Mitsuaki Isobe

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. doi request reprint The Asia Pacific meeting on vasculitis and ANCA 2012 workshop on Takayasu arteritis: advances in diagnosis and medical treatment
    Mitsuaki Isobe
    The Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyoku, Tokyo, 113 8519, Japan
    Clin Exp Nephrol 17:686-9. 2013
  2. ncbi request reprint Takayasu arteritis revisited: current diagnosis and treatment
    Mitsuaki Isobe
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Int J Cardiol 168:3-10. 2013
  3. ncbi request reprint T cell costimulation in the development of cardiac allograft vasculopathy: potential targets for therapeutic interventions
    Mitsuaki Isobe
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo 113 8519, Japan
    Arterioscler Thromb Vasc Biol 26:1447-56. 2006
  4. ncbi request reprint Gene therapy for heart transplantation-associated acute rejection, ischemia/reperfusion injury and coronary arteriosclerosis
    Mitsuaki Isobe
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Curr Gene Ther 4:145-52. 2004
  5. ncbi request reprint Hepatocyte growth factor: Effects on immune-mediated heart diseases
    Mitsuaki Isobe
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Bunkyoku, Tokyo, Japan
    Trends Cardiovasc Med 16:188-93. 2006
  6. doi request reprint Different roles of PPAR-γ activity on physiological and pathological alteration after myocardial ischemia
    Ayako Nagashima
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Cardiovasc Pharmacol 60:158-64. 2012
  7. doi request reprint Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway
    Takaaki Haga
    Department of Cardiovascular Medicine Tokyo Medical and Dental University 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Mol Cell Cardiol 46:719-27. 2009
  8. ncbi request reprint Pitavastatin suppresses acute and chronic rejection in murine cardiac allografts
    Jun ichi Suzuki
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Transplantation 83:1093-7. 2007
  9. ncbi request reprint Periodontal pathogen Aggregatibacter actinomycetemcomitans deteriorates pressure overload-induced myocardial hypertrophy in mice
    Asuka Sekinishi
    Department of Periodontology, Tokyo Medical and Dental University, Tokyo, Japan
    Int Heart J 53:324-30. 2012
  10. doi request reprint Treatment with telmisartan attenuates graft arteriosclerosis in murine cardiac allografts
    Hisanori Kosuge
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Heart Lung Transplant 29:562-7. 2010

Collaborators

Detail Information

Publications122 found, 100 shown here

  1. doi request reprint The Asia Pacific meeting on vasculitis and ANCA 2012 workshop on Takayasu arteritis: advances in diagnosis and medical treatment
    Mitsuaki Isobe
    The Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyoku, Tokyo, 113 8519, Japan
    Clin Exp Nephrol 17:686-9. 2013
    ..According to these changes in diagnosis and treatment, the prognosis of Takayasu arteritis has been improving. ..
  2. ncbi request reprint Takayasu arteritis revisited: current diagnosis and treatment
    Mitsuaki Isobe
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Int J Cardiol 168:3-10. 2013
    ..Based on these advances, the prognosis and quality of life of TA patients have improved to a great deal. However, there are many issues that remain to be solved in the management of TA. ..
  3. ncbi request reprint T cell costimulation in the development of cardiac allograft vasculopathy: potential targets for therapeutic interventions
    Mitsuaki Isobe
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyoku, Tokyo 113 8519, Japan
    Arterioscler Thromb Vasc Biol 26:1447-56. 2006
    ..In this review, we summarize the present knowledge of the role of these pathways in CAV development and the possibility of manipulating these pathways as a means to treat heart allograft vascular disease and atherosclerosis...
  4. ncbi request reprint Gene therapy for heart transplantation-associated acute rejection, ischemia/reperfusion injury and coronary arteriosclerosis
    Mitsuaki Isobe
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Curr Gene Ther 4:145-52. 2004
    ..This method could be useful to prevent graft failure without systemic adverse effects. Here we shall review current advances in gene therapies to prevent and treat organ failure of transplanted allografts...
  5. ncbi request reprint Hepatocyte growth factor: Effects on immune-mediated heart diseases
    Mitsuaki Isobe
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Bunkyoku, Tokyo, Japan
    Trends Cardiovasc Med 16:188-93. 2006
    ..The present review summarizes recent advances in the utility of HGF for heart diseases, especially immune-mediated heart diseases. Possible mechanisms of action in the suppression of T-cell-mediated immunity are also discussed...
  6. doi request reprint Different roles of PPAR-γ activity on physiological and pathological alteration after myocardial ischemia
    Ayako Nagashima
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Cardiovasc Pharmacol 60:158-64. 2012
    ..Because PPAR-γ initiates a variety of antiinflammatory responses, the effect on myocardial ischemia is to be elucidated...
  7. doi request reprint Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway
    Takaaki Haga
    Department of Cardiovascular Medicine Tokyo Medical and Dental University 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Mol Cell Cardiol 46:719-27. 2009
    ..Blockade of T cell activation through the 4-1BB/4-1BBL pathway regulates development of EAM; therefore, 4-1BB may be an effective target for treating myocarditis...
