K Ishiwata

Summary

Affiliation: Tokyo Metropolitan Institute of Gerontology
Country: Japan

Publications

  1. ncbi request reprint Evaluation of [11C]SA5845 and [11C]SA4503 for imaging of sigma receptors in tumors by animal PET
    Kazunori Kawamura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Naka cho 1 1, Itabashi ku, Tokyo 173 0022, Japan
    Ann Nucl Med 19:701-9. 2005
  2. doi request reprint Development of PET radiopharmaceuticals and their clinical applications at the Positron Medical Center
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 10:S180-96. 2010
  3. ncbi request reprint Evaluation of O-[11C]methyl-L-tyrosine and O-[18F]fluoromethyl-L-tyrosine as tumor imaging tracers by PET
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, Tokyo 173 0022, Japan
    Nucl Med Biol 31:191-8. 2004
  4. ncbi request reprint Potential of an adenosine A2A receptor antagonist [11C]TMSX for myocardial imaging by positron emission tomography: a first human study
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 17:457-62. 2003
  5. ncbi request reprint Preclinical studies on [11C]TMSX for mapping adenosine A2A receptors by positron emission tomography
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 17:205-11. 2003
  6. ncbi request reprint Sigma1 and dopamine D2 receptor occupancy in the mouse brain after a single administration of haloperidol and two dopamine D2-like receptor ligands
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, Tokyo 173 0022, Japan
    Nucl Med Biol 30:429-34. 2003
  7. ncbi request reprint Age-related changes of the binding of [3h]SA4503 to sigma1 receptors in the rat brain
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 17:73-7. 2003
  8. ncbi request reprint Adenosine A2A receptor imaging with [11C]KF18446 PET in the rat brain after quinolinic acid lesion: comparison with the dopamine receptor imaging
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Japan
    Ann Nucl Med 16:467-75. 2002
  9. ncbi request reprint No reduction of dopamine transporter binding sites in mice following treatment with the TIQ analogue 1-benzyl-1,2,3,4-tetrahydroisoquinoline
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi, Tokyo 173 0022, Japan
    Brain Res 960:282-5. 2003
  10. ncbi request reprint Preclinical studies on [11C]MPDX for mapping adenosine A1 receptors by positron emission tomography
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 16:377-82. 2002

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Evaluation of [11C]SA5845 and [11C]SA4503 for imaging of sigma receptors in tumors by animal PET
    Kazunori Kawamura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Naka cho 1 1, Itabashi ku, Tokyo 173 0022, Japan
    Ann Nucl Med 19:701-9. 2005
    ..Therefore, [11C]SA5845 and [11C]SA4503 may be potential ligands for PET imaging of sigma receptor-rich tumors...
  2. doi request reprint Development of PET radiopharmaceuticals and their clinical applications at the Positron Medical Center
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 10:S180-96. 2010
    ..Positron emission tomography (PET) has been used to provide a highly advanced PET-based diagnosis. The current status of the development of radiopharmaceuticals, and representative clinical and methodological results are reviewed...
  3. ncbi request reprint Evaluation of O-[11C]methyl-L-tyrosine and O-[18F]fluoromethyl-L-tyrosine as tumor imaging tracers by PET
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, Tokyo 173 0022, Japan
    Nucl Med Biol 31:191-8. 2004
    ..O-[(11)C]methyl-L-tyrosine was metabolically stable, whereas a negligible low amount of metabolites was observed for O-[(18)F]fluoromethyl-L-tyrosine. Both tracers showed the potential for tumor imaging...
  4. ncbi request reprint Potential of an adenosine A2A receptor antagonist [11C]TMSX for myocardial imaging by positron emission tomography: a first human study
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 17:457-62. 2003
    ..Peripherally [11C]TMSX was very stable in human: >90% of the radioactivity in plasma was detected as the unchanged form in a 60-min study. We concluded that [11C]TMSX PET has the potential for myocardial imaging...
  5. ncbi request reprint Preclinical studies on [11C]TMSX for mapping adenosine A2A receptors by positron emission tomography
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 17:205-11. 2003
    ..We have concluded that [11C]TMSX is suitable for mapping adenosine A2A receptors in the human brain by PET...
  6. ncbi request reprint Sigma1 and dopamine D2 receptor occupancy in the mouse brain after a single administration of haloperidol and two dopamine D2-like receptor ligands
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, Tokyo 173 0022, Japan
    Nucl Med Biol 30:429-34. 2003
    ..Sigma(1) receptor occupancy by haloperidol was reduced to 19% at day 2 when D(2) receptor occupancy disappeared. [(11)C]SA4503 would be applicable to the investigation of sigma(1) receptor occupancy of antispychotic drugs using PET...
  7. ncbi request reprint Age-related changes of the binding of [3h]SA4503 to sigma1 receptors in the rat brain
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 17:73-7. 2003
    ....
  8. ncbi request reprint Adenosine A2A receptor imaging with [11C]KF18446 PET in the rat brain after quinolinic acid lesion: comparison with the dopamine receptor imaging
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Japan
    Ann Nucl Med 16:467-75. 2002
    ..We concluded that [11C]KF18446 PET can detect change in the adenosine A2A receptors in the rat model, and will provide a new diagnostic tool for characterizing post-synaptic striatopallidal neurons in the stratum...
