamatani
    Division of Genomic Medicine, Department of Advanced Biomedical Engineering and Science, and Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Am J Hum Genet 75:190-203. 2004
  6. ncbi request reprint Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects: SLCO1B1*17 is more prevalent than *15
    Su Ryang Kim
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 22:456-61. 2007
  7. ncbi request reprint Incidence of and risk factors for interstitial pneumonia in patients with rheumatoid arthritis in a large Japanese observational cohort, IORRA
    Kumi Shidara
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjyuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 20:280-6. 2010
  8. ncbi request reprint CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population
    Yoshiro Saito
    Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan
    Pharmacogenet Genomics 17:461-71. 2007
  9. ncbi request reprint Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS)
    Su Ryang Kim
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 21:509-16. 2006
  10. pmc Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-gamma and anti-double-stranded DNA antibody production
    Manabu Kawamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Res Ther 8:R62. 2006

Detail Information

Publications130 found, 100 shown here

  1. pmc IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats
    Toru Yago
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Arthritis Res Ther 9:R96. 2007
    ..Thus, controlling IL-23 production and function could be a strategy for preventing inflammation and bone destruction in patients with rheumatoid arthritis...
  2. pmc Replication of association of the D-repeat polymorphism in asporin with osteoarthritis
    Shiro Ikegawa
    Arthritis Res Ther 8:403; author reply 403. 2006
  3. pmc A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population
    Tomoko Sugiura
    Institute of Rheumatology, Tokyo Women s Medical University School of Medicine, 10 22 Kawada cho, Shinjuku ku, Tokyo, Japan
    Arthritis Res Ther 8:R60. 2006
    ..Possession of the diplotype configuration of S01/S01 would be one of the genetic risk factors for susceptibility to arthritis in the Japanese population...
  4. pmc Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus
    Makoto Soejima
    Institute of Rheumatology, Tokyo Women s Medical University School of Medicine, Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Arthritis Res Ther 9:R23. 2007
    ..5%]; P = 0.024; odds ratio = 11.5, 95% confidence interval = 1.59-73.39). We conclude that lack of NAT2*4 haplotype is associated with adverse events with co-trimoxazole in Japanese patients with SLE...
  5. pmc Large-scale single-nucleotide polymorphism (SNP) and haplotype analyses, using dense SNP Maps, of 199 drug-related genes in 752 subjects: the analysis of the association between uncommon SNPs within haplotype blocks and the haplotypes constructed with hap
    Naoyuki Kamatani
    Division of Genomic Medicine, Department of Advanced Biomedical Engineering and Science, and Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Am J Hum Genet 75:190-203. 2004
    ..03...
  6. ncbi request reprint Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects: SLCO1B1*17 is more prevalent than *15
    Su Ryang Kim
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 22:456-61. 2007
    ..469, 0.000 (not detected), 0.037, and 0.133, respectively. These data would provide fundamental and useful information for pharmacogenetic studies on OATP1B1-transported drugs in Japanese...
  7. ncbi request reprint Incidence of and risk factors for interstitial pneumonia in patients with rheumatoid arthritis in a large Japanese observational cohort, IORRA
    Kumi Shidara
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjyuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 20:280-6. 2010
    ..The incidence of and risk factors for IP in RA patients were determined in a large observational cohort of RA patients in Japan...
  8. ncbi request reprint CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population
    Yoshiro Saito
    Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan
    Pharmacogenet Genomics 17:461-71. 2007
    ..Although large interindividual differences in CYP2C8 enzymatic activity and several nonsynonymous variations were reported, neither haplotype structures nor their associations with pharmacokinetic parameters of paclitaxel were reported...
  9. ncbi request reprint Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS)
    Su Ryang Kim
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 21:509-16. 2006
    ..In Blocks 1 and 3, 7 and 19 haplotypes were determined/inferred, respectively. Our findings provide fundamental and useful information for genotyping TYMS in the Japanese and probably other Asian populations...
  10. pmc Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-gamma and anti-double-stranded DNA antibody production
    Manabu Kawamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Res Ther 8:R62. 2006
    ..These findings suggest that ICOS is involved in abnormal T cell activation in SLE, and that blockade of the interaction between ICOS and its receptor may have therapeutic value in the treatment of this intractable disease...