  8. ncbi request reprint Pitavastatin suppresses acute and chronic rejection in murine cardiac allografts
    Jun ichi Suzuki
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Transplantation 83:1093-7. 2007
    ..We investigated the role of pitavastatin, a potent and newly developed HMG-CoA reductase inhibitor, in cardiac allograft rejection and mechanism of graft arterial disease (GAD) suppression...
  9. ncbi request reprint Periodontal pathogen Aggregatibacter actinomycetemcomitans deteriorates pressure overload-induced myocardial hypertrophy in mice
    Asuka Sekinishi
    Department of Periodontology, Tokyo Medical and Dental University, Tokyo, Japan
    Int Heart J 53:324-30. 2012
    ..These results suggested that the periodontal pathogen caused a deterioration of pressure overload-induced myocardial hypertrophy through MMP activation...
  10. doi request reprint Treatment with telmisartan attenuates graft arteriosclerosis in murine cardiac allografts
    Hisanori Kosuge
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Heart Lung Transplant 29:562-7. 2010
    ..We investigated the effect of telmisartan on chronic rejection...
  11. ncbi request reprint A CCR1 antagonist prevents the development of experimental autoimmune myocarditis in association with T cell inactivation
    Hideki Futamatsu
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Mol Cell Cardiol 40:853-61. 2006
    ..The CCR1 antagonist reduced the severity of EAM by inhibiting cytokine expression and inducing T cell inactivation. Thus, the CCR1 antagonist may provide a novel therapeutic strategy treatment of myocarditis...
  12. ncbi request reprint Pioglitazone prevents acute and chronic cardiac allograft rejection
    Hisanori Kosuge
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circulation 113:2613-22. 2006
    ..We investigated the role of pioglitazone in acute and chronic rejection in a murine cardiac transplantation model...
  13. doi request reprint The mechanism of anti-inflammatory effects of prostaglandin E2 receptor 4 activation in murine cardiac transplantation
    Masahito Ogawa
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Transplantation 87:1645-53. 2009
    ..Although it has been reported that EP4 agonists prolonged cardiac allograft survival, little has been elucidated the immunologic mechanism...
  14. ncbi request reprint Blockade of the interaction between PD-1 and PD-L1 accelerates graft arterial disease in cardiac allografts
    Noritaka Koga
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 24:2057-62. 2004
    ..PD-1 is involved in the negative regulation of some immune responses. We evaluated the role of PD-ligand 1 (PD-L1) in graft arterial disease (GAD) of cardiac allografts and in smooth muscle cells (SMCs)...
  15. doi request reprint Periodontal bacteria aggravate experimental autoimmune myocarditis in mice
    Norihiko Ashigaki
    Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 304:H740-8. 2013
    ..g.-injected EAM group compared with the PBS-injected EAM group (P < 0.05). These results showed that P.g. injection could deteriorate EAM in mice through CD11b-positive cells, cytokines, and MMP-9 expression...
  16. doi request reprint Clinical and electrophysiological characteristics of patients having atrial flutter with 1:1 atrioventricular conduction
    Mihoko Kawabata
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Europace 10:284-8. 2008
    ..The purpose of this retrospective study was to assess characteristics of patients who had suffered atrial flutter (AFL) with 1:1 atrioventricular (AV) conduction (1:1 AFL)...
  17. ncbi request reprint Influence of autonomic stimulation on the genesis of atrial fibrillation in remodeled canine atria not the same as in normal atria
    Toshiyuki Furukawa
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ J 73:468-75. 2009
    ..The role of autonomic effects in the occurrence and maintenance of atrial fibrillation (AF) has undergone little investigation in the remodeling heart...
  18. ncbi request reprint Blockade of the 4-1BB pathway attenuates graft arterial disease in cardiac allografts
    Hitoshi Saiki
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Int Heart J 49:105-18. 2008
    ..The 4-1BB pathway regulates not only T-cell activation but also SMC proliferation. Blockade of the 4-1BB pathway is a promising strategy to prevent progression of GAD...
  19. ncbi request reprint Tea catechins attenuate ventricular remodeling and graft arterial diseases in murine cardiac allografts
    Jun ichi Suzuki
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cardiovasc Res 69:272-9. 2006
    ..Tea catechins have many biological functions; these effects are induced by the suppression of several inflammatory factors. However, effects of catechins on cardiac allograft rejection have not been well investigated...
  20. ncbi request reprint Effect of adiponectin on cardiac allograft vasculopathy
    Takashi Ishihara
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ J 75:2005-12. 2011
    ..APN plays a beneficial role in reducing the progression of cardiac allograft vasculopathy through the AMPK pathway...
  21. ncbi request reprint Critical role of inducible costimulator signaling in the development of arteriosclerosis
    Hisanori Kosuge
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Arterioscler Thromb Vasc Biol 26:2660-5. 2006
    ..However, the effect of costimulatory molecules on the formation of neointimal hyperplasia has not been fully elucidated. We examined the role of the ICOS pathway in SMC proliferation...