  9. ncbi request reprint No reduction of dopamine transporter binding sites in mice following treatment with the TIQ analogue 1-benzyl-1,2,3,4-tetrahydroisoquinoline
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi, Tokyo 173 0022, Japan
    Brain Res 960:282-5. 2003
    ..p., twice per day for 10 days) induced a 14% decrease. These results indicate that 1-BnTIQ does not affect the density of DATs on dopaminergic neurons, and that it is not clear whether or not 2-methyl-TIQ is an active form of TIQ...
  10. ncbi request reprint Preclinical studies on [11C]MPDX for mapping adenosine A1 receptors by positron emission tomography
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 16:377-82. 2002
    ..The monkey brain was clearly visualized by PET with [11C]MPDX. We have concluded that [11C]MPDX is suitable for mapping adenosine A1 receptors in the human brain by PET...
  11. ncbi request reprint Evaluation of in vivo selective binding of [11C]doxepin to histamine H1 receptors in five animal species
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, Tokyo 173 0022, Japan
    Nucl Med Biol 31:493-502. 2004
    ..The specific binding evaluated with treatment with (+)-chlorpheniramine (H(1) antagonist) was in the range of 10-30% in mouse, rat, rabbit, and monkey, but was not detected in guinea pig...
  12. ncbi request reprint Potential of [11C]TMSX for the evaluation of adenosine A2A receptors in the skeletal muscle by positron emission tomography
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, Tokyo 173 0022, Japan
    Nucl Med Biol 31:949-56. 2004
    ..In a PET study of two subjects, theophylline-infusion slightly deceased the distribution volume of [11C]TMSX in the heart (20% reduction) and muscle (10% reduction), which suggested the specific binding...
  13. ncbi request reprint [Strategy for development of imaging biomarkers]
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute for Gerontology, 1 1 Naka cho, Itabashi ku, Tokyo, 173 0022 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:67-71. 2009
    ..Second PET studies are applied to patients with various disorders. In this manuscript, the author introduces experiences and concepts for development of radioligands for studying the central nervous system...
  14. doi request reprint Successive positron emission tomography measurement of cerebral blood flow and neuroreceptors in the human brain: an 11C-SA4503 study
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, Tokyo 173 0022, Japan
    Ann Nucl Med 22:411-6. 2008
    ....
  15. ncbi request reprint In vivo evaluation of P-glycoprotein modulation of 8 PET radioligands used clinically
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Nucl Med 48:81-7. 2007
    ..P-glycoprotein (P-gp) regulates the ability of endogenous and exogenous compounds to cross the blood-brain barrier. We investigated whether PET tracers used clinically for studying brain function are affected by P-gp...
  16. ncbi request reprint A feasibility study of [11C]SA4503-PET for evaluating sigmal receptor occupancy by neuroleptics: the binding of haloperidol to sigma1 and dopamine D2-like receptors
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 20:569-73. 2006
    ..We concluded that [11C]SA4503-PET can be used for evaluating the sigma1R occupancy rates by neuroleptics or other drugs...
  17. ncbi request reprint Tumor viability evaluation by positron emission tomography with [18F]FDG in the liver metastasis rat model
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 20:463-9. 2006
    ..The average TVI values increased with tumor growth and significantly correlated with the numbers of tumor nodules. The new concept may be useful for evaluating the tumor viability non-invasively and quantitatively by [18F]FDG-PET...
  18. ncbi request reprint Preclinical and clinical evaluation of O-[11C]methyl-L-tyrosine for tumor imaging by positron emission tomography
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0022, Japan
    Nucl Med Biol 32:253-62. 2005
    ..Finally, the brain tumor imaging was preliminarily demonstrated...
  19. ncbi request reprint Evaluation of (+)-p-[11C]methylvesamicol for mapping sigma1 receptors: a comparison with [11C]SA4503
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0022, Japan
    Nucl Med Biol 33:543-8. 2006
    ..On the other hand, the moderate affinity of [11C]SA4503 for VAChT is negligible in vivo...
  20. ncbi request reprint First visualization of adenosine A(2A) receptors in the human brain by positron emission tomography with [11C]TMSX
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Synapse 55:133-6. 2005
    ..The [11C]TMSX PET is of great interest for studying the pathophysiology of neurological and psychiatric disorders together with the [11C]raclopride PET for D2Rs evaluation and/or the [11C]MPDX PET for A1Rs evaluation...
  21. ncbi request reprint Positron emission tomography and ex vivo and in vitro autoradiography studies on dopamine D2-like receptor degeneration in the quinolinic acid-lesioned rat striatum: comparison of [11C]raclopride, [11C]nemonapride and [11C]N-methylspiperone
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, 172 0022, Tokyo, Japan
    Nucl Med Biol 29:307-16. 2002
    ..PET has the limited potential for evaluating the receptor degeneration in the present animal model...