  11. doi request reprint T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku, Tokyo 162 0054, Japan
    Bone 45:627-39. 2009
    ..Our novel peptide and polyclonal antibodies against the peptide inhibited human osteoclastogenesis and the function of mature osteoclasts, preventing cellular fusion by TCTA protein and a putative counterpart molecule...
  12. ncbi request reprint Validation of the associations between single nucleotide polymorphisms or haplotypes and responses to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a proposal for prospective pharmacogenomic study in clinical practice
    Atsuo Taniguchi
    Institute of Rheumatology, Tokyo Women s Medical University, Shinjuku ku, Tokyo 162 0054, Japan
    Pharmacogenet Genomics 17:383-90. 2007
    ..Pharmacogenomic evidence, if reliable, may be incorporated in the treatment of rheumatoid arthritis to achieve a more efficient activity control with minimized adverse events...
  13. ncbi request reprint Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Clin Rheumatol 26:2137-41. 2007
    ..In addition, SNPs in RANKL and IL-17 may be associated with radiographic progression in Japanese patients with early RA...
  14. ncbi request reprint Genetic variations and haplotype structures of transcriptional factor Nrf2 and its cytosolic reservoir protein Keap1 in Japanese
    Hiromi Fukushima-Uesaka
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 22:212-9. 2007
    ..These data would be fundamental and useful information for pharmacogenetic studies on Nrf2-regulated genes for xenobiotic metabolism and disposition...
  15. ncbi request reprint Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients
    Kimie Sai
    Division of Biosignaling, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, Japan
    Cancer Chemother Pharmacol 62:529-37. 2008
    ..In this study, the effects of CYP3A4 haplotypes including *16B on irinotecan PK/PD were investigated in irinotecan-administered patients...
  16. ncbi request reprint Improvement of disease activity of rheumatoid arthritis patients from 2000 to 2006 in a large observational cohort study IORRA in Japan
    Hisashi Yamanaka
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 17:283-9. 2007
    ..The suppression of disease activity resulted in a better outcome for patients...
  17. ncbi request reprint Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences
    Keiko Maekawa
    Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, 158 8501, Japan
    J Hum Genet 52:804-19. 2007
    ..This study provides fundamental information for pharmacogenetic studies for evaluating the efficacy and toxicity of 5-FU in Japanese and probably East Asians...
  18. ncbi request reprint Attenuation of experimental autoimmune myositis by blocking ICOS-ICOS ligand interaction
    Yasuhiro Katsumata
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Immunol 179:3772-9. 2007
    ..ICOS-ICOS ligand interaction would be a novel therapeutic target for PM...
  19. doi request reprint Combining effects of polymorphism of tumor necrosis factor alpha 5'-flanking region and HLA-DRB1 on radiological progression in patients with rheumatoid arthritis
    Naomi Ichikawa
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 19:134-9. 2009
    ..The combination of the polymorphism of the TNFA upstream promoter region and HLA-DRB1 allele was associated with radiological progression in the early stage of RA...
  20. ncbi request reprint Contribution of single nucleotide polymorphisms of the IL1A gene to the cleavage of precursor IL-1alpha and its transcription activity
    Yasushi Kawaguchi
    Institute of Rheumatology, Tokyo Women s Medical University School of Medicine, 10 22 Kawada cho, Shinjuku ku, Tokyo, Japan
    Immunogenetics 59:441-8. 2007
    ..Pre-IL-1alpha with Ala, which was high in frequency in SSc patients, was more resistant to be cleaved by proteases in human sera than pro-IL-1alpha with Ser...
  21. ncbi request reprint Beneficial action of statins in patients with rheumatoid arthritis in a large observational cohort
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 34:964-8. 2007
    ..To analyze the possible beneficial effects of statins on the disease activity of patients with rheumatoid arthritis (RA) using a database from a large observational cohort study...
  22. ncbi request reprint Efficacy profile of bucillamine in rheumatoid arthritis patients in a large observational cohort study, IORRA
    Masako Iwatani
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjiku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 16:376-80. 2006
    ..0%) than in the MTX (32.6%) and SASP groups (25.6%). These data support Buc as a candidate for being a first-line drug for the treatment of patients with RA...
  23. ncbi request reprint Influence of methotrexate dose on its efficacy and safety in rheumatoid arthritis patients: evidence based on the variety of prescribing approaches among practicing Japanese rheumatologists in a single institute-based large observational cohort (IORRA)
    Hisashi Yamanaka
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 17:98-105. 2007
    ..In addition, we have found that it is critical to pay attention to patient-reported adverse reactions...