  22. doi request reprint Novel effects of macrolide antibiotics on cardiovascular diseases
    Jun ichi Suzuki
    Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Tokyo, Japan
    Cardiovasc Ther 30:301-7. 2012
    ..In this article, we reviewed the roles of MMPs in cardiovascular diseases and the effects of macrolides on the prevention of adverse tissue remodeling...
  23. ncbi request reprint Suppression of neointimal hyperplasia after vascular injury by blocking 4-1BB/4-1BB ligand pathway
    Akiyo Karube
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Med Dent Sci 55:207-13. 2008
    ..T cell-mediated immunity is involved in the pathogenesis of atherosclerosis and arteriosclerosis. This study examined whether the 4-1BB pathway affects the development of arteriosclerosis after vascular injury...
  24. doi request reprint Heart failure with preserved versus reduced left ventricular systolic function: a prospective cohort of Shinken Database 2004-2005
    Ayumi Goda
    The Cardiovascular Institute, Tokyo, Japan
    J Cardiol 55:108-16. 2010
    ..The purpose of this study was to determine the prevalence, prognosis, and predictors for mortality of Japanese HF patients with preserved versus reduced LVEF in a prospective cohort fashion...
  25. doi request reprint Bleeding events and activated partial thromboplastin time with dabigatran in clinical practice
    Mihoko Kawabata
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Cardiol 62:121-6. 2013
    ..Moreover, we investigated which factors would contribute to the APTT values...
  26. ncbi request reprint The effects of pharmacological PAI-1 inhibition on thrombus formation and neointima formation after arterial injury
    Jun ichi Suzuki
    Tokyo Medical and Dental University, Graduate School of Medicine, Department of Cardiovascular Medicine, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Expert Opin Ther Targets 12:783-94. 2008
    ..Murine arterial injury models develop neointimal hyperplasia similar to that observed in clinical coronary arterial restenosis after PCI...
  27. doi request reprint Inhibition of IκB phosphorylation prevents load-induced cardiac dysfunction in mice
    Tetsu Tanaka
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Japan
    Am J Physiol Heart Circ Physiol 303:H1435-45. 2012
    ..In conclusion, IMD-1041 may be useful for preventing pressure overload-induced cardiac dysfunction and the transition of cardiac hypertrophy to contraction failure via suppression of NF-κB activation...
  28. ncbi request reprint A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model
    Go Haraguchi
    Department of Cardiovascular Medicine, Tokyo, Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Mol Cell Cardiol 41:885-92. 2006
    ..The RXR agonist HX630 exerts antiproliferative effects in VSMCs in vivo and in vitro. Thus, the RXR may serve as a therapeutic target for vascular injury and intimal thickening...
  29. ncbi request reprint Attenuation of graft arterial disease by manipulation of the LIGHT pathway
    Hisanori Kosuge
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 24:1409-15. 2004
    ..To clarify the mechanism underlying graft arterial disease (GAD), we investigated the role of the LIGHT pathway in the progression of GAD...
  30. doi request reprint Clarithromycin attenuates myocardial ischemia-reperfusion injury
    Takuya Nakajima
    Tokyo Medical and Dental University, Department of Cardiovascular Medicine, Japan
    Expert Opin Ther Targets 14:881-93. 2010
    ..However, little is known about the effect of clarithromycin in myocardial reperfusion injury via MMPs. Our objective was to clarify the role of MMPs regulated by clarithromycin in the progression of myocardial reperfusion injury...
  31. ncbi request reprint A specific inhibitor of plasminogen activator inhibitor-1 suppresses rat autoimmune myocarditis
    Jun ichi Suzuki
    University of Tokyo, Graduate School of Medicine, Department of Advanced Clinical Science and Therapeutics, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Expert Opin Ther Targets 12:1313-20. 2008
    ..Although inflammation is an essential pathological feature of acute myocarditis, the effects of PAI-1 inhibition on the development of acute myocarditis have not been well studied...
  32. doi request reprint Telmisartan, a unique ARB, improves left ventricular remodeling of infarcted heart by activating PPAR gamma
    Yasuhiro Maejima
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo, Japan
    Lab Invest 91:932-44. 2011
    ..An anti-inflammatory effect and PPAR-γ activation were suggested to be important in addition to suppression of Ang II activity...
  33. ncbi request reprint E-selectin blockade decreases adventitial inflammation and attenuates intimal hyperplasia in rat carotid arteries after balloon injury
    Ryo Gotoh
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 24:2063-8. 2004
    ..Because the role of E-selectin in this process is not fully understood, we studied the role of E-selectin in vascular injury with a flow chamber model and a rat model of carotid artery injury...
  34. ncbi request reprint HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation
    Ryoko Wakizono Azuma
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cardiovasc Res 64:412-20. 2004
    ....
  35. ncbi request reprint Tea catechins improve left ventricular dysfunction, suppress myocardial inflammation and fibrosis, and alter cytokine expression in rat autoimmune myocarditis
    Jun ichi Suzuki
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan, and Central Research Institute, ITO EN, Ltd, Shizuoka, Japan
    Eur J Heart Fail 9:152-9. 2007
    ..Myocarditis is a clinically serious disease. Tea catechins have been shown to reduce inflammation; however the effects of catechins on the development of myocarditis have not been well studied...
