Naoshi Ishikawa

Summary

Affiliation: Tokyo Metropolitan Institute of Gerontology
Country: Japan

Publications

  1. pmc Telomere length dynamics in the human pituitary gland: robust preservation throughout adult life to centenarian age
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2 Itabashi ku, Tokyo, Japan
    Age (Dordr) 34:795-804. 2012
  2. ncbi request reprint Molecular evolution of nucleoside diphosphate kinase genes: conserved core structures and multiple-layered regulatory regions
    Naoshi Ishikawa
    Cellular Signaling Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    J Bioenerg Biomembr 35:7-18. 2003
  3. pmc Accelerated in vivo epidermal telomere loss in Werner syndrome
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Aging (Albany NY) 3:417-29. 2011
  4. doi request reprint Changes of telomere length with aging
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 10:S197-206. 2010
  5. ncbi request reprint Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    J Pathol 221:201-9. 2010
  6. ncbi request reprint Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, 35 2, Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    Exp Gerontol 43:833-9. 2008
  7. pmc Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    PLoS ONE 8:e63860. 2013
  8. doi request reprint Telomere lengths in the oral epithelia with and without carcinoma
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo 173 0015, Japan
    Eur J Cancer 46:430-8. 2010
  9. pmc Association of telomere shortening in myocardium with heart weight gain and cause of death
    Masanori Terai
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Sci Rep 3:2401. 2013
  10. doi request reprint Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Mech Ageing Dev 131:614-24. 2010