  24. pmc NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity
    Yasushi Kawaguchi
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Res Ther 8:R104. 2006
    ..Polymorphisms in the NOS2 gene are associated with transcriptional activity of the NOS2 gene and with susceptibility to SSc-related PAH...
  25. doi request reprint Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
    Ryo Takata
    Laboratory for Biomarker Development, Center of Genomic Medicine, RIKEN, Tokyo, Japan
    Nat Genet 42:751-4. 2010
    ..6 x 10(-8)). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations...
  26. ncbi request reprint Elevation of serum matrix metalloproteinase-3 as a predictive marker for the long-term disability of rheumatoid arthritis patients in a prospective observational cohort IORRA
    Mikiko Shinozaki
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 17:403-8. 2007
    ....
  27. doi request reprint Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients
    Wako Urano
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    J Bone Miner Metab 27:574-83. 2009
    ..Our results suggest that MTX use is associated with a nonvertebral fracture risk, whereas MTHFR polymorphism status does not appear to be a clinically useful marker for predicting fracture risk in Japanese female RA patients...
  28. doi request reprint Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk
    Ri Cui
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Gastroenterology 137:1768-75. 2009
    ..Therefore, identification of epidemiologic factors that influence the development of ESCC would facilitate prevention and/or early detection of the disease...
  29. doi request reprint Multicenter, open-label study of long-term administration of febuxostat (TMX-67) in Japanese patients with hyperuricemia including gout
    Naoyuki Kamatani
    Institute of Rheumatology, Tokyo Women s Medical University, Teikyo University, Tokyo, Japan
    J Clin Rheumatol 17:S50-6. 2011
    ..0 mg/dL or less in about 80% of patients treated with 40 mg/d febuxostat, a nonpurine selective xanthine oxidase inhibitor, a few patients did not show this result...
  30. ncbi request reprint Single nucleotide polymorphisms and haplotype frequencies of CYP3A5 in a Japanese population
    Mayumi Saeki
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Hum Mutat 21:653. 2003
    ..Our findings suggest that CYP3A5*3 is the major defective allele and that other functional exonic SNPs are rare in the Japanese...
  31. ncbi request reprint Haplotypes and a novel defective allele of CES2 found in a Japanese population
    Su Ryang Kim
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Dispos 35:1865-72. 2007
    ..These findings are useful for further pharmacogenetic studies on CES2-activated prodrugs...
  32. ncbi request reprint Impact of shoulder, elbow, and knee joint involvement on assessment of rheumatoid arthritis using the American College of Rheumatology Core Data Set
    Eiichi Tanaka
    Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Rheum 53:864-71. 2005
    ..To determine the most sensitive scoring method for assessment of rheumatoid arthritis (RA) disease activity using the American College of Rheumatology Core Data Set...
  33. ncbi request reprint Impact of the haplotype CYP3A4*16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer
    Yukiko Nakajima
    National Institute of Health Sciences, Tokyo Women s Medical University, National Cancer Center Hospital, Japan
    Clin Pharmacol Ther 80:179-91. 2006
    ..We investigated the association between CYP3A4 haplotypes and pharmacokinetic parameters of paclitaxel metabolism...
  34. doi request reprint IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility
    Hai Ha Nguyen
    Laboratory for Biomarker Development, Center for Genome Medicine, RIKEN, Tokyo, Japan
    Hum Mol Genet 21:2076-85. 2012
    ....
  35. doi request reprint IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-alpha antibody: a novel mechanism of osteoclastogenesis by IL-17
    Toru Yago
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    J Cell Biochem 108:947-55. 2009
    ..The present study clearly demonstrated the novel mechanism by which IL-17 directly induces osteoclastogenesis from human monocytes alone. In addition, infliximab potently inhibits the osteoclastogenesis directly induced by IL-17...
  36. doi request reprint A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population
    Mitsuko Nakashima
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Nat Genet 42:768-71. 2010
    ..80 x 10(-13) (OR = 1.98). Association of rs8032158 located in NEDD4 on chromosome 15 yielded P = 5.96 x 10(-13) (OR = 1.51). Our findings provide new insights into the pathophysiology of keloid formation...