  36. ncbi request reprint The periodontal pathogen Aggregatibacter actinomycetemcomitans deteriorates ventricular remodeling after myocardial infarction in mice
    Tomoya Hanatani
    Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan
    Int Heart J 53:253-6. 2012
    ..a.-negative MI mice. The injection of A.a. into the mice without MI did not affect their hearts. We concluded that a periodontal pathogen infection might deteriorate ventricular remodeling after MI through inflammatory cell infiltration...
  37. doi request reprint Role of FDG PET-CT in Takayasu arteritis: sensitive detection of recurrences
    Daisuke Tezuka
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    JACC Cardiovasc Imaging 5:422-9. 2012
    ....
  38. doi request reprint The anti-inflammatory mechanism of prostaglandin e2 receptor 4 activation in rat experimental autoimmune myocarditis
    Pham Bao Ngoc
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Cardiovasc Pharmacol 57:365-72. 2011
    ..We concluded that a selective EP4 agonist inactivates T-cells, which turns out to moderate the progression of experimental autoimmune myocarditis. Therefore, EP4 can be an effective target for myocarditis treatment...
  39. ncbi request reprint Hepatocyte growth factor ameliorates the progression of experimental autoimmune myocarditis: a potential role for induction of T helper 2 cytokines
    Hideki Futamatsu
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ Res 96:823-30. 2005
    ..HGF reduced the severity of EAM by inducing T helper 2 cytokines and suppressing apoptosis of cardiomyocytes. HGF has potential as a new therapy for myocarditis...
  40. ncbi request reprint The effects of pharmacologic plasminogen activator inhibitor-1 inhibition in acute and chronic rejection in murine cardiac allografts
    Masahito Ogawa
    Department of Advanced Clinical Science and Therapeutics, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Transplantation 91:21-6. 2011
    ..However, little is known about the effect of PAI-1 in heart transplantation. Thus, the objective was to clarify the role of PAI-1 in the progression of cardiac rejection...
  41. ncbi request reprint Prognostic significance of early repolarization in inferolateral leads in Brugada patients with documented ventricular fibrillation: a novel risk factor for Brugada syndrome with ventricular fibrillation
    Hiro Kawata
    Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan
    Heart Rhythm 10:1161-8. 2013
    ..Little is known about the clinical and prognostic impact of early repolarization (ER) on patients with Brugada syndrome (BrS), especially those with documented ventricular fibrillation (VF)...
  42. ncbi request reprint Tea catechins attenuate chronic ventricular remodeling after myocardial ischemia in rats
    Jun ichi Suzuki
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Mol Cell Cardiol 42:432-40. 2007
    ..Catechins are potent for the suppression of chronic ventricular remodeling after myocardial ischemia because they are critically involved in the suppression of several inflammatory genes...
  43. doi request reprint A selective peroxisome proliferator-activated receptor-β/δ agonist attenuates neointimal hyperplasia after wire-mediated arterial injury
    Rikuta Hamaya
    Tokyo Medical and Dental University, Department of Cardiovascular Medicine, Tokyo, Japan
    Expert Opin Investig Drugs 22:1095-106. 2013
    ..Peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) belongs to a family of ligand-activated transcription factors...
  44. ncbi request reprint Distribution of the origin of adenosine triphosphatesensitive atrial tachycardias with the earliest activation recorded in the His bundle catheter: are they limited to the immediate vicinity of the His bundle?
    Tomofumi Nakamura
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ J 77:626-31. 2013
    ..The aim of this study was to assess the spatial distribution of the origins of adenosine triphosphate (ATP) sensitive focal atrial tachycardias (AT) that have their earliest activation recorded in the His bundle (HB) catheter...
  45. doi request reprint Impaired post-infarction cardiac remodeling in chronic kidney disease is due to excessive renin release
    Masahito Ogawa
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Lab Invest 92:1766-76. 2012
    ..Our data suggest that renal disorder results in ventricular dysfunction and deteriorates remodeling after MI through excessive RAS activation. Moreover, renin inhibition improved the changes caused by cardiorenal syndrome...
  46. ncbi request reprint A novel IKK inhibitor prevents progression of restenosis after arterial injury in mice
    Rikuta Hamaya
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Japan
    Int Heart J 53:133-8. 2012
    ..Thus, this drug may effectively prevent restenosis after coronary intervention and other cardiovascular diseases...
  47. ncbi request reprint A prostacycline analog prevents chronic myocardial remodeling in murine cardiac allografts
    Jun ichi Suzuki
    Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Int Heart J 53:64-7. 2012
    ..ONO-1301MS could be an effective strategy to suppress chronic myocardial remodeling in cardiac transplantation...
  48. doi request reprint Complex anatomy surrounding the left atrial posterior wall: analysis with 3D computed tomography
    Shingo Maeda
    Department of Cardiology, Musashino Red Cross Hospital, Tokyo, Japan
    Heart Vessels 27:58-64. 2012
    ..With a dilated LA, the esophagus may become easily susceptible to direct thermal injury during AF ablation. Visualization of the anatomic relationship may contribute to the prevention of the potential risk of an esophageal injury...