  22. ncbi request reprint Effects of single and repeated administration of 1,2,3,4-tetrahydroisoquinoline analogs on the binding of [11C]raclopride to dopamine D2 receptors in the mouse brain
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Japan
    J Neural Transm 108:1111-25. 2001
    ..These findings suggest that TIQ analogs profoundly stimulated dopamine release which resulted in the competitive inhibition of the binding of [11C]raclopride to dopamine D2 receptors, but did not induce degeneration of the receptors...
  23. ncbi request reprint Comparison of three PET dopamine D2-like receptor ligands, [11C]raclopride, [11C]nemonapride and [11C]N-methylspiperone, in rats
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 13:161-7. 1999
    ..The striatal activity with [11C]NEM remained high and that with [11C]MSP gradually increased. [11C]RAC and [11C]MSP, but not [11C]NEM, showed a high accumulation in the periorbital region...
  24. ncbi request reprint Evaluation of iodinated and brominated [11C]styrylxanthine derivatives as in vivo radioligands mapping adenosine A2A receptor in the central nervous system
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 14:247-53. 2000
    ....
  25. ncbi request reprint Further characterization of a CNS adenosine A2a receptor ligand [11C]KF18446 with in vitro autoradiography and in vivo tissue uptake
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japa
    Ann Nucl Med 14:81-9. 2000
    ..We conclude that [11C]KF18446 is a promising adenosine A2a receptor ligand for PET study...
  26. ncbi request reprint Synthesis and preliminary evaluation of a carbon-11-labeled adenosine transporter blocker [(11)C]KF21562
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1, Naka cho, Itabashi, 173 0022, Tokyo, Japan
    Nucl Med Biol 28:281-5. 2001
    ..These results show that the compound is not a suitable PET ligand for mapping adenosine transporters...
  27. ncbi request reprint Myocardial adenosine A2a receptor imaging of rabbit by PET with [11C]KF17837
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 11:219-25. 1997
    ..The effect of weak antagonists caffeine and alloxazine or a xanthine type A1 antagonist KF15372 on the radioactivity level was small. It is concluded that PET with [11C]KF17837 can image myocardial adenosine A2a receptors...
  28. ncbi request reprint Metabolite analysis of [11C]flumazenil in human plasma: assessment as the standardized value for quantitative PET studies
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Japan
    Ann Nucl Med 12:55-9. 1998
    ....
  29. ncbi request reprint In vivo binding of [11C]nemonapride to sigma receptors in the cortex and cerebellum
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Japan
    Nucl Med Biol 26:627-31. 1999
    ..We concluded that [11C]NEM binds in vivo not only to dopamine D2-like receptors in the striatum but also to sigma receptors in other regions such as cortex and cerebellum...
  30. ncbi request reprint Synthesis and preliminary evaluation of [11C]NE-100 labeled in two different positions as a PET sigma receptor ligand
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Japan
    Nucl Med Biol 25:195-202. 1998
    ..These results show that [O-methyl-11C]NE-100 has limited potential as a PET ligand for mapping sigma 1 receptors in the peripheral organs and the CNS because of high nonspecific binding...
  31. ncbi request reprint An alternative synthesis of [11C]raclopride for routine use
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 13:195-7. 1999
    ..The reaction was reproducible and reliable...
  32. ncbi request reprint [11C]Raclopride binding was reduced in vivo by sigma(1) receptor ligand SA4503 in the mouse brain, while [11C]SA4503 binding was not by raclopride
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Nucl Med Biol 28:787-92. 2001
    ....
  33. ncbi request reprint Carbon-11 labeled ethionine and propionine as tumor detecting agents
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 11:115-22. 1997
    ..The development of 18F-fluoroalkyl derivatives of MET is of interest as the next step...
  34. ncbi request reprint Evaluation of neurotoxicity of TIQ and MPTP and of parkinsonism-preventing effect of 1-MeTIQ by in vivo measurement of pre-synaptic dopamine transporters and post-synaptic dopamine D(2) receptors in the mouse striatum
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neurochem 79:868-76. 2001
    ..We concluded that the TIQ-induced parkinsonism model is different from the MPTP-induced model as evaluated by the radioligand-DATs binding and that (S)-1-MeTIQ has a preventing effect for the degeneration of the DATs to a certain extent...
  35. ncbi request reprint Quantitative ex vivo and in vitro receptor autoradiography using 11C-labeled ligands and an imaging plate: a study with a dopamine D2-like receptor ligand [11C]nemonapride
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Nucl Med Biol 26:291-6. 1999
    ..The injection dose of 11C-tracers for ex vivo ARG was also discussed. We found saturable binding sites of [11C]nemonapride in the cortex besides the striatum both ex vivo and in vitro...
  36. ncbi request reprint Effects of reserpine treatment on the dopamine receptor binding of [3H/11C]nemonapride in the mouse and rat brain
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 11:21-6. 1997
    ..The results suggest that the receptor binding of NEM was not significantly influenced by reserpine-induced depletion of endogenous dopamine probably because of its high affinity for the receptors...