  37. ncbi request reprint Genetic variations of the ABC transporter gene ABCB11 encoding the human bile salt export pump (BSEP) in a Japanese population
    Su Ryang Kim
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 24:277-81. 2009
    ..004 allele frequencies. These data provide fundamental and useful information for genotyping ABCB11 in the Japanese and probably other Asian populations...
  38. ncbi request reprint Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism
    Emiko Sugiyama
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    J Clin Oncol 25:32-42. 2007
    ..This study extended the investigation of the effects of CDA genetic polymorphisms on gemcitabine pharmacokinetics and toxicities...
  39. pmc Test of association between haplotypes and phenotypes in case-control studies: examination of validity of the application of an algorithm for samples from cohort or clinical trials to case-control samples using simulated and real data
    Shiori Furihata
    Algorithm Team Japan Biological Information Research Center, Japan Biological Informatics Consortium, Tokyo, Japan
    Genetics 174:1505-16. 2006
    ....
  40. ncbi request reprint Genetic variations and haplotype structures of the ABC transporter gene ABCC1 in a Japanese population
    Hiromi Fukushima-Uesaka
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 22:48-60. 2007
    ..This study would provide fundamental and useful information for the pharmacogenetic studies of MRP1-dependently effluxed drugs in Japanese...
  41. doi request reprint Therapeutic efficacy of intravenous cyclophosphamide concomitant with moderate- to high-dose prednisolone in two patients with fasciitis panniculitis syndrome
    Takashi Kato
    Institute of Rheumatology, Aoyama Hospital, Tokyo Women s Medical University, Tokyo, Japan
    Mod Rheumatol 18:193-9. 2008
    ..According to the clinical courses of our cases, IVCY combined with moderate- to high-dose PSL may be a new therapeutic choice for corticosteroid-resistant FPS patients...
  42. ncbi request reprint Diagnostic reliability of cerebral spinal fluid tests for acute confusional state (delirium) in patients with systemic lupus erythematosus: interleukin 6 (IL-6), IL-8, interferon-alpha, IgG index, and Q-albumin
    Yasuhiro Katsumata
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 34:2010-7. 2007
    ..To develop useful and reliable diagnostic tools for ACS, we evaluated the association of cerebral spinal fluid (CSF) tests with ACS and their predictive values for the diagnosis of ACS in SLE...
  43. ncbi request reprint Failure to confirm association between PDCD1 polymorphisms and rheumatoid arthritis in a Japanese population
    Takuji Iwamoto
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada, Shinjuku, Tokyo, 162 0054, Japan
    J Hum Genet 52:557-60. 2007
    ..We conclude that polymorphisms in the PDCD1 gene analyzed here are not associated with RA in a Japanese population...
  44. ncbi request reprint Effect of genetic polymorphisms on development of gout
    Wako Urano
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 40:1374-8. 2013
    ..To validate the association between genetic polymorphisms and gout in Japanese patients, and to investigate the cumulative effects of multiple genetic factors on the development of gout...
  45. doi request reprint A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region
    Yuji Urabe
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Hepatol 58:875-82. 2013
    ..We performed a genome-wide association study (GWAS) of hepatitis C virus (HCV)-induced liver cirrhosis (LC) to identify predictive biomarkers for the risk of LC in patients with chronic hepatitis C (CHC)...
  46. ncbi request reprint Disability and patient's appraisal of general health contribute to depressed mood in rheumatoid arthritis in a large clinical study in Japan
    Ayako Nakajima
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 16:151-7. 2006
    ..0001) were also strongly and significantly associated to the response variable "probability of depressed patients." Patient appraisal of poor general health and greater disability were associated with depressed mood in RA...
  47. ncbi request reprint Risk factors for total knee arthroplasty in rheumatoid arthritis
    Shigeki Momohara
    Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada, Shinjuku ku, Tokyo, 162 0054, Japan
    Mod Rheumatol 17:476-80. 2007
    ..These results suggest that, when treating RA patients, physicians should pay particular attention to pain complaints, the patient's daily activity level, and the RF factor status...
  48. doi request reprint A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population
    Kouya Shiraishi
    Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan
    Nat Genet 44:900-3. 2012
    ..4 × 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P(combined) = 2.7 × 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma...