  49. ncbi request reprint Effects of pharmacological suppression of plasminogen activator inhibitor-1 in myocardial remodeling after ischemia reperfusion injury
    Ryo Watanabe
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Int Heart J 52:388-92. 2011
    ..We conclude that the pharmacological inhibition of PAI-1 may not affect ventricular remodeling after myocardial I/R injury...
  50. pmc Pharmacological activation of the prostaglandin E2 receptor EP4 improves cardiac function after myocardial ischaemia/reperfusion injury
    Keiichi Hishikari
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo 113 8519, Japan
    Cardiovasc Res 81:123-32. 2009
    ..However, their pathophysiological significance in I/R remains obscure. Thus, we determined whether the activation of the prostanoid receptor, EP4, suppresses myocardial I/R injury...
  51. ncbi request reprint Roles of prostaglandin E2 in cardiovascular diseases
    Jun ichi Suzuki
    Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan
    Int Heart J 52:266-9. 2011
    ..In this review article, we discuss the effects of PGE(2) receptor agonists on the development of cardiovascular diseases...
  52. ncbi request reprint A novel IKK inhibitor suppresses heart failure and chronic remodeling after myocardial ischemia via MMP alteration
    Shin Wakatsuki
    Tokyo Medical and Dental University, Department of Cardiovascular Medicine, 1 5 45 Yushima, Bunkyo, Tokyo, Japan
    Expert Opin Ther Targets 12:1469-76. 2008
    ..Conclusion: We revealed that the IKK blockade is potent for the suppression of chronic ventricular remodeling after myocardial ischemia...
  53. ncbi request reprint Inhibition of NF-κB activation by a novel IKK inhibitor reduces the severity of experimental autoimmune myocarditis via suppression of T-cell activation
    Ryo Watanabe
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Yushima, Bunkyo, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 305:H1761-71. 2013
    ..The IKK inhibitor ameliorated EAM by suppressing inflammatory reactions via suppression of T-cell activation. ..
  54. ncbi request reprint Chronic hemodynamic effects after radiofrequency catheter ablation of frequent monomorphic ventricular premature beats
    Yukio Sekiguchi
    Cardiovascular Division, Musashino Red Cross Hospital, Tokyo, Japan
    J Cardiovasc Electrophysiol 16:1057-63. 2005
    ..However, the chronic hemodynamic effects of these VPBs have not been precisely evaluated...
  55. ncbi request reprint Toll-like receptor-2 plays a fundamental role in periodontal bacteria-accelerated abdominal aortic aneurysms
    Norio Aoyama
    Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Circ J 77:1565-73. 2013
    ..The purpose of this study was to clarify the role of Toll-like receptors (TLRs), which are key receptors of virulence factors of many periodontal bacteria, on periodontopathic bacteria-accelerated AAA progression...
  56. ncbi request reprint A cyclooxygenase-2 inhibitor alters Th1/Th2 cytokine balance and suppresses autoimmune myocarditis in rats
    Jun ichi Suzuki
    Department of Cardiovascular Medicine, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Bunkyo, Japan
    J Mol Cell Cardiol 40:688-95. 2006
    ..The COX-2 inhibitor altered Th1/Th2 cytokine balance and inhibited cell proliferation in vitro. The COX-2 inhibitor suppresses the development of EAM. COX-2 regulation is promising for treating acute myocarditis...
  57. ncbi request reprint Inhibition of NF-{kappa}B improves left ventricular remodeling and cardiac dysfunction after myocardial infarction
    Yasuyuki Onai
    Dept of Cardiovascular Medicine, Tokyo Medical and Dental Univ, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Physiol Heart Circ Physiol 292:H530-8. 2007
    ..In conclusion, inhibition of NF-kappaB activation may reduce the proinflammatory reactions and modulate the extracellular matrix and provide an effective approach to prevent adverse cardiac remodeling after MI...
  58. ncbi request reprint Preprocedural therapeutic international normalized ratio influence on bleeding complications in atrial fibrillation ablation with continued anticoagulation with warfarin
    Tatsuya Hayashi
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Circ J 77:338-44. 2013
    ....
  59. doi request reprint Porphyromonas gingivalis accelerates neointimal formation after arterial injury
    Naho Kobayashi
    Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    J Vasc Res 49:417-24. 2012
    ..However, the effects of a periodontal infection on vascular remodeling have not been examined. We assess the hypothesis that periodontal infection could promote neointimal formation after an arterial injury...
  60. doi request reprint Progression of hyponatremia is associated with increased cardiac mortality in patients hospitalized for acute decompensated heart failure
    Masanori Konishi
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Card Fail 18:620-5. 2012
    ....
  61. ncbi request reprint Improved prognosis of Takayasu arteritis over the past decade--comprehensive analysis of 106 patients
    Hirokazu Ohigashi
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ J 76:1004-11. 2012
    ..We aimed to describe the recent clinical characteristics of Takayasu arteritis (TA)...
  62. doi request reprint Utility of distinctive local electrogram pattern and aortographic anatomical position in catheter manipulation at coronary cusps
    Takeshi Sasaki
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    J Cardiovasc Electrophysiol 22:521-9. 2011
    ..However, the relation between local electrograms recorded at each CC during sinus rhythm and their anatomical position as assessed by aortography has not yet been systematically described...
