Keiichi Iwaya

Summary

Affiliation: Tokyo Medical University
Country: Japan

Publications

  1. ncbi request reprint Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma
    Keiichi Iwaya
    Department of Diagnostic Pathology, Tokyo Medical University, Tokyo, Japan
    Cancer Sci 98:992-9. 2007
  2. ncbi request reprint Coexpression of Arp2 and WAVE2 predicts poor outcome in invasive breast carcinoma
    Keiichi Iwaya
    Department of Diagnostic Pathology, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Mod Pathol 20:339-43. 2007
  3. ncbi request reprint Involvement of Arp2/3 complex in the process of colorectal carcinogenesis
    Toshiya Otsubo
    Department of Pathology, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Mod Pathol 17:461-7. 2004
  4. ncbi request reprint Expression of CD10 by stromal cells during colorectal tumor development
    Hitoshi Ogawa
    Department of Pathology, Tokyo Medical University, Tokyo, Japan
    Hum Pathol 33:806-11. 2002
  5. ncbi request reprint Coexpression of actin-related protein 2 and Wiskott-Aldrich syndrome family verproline-homologous protein 2 in adenocarcinoma of the lung
    Seitaro Semba
    Department of Diagnostic Pathology, Tokyo Medical University, Tokyo, Japan
    Clin Cancer Res 12:2449-54. 2006
  6. doi request reprint Subungual melanoma: histological examination of 50 cases from early stage to bone invasion
    Miki Izumi
    Department of Diagnostic Pathology, Tokyo Medical University, Tokyo, Japan
    J Dermatol 35:695-703. 2008
  7. ncbi request reprint Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis
    Keiichi Iwaya
    Department of Pathology, Tokyo Medical University, Tokyo, Japan
    Clin Exp Metastasis 20:525-9. 2003
  8. ncbi request reprint Keratocystoma of the parotid gland: a report of two cases of an unusual pathologic entity
    Toshitaka Nagao
    Department of Surgical Pathology, Tokyo Medical University Hospital, Tokyo, Japan
    Mod Pathol 15:1005-10. 2002
  9. doi request reprint Ten cases of sebaceous carcinoma arising in nevus sebaceus
    Miki Izumi
    Department of Diagnostic Pathology, Tokyo Medical University, Tokyo, Japan
    J Dermatol 35:704-11. 2008
  10. doi request reprint Overexpression of HER2 signaling to WAVE2-Arp2/3 complex activates MMP-independent migration in breast cancer
    Mayumi Yokotsuka
    Department of Diagnostic Pathology, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Breast Cancer Res Treat 126:311-8. 2011