Collaborators

Detail Information

Publications25

  1. pmc Telomere length dynamics in the human pituitary gland: robust preservation throughout adult life to centenarian age
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2 Itabashi ku, Tokyo, Japan
    Age (Dordr) 34:795-804. 2012
    ..These data indicate that innate telomere length is highly conserved in the pituitary and suggest that pituitary telomere length provides a good basic indicator for studies of telomere biology...
  2. ncbi request reprint Molecular evolution of nucleoside diphosphate kinase genes: conserved core structures and multiple-layered regulatory regions
    Naoshi Ishikawa
    Cellular Signaling Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    J Bioenerg Biomembr 35:7-18. 2003
    ..In terms of this process, the transcription system would control another layer of gene expression: posttranscriptional (translational) regulation...
  3. pmc Accelerated in vivo epidermal telomere loss in Werner syndrome
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Aging (Albany NY) 3:417-29. 2011
    ....
  4. doi request reprint Changes of telomere length with aging
    Kaiyo Takubo
    Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Geriatr Gerontol Int 10:S197-206. 2010
    ..Our Q-FISH method using our original software program "Tissue Telo" is excellent for measuring telomere lengths using tissue sections and PNA probes...
  5. ncbi request reprint Q-FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situ
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    J Pathol 221:201-9. 2010
    ..We have demonstrated conclusively that oesophageal CIS arises from epithelium with short telomeres and chromosomal instability in the absence of histological inflammation...
  6. ncbi request reprint Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, 35 2, Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    Exp Gerontol 43:833-9. 2008
    ..The reduction of telomere length with age and in each cell layer is consistent with the telomere biology theory of cell proliferation and differentiation in oral mucosa...
  7. pmc Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    PLoS ONE 8:e63860. 2013
    ..Telomere shortening may not generate cancer directly, but may create conditions under which SCC can develop more easily, depending on subsequent exposure to carcinogens...
  8. doi request reprint Telomere lengths in the oral epithelia with and without carcinoma
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo 173 0015, Japan
    Eur J Cancer 46:430-8. 2010
    ..Thus we have conclusively demonstrated that CIS arises from epithelium with short telomeres...
  9. pmc Association of telomere shortening in myocardium with heart weight gain and cause of death
    Masanori Terai
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Sci Rep 3:2401. 2013
    ..Here we show that telomeres in myocardial tissue become shortened with aging and heart disease, and that heart disease was associated with a gain of heart weight and telomere shortening in the myocardium. ..
  10. doi request reprint Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence
    Kaiyo Takubo
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    Mech Ageing Dev 131:614-24. 2010
    ..6%). Our results indicate that chromosomes having excessively shortened telomeres at late PDLs begin to show features of instability such as fusions and anaphase bridges...
  11. ncbi request reprint Investigation of telomere length dynamics in induced pluripotent stem cells using quantitative fluorescence in situ hybridization
    Masanori Terai
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan Department of Judotherapy, Faculty of Health Sciences, Tokyo Ariake University of Medical and Health Sciences, Tokyo 135 0063, Japan Electronic address
    Tissue Cell 45:407-13. 2013
    ....
  12. ncbi request reprint Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older
    Ken ichi Nakamura
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Exp Gerontol 42:944-50. 2007
    ..Our study lends indispensable support to the hypothesis that longer telomeres protect the genome from instability (a major cause of carcinogenesis) and are beneficial for longevity...
  13. ncbi request reprint Accelerated in vivo epidermal telomere loss in Werner syndrome
    Naoshi Ishikawa
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Aging (Albany NY) 3:417-29. 2011
    ....
  14. doi request reprint Alcoholics show reduced telomere length in the oesophagus
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Pathol 223:410-6. 2011
    ..Further studies to clarify the reason for the large annual loss of telomere length with rapid turnover or lower telomerase activity in the oesophageal epithelium of alcoholics will be necessary...
  15. ncbi request reprint Quantitative fluorescence in situ hybridization measurement of telomere length in skin with/without sun exposure or actinic keratosis
    Hiroyuki Ikeda
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan Department of Dermatology, Dokkyo Medical University, School of Medicine, Mibu, Tochigi 321 0293, Japan
    Hum Pathol 45:473-80. 2014
    ..Our findings demonstrate that sun exposure induces telomere shortening and that actinic keratosis arises from epidermis with shorter telomeres despite the absence of any histologic atypia. ..
  16. ncbi request reprint Short telomeres and chromosome instability prior to histologic malignant progression and cytogenetic aneuploidy in papillary urothelial neoplasms
    Naotaka Izumiyama-Shimomura
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Urol Oncol 32:135-45. 2014
    ..Evaluation of the relationships existing among 3 histologic types of urothelial tumors, chromosomal instability, and telomere length...
  17. pmc Q-FISH Measurement of Hepatocyte Telomere Lengths in Donor Liver and Graft after Pediatric Living-Donor Liver Transplantation: Donor Age Affects Telomere Length Sustainability
    Youichi Kawano
    Department of Surgery, Nippon Medical School, Tokyo, Japan Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    PLoS ONE 9:e93749. 2014
    ....
  18. doi request reprint Telomere lengths at birth in trisomies 18 and 21 measured by Q-FISH
    Ken ichi Nakamura
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan Electronic address
    Gene 533:199-207. 2014
    ..Therefore, it would be advisable for them to avoid lifestyle habits and characteristics such as obesity, cigarette smoking, chronic stress, and alcohol intake, which lead to marked telomere shortening. ..
  19. ncbi request reprint Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method
    Junko Aida
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Hum Pathol 38:1192-200. 2007
    ....
  20. ncbi request reprint Nucleoside diphosphate kinases in mammalian signal transduction systems: recent development and perspective
    Narimichi Kimura
    Cellular Signaling Research Group, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan
    J Bioenerg Biomembr 35:41-7. 2003
    ..Consequently, we propose a hypothesis that NDP kinases might act like a molecular switch to determine the cell fate toward proliferation or differentiation in response to environmental signals...
  21. ncbi request reprint Short telomeres in an oral precancerous lesion: Q-FISH analysis of leukoplakia
    Junko Aida
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo, Japan
    J Oral Pathol Med 41:372-8. 2012
    ..Therefore, we consider OKD-type leukoplakia to be a true precancerous lesion...
  22. ncbi request reprint β-Cell Telomere Attrition in Diabetes: Inverse Correlation Between HbA1c and Telomere Length
    Yoshiaki Tamura
    Departments of Diabetes, Metabolism, and Endocrinology Y T, Y K, Y C, S M, A A, H I and Pathology T Ar, Tokyo Metropolitan Geriatric Hospital, and Research Team for Geriatric Pathology and Department of Pathology N I S, K N, N I, J A, K T, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo 173 0015, Japan and Diabetes Center T Ai, Aizawa Hospital, Matsumoto, Nagano 390 8510, Japan
    J Clin Endocrinol Metab 99:2771-7. 2014
    ..Although accelerated β-cell telomere shortening may be associated with diabetes that shows a dramatically increased incidence with aging, β-cell telomere length in diabetes has never been explored...
  23. doi request reprint Maternal grafts protect daughter recipients from acute cellular rejection after pediatric living donor liver transplantation for biliary atresia
    Yukihiro Sanada
    Department of Transplant Surgery, Jichi Medical University, Shimotsuke City, Japan Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Transpl Int 27:383-90. 2014
    ..Our findings support the possibility that maternal antigens may have an important clinical impact on graft tolerance in LDLT for patients with BA...
  24. ncbi request reprint Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field
    Makoto Kammori
    Division of Breast and Endocrine Surgery, Department of Surgery, Nihon University School of Medicine, Tokyo 173 8610, Japan
    Int J Mol Med 20:793-9. 2007
    ..This study furthers our understanding of the mechanism by which telomere shortening and chromosomal instability lead to carcinogenesis and field cancerization in the esophagus...
  25. doi request reprint The teleost Oryzias latipes shows telomere shortening with age despite considerable telomerase activity throughout life
    Hitoshi Hatakeyama
    Laboratory of Comparative Cellular Biology, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Mech Ageing Dev 129:550-7. 2008
    ....