  63. ncbi request reprint Clinical implications of reconnection between the left atrium and isolated pulmonary veins provoked by adenosine triphosphate after extensive encircling pulmonary vein isolation
    Hitoshi Hachiya
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    J Cardiovasc Electrophysiol 18:392-8. 2007
    ..However, the clinical implication of reconnection between the left atrium (LA) and isolated PVs provoked by ATP (ATP-reconnection) remains unknown...
  64. doi request reprint Superior vena cava as initiator of atrial fibrillation: factors related to its arrhythmogenicity
    Koji Higuchi
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Heart Rhythm 7:1186-91. 2010
    ..However, SVC isolation may cause serious complications, and indications for SVC isolation combined with pulmonary vein (PV) isolation are unclear...
  65. ncbi request reprint Comparative effects of carvedilol vs bisoprolol for severe congestive heart failure
    Masanori Konishi
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ J 74:1127-34. 2010
    ..This study was designed to compare the effects of them in patients with severe HF...
  66. ncbi request reprint HMG-CoA reductase inhibitor fluvastatin prevents angiotensin II-induced cardiac hypertrophy via Rho kinase and inhibition of cyclin D1
    Kino Morikawa-Futamatsu
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    Life Sci 79:1380-90. 2006
    ..This novel mechanism discovered for fluvastatin could be revealed how HMG-CoA reductase inhibitors are preventing cardiac hypertrophy...
  67. doi request reprint Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase
    Mimi Tamamori-Adachi
    Department of Biochemical Genetics, Medical Research Institute and Laboratory for Gene Structure and Regulation, School of Biomedical Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Cardiovasc Res 80:181-90. 2008
    ..Here, we examined whether Skp2 can also improve cardiomyocyte regeneration and post-ischaemic cardiac performance in vivo...
  68. ncbi request reprint Characteristics of chronic rejection in heart transplantation: important elements of pathogenesis and future treatments
    Jun ichi Suzuki
    Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Circ J 74:233-9. 2010
    ..The pathological and immunological characteristics of CAV and some promising methodologies for prevention of the disease are reviewed...
  69. doi request reprint Clarithromycin attenuates acute and chronic rejection via matrix metalloproteinase suppression in murine cardiac transplantation
    Masahito Ogawa
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Am Coll Cardiol 51:1977-85. 2008
    ..However, little is known about the effect of CAM in heart transplantation via MMP-9. The purpose of this study was to clarify the role of MMPs regulated by CAM in the progression of rejection...
  70. ncbi request reprint Attenuation of autoimmune myocarditis in rats by mesenchymal stem cell transplantation through enhanced expression of hepatocyte growth factor
    Hiroyuki Okada
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Int Heart J 48:649-61. 2007
    ..Enhanced expression of hepatocyte growth factor was associated with these effects. Autoimmune myocarditis may be a good clinical target for MSC transplantation...
  71. ncbi request reprint Additive effects of β-blockers on renin-angiotensin system inhibitors for patients after acute myocardial infarction treated with primary coronary revascularization
    Masanori Konishi
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Japan
    Circ J 75:1982-91. 2011
    ..Although some β-blockers are effective for patients after acute myocardial infarction (AMI), few studies have compared their additive effects on renin-angiotensin system inhibitors (RAS-Is)...
  72. ncbi request reprint Inhibition of endostatin/collagen XVIII deteriorates left ventricular remodeling and heart failure in rat myocardial infarction model
    Kazuya Isobe
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ J 74:109-19. 2010
    ..The results imply that endogenous endostatin/collagen XVIII may suppress aberrant LV remodeling and heart failure after MI. (Circ J 2010; 74: 109 - 119)...
  73. doi request reprint Pioglitazone reduces systematic inflammation and improves mortality in apolipoprotein E knockout mice with sepsis
    Go Haraguchi
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 113 8519, Tokyo, Japan
    Intensive Care Med 34:1304-12. 2008
    ..ApoE knockout mice have a high mortality rate due to sepsis because the endotoxin is not cleared...
  74. ncbi request reprint A critical role of COX-2 in the progression of neointimal formation after wire injury in mice
    Masahito Ogawa
    Tokyo Medical and Dental University, Department of Cardiovascular Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Expert Opin Ther Targets 13:505-11. 2009
    ..Although selective COX-2 inhibitors affect pathological conditions in inflammatory diseases, little is known about the effects on vascular remodeling after mechanical injury...
  75. ncbi request reprint Electrocardiography characteristics of isolated non-compaction of ventricular myocardium in Japanese adult patients
    Masaaki Shoji
    Department of Cardiology, Cardiovascular Institute, Tokyo, Japan
    Circ J 74:1431-5. 2010
    ..Recently it was reported that there are some patients who seem apparently healthy in adult INVM. Clinical characteristics including that for electrocardiograms (ECG) of adult INVM, however, are unknown for Japanese subjects...