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma
    Keiichi Iwaya
    Department of Diagnostic Pathology, Tokyo Medical University, Tokyo, Japan
    Cancer Sci 98:992-9. 2007
    ..These results indicate that the colocalization of Arp2 and WAVE2 is an independent risk factor for liver metastasis of colorectal carcinoma...
  2. ncbi request reprint Coexpression of Arp2 and WAVE2 predicts poor outcome in invasive breast carcinoma
    Keiichi Iwaya
    Department of Diagnostic Pathology, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Mod Pathol 20:339-43. 2007
    ..0308) and death (P=0.0455). These results indicate that coexpression of Arp2 and WAVE2 is a significant prognostic factor that is closely associated with aggressive morphology of invasive ductal carcinoma of the breast...
  3. ncbi request reprint Involvement of Arp2/3 complex in the process of colorectal carcinogenesis
    Toshiya Otsubo
    Department of Pathology, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Mod Pathol 17:461-7. 2004
    ..These results suggest that formation of Arp2/3 complex by both neoplastic and stromal cells contributes to the increased motility of both cell types and thus provides suitable conditions for invasion...
  4. ncbi request reprint Expression of CD10 by stromal cells during colorectal tumor development
    Hitoshi Ogawa
    Department of Pathology, Tokyo Medical University, Tokyo, Japan
    Hum Pathol 33:806-11. 2002
    ..These results indicate that CD10 expression is an integral part of colorectal carcinogenesis. CD10 expression seems to contribute to the invasion and thus probably facilitates metastasis...
  5. ncbi request reprint Coexpression of actin-related protein 2 and Wiskott-Aldrich syndrome family verproline-homologous protein 2 in adenocarcinoma of the lung
    Seitaro Semba
    Department of Diagnostic Pathology, Tokyo Medical University, Tokyo, Japan
    Clin Cancer Res 12:2449-54. 2006
    ..In this study, colocalization of Arp2 and WAVE2 in adenocarcinoma of the lung was investigated to elucidate its prognostic value...
  6. doi request reprint Subungual melanoma: histological examination of 50 cases from early stage to bone invasion
    Miki Izumi
    Department of Diagnostic Pathology, Tokyo Medical University, Tokyo, Japan
    J Dermatol 35:695-703. 2008
    ....
  7. ncbi request reprint Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis
    Keiichi Iwaya
    Department of Pathology, Tokyo Medical University, Tokyo, Japan
    Clin Exp Metastasis 20:525-9. 2003
    ..These data indicate that the cytoplasmic and/or nuclear staining of beta-catenin is a biological marker of metastatic potential of osteosarcoma to the lung...
  8. ncbi request reprint Keratocystoma of the parotid gland: a report of two cases of an unusual pathologic entity
    Toshitaka Nagao
    Department of Surgical Pathology, Tokyo Medical University Hospital, Tokyo, Japan
    Mod Pathol 15:1005-10. 2002
    ..We believe that this lesion represents a benign cystic neoplasm rather than a malignant tumor or pseudoneoplastic metaplastic condition. It is important to recognize that this peculiar benign tumor does originate from the salivary gland...
  9. doi request reprint Ten cases of sebaceous carcinoma arising in nevus sebaceus
    Miki Izumi
    Department of Diagnostic Pathology, Tokyo Medical University, Tokyo, Japan
    J Dermatol 35:704-11. 2008
    ..These clinicopathological features of sebaceous carcinomas developing in the nevus sebaceus seem to indicate different biological entities from de novo sebaceous carcinoma...
  10. doi request reprint Overexpression of HER2 signaling to WAVE2-Arp2/3 complex activates MMP-independent migration in breast cancer
    Mayumi Yokotsuka
    Department of Diagnostic Pathology, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Breast Cancer Res Treat 126:311-8. 2011
    ..0001). These data indicate that an abnormal signal resulting from HER2 gene amplification activates lamellipodia formation in breast cancer cells, which initiates their metalloproteinase-independent migration...
  11. ncbi request reprint Sebaceous carcinoma of the eyelids: thirty cases from Japan
    Miki Izumi
    Department of Diagnostic Pathology, Tokyo Medical University, Shinjuku ku, Tokyo, Japan
    Pathol Int 58:483-8. 2008
    ....
  12. ncbi request reprint Ubiquitin-immunoreactive degradation products of cytokeratin 8/18 correlate with aggressive breast cancer
    Keiichi Iwaya
    Department of Pathology, Tokyo Medical University, Shinjuku ku, Tokyo 160 8402, Japan
    Cancer Sci 94:864-70. 2003
    ..These results indicate that CK 8/18 degradation products are detected specifically in breast cancer and may determine its aggressiveness...
  13. ncbi request reprint Involvement of Arp2/3 complex in MCP-1-induced chemotaxis
    Yasuo Mukai
    Department of Diagnostic Pathology, Tokyo Medical University, Tokyo, Japan
    Biochem Biophys Res Commun 334:395-402. 2005
    ..These results indicate that interaction between the Arp2/3 complex and WASP stimulates actin polymerization and integrin beta-1-mediated adhesion during MCP-1-induced chemotaxis of THP-1 cells...
  14. ncbi request reprint Angiomyoid proliferative lesion: an unusual stroma-rich variant of Castleman's disease of hyaline-vascular type
    Miki Izumi
    Department of Pathology, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, Tokyo, 160 8402 Japan
    Virchows Arch 441:400-5. 2002