  37. ncbi request reprint Search for PET probes for imaging the globus pallidus studied with rat brain ex vivo autoradiography
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Japan
    Ann Nucl Med 14:461-6. 2000
    ..The metabolic activity of the globus pallidus could then be measured by PET with [18F]FDG, and [11C]KF18446 may be a candidate tracer for imaging the pallidal terminals projecting from the striatum...
  38. ncbi request reprint Neuroreceptor bindings and synaptic activity in visual system of monocularly enucleated rat
    M Kiyosawa
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduate School, Tokyo, Japan
    Jpn J Ophthalmol 45:264-9. 2001
    ....
  39. ncbi request reprint Preclinical evaluation of [11C]SA4503: radiation dosimetry, in vivo selectivity and PET imaging of sigma1 receptors in the cat brain
    K Kawamura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Japan
    Ann Nucl Med 14:285-92. 2000
    ..We have concluded that [11C]SA4503 has the potential for mapping sigma1 receptor by PET...
  40. ncbi request reprint A stereotaxic method of anatomical localization by means of H(2)15O positron emission tomography applicable to the brain activation study in cats: registration of images of cerebral blood flow to brain atlas
    Y Sakiyama
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 11:315-9. 1997
    ..There were precise regional correlations between the PET image and anatomy in a PET activation study of the cat by means of stereotaxic image reorientation...
  41. doi request reprint Comparison of regional lower limb glucose metabolism in older adults during walking
    H Shimada
    Research Team for Promoting Independence of the Elderly, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Scand J Med Sci Sports 19:389-97. 2009
    ..These results suggest that intervention to facilitate efficient muscle activity during walking should be practiced to improve gait endurance in older adults with impaired walking patterns...
  42. doi request reprint Decreased dopamine D receptor binding in essential blepharospasm
    C Horie
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Acta Neurol Scand 119:49-54. 2009
    ..The purpose of this study was to investigate whether dopamine D(2) receptor binding was altered in the striatum of essential blepharospasm patients...
  43. ncbi request reprint Synthesis and evaluation of vesamicol analog (-)-O-[11C]methylvesamicol as a PET ligand for vesicular acetylcholine transporter
    Kazunori Kawamura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 20:417-24. 2006
    ..Therefore, (-)-[11C]OMV-PET together with help of [11C]SA4503-PET may evaluate VAChTs...
  44. ncbi request reprint Synthesis and evaluation of fluorine-18-labeled SA4503 as a selective sigma1 receptor ligand for positron emission tomography
    Kazunori Kawamura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo 173 0022, Japan
    Nucl Med Biol 34:571-7. 2007
    ..18)F]FM-SA4503 showed specific binding to sigma(1) receptors in mice and monkeys; therefore, [(18)F]FM-SA4503 has the potential for mapping sigma(1) receptors in the brain...
  45. ncbi request reprint Auditory triggered mental imagery of shape involves visual association areas in early blind humans
    A G de Volder
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Neuroimage 14:129-39. 2001
    ..Since shape imagery by early blind subjects does involve similar visual structures as controls at an adult age, it indicates their developmental crossmodal reorganization to allow perceptual representation in the absence of vision...
  46. ncbi request reprint Visualization of sigma1 receptors in eyes by ex vivo autoradiography and in vivo positron emission tomography
    Wei Fang Wang
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Exp Eye Res 75:723-30. 2002
    ..In conclusion, the iris-ciliary body and retina are rich in sigma(1) receptors, and PET may be used to investigate the in vivo distribution of these neuroreceptors in the eye...
  47. doi request reprint Shortened protocol in practical [11C]SA4503-PET studies for sigma1 receptor quantification
    Muneyuki Sakata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Ann Nucl Med 22:143-6. 2008
    ..In conclusion, if approximately 10% differences in the estimated results are acceptable for a specific purpose, then a 60-min measurement protocol is capable of providing reliable results...
  48. ncbi request reprint Investigation of the use of positron emission tomography for neuroreceptor imaging in rabbit eyes
    Wei Fang Wang
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ophthalmic Res 36:255-63. 2004
    ..However, the PET signal in the eyes was unexpectedly higher than the autoradiography signal. The identification of radioligand-neuroreceptor binding by PET in the rabbit eyes is not specific enough...
  49. ncbi request reprint Adenosine A1 and benzodiazepine receptors and glucose metabolism in the visual structures of rats monocularly deprived by enucleation or eyelid suture at a sensitive period
    Wei Fang Wang
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    Jpn J Ophthalmol 47:182-90. 2003
    ..To determine the changes in the adenosine A(1) and benzodiazepine receptor density and in glucose metabolism in the visual centers of the rat brain following monocular enucleation or eyelid suture on postnatal day 10 (PN10)...
  50. doi request reprint Regional analysis of age-related decline in dopamine transporters and dopamine D2-like receptors in human striatum
    Kenji Ishibashi
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0022, Japan
    Synapse 63:282-90. 2009
    ..The purpose of this study was to evaluate the mechanisms of age-related decline of dopamine transporter (DAT) and dopamine D(2)-like receptor (D2R) densities in the human striatum by focusing on regional difference...