  76. doi request reprint A critical role of sympathetic nerve regulation for the treatment of impaired daily rhythm in hypertensive Dahl rats
    Jun ichi Suzuki
    Department of Advanced Clinical Science and Therapeutics, University of Tokyo, 7 3 1 Hongo, Tokyo, Japan
    Hypertens Res 33:1060-5. 2010
    ..We showed that an impaired daily rhythm was closely related to the development of hypertension. Regulation of sympathetic nerve alterations may have a key role in the treatment of hypertension and circadian rhythm disorder...
  77. ncbi request reprint Long-term follow up of initial clinical cases with NF-kappaB decoy oligodeoxynucleotide transfection at the site of coronary stenting
    Kensuke Egashira
    Department of Cardiovascular Medicine, Kyushu University School of Medicine, Fukuoka, Japan
    J Gene Med 10:805-9. 2008
    ..To evaluate the safety and effectiveness of NF-kappaB decoy oligodeoxynucleotides (ODN) to prevent restenosis, we initiated an open-label phase I/IIa clinical trial...
  78. ncbi request reprint Comparison of biomarkers for predicting disease severity and long-term respiratory prognosis in patients with acute pulmonary embolism
    Hirokazu Ohigashi
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Int Heart J 51:416-20. 2010
    ..1 versus 91.1 pg/mL, P = 0.02). Plasma BNP at admission is not only a reliable marker of RVD and predictor of short-term prognosis, but also a predictor of long-term respiratory prognosis in acute PE patients...
  79. ncbi request reprint Attenuation of experimental autoimmune myocarditis by blocking activated T cells through inducible costimulatory molecule pathway
    Hideki Futamatsu
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cardiovasc Res 59:95-104. 2003
    ..Inducible costimulator (ICOS) is a member of the CD28 family. Although inflammation is an essential pathological feature of myocarditis, the role of ICOS in myocarditis remains unclear...
  80. ncbi request reprint Synergistic effect of combined HMG-CoA reductase inhibitor and angiotensin-II receptor blocker therapy in patients with chronic heart failure: the HF-COSTAR trial
    Yasuhiro Maejima
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Circ J 75:589-95. 2011
    ..We hypothesized that statins might alter the effect of ARBs on cardiac function in patients with HF...
  81. ncbi request reprint Novel ECG predictor of difficult cases of outflow tract ventricular tachycardia: peak deflection index on an inferior lead
    Hitoshi Hachiya
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ J 74:256-61. 2010
    ..An ECG predictor of ablation success has not been determined for difficult cases of outflow tract ventricular tachycardia/ventricular premature contractions (OT-VT/VPC)...
  82. ncbi request reprint Utility of gallium-67 scintigraphy for evaluation of cardiac sarcoidosis with ventricular tachycardia
    Hideki Futamatsu
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, 113 8519, Japan
    Int J Cardiovasc Imaging 22:443-8. 2006
    ..However, there is no established method for potential VT in patients with cardiac sarcoidosis. Thus, we investigated the utility of evaluation of gallium-67 scintigraphy for potential VT in patients with cardiac sarcoidosis...
  83. doi request reprint Clinical characteristics of acute decompensated heart failure with rapid onset of symptoms
    Masanori Konishi
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Card Fail 15:300-4. 2009
    ..The clinical characteristics of 194 consecutive ADHF patients with abrupt onset of symptoms were investigated...
  84. ncbi request reprint Successful radiofrequency ablation of ventricular premature contractions within the coronary sinus
    Yasuteru Yamauchi
    Division of Cardiology, Musashino Red Cross Hospital, Tokyo, Japan
    Pacing Clin Electrophysiol 28:1250-2. 2005
    ..Detailed pace-mapping using a high output pacing stimulator was utilized to successfully ablate VPCs within the coronary sinus...
  85. ncbi request reprint Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage
    Yasuhiro Maejima
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Aging Cell 7:125-36. 2008
    ..promyelocytic leukemia-related p53 acetylation may be an underlying mechanism of senescence-like alterations in cardiomyocytes. These findings indicate a novel mechanism of myocardial dysfunction induced by oxidative stress...
  86. ncbi request reprint Induction of immunologic tolerance to cardiac allograft by simultaneous blockade of inducible co-stimulator and cytotoxic T-lymphocyte antigen 4 pathway
    Hisanori Kosuge
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
    Transplantation 75:1374-9. 2003
    ..To investigate the role of ICOS in allograft rejection, the authors studied graft survival after cardiac transplantation in mice...
  87. ncbi request reprint Long-term efficacy of hybrid pharmacologic and ablation therapy in patients with pilsicainide-induced atrial flutter
    Kenzo Hirao
    Department of Cardiovascular Medicine, School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Cardiol 28:338-42. 2005
    ..With respect to choosing this method among the rhythm control therapies, its long-term efficacy and the prevalence of AFL in patients with AF are very important and have not been fully elucidated...
  88. doi request reprint Role of oral amiodarone in patients with atrial fibrillation and congestive heart failure
    Mihoko Kawabata
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan mihoko
    J Cardiol 58:108-15. 2011
    ..It is also recommended for controlling AF in patients with congestive heart failure (CHF). We retrospectively examined the efficacy and safety of oral amiodarone in patients with AF and CHF...
