Naoshi Ishikawa

Summary

Affiliation: Tokyo Metropolitan Institute of Gerontology
Country: Japan

Publications

  1. ncbi Telomere length dynamics in the human pituitary gland: robust preservation throughout adult life to centenarian age
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2 Itabashi ku, Tokyo, Japan
    Age (Dordr) 34:795-804. 2012
  2. ncbi Molecular evolution of nucleoside diphosphate kinase genes: conserved core structures and multiple-layered regulatory regions
    Naoshi Ishikawa
    Cellular Signaling Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    J Bioenerg Biomembr 35:7-18. 2003
  3. ncbi Accelerated in vivo epidermal telomere loss in Werner syndrome
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Aging (Albany NY) 3:417-29. 2011
  4. ncbi Changes of telomere length with aging
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 10:S197-206. 2010
  5. ncbi Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    J Pathol 221:201-9. 2010
  6. ncbi Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, 35 2, Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    Exp Gerontol 43:833-9. 2008
  7. ncbi Telomere lengths in the oral epithelia with and without carcinoma
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo 173 0015, Japan
    Eur J Cancer 46:430-8. 2010
  8. ncbi Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Mech Ageing Dev 131:614-24. 2010
  9. ncbi Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older
    Ken ichi Nakamura
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Exp Gerontol 42:944-50. 2007
  10. ncbi Alcoholics show reduced telomere length in the oesophagus
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Pathol 223:410-6. 2011

Collaborators

Detail Information

Publications16

  1. ncbi Telomere length dynamics in the human pituitary gland: robust preservation throughout adult life to centenarian age
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2 Itabashi ku, Tokyo, Japan
    Age (Dordr) 34:795-804. 2012
    ..These data indicate that innate telomere length is highly conserved in the pituitary and suggest that pituitary telomere length provides a good basic indicator for studies of telomere biology...
  2. ncbi Molecular evolution of nucleoside diphosphate kinase genes: conserved core structures and multiple-layered regulatory regions
    Naoshi Ishikawa
    Cellular Signaling Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    J Bioenerg Biomembr 35:7-18. 2003
    ..In terms of this process, the transcription system would control another layer of gene expression: posttranscriptional (translational) regulation...
  3. ncbi Accelerated in vivo epidermal telomere loss in Werner syndrome
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Aging (Albany NY) 3:417-29. 2011
    ....
  4. ncbi Changes of telomere length with aging
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 10:S197-206. 2010
    ..Our Q-FISH method using our original software program "Tissue Telo" is excellent for measuring telomere lengths using tissue sections and PNA probes...
  5. ncbi Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    J Pathol 221:201-9. 2010
    ..We have demonstrated conclusively that oesophageal CIS arises from epithelium with short telomeres and chromosomal instability in the absence of histological inflammation...
  6. ncbi Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, 35 2, Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    Exp Gerontol 43:833-9. 2008
    ..The reduction of telomere length with age and in each cell layer is consistent with the telomere biology theory of cell proliferation and differentiation in oral mucosa...
  7. ncbi Telomere lengths in the oral epithelia with and without carcinoma
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo 173 0015, Japan
    Eur J Cancer 46:430-8. 2010
    ..Thus we have conclusively demonstrated that CIS arises from epithelium with short telomeres...
  8. ncbi Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Mech Ageing Dev 131:614-24. 2010
    ..6%). Our results indicate that chromosomes having excessively shortened telomeres at late PDLs begin to show features of instability such as fusions and anaphase bridges...
  9. ncbi Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older
    Ken ichi Nakamura
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Exp Gerontol 42:944-50. 2007
    ..Our study lends indispensable support to the hypothesis that longer telomeres protect the genome from instability (a major cause of carcinogenesis) and are beneficial for longevity...
  10. ncbi Alcoholics show reduced telomere length in the oesophagus
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Pathol 223:410-6. 2011
    ..Further studies to clarify the reason for the large annual loss of telomere length with rapid turnover or lower telomerase activity in the oesophageal epithelium of alcoholics will be necessary...
  11. ncbi Accelerated in vivo epidermal telomere loss in Werner syndrome
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Aging (Albany NY) 3:417-29. 2011
    ....
  12. ncbi Nucleoside diphosphate kinases in mammalian signal transduction systems: recent development and perspective
    Narimichi Kimura
    Cellular Signaling Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    J Bioenerg Biomembr 35:41-7. 2003
    ..Consequently, we propose a hypothesis that NDP kinases might act like a molecular switch to determine the cell fate toward proliferation or differentiation in response to environmental signals...
  13. ncbi Short telomeres in an oral precancerous lesion: Q-FISH analysis of leukoplakia
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    J Oral Pathol Med 41:372-8. 2012
    ..Therefore, we consider OKD-type leukoplakia to be a true precancerous lesion...
  14. ncbi Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Hum Pathol 38:1192-200. 2007
    ....
  15. ncbi Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field
    Makoto Kammori
    Division of Breast and Endocrine Surgery, Department of Surgery, Nihon University School of Medicine, Tokyo 173 8610, Japan
    Int J Mol Med 20:793-9. 2007
    ..This study furthers our understanding of the mechanism by which telomere shortening and chromosomal instability lead to carcinogenesis and field cancerization in the esophagus...
  16. ncbi The teleost Oryzias latipes shows telomere shortening with age despite considerable telomerase activity throughout life
    Hitoshi Hatakeyama
    Laboratory of Comparative Cellular Biology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Mech Ageing Dev 129:550-7. 2008
    ....