  51. doi request reprint Low density of sigma1 receptors in early Alzheimer's disease
    Masahiro Mishina
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Ann Nucl Med 22:151-6. 2008
    ..However, in vivo imaging of sigma(1) receptors in the brain of AD patients has not been reported. The aim of this study is to investigate the mapping of sigma(1) receptors in AD using [(11)C]SA4503 positron emission tomography (PET)...
  52. doi request reprint Glucose hypermetabolism in the thalamus of patients with drug-induced blepharospasm
    Y Suzuki
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduate School, Tokyo, Japan Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan All Japan Federation of Social Insurance Associations Mishima Hospital, Mishima, Japan Electronic address
    Neuroscience 263:240-9. 2014
    ..We suggest that the functional brain alteration in drug-induced blepharospasm patients is similar to that in EB patients, and that alteration of the GABAergic system might be related to the pathology of both blepharospasm types. ..
  53. ncbi request reprint Enzymatic synthesis of no-carrier-added 6-[18F]fluoro-L-dopa with beta-tyrosinase
    S Kaneko
    Positon Medical Center, Tokyo Metropolitan Institute of Gerontology, Naka cho Itabashi, Japan
    Appl Radiat Isot 50:1025-32. 1999
    ..0% based on [18F]F- (decay-corrected). The synthesis time was 150 min from the EOB and the specific activity was > 200 GBq/micromol...
  54. doi request reprint Presynaptic and postsynaptic nigrostriatal dopaminergic functions in multiple system atrophy
    Masaya Hashimoto
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Neuroreport 19:145-50. 2008
    ....
  55. ncbi request reprint Imaging of adenosine A1 receptors in the human brain by positron emission tomography with [11C]MPDX
    Nobuyoshi Fukumitsu
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan
    Ann Nucl Med 17:511-5. 2003
    ..The [11C]MPDX PET has the potential for mapping adenosine A1 receptors in the human brain...
  56. doi request reprint Competition between 11C-raclopride and endogenous dopamine in Parkinson's disease
    Kenji Ishibashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Nucl Med Commun 31:159-66. 2010
    ..The aim of this study was to understand whether the increase in 11C-raclopride binding in the striatum of patients with Parkinson's disease (PD) is associated with the depletion of endogenous dopamine...
  57. ncbi request reprint Adenosine A1 receptor mapping of the human brain by PET with 8-dicyclopropylmethyl-1-11C-methyl-3-propylxanthine
    Nobuyoshi Fukumitsu
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Nucl Med 46:32-7. 2005
    ..In this study, we quantitatively evaluated the distribution of a major subtype A(1) adenosine receptor in the human brain by PET with a newly developed radioligand, 8-dicyclopropylmethyl-1-(11)C-methyl-3-propylxanthine ((11)C-MPDX)...
  58. ncbi request reprint Functional and neuroreceptor imaging of the brain in bicuculline-induced dystonic rats
    - QingGeLeTu
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    Tohoku J Exp Med 217:313-20. 2009
    ..In conclusion, we have succeeded in generating a rat model of dystonia, and observed the activation of the basal ganglia-thalamo-cortical motor circuit that is related to dystonia...
  59. ncbi request reprint Quantification of adenosine A2A receptors in the human brain using [11C]TMSX and positron emission tomography
    Mika Naganawa
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1, Naka, Itabashi, Tokyo, 173 0022, Japan
    Eur J Nucl Med Mol Imaging 34:679-87. 2007
    ..We also studied the applicability of a simplified Logan plot by omitting metabolite correction and arterial blood sampling...
  60. ncbi request reprint MAP-based kinetic analysis for voxel-by-voxel compartment model estimation: detailed imaging of the cerebral glucose metabolism using FDG
    Yuichi Kimura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1, Naka, Itabashi, Tokyo 173 0022, Japan
    Neuroimage 29:1203-11. 2006
    ..The parametric images exhibited an acceptable linear relation with the simulations and the ROI-based results, and the calculation time took about 10 min. We therefore concluded that our proposed MAP-based algorithm is practical...
  61. ncbi request reprint Quantitative analysis of adenosine A1 receptors in human brain using positron emission tomography and [1-methyl-11C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine
    Yuichi Kimura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo 173 0022, Japan
    Nucl Med Biol 31:975-81. 2004
    ..The image of the binding potential of the MPDX is physiologically reasonable. We conclude that MPDX is applicable to the visualization of the A1Rs in the brain with Logan plot...
  62. ncbi request reprint Mapping adenosine A(1) receptors in the cat brain by positron emission tomography with [(11)C]MPDX
    Yuhei Shimada
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, Tokyo 172 0022, Tokyo, Japan
    Nucl Med Biol 29:29-37. 2002
    ..The regional A(1) receptor distribution evaluated with kinetic analysis is consistent with that previously measured in vitro. [(11)C]MPDX PET has a potential for mapping adenosine A(1) receptors in brain...
  63. ncbi request reprint PET imaging of adenosine A(1) receptors with (11)C-MPDX as an indicator of severe cerebral ischemic insult
    Tadashi Nariai
    Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan
    J Nucl Med 44:1839-44. 2003
    ....