  49. doi request reprint A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population
    Tetsuya Oishi
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato, Tokyo, 108 8639, Japan
    J Hum Genet 53:151-62. 2008
    ..Individuals with risk genotype of both ITPR3 and NKX2.5 loci have higher risk for SLE (odds ratio=5.77). Our data demonstrate that genetic and functional interactions of ITPR3 and NKX2.5 play a crucial role in the pathogenesis of SLE...
  50. doi request reprint Risk factors for wrist surgery in rheumatoid arthritis
    Shigeki Momohara
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Clin Rheumatol 27:1387-91. 2008
    ..The identification of the risk factors for wrist surgery provides important insights into the course of the disease and its impact on patients, as well as the potential consequences for health care resource utilization planning...
  51. doi request reprint Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population
    Shu Kobayashi
    Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Rheum 58:1940-6. 2008
    ..The present study was undertaken to investigate the effect of STAT4 on susceptibility to RA and SLE in the Japanese...
  52. ncbi request reprint Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population
    Kimie Sai
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 23:139-47. 2008
    ..Moreover, the allele 1446C>T (Thr482Thr), which has increased activity, was not detected in our Japanese population. These findings imply possible differences in MRP2-mediated drug responses between Asians and Caucasians...
  53. doi request reprint Making a haplotype catalog with estimated frequencies based on SNP homozygotes
    Yumi Yamaguchi-Kabata
    Laboratory for Statistical Analysis, Center for Genomic Medicine, The Institute of Physical and Chemical Research RIKEN, Minato ku, Tokyo, Japan
    J Hum Genet 55:500-6. 2010
    ..In addition, the unambiguously determined haplotypes with their estimated frequencies can be used as a catalog of haplotypes for the population, which is useful for the design of genome-wide association studies...
  54. doi request reprint Genome-wide association study of hematological and biochemical traits in a Japanese population
    Yoichiro Kamatani
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:210-5. 2010
    ..05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated...
  55. doi request reprint Risk factors associated with incident fractures in Japanese men with rheumatoid arthritis: a prospective observational cohort study
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, Japan
    J Bone Miner Metab 26:499-505. 2008
    ..High HAQ disability score and baseline doses of daily prednisolone may correlate with incident clinical vertebral fracture in Japanese men with RA...
  56. ncbi request reprint Genetic polymorphisms of UGT1A6 in a Japanese population
    Mayumi Saeki
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 20:85-90. 2005
    ..Our results provide fundamental and useful information for genotyping UGT1A6 in the Japanese, and probably Asian populations...
  57. ncbi request reprint One third of Japanese patients with rheumatoid arthritis use complementary and alternative medicine
    Hiroshi Kajiyama
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 16:355-9. 2006
    ..Approximately 35% of RA patients used CAM in Japan. Female patients and patients dissatisfied with DMARDs used CAM more frequently, regardless of their disease activity...
  58. ncbi request reprint Increased CD40 expression on articular chondrocytes from patients with rheumatoid arthritis: contribution to production of cytokines and matrix metalloproteinases
    Haruhiko Gotoh
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 31:1506-12. 2004
    ....
  59. ncbi request reprint Risk factors associated with incident clinical vertebral and nonvertebral fractures in Japanese women with rheumatoid arthritis: a prospective 54-month observational study
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 34:303-10. 2007
    ..To evaluate the association between potential risk factors and incident clinical fractures in Japanese patients with rheumatoid arthritis (RA)...
  60. ncbi request reprint IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Eur J Immunol 35:3353-63. 2005
    ..Contrary to our hypothesis, IFN-gamma(+) human T cells induced osteoclastogenesis through the expression of RANKL, suggesting that Th1 cells play a direct role in bone resorption in Th1 dominant diseases such as RA...
  61. doi request reprint A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population
    Chizu Tanikawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Genet 44:430-4, S1-2. 2012
    ..rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)). Our findings demonstrate a role for genetic variants in the pathogenesis of duodenal ulcer...
  62. doi request reprint Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA
    Siew Kee Low
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Hum Mol Genet 21:2102-10. 2012
    ..Identification of genetic variants on EDNRA is of clinical significance probably due to its role in vessel hemodynamic stress. Our findings should contribute to a better understanding of physiopathology of IA...