    ..This condition encompasses proliferation of small vessels and myoid cells. Its characteristics include an asymptomatic, solitary nodule that predominantly develops in the retroperitoneum...
  15. ncbi request reprint TLS-CHOP target gene DOL54 expression in liposarcomas and malignant fibrous histiocytomas
    Hideharu Domoto
    Department of Pathology, Tokyo Medical University, Tokyo, Japan
    Pathol Int 52:497-500. 2002
    ..In this manner, M-LPS/RC-LPS and MFH lesions may share tumorigenic characteristics, resulting from the unscheduled expression of DOL54...
  16. doi request reprint Clinical significance of DJ-1 as a secretory molecule: retrospective study of DJ-1 expression at mRNA and protein levels in ductal carcinoma of the breast
    Benio Tsuchiya
    Division of Molecular Diagnostics, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan
    Histopathology 61:69-77. 2012
    ..DJ-1 is a molecule secreted into serum by some breast cancer cells. However, little is known about the clinical significance of the DJ-1 expression...
  17. ncbi request reprint A case of myxoid adrenocortical carcinoma with extensive lipomatous metaplasia
    Miki Izumi
    Department of Pathology, Tokyo Medical University, Tokyo, Japan
    Arch Pathol Lab Med 127:227-30. 2003
    ..Lipomatous metaplasia is another peculiar feature of adrenocortical lesions that has been reported only in benign conditions. To our knowledge, this is the first reported case of adrenocortical carcinoma with lipomatous metaplasia...
  18. doi request reprint An atypical case of atypical lipomatous tumor
    Takashi Miyakura
    Department of Dermatology, Tokyo Medical University, Miyamoto Dermatology Clinic, Tokyo, Japan
    Am J Dermatopathol 30:590-2. 2008
    ..We considered our case to be a variant of atypical lipomatous tumor, although it did not correspond to any of the 4 atypical lipomatous tumor subgroups. There has been no recurrence to date...
  19. ncbi request reprint Stromal expression of CD10 in invasive breast carcinoma: a new predictor of clinical outcome
    Keiichi Iwaya
    First Department of Pathology, Tokyo Medical University, 160 8402 Shinjuku 6 1 1, Shinjuku ku, Tokyo, Japan
    Virchows Arch 440:589-93. 2002
    ..0059), and CD10 was the single significant prognostic factor for overall survival in the univariate analysis ( P=0.0021). These results suggest that stromal expression of CD10 in breast cancer is an important novel prognostic factor...
  20. ncbi request reprint High levels of DJ-1 protein in nipple fluid of patients with breast cancer
    Miki Oda
    Department of Basic Pathology, National Defense Medical College, Saitama, Japan
    Cancer Sci 103:1172-6. 2012
    ..These data indicate that breast cancer cells secrete DJ-1 protein in vivo, and that its level is a potential indicator of breast cancer in patients with nipple discharge...
  21. ncbi request reprint Epidermal growth factor-dependent enhancement of invasiveness of squamous cell carcinoma of the breast
    Fuyo Kimura
    Department of Breast Oncology, Tokyo Medical University, Tokyo, Japan
    Cancer Sci 101:1133-40. 2010
    ..These results suggest that EGF-dependent enhancement of cell motility by formation of invadopodia associated with cortactin is a cause of the clinical aggressiveness of squamous cell carcinoma of the breast...
  22. ncbi request reprint Hybrid carcinomas of the salivary glands: report of nine cases with a clinicopathologic, immunohistochemical, and p53 gene alteration analysis
    Toshitaka Nagao
    Department of Surgical Pathology, Tokyo Medical University Hospital, Tokyo, Japan
    Mod Pathol 15:724-33. 2002
    ..Therefore, there is the possibility that such molecular-genetic events take an integral part for inducing the transformation from histologically lower to higher grade tumor during the hybrid carcinoma genesis of the salivary glands...
  23. ncbi request reprint Accumulation of ubiquitin-conjugated cytokeratin fragments in tumor cells
    Keiichi Iwaya
    Department of Diagnostic Pathology, Tokyo Medical University, Nishi Shinjuku 6 7 1, Shinjuku ku, Tokyo 160 0023, Japan
    Semin Cancer Biol 15:309-18. 2005
    ..Modified CK also deregulates mechanisms of mitosis and apoptosis, and leads to immortalization. Therapeutic targeting of ubiquitin or ubiquitilated proteins may reduce the malignant potential of cancer cells...
  24. ncbi request reprint Pathological characterization of Kank in renal cell carcinoma
    Badal Chandra Roy
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Exp Mol Pathol 78:41-8. 2005
    ..The expression of Kank in the cytoplasm and at the sites of membrane ruffling in HEK293 and VMRC-RCW cells and in a primary culture of renal tubular cells was also detected by fluorescence-based immunostaining...
  25. ncbi request reprint Sarcomatoid variant of salivary duct carcinoma: clinicopathologic and immunohistochemical study of eight cases with review of the literature
    Toshitaka Nagao
    Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Clin Pathol 122:222-31. 2004
    ..6 months). These results indicate that sarcomatoid SDC is a highly aggressive tumor, similar to conventional SDC...
  26. ncbi request reprint [Three-dimentional volumetric interpolated breath-hold magnetic resonance imaging for the diagnosis of breast tumors]
    Syun Nakayama
    Third Department of Surgery, Tokyo Medical University
    Nihon Rinsho 62:790-8. 2004
    ..Using these capabilities of 3D-VIBE MRI, we have attempted to diagnose and evaluate breast tumors for preoperative planning...