  89. doi request reprint Torsades de pointes related to transient marked QT prolongation following successful emergent percutaneous coronary intervention for acute coronary syndrome
    Mihoko Kawabata
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Electrocardiol 41:117-22. 2008
    ....
  90. ncbi request reprint Electrocardiographic characteristics of repetitive monomorphic right ventricular tachycardia originating near the His-bundle
    Yasuteru Yamauchi
    Division of Cardiology, Musashino Red Cross Hospital, Tokyo, Japan
    J Cardiovasc Electrophysiol 16:1041-8. 2005
    ..The aim of this study was to investigate ECG characteristics of VT/VPCs originating near the His-bundle in comparison with right ventricular outflow tract (RVOT)-VT/VPCs...
  91. ncbi request reprint Anti-vascular cell adhesion molecule-1 and anti-very late antigen-4 monoclonal antibodies inhibit neointimal hyperplasia in the murine model of arterial injury
    Jun ichi Suzuki
    Department of Cardiovascular Medicine, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Acta Cardiol 59:147-52. 2004
    ..Adhesion of vascular cell adhesion molecule (VCAM)-1 and its ligand very late antigen (VLA)-4 plays an important role in neointimal formation after vascular injury...
  92. ncbi request reprint Oxygen therapy prevents ventricular arrhythmias in patients with congestive heart failure and sleep apnea
    Jun ichi Suzuki
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University Graduate School of Medicine and Dentistry, Japan
    Circ J 70:1142-7. 2006
    ..The beneficial effects of oxygen treatment for ventricular arrhythmia have not yet been clarified, so the present study was designed to evaluate the effects of oxygen treatment for premature ventricular contraction (PVC)...
  93. ncbi request reprint Delayed thrombogenesis following radiofrequency catheter ablation
    Tetsuo Sasano
    Cardiovascular Department, Yokohama Red Cross Hospital, Japan
    Circ J 66:671-6. 2002
    ..The thrombogenesis caused by RF-CA has 2 phases; in the acute phase, there is hemostasis during placement of the catheters, and in the delayed phase thrombogenesis is the result of endothelial damage from the RF current...
  94. ncbi request reprint Dietary consumption of green tea catechins attenuate hyperlipidaemia-induced atherosclerosis and systemic organ damage in mice
    Jun ichi Suzuki
    Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Acta Cardiol 60:271-6. 2005
    ..The effects of consuming green tea catechins on the development of hyperlipidaemia-induced systemic organ damage have not been well studied; we investigated the effect using low density lipoprotein receptor knockout mice...
  95. ncbi request reprint Endothelial E-selectin potentiates neovascularization via endothelial progenitor cell-dependent and -independent mechanisms
    Yasunobu Nishiwaki
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 27:512-8. 2007
    ....
  96. ncbi request reprint Ultrasound-microbubble-mediated NF-kappaB decoy transfection attenuates neointimal formation after arterial injury in mice
    Hiroshi Inagaki
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Vasc Res 43:12-8. 2006
    ..Decoy transfection is a significant methodology for suppressing gene activation. The decoy can be synthesized easily; however, the major obstacle is the difficulty involved in effective in vivo delivery...
  97. ncbi request reprint Successful catheter ablation of focal left atrial tachycardia originating from the mitral annulus aorta junction
    Kiyoshi Otomo
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Int Heart J 47:461-8. 2006
    ..The MA-Ao junction should be recognized as an important arrhythmogenic region...
  98. ncbi request reprint Mechanism of the conversion of a pulmonary vein tachycardia to atrial fibrillation in normal canine hearts: role of autonomic nerve stimulation
    Tomoe Horikawa-Tanami
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Cardiovasc Electrophysiol 18:534-41. 2007
    ..The purpose of this study was to elucidate the mechanism of the conversion of a tachycardia within a PV into AF under autonomic stimulation and the termination mechanism of the AF in normal canine hearts...
  99. ncbi request reprint Anti-arrhythmic efficacy of nifekalant hydrochloride, a pure class III anti-arrhythmic agent, in patients with healed myocardial infarction and inducible sustained ventricular tachycardia
    Masayuki Igawa
    Department of Cardiology, Yokosuka Kyosai Hospital, Kanagawa, and Department of Cardiovascular Medicine, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Cardiovasc Pharmacol 40:735-42. 2002
    ..It was concluded that nifekalant could be used safely and showed comparable effectiveness to procainamide for the suppression of VT induction...
  100. ncbi request reprint P-selectin expression, but not GPIIb/IIIa activation, is enhanced in the inflammatory stage of Takayasu's arteritis
    Natsuko Kasuya
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ J 70:600-4. 2006
    ..To investigate the link between platelet activation and disease activity, flow cytometric analyses of platelet P-selectin and activated GPIIb/IIIa expression were performed in patients with TA...
  101. ncbi request reprint Poststenting axial redistribution of atherosclerotic plaque into the reference segments and lumen reduction at the stent edge: a volumetric intravascular ultrasound study
    Magdy Algowhary
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Int Heart J 47:159-71. 2006
    ..Although PSh correlated with the immediate reduction in stent edge lumen volume, it did not correlate with the late lumen reduction...