  63. doi request reprint PlatinumCNV: a Bayesian Gaussian mixture model for genotyping copy number polymorphisms using SNP array signal intensity data
    Natsuhiko Kumasaka
    Research Group for Medical Informatics, Center for Genomic Medicine, RIKEN, Shirokane dai, Minato ku, Tokyo, Japan
    Genet Epidemiol 35:831-44. 2011
    ..The methods described in this work are implemented in a software package, PlatinumCNV, available on the Internet...
  64. pmc Common variants in a novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese
    Ikuyo Kou
    Laboratory for Bone and Joint Diseases, Center for Genomic Medicine, RIKEN, Tokyo, Japan
    PLoS ONE 6:e19641. 2011
    ..Our findings would give a new insight into osteoporosis etiology and pathogenesis...
  65. ncbi request reprint Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK)
    Su Ryang Kim
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 23:379-84. 2008
    ..Our findings suggest considerable ethnic differences in genetic variations of DCK and provide fundamental and useful information for genotyping DCK in the Japanese and probably other Asian populations...
  66. ncbi request reprint Association between PADI4 and rheumatoid arthritis: a replication study
    Katsunori Ikari
    Institute of Rheumatology, Tokyo Women s Medical University, Kwada, Tokyo, Japan
    Arthritis Rheum 52:3054-7. 2005
    ..The present study was undertaken to further investigate the association of PADI4 with RA, using a series of population-based samples from subjects with the same ethnic background as the subjects in the original study...
  67. ncbi request reprint High CCL18/PARC expression in articular cartilage and synovial tissue of patients with rheumatoid arthritis
    Shigeki Momohara
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 34:266-71. 2007
    ..We studied the role of CCL18/pulmonary and activation-regulated chemokine (PARC) in rheumatoid arthritis (RA)...
  68. doi request reprint A1330V polymorphism of low-density lipoprotein receptor-related protein 5 gene and self-reported incident fractures in Japanese female patients with rheumatoid arthritis
    Takefumi Furuya
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 19:140-6. 2009
    ..Our results suggest that this LPR5 polymorphism does not appear to be a clinically useful marker for the prediction of fracture risk in Japanese female RA patients, although it is associated with increased serum total cholesterol levels...
  69. doi request reprint Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese
    Pei Chieng Cha
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Hum Mol Genet 19:4735-44. 2010
    ..Our study also implied that common SNPs other than those in the CYP2C9, VKORC1 and CYP4F2 genes that show strong effect on the therapeutic warfarin dose might not exist...
  70. ncbi request reprint Novel genetic variations and haplotypes of hepatocyte nuclear factor 4alpha (HNF4A) found in Japanese type II diabetic patients
    Hiromi Fukushima-Uesaka
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 21:337-46. 2006
    ..Haplotype analysis determined/inferred 10, 16, and 12 haplotypes for block 1, 2, and 3, respectively. Our results on HNF4A variations and haplotypes would be useful for pharmacogenetic studies in Japanese...
  71. ncbi request reprint Adverse effects of sulfasalazine in patients with rheumatoid arthritis are associated with diplotype configuration at the N-acetyltransferase 2 gene
    Eiichi Tanaka
    Institute of Rheumatology and Division of Statistical Genetics, Tokyo Women s Medical University, Japan
    J Rheumatol 29:2492-9. 2002
    ..We examine whether there was a correlation between diplotype configurations (combinations of 2 haplotypes for a subject) at the NAT2 gene and the adverse effects of SSZ used for the treatment of rheumatoid arthritis (RA)...
  72. ncbi request reprint Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects
    Akira Saito
    Division of Genomic Medicine, Department of Advanced Biomedical Engineering and Science, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    J Hum Genet 54:317-23. 2009
    ....
  73. ncbi request reprint Molecular targets of rheumatoid arthritis
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Inflamm Allergy Drug Targets 7:53-66. 2008
    ..In this review, we will summarize the use of biologics, the pros and cons of the use of biologics, and discuss on the potential molecular targets of RA...
  74. doi request reprint Impact of LIMK1, MMP2 and TNF-α variations for intracranial aneurysm in Japanese population
    Siew Kee Low
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Hum Genet 56:211-6. 2011
    ..This study gave insights on the importance of stratified analysis between genders, and suggested that the underlying mechanism of IA pathogenesis might differ between females and males...
  75. ncbi request reprint Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by single locus and haplotype analyses
    Wako Urano
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Pharmacogenetics 12:183-90. 2002
    ..Pharmacokinetic studies are necessary to prove the association...