  64. doi request reprint Preclinical and the first clinical studies on [11C]CHIBA-1001 for mapping alpha7 nicotinic receptors by positron emission tomography
    Jun Toyohara
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo, 173 0015, Japan
    Ann Nucl Med 23:301-9. 2009
    ..In this study, we performed preclinical and first clinical PET studies using [(11)C]CHIBA-1001 for imaging alpha7 nAChRs in the human brain...
  65. ncbi request reprint Glucose hypermetabolism in the thalamus of patients with essential blepharospasm
    Yukihisa Suzuki
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
    J Neurol 254:890-6. 2007
    ..Hyperactivity in the thalamus may be a key pathophysiological change common to EB and other types of focal dystonia. The activity of the striatum and cerebellum are likely to be sensory dependent...
  66. doi request reprint Expanding the clinical phenotype of SNCA duplication carriers
    Kenya Nishioka
    Department of Neurology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Mov Disord 24:1811-9. 2009
    ..Further studies of SNCA duplication carriers will help identify disease-modifiers and may open novel avenues for future treatment...
  67. ncbi request reprint Improved synthesis of [11C]SA4503, [11C]MPDX and [11C]TMSX by use of [11C]methyl triflate
    Kazunori Kawamura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Ann Nucl Med 18:165-8. 2004
    ..Here we demonstrate the improved syntheses of these compounds by use of [11C]methyl triflate, a highly reactive alternative to [11C]methyl iodide...
  68. ncbi request reprint Comparison of 18F-fluoromethylcholine and 2-deoxy-D-glucose in the distribution of tumor and inflammation
    Kazuo Kubota
    Division of Nuclear Medicine, Department of Radiology, International Medical Center of Japan, Tokyo, Japan
    Ann Nucl Med 20:527-33. 2006
    ..The distribution characteristics of 18F-fluoromethylcholine (18F-choline) in tumor and inflammatory tissue were compared with those of 14C or 3H-2-deoxyglucose (2DG) as a substitute for fluorodeoxyglucose (FDG)...
  69. ncbi request reprint An increase of sigma receptors in the aged monkey brain
    Kazunori Kawamura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 173 0022, Tokyo, Japan
    Neurobiol Aging 24:745-52. 2003
    ..We concluded that the sigma(1) receptor binding sites increased in the aging process of the monkey brain...
  70. ncbi request reprint Age-related changes of the [11C]CFT binding to the striatal dopamine transporters in the Fischer 344 rats: a PET study
    Kazunori Kawamura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Japan
    Ann Nucl Med 17:249-53. 2003
    ..The PET finding was not necessarily coincident with the result investigated in vitro previously. Therefore, careful interpretation is necessary for PET studies using [11C]CFT and small animals such as rats...
  71. doi request reprint Effects of a robotic walking exercise on walking performance in community-dwelling elderly adults
    Hiroyuki Shimada
    Research Team for Promoting Independence of the Elderly, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Geriatr Gerontol Int 9:372-81. 2009
    ..Our aim was to quantify the effects of a walking exercise with the SAS on walking performance and glucose metabolism during walking in community-dwelling elderly adults...
  72. ncbi request reprint Imaging of sigma1 receptors in the human brain using PET and [11C]SA4503
    Jun Toyohara
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1, Naka, Itabashi, Tokyo, 173 0022, Japan
    Cent Nerv Syst Agents Med Chem 9:190-6. 2009
    ..11)C]SA4503-PET is useful for studying the pathophysiology of neurological and psychiatric disorders such as schizophrenia and for evaluation of the pharmacodynamics of psychiatric drugs...
  73. ncbi request reprint Demonstration of competition between endogenous dopamine and [11C]raclopride binding in in vitro brain slices using a dynamic autoradiography technique
    Toru Sasaki
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0022, Japan
    Synapse 44:42-50. 2002
    ..These results provide supportive evidence for in vivo binding competition between radioligand and endogenous neurotransmitter...
  74. ncbi request reprint Synthesis and evaluation of 11C- and 18F-labeled 1-[2-(4-alkoxy-3-methoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazines as sigma receptor ligands for positron emission tomography studies
    Kazunori Kawamura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Nucl Med Biol 30:273-84. 2003
    ..All radioligands showed the receptor-specific binding in the brain, and visualized similar regional brain distributions by ex vivo autoradiography. The [(11)C]ethoxy analogs were relatively labile for metabolism...
  75. doi request reprint A statistical clustering approach to visualizing the relationship between early and delayed images in whole-body FDG-PET
    Keiichi Oda
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Radiol Phys Technol 2:145-50. 2009
    ..The S3 areas showed benignity or physiologic accumulation. The segmented images, S1, S2, and S3, were useful for clinical diagnosis with dual-phase FDG-PET scans and offer an easy way of exploring the longitudinal alteration in the SUV...
  76. ncbi request reprint Different brain kinetics of two sigma 1 receptor ligands, [3H](+)-pentazocine and [11C]SA4503, by P-glycoprotein modulation
    Kazunori Kawamura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0022, Japan
    Synapse 48:80-6. 2003
    ..We concluded that the P-glycoprotein modulation resulted in the different brain kinetics of the two radioligands. The radiolabeled SA4503 is suitable as an in vivo probe, but radiolabeled (+)-pentazocine is not...
