Research Topics

Gaku Ichihara


Affiliation: Tokyo University of Science
Country: Japan


  1. Zong C, Zhang X, Huang C, Chang J, Garner C, Sakurai T, et al. Role of cytochrome P450s in the male reproductive toxicity of 1-bromopropane. Toxicol Res (Camb). 2016;5:1522-1529 pubmed publisher
    ..The control of P450 activity reduced 1BP-induced male reproductive toxicities including spermiation failure, reduction of epididymal sperm count and motility, and formation of PAS-positive round structures at postspermiation stages. ..
  2. Vranic S, Shimada Y, Ichihara S, Kimata M, Wu W, Tanaka T, et al. Toxicological Evaluation of SiO₂ Nanoparticles by Zebrafish Embryo Toxicity Test. Int J Mol Sci. 2019;20: pubmed publisher
    ..These results indicate that zebrafish chorion acts as a physical barrier against SiO₂ NPs, and removing the chorions in ZFET might be necessary for evaluation of toxicity of NPs. ..
  3. Ichihara G, Amarnath V, Valentine H, Takeshita T, Morimoto K, Sobue T, et al. Pyrrole adducts in globin and plasma of workers exposed to hexane. Int Arch Occup Environ Health. 2019;: pubmed publisher
  4. Huang Z, Ichihara S, Oikawa S, Chang J, Zhang L, Hu S, et al. Hippocampal phosphoproteomics of F344 rats exposed to 1-bromopropane. Toxicol Appl Pharmacol. 2015;282:151-60 pubmed publisher
    ..Our results suggest that the pathogenesis of 1-BP-induced hippocampal damage involves inhibition of antiapoptosis process. Phosphoproteins identified in this study can potentially serve as biomarkers for 1-BP-induced neurotoxicity. ..
  5. Wu W, Ichihara G, Hashimoto N, Hasegawa Y, Hayashi Y, Tada Oikawa S, et al. Synergistic effect of bolus exposure to zinc oxide nanoparticles on bleomycin-induced secretion of pro-fibrotic cytokines without lasting fibrotic changes in murine lungs. Int J Mol Sci. 2014;16:660-76 pubmed publisher
    ..The present study demonstrated the synergistic effect of pulmonary exposure to ZnO nanoparticles and subcutaneous infusion of BLM on the secretion of pro-fibrotic cytokines in the lungs. ..
  6. Tada Oikawa S, Ichihara G, Fukatsu H, Shimanuki Y, Tanaka N, Watanabe E, et al. Titanium Dioxide Particle Type and Concentration Influence the Inflammatory Response in Caco-2 Cells. Int J Mol Sci. 2016;17:576 pubmed publisher
    ..Further studies are required to determine the in vivo relevance of these findings to avoid the hazards of ingested particles. ..
  7. Zong C, Garner C, Huang C, Zhang X, Zhang L, Chang J, et al. Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P450. Toxicol Lett. 2016;258:249-258 pubmed publisher
    ..The study suggests that further experiments with liver-specific control of P450 activity using gene technology might provide better murine models for 1-bromopropane-induced neurotoxicity. ..