  76. ncbi request reprint Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction
    Nobuaki Ishii
    Laboratory for Cardiovascular Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    J Hum Genet 51:1087-99. 2006
    ..Moreover, unidentified nuclear protein(s) bound more intensely to risk allele than non-risk allele. These results indicate that the altered expression of MIAT by the SNP may play some role in the pathogenesis of MI...
  77. ncbi request reprint Failure to confirm association between SLC22A4 polymorphism and rheumatoid arthritis in a Japanese population
    Mahito Kuwahara
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Rheum 52:2947-8. 2005
  78. ncbi request reprint Interferon-inducible protein 10/CXCL10 is increased in the cerebrospinal fluid of patients with central nervous system lupus
    Hiroshi Okamoto
    Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Rheum 50:3731-2. 2004
  79. ncbi request reprint Unified method for Bayesian calculation of genetic risk
    Shin ichi Kuno
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Hum Genet 51:387-90. 2006
    ..In addition, GRISK does not disregard any possible events in inheritance. This program was developed as a Japanese macro for Excel to run on Windows...
  80. ncbi request reprint Comparison between various strategies for the disease-gene mapping using linkage disequilibrium analyses: studies on adenine phosphoribosyltransferase deficiency used as an example
    Shin ichi Kuno
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Hum Genet 49:463-73. 2004
    ..Our study suggested that the use of haplotype analysis based on the haplotype-block structure is more powerful than single-marker locus analysis for the detection of disease-related loci...
  81. ncbi request reprint Amplification of the synovial inflammatory response through activation of mitogen-activated protein kinases and nuclear factor kappaB using ligation of CD40 on CD14+ synovial cells from patients with rheumatoid arthritis
    Masayoshi Harigai
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Arthritis Rheum 50:2167-77. 2004
    ..To determine the signal transduction pathways in CD14+ synovial cells from patients with rheumatoid arthritis (RA) after CD40 ligation, and to examine their role in amplifying synovial inflammation in affected joints...
  82. doi request reprint A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
    Toshimasa Yamauchi
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:864-8. 2010
    ..78 × 10⁻¹⁴, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D...
  83. pmc Estimation of haplotype frequencies, linkage-disequilibrium measures, and combination of haplotype copies in each pool by use of pooled DNA data
    Toshikazu Ito
    Algorithm Team, Japan Biological Information Research Center, Japan Biological Informatics Consortium, Tokyo, Japan
    Am J Hum Genet 72:384-98. 2003
    ....
  84. ncbi request reprint Relative transcriptional activities of SAA1 promoters polymorphic at position -13(T/C): potential association between increased transcription and amyloidosis
    Masato Moriguchi
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Amyloid 12:26-32. 2005
    ..We suggest that having the -13T SNP in the SAA1 promoter correlates with the amyloidogenicity in part as a result of this increased transcriptional activity...
  85. doi request reprint Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations
    Daiki Miki
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Nat Genet 42:893-6. 2010
    ..Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations...
  86. ncbi request reprint Serum amyloid A activates nuclear factor-kappaB in rheumatoid synovial fibroblasts through binding to receptor of advanced glycation end-products
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 35:752-6. 2008
    ..Rheumatoid arthritis (RA) is a chronic, symmetric polyarticular joint disease and serum amyloid A (SAA) is an acute-phase protein that is upregulated during the course of RA. We investigated the role of SAA in the pathogenesis of RA...
  87. ncbi request reprint Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients
    Yukiko Nakajima
    Project Team for Pharmacogenetics, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, 158 8501, Japan
    Eur J Clin Pharmacol 61:25-34. 2005
    ..Utilizing single nucleotide polymorphisms (SNPs) of the EPHX1 gene encoding mEH, we identified the haplotypes of EPHX1 blocks and investigated the association between the block haplotypes and CBZ-epoxide metabolism...
  88. ncbi request reprint Granzyme B induces apoptosis of chondrocytes with natural killer cell-like cytotoxicity in rheumatoid arthritis
    Seiji Saito
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    J Rheumatol 35:1932-43. 2008
    ..We have now investigated whether granzyme B directly induces apoptosis in chondrocytes and whether chondrocytes possess NK cell-like function...