  77. doi request reprint Influence of mild hyperglycemia on cerebral FDG distribution patterns calculated by statistical parametric mapping
    Keiichi Kawasaki
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, Tokyo, Japan
    Ann Nucl Med 22:191-200. 2008
    ..The objective of this study was to investigate the influence of mild hyperglycemia (plasma glucose range 110-160 mg/dl) on the cerebral FDG distribution patterns calculated by statistical parametric mapping (SPM)...
  78. ncbi request reprint Meningio-angiomatosis in a patient with focal epilepsy: value of PET in diagnoses and preoperative planning of surgery
    Y Ohta
    Department of Neurosurgery, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Acta Neurochir (Wien) 145:587-90; discussion 590-1. 2003
    ..In addition, we presented our protocol of functional neuro-imaging which was useful in terms of the functional neurosurgery...
  79. doi request reprint Effects of an automated stride assistance system on walking parameters and muscular glucose metabolism in elderly adults
    H Shimada
    Research Team for Promoting Independence of the Elderly, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashiku Tokyo 173 015, Japan
    Br J Sports Med 42:922-9. 2008
    ..To identify the effects of an automated stride assistance system (SAS) on walking scores and muscle activities in the lower extremities of elderly people...
  80. ncbi request reprint A case of hemiparkinsonism following ischemic lesion of the contralateral substantia nigra: a PET study
    S Orimo
    Department of Neurology, Kanto Central Hospital, Kami yoga, Tokyo, Japan
    Eur Neurol 51:175-7. 2004
  81. doi request reprint Voxel- and ROI-based statistical analyses of PET parameters for guidance in the surgical treatment of intractable mesial temporal lobe epilepsy
    Yoshihisa Ohta
    Department of Neurosurgery, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Ann Nucl Med 22:495-503. 2008
    ..We compared predictive values obtained from two methods: a voxel-based statistical analysis using statistical parametric mapping (SPM) and an asymmetry index obtained by placing regions of interest (ROIs) on PET images...
  82. ncbi request reprint Aortic wall inflammation due to Takayasu arteritis imaged with 18F-FDG PET coregistered with enhanced CT
    Yasushi Kobayashi
    Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Nucl Med 46:917-22. 2005
    ..The value of using (18)F-FDG PET coregistered with enhanced CT in determining vascular lesion sites and inflammatory activity was assessed...
  83. ncbi request reprint Quantitative in vivo measurement of central benzodiazepine receptors in the brain of cats by use of positron-emission tomography and [11C]flumazenil
    Yuhei Shimada
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, Tokyo 172 0022, Japan
    Am J Vet Res 64:999-1002. 2003
    ..To map central benzodiazepine receptors (BZRs) in the brain of cats by use of positron-emission tomography (PET) and [11C]flumazenil...
  84. ncbi request reprint [Three-dimensional projection display of striatum dopamine function measured by PET]
    Keiichi Oda
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology
    Nihon Hoshasen Gijutsu Gakkai Zasshi 58:1573-8. 2002
    ....
  85. ncbi request reprint Imaging of somatotopic representation of sensory cortex with intrinsic optical signals as guides for brain tumor surgery
    Tadashi Nariai
    Department of Neurosurgery and Physiology, Tokyo Medical and Dental University, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neurosurg 103:414-23. 2005
    ..In the present study, the authors report on the use of this technique as an intraoperative guide for the safe resection of tumors adjacent to or within the sensorimotor cortex...
  86. ncbi request reprint Usefulness of L-[methyl-11C] methionine-positron emission tomography as a biological monitoring tool in the treatment of glioma
    Tadashi Nariai
    Department of Neurosurgery, Tokyo Medical and Dental University, Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Neurosurg 103:498-507. 2005
    ....
  87. doi request reprint Photophobia in essential blepharospasm--a positron emission tomographic study
    Hirofumi Emoto
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Mov Disord 25:433-9. 2010
    ..Either hyperactivity of the thalamus or hypoactivity of the superior colliculus, or both may be associated with excessive blinking in these patients...
  88. doi request reprint Validation of cardiac (123)I-MIBG scintigraphy in patients with Parkinson's disease who were diagnosed with dopamine PET
    Kenji Ishibashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Nucl Med Mol Imaging 37:3-11. 2010
    ..The diagnosis was confirmed by positron emission tomography (PET) imaging with (11)C-labelled 2beta-carbomethoxy-3beta-(4-fluorophenyl)-tropane ((11)C-CFT) and (11)C-raclopride (together designated as dopamine PET)...
  89. doi request reprint PET pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma
    Tadashi Nariai
    Department of Neurosurgery, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Appl Radiat Isot 67:S348-50. 2009
    ..We report a positron emission tomography (PET) imaging method to estimate T/N ratio of tissue boron concentration based on pharmacokinetic analysis of amino acid probes...
  90. ncbi request reprint In vivo assessment of adenoviral vector-mediated gene expression of dopamine D(2) receptors in the rat striatum by positron emission tomography
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8550 Japan
    Synapse 43:195-200. 2002
    ..The results of the current study demonstrate that PET can be used for longitudinal in vivo assessment of D(2)R expression mediated by adenoviral vector in rat brain...