  89. ncbi request reprint Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout
    Wako Urano
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Sinjuku ku, Tokyo 162 0054, Japan
    Ann Rheum Dis 69:1232-4. 2010
    ..This study investigated the roles of SLC17A1 in the development of gout...
  90. ncbi request reprint Identification of an IL1A gene segment that determines aberrant constitutive expression of interleukin-1 alpha in systemic sclerosis
    Yasushi Kawaguchi
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Arthritis Rheum 48:193-202. 2003
    ..To further explore the mechanisms of transcriptional regulation of the IL1A gene in fibroblasts from the affected skin of patients with systemic sclerosis (SSc)...
  91. ncbi request reprint The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis
    Wako Urano
    The Institute of Rheumatology, Tokyo Women s Medical University, Japan
    J Rheumatol 29:1950-3. 2002
    ..To clarify the mechanism of decreased serum uric acid (SUA) concentrations during acute gouty arthritis...
  92. ncbi request reprint Expression of hepatocyte growth factor and its receptor (c-met) in skin fibroblasts from patients with systemic sclerosis
    Yasushi Kawaguchi
    Institute of Rheumatology, Tokyo Women s Medical University School of Medicine, Japan
    J Rheumatol 29:1877-83. 2002
    ..To determine the effect of excessive induction of hepatocyte growth factor (HGF)/c-met signaling in fibroblasts derived from patients with systemic sclerosis (SSc)...
  93. ncbi request reprint A case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated by corticosteroid and mizoribine, followed by mizoribine alone
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Intern Med 49:1449-53. 2010
    ..Thus, this case may be associated with IgG4. The present case is the first case in which mizoribine was effective for Mikulicz's disease and IgG4-related plasmacytic syndrome...
  94. ncbi request reprint Increased IL-15 production of muscle cells in polymyositis and dermatomyositis
    Tomoko Sugiura
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Int Immunol 14:917-24. 2002
    ..Blocking of IL-15 production might be of therapeutic value in PM/DM...
  95. ncbi request reprint Web-based detection of genotype errors in pedigree data
    Masayuki Saito
    Division of Statistical Genetics, Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    J Hum Genet 47:377-9. 2002
    ..The present program will be useful to researchers for checking genotypic data and for preparing correct input files for linkage analysis...
  96. doi request reprint Molecular aspects of rheumatoid arthritis: role of transcription factors
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    FEBS J 275:4463-70. 2008
    ..and matrix metalloproteinases. Expression of these molecules is controlled at the transcription level and activation of a limited number of transcription factors is involved in this process...
  97. pmc Clinical investigation in highly disease-affected rheumatoid arthritis patients in Japan with adalimumab applying standard and general evaluation: the CHANGE study
    Nobuyuki Miyasaka
    Department of Medicine and Rheumatology, Graduate School of Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Mod Rheumatol 18:252-62. 2008
    ..These results and comparable ACR20 responses in Western patients support adalimumab 40 mg every other week as the appropriate dosage to treat RA in Japanese patients...
  98. ncbi request reprint Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population
    Yoichiro Kamatani
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato, Tokyo, 108 8639, Japan
    J Hum Genet 53:64-73. 2008
    ..Our findings strongly imply that the TNXB gene is a candidate gene susceptible to SLE in the Japanese population...
  99. doi request reprint Decreased percentages of regulatory T cells in peripheral blood of patients with Behcet's disease before ocular attack: a possible predictive marker of ocular attack
    Yuki Nanke
    Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo 162 0054, Japan
    Mod Rheumatol 18:354-8. 2008
    ..In addition, decreased percentages of Treg cells may be a predictive marker of ocular attack in BD patients allowing treatment of BD patients before an ocular attack...
  100. ncbi request reprint Anti-arthritis effects of vitamin K(2) (menaquinone-4)--a new potential therapeutic strategy for rheumatoid arthritis
    Hiroshi Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    FEBS J 274:4588-94. 2007
    ..We conclude that MK-4 may represent a new agent for the treatment of rheumatoid arthritis in the setting of combination therapy with other disease-modifying antirheumatic drugs...
  101. ncbi request reprint Cluster analysis and association study of structured multilocus genotype data
    Takahiro Nakamura
    Division of Statistical Genetics, Institute of Rheumatology, Tokyo Women s Medical University, 10 22 Kawada cho, Shinjuku ku, Tokyo, 162 0054, Japan
    J Hum Genet 50:53-61. 2005
    ....