  91. ncbi request reprint Radiosynthesis and in vivo evaluation of 11C-labeled 1,5-diarylpyrazole derivatives for mapping cyclooxygenases
    Yoshihiko Fujisaki
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Ann Nucl Med 19:617-25. 2005
    ..The results suggest that neither [11C]1 nor [11C]2 is a suitable radioligand for in vivo biomarkers of COX enzymes, mainly because of marked non-specific binding...
  92. ncbi request reprint Radiosynthesis and biodistribution in mice of a 18F-labeled analog of O-1302 for use in cerebral CB1 cannabinoid receptor imaging
    Yumiko Nojiri
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Biol Pharm Bull 31:1274-8. 2008
    ..Radioligand [18F]1 does not have the required properties for imaging the cerebral cannabinoid CB1 receptor in vivo...
  93. ncbi request reprint Synthesis and evaluation of 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-[11C]ethyl-1,3-dihydro-2H-benzimidazol-2-one as a brain ORL1 receptor imaging agent for positron emission tomography
    Mikako Ogawa
    Department of Biofunctional Research, National Institute for Longevity Sciences, Obu 474 8522, Japan
    Nucl Med Biol 30:51-9. 2003
    ..Therefore, [(11)C]CPEB is not a suitable tracer for in vivo ORL1 receptor imaging...
  94. ncbi request reprint Synthesis and evaluation of (11)C-labeled (S)-N-[[1-(2-phenylethyl) pyrrolidin-2-yl]methyl]-3-methylthiobenzamide as a PET 5-HT(1A) receptor ligand
    Masakazu Fujio
    Mitsubishi Pharma Corporation, 7 25, Koyata 3 Chome, Iruma, Saitama, 358 0026, Japan
    Nucl Med Biol 29:657-63. 2002
    ..Uptake of [(11)C](S)-PPMMB was not reduced by carrier-loading nor by pretreatment with 5-HT(1A) receptor ligands. [(11)C](S)-PPMMB is therefore not a suitable radioligand for mapping 5-HT(1A) receptors using positron emission tomography...
  95. ncbi request reprint Mapping of human cerebral sigma1 receptors using positron emission tomography and [11C]SA4503
    Muneyuki Sakata
    Graduate School of Information Science, Nara Institute of Science and Technology, Japan
    Neuroimage 35:1-8. 2007
    ..We concluded that this method enables the quantitative analysis of sigma1Rs in the human brain...
  96. ncbi request reprint Use of reference tissue models for quantification of histamine H1 receptors in human brain by using positron emission tomography and [11c]doxepin
    Atsuro Suzuki
    Department of Quantum Science and Energy Engineering, Tohoku University, Sendai, Japan
    Ann Nucl Med 19:425-33. 2005
    ..By including the results of noise analysis, LGAR became a reliable method for parameter estimation of [11C]doxepin data in the cortical regions...
  97. ncbi request reprint Greater adenosine A(2A) receptor densities in cardiac and skeletal muscle in endurance-trained men: a [11C]TMSX PET study
    Masaki Mizuno
    Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama 359 1192, Japan
    Nucl Med Biol 32:831-6. 2005
    ..7+/-0.3 vs. 1.2+/-0.2 ml g(-1), respectively). These results indicate that the densities of adenosine A(2A) receptors in the cardiac and skeletal muscles are greater in the endurance-trained men than in the untrained men...
  98. ncbi request reprint Extraction of a plasma time-activity curve from dynamic brain PET images based on independent component analysis
    Mika Naganawa
    Department of Information Processing, Graduate School of Information Science, Nara Institute of Science and Technology, Nara 630 0192, Japan
    IEEE Trans Biomed Eng 52:201-10. 2005
    ..These results demonstrated that EPICA is useful for extracting the pTAC from dynamic PET images without the necessity of serial arterial blood sampling...
  99. ncbi request reprint Synthesis and binding affinities of methylvesamicol analogs for the acetylcholine transporter and sigma receptor
    Kazuhiro Shiba
    Division of Tracer Kinetics, Advanced Science Research Center, Kanazawa University, Kanazawa, Japan
    Bioorg Med Chem 14:2620-6. 2006
    ....
  100. ncbi request reprint Simplified PET measurement for evaluating histamine H1 receptors in human brains using [11C]doxepin
    Hideki Mochizuki
    Department of Pharmacology, Tohoku University School of Medicine, Sendai 980 8575, Japan
    Nucl Med Biol 31:1005-11. 2004
    ..We found that the static 70- to 90-min images normalized using the plasma radioactivity at 10 min postinjection reflected the DV of [(11)C]DOX-H1R binding...
  101. ncbi request reprint PET tracers for imaging of the dopaminergic system
    Philip H Elsinga
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, The Netherlands
    Curr Med Chem 13:2139-53. 2006
    ..This paper gives an overview of the current status on dopamine PET-tracers and the development of new lead compounds as potential PET-tracers by medicinal chemistry...